孕妇对无创产前DNA检测的认知水平与社会因素分析
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摘要
了解孕妇对无创产前DNA检测的认知及在选择该技术时的影响因素。采用单中心随机问卷调查的方法,共发放问卷500份,收回有效问卷456份(91.2%)。结果显示对无创产前DNA检测真正熟悉的孕妇只有9.2%,不了解该技术孕妇占55.9%。选择该技术的孕妇与地区、受教育水平、经济条件有关。孕妇对该技术的认知水平较低,收到高风险检测报告时存在一定的困扰,甚至不接受诊断而直接终止妊娠。医务人员应加大检测前咨询,特别对农村、文化程度较低、家庭经济收入不高的孕妇,要告知NIPT技术应用、局限性、高风险处理等,减少孕妇心理压力,降低对社会的后续影响。
To explore the knowledge and attitudes of pregnant women to non-invasive prenatal DNA testing(NIPT)technology,as well as related factors in the choice of NIPT technology.A total of 500 questionnaires were provided for the pregnant women and 456(91.2%)of the valid questionnaires were collected.The results showed that only 9% of pregnant women who were known well with NIPT.Further analysis found that pregnant women who opted for NIPT technology may be related to the region,the level of education,and economic conditions.Cognitive level of pregnant women on the NIPT technology is low,and there is a certain distress when received the test report,or even terminate the pregnancy without undergoing fetal chromosome diagnosis using amniocentesis.Doctors should increase the consultation for pregnant women before NIPT technology,especially for rural areas,low level of education,and low family income of pregnant women.Doctors should inform NIPT technology applications,limitations,high-risk treatment to reduce the psychological pressure of pregnant women and reduce the impact to society.
To explore the knowledge and attitudes of pregnant women to non-invasive prenatal DNA testing(NIPT)technology,as well as related factors in the choice of NIPT technology.A total of 500 questionnaires were provided for the pregnant women and 456(91.2%)of the valid questionnaires were collected.The results showed that only 9% of pregnant women who were known well with NIPT.Further analysis found that pregnant women who opted for NIPT technology may be related to the region,the level of education,and economic conditions.Cognitive level of pregnant women on the NIPT technology is low,and there is a certain distress when received the test report,or even terminate the pregnancy without undergoing fetal chromosome diagnosis using amniocentesis.Doctors should increase the consultation for pregnant women before NIPT technology,especially for rural areas,low level of education,and low family income of pregnant women.Doctors should inform NIPT technology applications,limitations,high-risk treatment to reduce the psychological pressure of pregnant women and reduce the impact to society.
引文
[1]郑琳,吴忠琴.无创DNA检测在产前诊断胎儿染色体非整倍体疾病中的应用[J].中国优生与遗传杂志,2016,24(4):42-43.
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[12]冯暄,闫有圣,胡秀琴,等.2654例无创产前基因检测结果分析[J].检验医学与临床,2016,13(23):3283-3286.
[13]侯桂玉,郭跃文,蒋丽江,等.超声NT、血清学筛查与无创产前基因检测联合筛查高危孕妇胎儿染色体非整倍体580例分析[J].深圳中西医结合杂志,2016,26(10):21-23.
[14]吴美梅.无创产前基因检测在胎儿染色体非整倍体中的临床观察[J].中国妇幼保健,2016,31(21):4505-4506.
[2]杨洁霞,郭芳芳,彭海山,等.无创产前基因检测技术在胎儿染色体非整倍体筛查中的应用研究[J].中国产前诊断杂志(电子版),2016,8(3):31-34.
[3]肖葛根.无创产前DNA检测的文献分析:易忽略的伦理和社会问题[J].医学与哲学,2017,38(8B):79-83.
[4]AHMED S,JAFRI H,RASHID Y,et al.Attitudes towards non-invasive prenatal diagnosis among obstetricians in Pakistan,a developing,Islamic country[J].Prenat Diagn,2017,37(3):289-295.
[5]赖峥菲,王佳燕,陈敏,等.加强健康宣教对孕妇无创产前诊断认知率的影响[J].现代诊断与治疗,2015,26(13):3083-3084.
[6]MIKAMO S,NAKATSUKA M.Knowledge and Attitudes toward Non-invasive Prenatal Testing among Pregnant Japanese Women[J].Acta Med Okayama,2015,69(3):155-163.
[7]BRAJENOVIC′-MILIC′B,BABIC′I,RISTIC′S,et al.Pregnant women's attitudes toward amniocentesis before receiving Down syndrome screening results[J].Womens Health,2008,18(2):79-84.
[8]VAN SCHENDEL R V,PAGE-CHRISTIAENS G C,BEULEN L,et al.Trial by Dutch laboratories for evaluation of non-invasive prenatal testing.PartⅡ-women's perspectives[J].Prenat Diagn,2016,36(12):1091-1098.
[9]KOSEC V,ZEC I,TISLARIC′-MEDENJAK D,et al.Pregnant women's knowledge and attitudes to prenatal screening for fetal chromosomal abnormalities:Croatian multicentric survey[J].Coll Antropol,2013,37(2):483-489.
[10]DAHL K,HVIDMAN L,JRGENSEN F S,et al.First-trimester Down syndrome screening:pregnant women's knowledge[J].Ultrasound Obstet Gynecol,2011,38(2):145-151.
[11]高明雅,赵柏丽,王亚男.934例孕妇无创DNA产前检测结果分析[J].中国优生与遗传杂志,2016,24(11):36-38.
[12]冯暄,闫有圣,胡秀琴,等.2654例无创产前基因检测结果分析[J].检验医学与临床,2016,13(23):3283-3286.
[13]侯桂玉,郭跃文,蒋丽江,等.超声NT、血清学筛查与无创产前基因检测联合筛查高危孕妇胎儿染色体非整倍体580例分析[J].深圳中西医结合杂志,2016,26(10):21-23.
[14]吴美梅.无创产前基因检测在胎儿染色体非整倍体中的临床观察[J].中国妇幼保健,2016,31(21):4505-4506.