COG拴留复合体对高尔基体功能的重要性
|
摘要
膜泡运输是真核细胞生命活动的最基本的形式,是大分子物质运输和交流的基础。膜泡运输是起始于运输囊泡在供体膜上的出芽,随后沿细胞骨架定向移动,到达靶位膜的拴留、锚定以及膜融合过程。其中拴留因子在拴留过程中起重要作用,是介导运输囊泡和靶位膜之间首次接触的决定性因子。COG(conserved oligomeric golgi)复合体是进化上保守的多亚基拴留复合体(multisubunit tethering complex,MTC),是细胞内膜泡运输和维持高尔基体稳定性及完整性所必需的因子。在酵母和哺乳类细胞中,COG是八聚体复合体,定位于高尔基体,负责由COPI介导的高尔基体驻留蛋白比如糖基化酶lycosyltransferase在高尔基体内部的逆向膜泡运输。到目前为止,许多先天性糖基化障碍(congenital disorders of glycosylation,CDG)患者已被鉴定为COG复合体中的突变所致,说明了COG复合体在糖基化过程中的重要性。本综述将结合前人对COG复合体的研究成果对其最新研究进展进行概括性叙述。
In eukaryotic cells, vesicle trafficking is the most basic approach of life activities and is the basis for the transport and exchange of macromolecular material. Membrane trafficking initiates from the budding of the transport vesicles on the donor membrane, then moves along the cytoskeleton, tether and anchor on the target membrane to complete fusion. The tether factors play an important role in the process of tethering, which is a decisive factor of the first contact between the transport vesicles and the target membrane. COG complex(conserved oligomeric golgi) is an evolutionarily conserved multisubunit tethering complex(MTC), which is anessential factor for vesicle traffickingaswell asstability and integritymaintaining of the Golgi apparatus. In yeast and mammalian cells, COG is an octamer complex localized on the Golgi apparatus, which is involved in COPI-mediated Golgi-resident proteins, such asglycosyl enzyme and lycosyl transferases, in intra-Golgi retrograde vesicle transporting. So far, many CDG(congenital disorders of glycosylation) patients have been identified with deficiencies in the COG complex, which showed the importance of COG complex in the course of glycosylation. In this review, we made a general statement of the latest research progress of COG complex based on our predecessors.
In eukaryotic cells, vesicle trafficking is the most basic approach of life activities and is the basis for the transport and exchange of macromolecular material. Membrane trafficking initiates from the budding of the transport vesicles on the donor membrane, then moves along the cytoskeleton, tether and anchor on the target membrane to complete fusion. The tether factors play an important role in the process of tethering, which is a decisive factor of the first contact between the transport vesicles and the target membrane. COG complex(conserved oligomeric golgi) is an evolutionarily conserved multisubunit tethering complex(MTC), which is anessential factor for vesicle traffickingaswell asstability and integritymaintaining of the Golgi apparatus. In yeast and mammalian cells, COG is an octamer complex localized on the Golgi apparatus, which is involved in COPI-mediated Golgi-resident proteins, such asglycosyl enzyme and lycosyl transferases, in intra-Golgi retrograde vesicle transporting. So far, many CDG(congenital disorders of glycosylation) patients have been identified with deficiencies in the COG complex, which showed the importance of COG complex in the course of glycosylation. In this review, we made a general statement of the latest research progress of COG complex based on our predecessors.
