广西壮族自治区先天性甲状腺功能减低症筛查TSH切值在GSP分析仪上的设定
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摘要
目的建立广西壮族自治区地区新生儿先天性甲状腺功能减低症促甲状腺激素(TSH)筛查在全自动免疫荧光分析仪(GSP)上的切值。方法对已用1235全自动时间分辨荧光免疫分析仪检测的2 044例干血片进行GSP上的TSH检测,将数据进行分析,使用百分位数法和应试者操作特征曲线(ROC)研究在GSP上先天性甲状腺功能减低症筛查的TSH最佳切值点。结果百分位数法99%可信限位为32.4μIU/mL;ROC曲线法临界值为8.22μIU/mL。结论参考ROC曲线法,切值定在8.0μIU/mL。
Objective To establish the screening values for thyroid-stimulating hormone(TSH)screening on the automatic immunofluorescence analyzer(GSP)in newborns with congenital hypothyroidism in Guangxi.Methods Using 1235 automatic detection of time-resolved fluorescence immunoassay analyzer,2 044 cases of dried blood tablets were performed for TSH testing on GSP,the data was analyzed using the percentile method and the candidate operating characteristic curve(ROC)to study the optimal cut-off point for TSH screening for congenital hypothyroidism.Results The 99% confidence limit for the percentile method was32.4μIU/mL;the critical value for the ROC curve method was 8.22μIU/mL.Conclusion With reference to ROC curve method,the tangent value is 8.0μIU/mL.
Objective To establish the screening values for thyroid-stimulating hormone(TSH)screening on the automatic immunofluorescence analyzer(GSP)in newborns with congenital hypothyroidism in Guangxi.Methods Using 1235 automatic detection of time-resolved fluorescence immunoassay analyzer,2 044 cases of dried blood tablets were performed for TSH testing on GSP,the data was analyzed using the percentile method and the candidate operating characteristic curve(ROC)to study the optimal cut-off point for TSH screening for congenital hypothyroidism.Results The 99% confidence limit for the percentile method was32.4μIU/mL;the critical value for the ROC curve method was 8.22μIU/mL.Conclusion With reference to ROC curve method,the tangent value is 8.0μIU/mL.
引文
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[4]周婧瑶,欧明才,罗晓菊,等.四川省新生儿CH筛查切值的探讨[J].中国妇幼健康研究,2013,24(5):638-640.
[5]陈肖肖,秦玉峰,曲一平,等.新生儿先天性甲状腺功能减退症筛查中TSH切值的探讨[J].中华内分泌代谢杂志,2008,24(6):639-640.
[6]石祖亮,易松,刘旭,等.湖北省新生儿先天性甲状腺功能低下症TSH筛查切值的研究[J].中国优生与遗传杂志,2010,18(5):89-90.
[7]谢洁娜,张延玮,郭书邑.汕头市新生儿先天性甲状腺功能减低症TSH筛查切值的研究[J].国际检验医学杂志,2017,38(1):77-79.
[8]朱文斌,郑玉兰,王旌,等.新生儿甲低筛查TSH切值的讨论[J].中国妇幼保健,2009,24(4):503-504.
[9]王亚男,刘永,赵柏丽.洛阳地区79 829例新生儿先天性甲状腺功能低下症和苯丙酮尿症筛查结果分析[J].中国优生与遗传杂志,2017,25(1):96-97.
[10]牟凯,刘艳,刘继红,等.淄博地区先天性甲状腺功能减低症筛查中TSH切值在GSP上的研究[J].中国优生与遗传杂志,2017,25(4):98-99.
[11]钱家乐,陈少科,罗静思,等.广西壮族自治区2009-2011年先天性甲状腺功能减低症调查[J].中华流行病学杂志,2012,33(7):753-754.
[2]赵振东,王洁,温英梅,等.海南省新生儿疾病筛查TSH实验切值设定[J].中国妇幼保健,2012,27(36):6065-6066.
[3]范歆,陈少科,林彩娟,等.广西先天性甲状腺功能减退症新生儿筛查分析及切值的探讨[J].中国儿童保健杂志,2012,20(3):248-250.
[4]周婧瑶,欧明才,罗晓菊,等.四川省新生儿CH筛查切值的探讨[J].中国妇幼健康研究,2013,24(5):638-640.
[5]陈肖肖,秦玉峰,曲一平,等.新生儿先天性甲状腺功能减退症筛查中TSH切值的探讨[J].中华内分泌代谢杂志,2008,24(6):639-640.
[6]石祖亮,易松,刘旭,等.湖北省新生儿先天性甲状腺功能低下症TSH筛查切值的研究[J].中国优生与遗传杂志,2010,18(5):89-90.
[7]谢洁娜,张延玮,郭书邑.汕头市新生儿先天性甲状腺功能减低症TSH筛查切值的研究[J].国际检验医学杂志,2017,38(1):77-79.
[8]朱文斌,郑玉兰,王旌,等.新生儿甲低筛查TSH切值的讨论[J].中国妇幼保健,2009,24(4):503-504.
[9]王亚男,刘永,赵柏丽.洛阳地区79 829例新生儿先天性甲状腺功能低下症和苯丙酮尿症筛查结果分析[J].中国优生与遗传杂志,2017,25(1):96-97.
[10]牟凯,刘艳,刘继红,等.淄博地区先天性甲状腺功能减低症筛查中TSH切值在GSP上的研究[J].中国优生与遗传杂志,2017,25(4):98-99.
[11]钱家乐,陈少科,罗静思,等.广西壮族自治区2009-2011年先天性甲状腺功能减低症调查[J].中华流行病学杂志,2012,33(7):753-754.