太子参灵芝口含片的制备工艺研究
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摘要
目的提取太子参多糖,灵芝中多糖及灵芝三萜成分,制成口含片并对其工艺进行评价。方法压制太子参灵芝口含片,并通过TLC薄层色谱法确定口含片中有效成分,通过测定片重差异,硬度测定仪测定含片硬度,脆碎度测定仪测定含片脆碎度,苯酚-硫酸法测定含片中多糖含量评价所制得的口含片。结果初步确认制得的口含片中含有灵芝及太子参有效成分并将提取出的多糖及三萜物质与辅料制成口含片,得到的含片片重差异小于5%,含片硬度为169.3N,含片直径为10.11mm,厚度为10.13mm。脆碎度小于1%,太子参多糖的平均含量为3.67%,灵芝多糖的平均含量为1.83%。结论所制得的口含片符合片剂标准,可为太子参灵芝在片剂制备上提供有意义的参考。
OBJECTIVE The extraction of Radix Pseudostellariae polysaccharides,Ganodorma Lucidum polysaccharides and Ganoderma lucidum triterpenoids to produce oral tablets and to evaluate the preparation technology.METHODS The determination of the prepared oral tablets,TLC was carried out to preliminary confirm the active ingredients inside;hardness analyzer was used to define the tablet hardness;friability analyzer was used to test the friability of the tablet,and phenol-sulfuric acid method was applied to determine the polysaccharide content in the produced oral tablets.RESULTS The tablet weight difference was less than 5%,the tablet hardness was 169.3 N,tablet diameter was 10.11 mm and the thickness was 10.13 mm.The friability was less than 1% and the average content of radix pseudostellariae polysaccharides was 3.67%,the average content of ganoderma polysaccharides was 1.83%.CONCLUSION The prepared tablet is consistent with the tablet standard,and it could provide meaningful reference for the preparation of ganoderma lucidum oral tablet.
OBJECTIVE The extraction of Radix Pseudostellariae polysaccharides,Ganodorma Lucidum polysaccharides and Ganoderma lucidum triterpenoids to produce oral tablets and to evaluate the preparation technology.METHODS The determination of the prepared oral tablets,TLC was carried out to preliminary confirm the active ingredients inside;hardness analyzer was used to define the tablet hardness;friability analyzer was used to test the friability of the tablet,and phenol-sulfuric acid method was applied to determine the polysaccharide content in the produced oral tablets.RESULTS The tablet weight difference was less than 5%,the tablet hardness was 169.3 N,tablet diameter was 10.11 mm and the thickness was 10.13 mm.The friability was less than 1% and the average content of radix pseudostellariae polysaccharides was 3.67%,the average content of ganoderma polysaccharides was 1.83%.CONCLUSION The prepared tablet is consistent with the tablet standard,and it could provide meaningful reference for the preparation of ganoderma lucidum oral tablet.
引文
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[14]王西龙,王允,毕研平,等.太子参多糖提取工艺优选[J].现代医药卫生,2006,22(7):964-966.
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[17]李保明,刘超,王洪庆,等.灵芝总三萜酸含量测定方法的研究[J].中国中药杂志,2007,32(12):1234-1236.
[2]刘训红,韩乐,王丽娟,等.太子参药材质量标准研究[J].中国药房,2010,(19):1769-1771.
[3]倪峰,郑兴中,叶华.太子参的药效作用探讨[J].康复学报,1996,(2):38-40.
[4]林泗定,戴启文,张鸿程,等.太子参化学成分和生物活性研究进展[J].中国民族民间医药,2010,19(19):33-34.
[5]晏春耕,曹瑞芳.太子参药材性状与多糖含量的研究[J].安徽农学通报,2009,15(11):81-82.
[6]邹立思,傅兴圣,刘训红,等.太子参药材中环肽A、B含量分析及其动态研究[J].南京中医药大学学报,2013,29(2):175-178.
[7]傅兴圣,刘训红,许虎,等.太子参研究现状与研发趋势[J].中国新药杂志,2012,(7):757-760.
[8]叶志能,李德远,王斌,等.灵芝多糖研究进展[J].食品研究与开发,2012,33(1):225-228.
[9]毛健,马海乐.灵芝多糖的研究进展[J].食品科学,2010,31(1):295-299.
[10]高建莉,禹志领,李绍平,等.灵芝三萜类成分研究进展[J].中国食用菌,2005,24(4):6-11.
[11]晏春耕.药用植物太子参的研究及其应用[J].现代中药研究与实践,2008,22(2):61-65.
[12]陈家从.太子参食用开发的初步论证研究[J].中国医药指南,2011,09(9):7-8.
[13]袁媛,杨毅,开桂青,等.灵芝三萜提取工艺研究[J].安徽化工,2007,33(4):27-29.
[14]王西龙,王允,毕研平,等.太子参多糖提取工艺优选[J].现代医药卫生,2006,22(7):964-966.
[15]李艳,赵海燕,吕建宁.灵芝多糖提取工艺研究[J].中成药,2006,28(7):1052-1054.
[16]李晓晖,李书平,何云庆,等.灵芝多糖的含量测定研究[J].中草药,1997,(9):530-531.
[17]李保明,刘超,王洪庆,等.灵芝总三萜酸含量测定方法的研究[J].中国中药杂志,2007,32(12):1234-1236.