引文
Bonifacino J.S.,and Glick B.S.,2004,The mechanisms of vesicl budding and fusion,Cell,116(2):153-166
Brown F.C.,and Pfeffer S.R.,2010,An update on transport vesi cle tethering,Molecular Membrane Biology,27(8):457-461
Cai H.,Yu S.,Menon S.,Cai Y.,Lazarova D.,Fu C.,Reinisch K.Hay J.C.,and Ferro-Novick S.,2007,TRAPPI tethers COPIvesicles by binding the coat subunit Sec23,Nature,445(7130):941-944
Cavanaugh L.F.,Chen X.,Richardson B.C.,Ungar D.,Pelczer I.Rizo J.,and Hughson F.M.,2007,Structural analysis of con served oligomeric Golgi complex subunit 2,The Journal o Biological Chemistry,282(32):23418-23426
Climer L.K.,Dobretsov M.,and Lupashin V.,2015,Defects in th COG complex and COG-related trafficking regulators affec neuronal Golgi function,Frontiers in Neuroscience,9:405
Desfougeres Y.,D'Agostino M.,and Mayer A.,2015,A modula tethering complex for endosomal recycling,Nature Cell Bi ology,17(5):540-541
Domanska M.K.,Kiessling V.,Stein A.,Fasshauer D.,and Tamm L.K.,2009,Single vesicle millisecond fusion kinetic reveals number of SNARE complexes optimal for fas SNARE-mediated membrane fusion,The Journal of Biolog ical Chemistry,284(46):32158-32166
Fiebig K.M.,Rice L.M.,Pollock E.,and Brunger A.T.,1999Folding intermediates of SNARE complex assembly,Natur Structural and Molecular Biology,6(2):117-123
Fisher P.,and Ungar D.,2016,Bridging the gap between glyco sylation and vesicle traffic,Frontiers in Cell and Develop mental Biology,4:15
Fukuda M.,Kanno E.,Ishibashi K.,and Itoh T.,2008,Larg scale screening for novel rab effectors reveals unexpected broad Rab binding specificity,Molecular&Cellular Pro teomics,7(6):1031-1042
Giot L.,Bader J.S.,Brouwer C.,Chaudhuri A.,Kuang B.,Li Y.Hao Y.L.,Ooi C.E.,Godwin B.,Vitols E.,Vijayadamoda G.,Pochart P.,Machineni H.,Welsh M.,Kong Y.,Zerhusen B.,Malcolm R.,Varrone Z.,Collis A.,Minto M.,Burgess S.Mc Daniel L.,Stimpson E.,Spriggs F.,Williams J.,Neurath K.,Ioime N.,Agee M.,Voss E.,Furtak K.,Renzulli R.Aanensen N.,Carrolla S.,Bickelhaupt E.,Lazovatsky Y.Da Silva A.,Zhong J.,Stanyon C.A.,Finley R.L.,Jr.White K.P.,Braverman M.,Jarvie T.,Gold S.,Leach M.Knight J.,Shimkets R.A.,Mc Kenna M.P.,Chant J.,and Rothberg J.M.,2003,A protein interaction map o Drosophila melanogaster,Science,302(5651):1727-1736
Ha J.Y.,Chou H.T.,Ungar D.,Yip C.K.,Walz T.,and Hughson F.M.,2016,Molecular architecture of the complete COGtethering complex,Nature Structural&Molecular Biology23:758-760
Ha J.Y.,Pokrovskaya I.D.,Climer L.K.,Shimamura G.R.,Kud lyk T.,Jeffrey P.D.,Lupashin V.V.,and Hughson F.M.2014,Cog5-Cog7 crystal structure reveals interactions es sential for the function of a multisubunit tethering complex Proceedings of the National Academy of Sciences,111(44)15762-15767
Hong W.,and Lev S.,2014,Tethering the assembly of SNAREcomplexes,Trends in Cell Biology,24(1):35-43
Hua Y.,and Scheller R.H.,2001,Three SNARE complexes co operate to mediate membrane fusion,Proceedings of the Na tional Academy of Sciences,98(14):8065-8070
|Huybrechts S.,De Laet C.,Bontems P.,Rooze S.,Souayah H.Sznajer Y.,Sturiale L.,Garozzo D.,Matthijs G.,Ferster A.Jaeken J.,and Goyens P.,2012,Deficiency of Subunit 6 o the Conserved Oligomeric Golgi Complex(COG6-CDG)Second Patient,Different Phenotype,JIMD Reports,4103-108
