NT-pro BNP、C-反应蛋白及D-二聚体水平与急性缺血性脑卒中的相关性
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摘要
目的探讨B型脑钠肽前体(NT-pro BNP)、C-反应蛋白(CRP)及D-二聚体(DD)水平与急性缺血性脑卒中(ASI)的相关性。方法选取2017年4月至2018年4月我院59例急性缺血性脑卒中患者作为研究对象纳入实验组,根据神经功能缺损程度进行分组,其中30例NIHSS≤10患者纳入实验Ⅰ组,29例NIHSS>10患者纳入实验Ⅱ组,入院后给予常规治疗。同期选取我院30例健康体检人群作为研究对象纳入对照组。分析三组NT-pro BNP、CRP及DD的水平与急性缺血性脑卒中的关系。结果实验Ⅰ组和实验Ⅱ组的血清NT-pro BNP、CRP及DD表达水平均高于对照组,差异具有统计学意义(P<0.05);NIHSS评分越高,血清NT-pro BNP、CRP及DD表达水平越高。结论血清NT-pro BNP、CRP及DD表达水平可以反映ASI患者的病情程度,这对临床早期检测ASI以及病情评估有一定的参考意义。
Objective To investigate the correlation between the levels of NT-pro BNP, C-reactive protein(CRP) and D-dimer(DD) and acute ischemic stroke(ASI). Methods Fifty-nine patients with acute ischemic stroke in our hospital from April 2017 to April 2018 were selected as the study subjects and divided into experimental group according to the degree of neurological deficit. Thirty patients with NIHSS<10 were included in experimental groupⅠ, 29 patients with NIHSS>10 were included in experimental group Ⅱ. After admission, routine treatment was given.At the same time, 30 healthy people in our hospital were selected as the study subjects and included in the control group. The relationship between NT-pro BNP, CRP and DD levels and acute ischemic stroke was analyzed. Results The expression levels of NT-pro BNP, CRP and DD in serum of group Ⅰ and group Ⅱ were higher than those of control group(P<0.05). The higher the NIHSS score, the higher the expression levels of NT-pro BNP, CRP and DD in serum.Conclusion The levels of NT-pro BNP, CRP and DD in serum can reflect the severity of ASI patients, which has certain reference significance for early detection of ASI and evaluation of the disease.
Objective To investigate the correlation between the levels of NT-pro BNP, C-reactive protein(CRP) and D-dimer(DD) and acute ischemic stroke(ASI). Methods Fifty-nine patients with acute ischemic stroke in our hospital from April 2017 to April 2018 were selected as the study subjects and divided into experimental group according to the degree of neurological deficit. Thirty patients with NIHSS<10 were included in experimental groupⅠ, 29 patients with NIHSS>10 were included in experimental group Ⅱ. After admission, routine treatment was given.At the same time, 30 healthy people in our hospital were selected as the study subjects and included in the control group. The relationship between NT-pro BNP, CRP and DD levels and acute ischemic stroke was analyzed. Results The expression levels of NT-pro BNP, CRP and DD in serum of group Ⅰ and group Ⅱ were higher than those of control group(P<0.05). The higher the NIHSS score, the higher the expression levels of NT-pro BNP, CRP and DD in serum.Conclusion The levels of NT-pro BNP, CRP and DD in serum can reflect the severity of ASI patients, which has certain reference significance for early detection of ASI and evaluation of the disease.
引文
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[9]朱以诚,崔丽英,高山,等.丁苯酞注射液治疗急性脑梗死的多中心、随机、双盲双模拟、对照Ⅲ期临床试验[J].中华神经科杂志,2014,47(2):113-118.
[10]陈传华,马祥波,刘俊峰,等.联合检测慢性阻塞性肺NT-ProBNP、PCT及D二聚体水平的价值[J].现代医院,2015,15(5):93-95.
[2]傅凯丽,霍磊.半夏白术天麻汤联合氯吡格雷对急性缺血性脑卒中患者运动功能、血小板功能、血清超敏C反应蛋白和可溶性P选择素水平的影响[J].中国中医急症,2018,27(3):422-425.
[3]中国中西医结合学会急救医学专业委员会.中国急性缺血性脑卒中中西医急诊诊治专家共识[J].中华危重病急救医学,2018,30(3):193-197.
[4]车锋丽,杜会山,魏建朝,等.急性缺血性脑卒中病人静脉溶栓治疗的临床预后影响因素分析[J].中西医结合心脑血管病杂志,2018,16(4):400-403.
[5]洪居陆,李慧,申小明.基于定量磁敏感成像的急性缺血性脑卒中磁化率分析[J].中国医学影像技术,2018,34(2):185-189.
[6]吴智鑫,李莹莹,梁斯娜,等.B型脑钠肽联合D-二聚体对心源性栓塞型脑卒中患者的快速筛选价值[J].实用医学杂志,2018,34(1):44-48.
[7]司小东.老年急性缺血性脑卒中病人心踝指数与血管内皮生长因子、D二聚体水平的相关性研究[J].中西医结合心脑血管病杂志,2016,14(15):1805-1806,1810.
[8]刘杨,李丹,马丽君.NT-pro BNP及D-二聚体水平变化对急性缺血性脑卒中患者预后的影响[J].现代医学进展,2016,16(21):4082-4084.
[9]朱以诚,崔丽英,高山,等.丁苯酞注射液治疗急性脑梗死的多中心、随机、双盲双模拟、对照Ⅲ期临床试验[J].中华神经科杂志,2014,47(2):113-118.
[10]陈传华,马祥波,刘俊峰,等.联合检测慢性阻塞性肺NT-ProBNP、PCT及D二聚体水平的价值[J].现代医院,2015,15(5):93-95.