摘要
目的探讨非心源性复发性脑梗死的有关影响因素,为二级预防提供依据。方法将2016年8月~2018年6月于山东大学附属济南市中心医院神经内科住院的急性脑梗死患者1063例,分为初发和复发组,收集病例资料,采用Logistic回归分析各因素与非心源性复发性脑梗死的相关性。结果①两组间性别、年龄、吸烟率、饮酒率以及同型半胱氨酸、尿酸差别无统计学意义(P>0.05)。复发组与初发组相比,高血压、糖尿病发生率以及血清视黄醇结合蛋白、前白蛋白、白蛋白、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇水平差别有统计学意义(P<0.05)。②Logistic回归分析显示高血压、糖尿病、前白蛋白、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇有统计学意义(P<0.05)。结论脑梗死二级预防中除了高血压、糖尿病、血脂等多见的影响要素外,还应注意血清前白蛋白对于非心源性复发性脑梗死的重要保护作用。
Objective To investigate the related influencing factors of noncardiogenic recurrent cerebral infarction,and to provide a basis for secondary prevention.Methods Acute cerebral infarction patients,who were hospitalized at the department of neurology,Jinan Central Hospital Affiliated to Shandong University from August 2016 to June 2018,were divided into the primary group and the recurrent group.Logistic regression were used to analyze the correlation between various factors and noncardiogenic recurrent cerebral infarction.Results ①There were no statistically significant differences between the two groups in gender,age,smoking and drinking history,homocysteine and uric acid(P>0.05).The incidence of hypertension and diabetes,and the levels of serum retinol binding protein,prealbumin,albumin,low-density lipoprotein cholesterol and high-density lipoprotein cholesterol were statistically significant in the recurrent group compared with primary group(P<0.05).②Logistic regression analysis showed that the hypertension,diabetes,prealbumin,low density lipoprotein cholesterol and high density lipoprotein cholesterol were statistically significant(P<0.05).Conclusion In the secondary prevention of cerebral infarction,in addition to the common influencing factors such as hypertension,diabetes and blood lipid,the important protective effect of serum prealbumin on noncardiogenic recurrent cerebral infarction should also be emphasized.
引文
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