Kingsley D.M.,Kozarsky K.F.,Segal M.,and Krieger M.,1986Three types of low density lipoprotein receptor-deficien mutant have pleiotropic defects in the synthesis of N-linked O-linked,and lipid-linked carbohydrate chains,J.Cell.Biol102(2):1576-1585
Kodera H.,Ando N.,Yuasa I.,Wada Y.,Tsurusaki Y.Nakashima M.,Miyake N.,Saitoh S.,Matsumoto N.,and Saitsu H.,2015,Mutations in COG2 encoding a subunit o the conserved oligomeric golgi complex cause a congenita disorder of glycosylation,Clinical Genetics,87(5):455-460
Krieger M.,Brown M.S.,and Goldstein J.L.,1981,Isolation o Chinese hamster cell mutants defective in the receptor-medi ated endocytosis of low density lipoprotein,Journal o Molecular Biology,150(2):167-184
Kristensen A.R.,Gsponer J.,and Foster L.J.,2012,A high throughput approach for measuring temporal changes in th interactome,Nature Methods,9(9):907-909
Kudlyk T.,Willett R.,Pokrovskaya I.D.,and Lupashin V.,2013COG6 interacts with a subset of the Golgi SNAREs and i important for the Golgi complex integrity,Traffic,14(2)194-204
Laufman O.,Freeze H.H.,Hong W.,and Lev S.,2013a,Deficien cy of the Cog8 subunit in normal and CDG-derived cells im pairs the assembly of the COG and Golgi SNARE complex es,Traffic,14(10):1065-1077
Laufman O.,Hong W.,and Lev S.,2011,The COG complex in teracts directly with Syntaxin 6 and positively regulates en dosome-to-TGN retrograde transport,J.Cell.Biol.,194(3)459-472
Laufman O.,Hong W.,and Lev S.,2013b,The COG complex in teracts with multiple Golgi SNAREs and enhances fuso genic assembly of SNARE complexes,J.Cell.Sci.,126(6)1506-1516
Laufman O.,Kedan A.,Hong W.,and Lev S.,2009,Direct inter action between the COG complex and the SM protein,Sly1is required for Golgi SNARE pairing,The EMBO Journal28(14):2006-2017
Lees J.A.,Yip C.K.,Walz T.,and Hughson F.M.,2010,Molecu lar organization of the COG vesicle tethering complex,Na ture Structural&Molecular Biology,17(11):1292-1297
Miller V.J.,Sharma P.,Kudlyk T.A.,Frost L.,Rofe A.P.,Watson I.J.,Duden R.,Lowe M.,Lupashin V.V.,and Ungar D.2013,Molecular insights into vesicle tethering at the Golg by the conserved oligomeric Golgi(COG)complex and th golgin TATA element modulatory factor(TMF),The Jour nal of Biological Chemistry,288(6):4229-4240
Miller V.J.,and Stephens D.J.,2013,Membrane contact sites--an interesting species,an interesting mix,EMBO Reports,14(5):396-397
Miller V.J.,and Ungar D.,2012,Re'COG'nition at the Golgi Traffic,13(7):891-897
Munson M.,and Novick P.,2006,The exocyst defrocked,framework of rods revealed,Nature Structural&Molecula Biology,13(7):577-581
Oka T.,Ungar D.,Hughson F.M.,and Krieger M.,2004,Th COG and COPI complexes interact to control the abundanc of GEARs,a subset of Golgi integral membrane proteins Mol.Biol.Cell,15(5):2423-2435
Oka T.,Vasile E.,Penman M.,Novina C.D.,Dykxhoorn D.M.Ungar D.,Hughson F.M.,and Krieger M.,2005,Geneti analysis of the subunit organization and function of the con served oligomeric Golgi(COG)complex:studies o COG5-and COG7-deficient mammalian cells,The Journa of Biological Chemistry,280(38):32736-32745
Poirier M.A.,Xiao W.,Macosko J.C.,Chan C.,Shin Y.K.,and Bennett M.K.,1998,The synaptic SNARE complex is a par allel four-stranded helical bundle,Nature Nature Structura&Molecular Biology,5(9):765-769
Ram R.J.,Li B.,and Kaiser C.A.,2002,Identification of Sec36p Sec37p,and Sec38p:components of yeast complex that con tains Sec34p and Sec35p,Mol.Biol.Cell,13(5):1484-1500
Richardson B.C.,Smith R.D.,Ungar D.,Nakamura A.,Jeffrey PD.,Lupashin V.V.,and Hughson F.M.,2009,Structural ba sis for a human glycosylation disorder caused by mutation o the COG4 gene,Proceedings of the National Academy o Sciences,106(32):13329-13334
Rymen D.,Keldermans L.,Race V.,Regal L.,Deconinck N.Dionisi-Vici C.,Fung C.W.,Sturiale L.,Rosnoblet C.Foulquier F.,Matthijs G.,and Jaeken J.,2012,COG5-CDGexpanding the clinical spectrum,Orphanet Journal of Rare Diseases,7(1):94
Rymen D.,Winter J.,Van Hasselt P.M.,Jaeken J.,Kasapkara C.Gokcay G.,Haijes H.,Goyens P.,Tokatli A.,Thiel C.Bartsch O.,Hecht J.,Krawitz P.,Prinsen H.C.,Mildenberg er E.,Matthijs G.,and Kornak U.,2015,Key features and clinical variability of COG6-CDG,Molecular Genetics and Metabolism,116(3):163-170
Schultz J.,Doerks T.,Ponting C.P.,Copley R.R.,and Bork P.2000,More than 1 000 putative new human signalling pro teins revealed by EST data mining,Nature Genetics,25(2)201-204
Shestakova A.,Suvorova E.,Pavliv O.,Khaidakova G.,and Lu pashin V.,2007,Interaction of the conserved oligomeric Golgi complex with t-SNARE Syntaxin5a/Sed5 enhance intra-Golgi SNARE complex stability,J.Cell.Biol.,179(6)1179-1192
Sivaram M.V.,Furgason M.L.,Brewer D.N.,and Munson M.2006,The structure of the exocyst subunit Sec6p defines a conserved architecture with diverse roles,Nature Structura&Molecular Biology,13(6):555-556
Sohda M.,Misumi Y.,Yamamoto A.,Nakamura N.,Ogata S.Sakisaka S.,Hirose S.,Ikehara Y.,and Oda K.,2010,Inter action of Golgin-84 with the COG complex mediates the in tra-Golgi retrograde transport,Traffic,11(2):1552-1566
Sohda M.,Misumi Y.,Yoshimura S.,Nakamura N.,Fusano T.Ogata S.,Sakisaka S.,and Ikehara Y.,2007,The interaction of two tethering factors,p115 and COG complex,is required for Golgi integrity,Traffic,8(3):270-284
Suvorova E.S.,Duden R.,and Lupashin V.V.,2002,Th Sec34/Sec35p complex,a Ypt1p effector required for retro grade intra-Golgi trafficking,interacts with Golgi SNAREand COPI vesicle coat proteins,J.Cell.Biol.,157(4):631-643
Suvorova E.S.,Kurten R.C.,and Lupashin V.V.,2001,Identifica tion of a human orthologue of Sec34p as a component of the cis-Golgi vesicle tethering machinery,The Journal of Bio logical Chemistry,276(25):22810-22818
Tan X.,Cao K.,Liu F.,Li Y.,Li P.,Gao C.,Ding Y.,Lan Z.,Sh Z.,Rui Q.,Feng Y.,Liu Y.,Zhao Y.,Wu C.,Zhang Q.,LY.,Jiang L.,and Bao Y.,2016,Arabidopsis COG complex subunits COG3 and COG8 modulate Golgi morphology vesicle trafficking homeostasis and are essential for pollen tube growth,PLo S genet.,12:e1006140
Tang B.L.,Low D.Y.,Lee S.S.,Tan A.E.,and Hong W.,1998Molecular cloning and localization of human syntaxin 16,member of the syntaxin family of SNARE proteins,Bio chemical and Biophysical Research Communications,242(3):673-679
Ungar D.,Oka T.,Brittle E.E.,Vasile E.,Lupashin V.V.,Chat terton J.E.,Heuser J.E.,Krieger M.,and Waters M.G.,2002Characterization of a mammalian Golgi-localized protein complex,COG,that is required for normal Golgi morpholo gy and function,J.Cell.Biol.,157(3):405-415
Ungar D.,Oka T.,Krieger M.,and Hughson F.M.,2006,Retro grade transport on the COG railway,Trends in Cell Biology16(2):113-120
Ungar D.,Oka T.,Vasile E.,Krieger M.,and Hughson F.M.2005,Subunit architecture of the conserved oligomeric Gol gi complex,The Journal of Biological Chemistry,280(38)32729-32735
Vasan N.,Hutagalung A.,Novick P.,and Reinisch K.M.,2010Structure of a C-terminal fragment of its Vps53 subunit sug gests similarity of Golgi-associated retrograde protein(GARP)complex to a family of tethering complexes,Pro ceedings of the National Academy of Sciences,107(32)14176-14181
Vasile E.,Oka T.,Ericsson M.,Nakamura N.,and Krieger M.2006,Intra Golgi distribution of the Conserved Oligomeri Golgi(COG)complex,Experimental Cell Research,312(16):3132-3141
Vukasinovic N.,and Zarsky V.,2016,Tethering complexes in the Arabidopsis endomembrane system,Frontiers in Cell and Developmental Biology,4:46
Whyte J.R.,and Munro S.,2001,The Sec34/35 Golgi transpor complex is related to the exocyst,defining a family of com plexes involved in multiple steps of membrane traffic,De velopmental Cell,1(4):527-537
Whyte J.R.,and Munro S.,2002,Vesicle tethering complexes in membrane traffic,J.Cell.Sci.,115(13):2627-2637
Willett R.,Blackburn J.B.,Climer L.,Pokrovskaya I.,Kudlyk T.Wang W.,and Lupashin V.,2016,COG lobe B sub-com plex engages v-SNARE GS15 and functions via regulated interaction with lobe A sub-complex,Scientific Reports,629139
Willett R.,Kudlyk T.,Pokrovskaya I.,Schonherr R.,Ungar D.Duden R.,and Lupashin V.,2013a,COG complexes form spatial landmarks for distinct SNARE complexes,Natur Communications,4:1553
Willett R.,Ungar D.,and Lupashin V.,2013b,The Golgi puppe master:COG complex at center stage of membrane trafficking interactions,Histochemistryand Cell Biology,140(3):271-283
Yu C.C.,Yang J.C.,Chang Y.C.,Chuang J.G.,Lin C.W.,Wu MS.,and Chow L.P.,2013,VCP phosphorylation-dependen interaction partners prevent apoptosis in Helicobacter py lori-infected gastric epithelial cells,PLo S One,8(1):e55724
Yu I.M.,and Hughson F.M.,2010,Tethering factors as organiz ers of intracellular vesicular traffic,Annual Review of Cel and Developmental Biology,26:137-156
Zhang X.,and Wang Y.,2016,Glycosylation quality control by the Golgi structure,Journal of Molecular Biology,428(16)3183-3193
Zolov S.N.,and Lupashin V.V.,2005,Cog3p depletion block vesicle-mediated Golgi retrograde trafficking in He La cells J.Cell.Biol.,168(5):747-759
Brown F.C.,and Pfeffer S.R.,2010,An update on transport vesi cle tethering,Molecular Membrane Biology,27(8):457-461
Cai H.,Yu S.,Menon S.,Cai Y.,Lazarova D.,Fu C.,Reinisch K.Hay J.C.,and Ferro-Novick S.,2007,TRAPPI tethers COPIvesicles by binding the coat subunit Sec23,Nature,445(7130):941-944
Cavanaugh L.F.,Chen X.,Richardson B.C.,Ungar D.,Pelczer I.Rizo J.,and Hughson F.M.,2007,Structural analysis of con served oligomeric Golgi complex subunit 2,The Journal o Biological Chemistry,282(32):23418-23426
Climer L.K.,Dobretsov M.,and Lupashin V.,2015,Defects in th COG complex and COG-related trafficking regulators affec neuronal Golgi function,Frontiers in Neuroscience,9:405
Desfougeres Y.,D'Agostino M.,and Mayer A.,2015,A modula tethering complex for endosomal recycling,Nature Cell Bi ology,17(5):540-541
Domanska M.K.,Kiessling V.,Stein A.,Fasshauer D.,and Tamm L.K.,2009,Single vesicle millisecond fusion kinetic reveals number of SNARE complexes optimal for fas SNARE-mediated membrane fusion,The Journal of Biolog ical Chemistry,284(46):32158-32166
Fiebig K.M.,Rice L.M.,Pollock E.,and Brunger A.T.,1999Folding intermediates of SNARE complex assembly,Natur Structural and Molecular Biology,6(2):117-123
Fisher P.,and Ungar D.,2016,Bridging the gap between glyco sylation and vesicle traffic,Frontiers in Cell and Develop mental Biology,4:15
Fukuda M.,Kanno E.,Ishibashi K.,and Itoh T.,2008,Larg scale screening for novel rab effectors reveals unexpected broad Rab binding specificity,Molecular&Cellular Pro teomics,7(6):1031-1042
Giot L.,Bader J.S.,Brouwer C.,Chaudhuri A.,Kuang B.,Li Y.Hao Y.L.,Ooi C.E.,Godwin B.,Vitols E.,Vijayadamoda G.,Pochart P.,Machineni H.,Welsh M.,Kong Y.,Zerhusen B.,Malcolm R.,Varrone Z.,Collis A.,Minto M.,Burgess S.Mc Daniel L.,Stimpson E.,Spriggs F.,Williams J.,Neurath K.,Ioime N.,Agee M.,Voss E.,Furtak K.,Renzulli R.Aanensen N.,Carrolla S.,Bickelhaupt E.,Lazovatsky Y.Da Silva A.,Zhong J.,Stanyon C.A.,Finley R.L.,Jr.White K.P.,Braverman M.,Jarvie T.,Gold S.,Leach M.Knight J.,Shimkets R.A.,Mc Kenna M.P.,Chant J.,and Rothberg J.M.,2003,A protein interaction map o Drosophila melanogaster,Science,302(5651):1727-1736
Ha J.Y.,Chou H.T.,Ungar D.,Yip C.K.,Walz T.,and Hughson F.M.,2016,Molecular architecture of the complete COGtethering complex,Nature Structural&Molecular Biology23:758-760
Ha J.Y.,Pokrovskaya I.D.,Climer L.K.,Shimamura G.R.,Kud lyk T.,Jeffrey P.D.,Lupashin V.V.,and Hughson F.M.2014,Cog5-Cog7 crystal structure reveals interactions es sential for the function of a multisubunit tethering complex Proceedings of the National Academy of Sciences,111(44)15762-15767
Hong W.,and Lev S.,2014,Tethering the assembly of SNAREcomplexes,Trends in Cell Biology,24(1):35-43
Hua Y.,and Scheller R.H.,2001,Three SNARE complexes co operate to mediate membrane fusion,Proceedings of the Na tional Academy of Sciences,98(14):8065-8070
|Huybrechts S.,De Laet C.,Bontems P.,Rooze S.,Souayah H.Sznajer Y.,Sturiale L.,Garozzo D.,Matthijs G.,Ferster A.Jaeken J.,and Goyens P.,2012,Deficiency of Subunit 6 o the Conserved Oligomeric Golgi Complex(COG6-CDG)Second Patient,Different Phenotype,JIMD Reports,4103-108
Kingsley D.M.,Kozarsky K.F.,Segal M.,and Krieger M.,1986Three types of low density lipoprotein receptor-deficien mutant have pleiotropic defects in the synthesis of N-linked O-linked,and lipid-linked carbohydrate chains,J.Cell.Biol102(2):1576-1585
Kodera H.,Ando N.,Yuasa I.,Wada Y.,Tsurusaki Y.Nakashima M.,Miyake N.,Saitoh S.,Matsumoto N.,and Saitsu H.,2015,Mutations in COG2 encoding a subunit o the conserved oligomeric golgi complex cause a congenita disorder of glycosylation,Clinical Genetics,87(5):455-460
Krieger M.,Brown M.S.,and Goldstein J.L.,1981,Isolation o Chinese hamster cell mutants defective in the receptor-medi ated endocytosis of low density lipoprotein,Journal o Molecular Biology,150(2):167-184
Kristensen A.R.,Gsponer J.,and Foster L.J.,2012,A high throughput approach for measuring temporal changes in th interactome,Nature Methods,9(9):907-909
Kudlyk T.,Willett R.,Pokrovskaya I.D.,and Lupashin V.,2013COG6 interacts with a subset of the Golgi SNAREs and i important for the Golgi complex integrity,Traffic,14(2)194-204
Laufman O.,Freeze H.H.,Hong W.,and Lev S.,2013a,Deficien cy of the Cog8 subunit in normal and CDG-derived cells im pairs the assembly of the COG and Golgi SNARE complex es,Traffic,14(10):1065-1077
Laufman O.,Hong W.,and Lev S.,2011,The COG complex in teracts directly with Syntaxin 6 and positively regulates en dosome-to-TGN retrograde transport,J.Cell.Biol.,194(3)459-472
Laufman O.,Hong W.,and Lev S.,2013b,The COG complex in teracts with multiple Golgi SNAREs and enhances fuso genic assembly of SNARE complexes,J.Cell.Sci.,126(6)1506-1516
Laufman O.,Kedan A.,Hong W.,and Lev S.,2009,Direct inter action between the COG complex and the SM protein,Sly1is required for Golgi SNARE pairing,The EMBO Journal28(14):2006-2017
Lees J.A.,Yip C.K.,Walz T.,and Hughson F.M.,2010,Molecu lar organization of the COG vesicle tethering complex,Na ture Structural&Molecular Biology,17(11):1292-1297
Miller V.J.,Sharma P.,Kudlyk T.A.,Frost L.,Rofe A.P.,Watson I.J.,Duden R.,Lowe M.,Lupashin V.V.,and Ungar D.2013,Molecular insights into vesicle tethering at the Golg by the conserved oligomeric Golgi(COG)complex and th golgin TATA element modulatory factor(TMF),The Jour nal of Biological Chemistry,288(6):4229-4240
Miller V.J.,and Stephens D.J.,2013,Membrane contact sites--an interesting species,an interesting mix,EMBO Reports,14(5):396-397
Miller V.J.,and Ungar D.,2012,Re'COG'nition at the Golgi Traffic,13(7):891-897
Munson M.,and Novick P.,2006,The exocyst defrocked,framework of rods revealed,Nature Structural&Molecula Biology,13(7):577-581
Oka T.,Ungar D.,Hughson F.M.,and Krieger M.,2004,Th COG and COPI complexes interact to control the abundanc of GEARs,a subset of Golgi integral membrane proteins Mol.Biol.Cell,15(5):2423-2435
Oka T.,Vasile E.,Penman M.,Novina C.D.,Dykxhoorn D.M.Ungar D.,Hughson F.M.,and Krieger M.,2005,Geneti analysis of the subunit organization and function of the con served oligomeric Golgi(COG)complex:studies o COG5-and COG7-deficient mammalian cells,The Journa of Biological Chemistry,280(38):32736-32745
Poirier M.A.,Xiao W.,Macosko J.C.,Chan C.,Shin Y.K.,and Bennett M.K.,1998,The synaptic SNARE complex is a par allel four-stranded helical bundle,Nature Nature Structura&Molecular Biology,5(9):765-769
Ram R.J.,Li B.,and Kaiser C.A.,2002,Identification of Sec36p Sec37p,and Sec38p:components of yeast complex that con tains Sec34p and Sec35p,Mol.Biol.Cell,13(5):1484-1500
Richardson B.C.,Smith R.D.,Ungar D.,Nakamura A.,Jeffrey PD.,Lupashin V.V.,and Hughson F.M.,2009,Structural ba sis for a human glycosylation disorder caused by mutation o the COG4 gene,Proceedings of the National Academy o Sciences,106(32):13329-13334
Rymen D.,Keldermans L.,Race V.,Regal L.,Deconinck N.Dionisi-Vici C.,Fung C.W.,Sturiale L.,Rosnoblet C.Foulquier F.,Matthijs G.,and Jaeken J.,2012,COG5-CDGexpanding the clinical spectrum,Orphanet Journal of Rare Diseases,7(1):94
Rymen D.,Winter J.,Van Hasselt P.M.,Jaeken J.,Kasapkara C.Gokcay G.,Haijes H.,Goyens P.,Tokatli A.,Thiel C.Bartsch O.,Hecht J.,Krawitz P.,Prinsen H.C.,Mildenberg er E.,Matthijs G.,and Kornak U.,2015,Key features and clinical variability of COG6-CDG,Molecular Genetics and Metabolism,116(3):163-170
Schultz J.,Doerks T.,Ponting C.P.,Copley R.R.,and Bork P.2000,More than 1 000 putative new human signalling pro teins revealed by EST data mining,Nature Genetics,25(2)201-204
Shestakova A.,Suvorova E.,Pavliv O.,Khaidakova G.,and Lu pashin V.,2007,Interaction of the conserved oligomeric Golgi complex with t-SNARE Syntaxin5a/Sed5 enhance intra-Golgi SNARE complex stability,J.Cell.Biol.,179(6)1179-1192
Sivaram M.V.,Furgason M.L.,Brewer D.N.,and Munson M.2006,The structure of the exocyst subunit Sec6p defines a conserved architecture with diverse roles,Nature Structura&Molecular Biology,13(6):555-556
Sohda M.,Misumi Y.,Yamamoto A.,Nakamura N.,Ogata S.Sakisaka S.,Hirose S.,Ikehara Y.,and Oda K.,2010,Inter action of Golgin-84 with the COG complex mediates the in tra-Golgi retrograde transport,Traffic,11(2):1552-1566
Sohda M.,Misumi Y.,Yoshimura S.,Nakamura N.,Fusano T.Ogata S.,Sakisaka S.,and Ikehara Y.,2007,The interaction of two tethering factors,p115 and COG complex,is required for Golgi integrity,Traffic,8(3):270-284
Suvorova E.S.,Duden R.,and Lupashin V.V.,2002,Th Sec34/Sec35p complex,a Ypt1p effector required for retro grade intra-Golgi trafficking,interacts with Golgi SNAREand COPI vesicle coat proteins,J.Cell.Biol.,157(4):631-643
Suvorova E.S.,Kurten R.C.,and Lupashin V.V.,2001,Identifica tion of a human orthologue of Sec34p as a component of the cis-Golgi vesicle tethering machinery,The Journal of Bio logical Chemistry,276(25):22810-22818
Tan X.,Cao K.,Liu F.,Li Y.,Li P.,Gao C.,Ding Y.,Lan Z.,Sh Z.,Rui Q.,Feng Y.,Liu Y.,Zhao Y.,Wu C.,Zhang Q.,LY.,Jiang L.,and Bao Y.,2016,Arabidopsis COG complex subunits COG3 and COG8 modulate Golgi morphology vesicle trafficking homeostasis and are essential for pollen tube growth,PLo S genet.,12:e1006140
Tang B.L.,Low D.Y.,Lee S.S.,Tan A.E.,and Hong W.,1998Molecular cloning and localization of human syntaxin 16,member of the syntaxin family of SNARE proteins,Bio chemical and Biophysical Research Communications,242(3):673-679
Ungar D.,Oka T.,Brittle E.E.,Vasile E.,Lupashin V.V.,Chat terton J.E.,Heuser J.E.,Krieger M.,and Waters M.G.,2002Characterization of a mammalian Golgi-localized protein complex,COG,that is required for normal Golgi morpholo gy and function,J.Cell.Biol.,157(3):405-415
Ungar D.,Oka T.,Krieger M.,and Hughson F.M.,2006,Retro grade transport on the COG railway,Trends in Cell Biology16(2):113-120
Ungar D.,Oka T.,Vasile E.,Krieger M.,and Hughson F.M.2005,Subunit architecture of the conserved oligomeric Gol gi complex,The Journal of Biological Chemistry,280(38)32729-32735
Vasan N.,Hutagalung A.,Novick P.,and Reinisch K.M.,2010Structure of a C-terminal fragment of its Vps53 subunit sug gests similarity of Golgi-associated retrograde protein(GARP)complex to a family of tethering complexes,Pro ceedings of the National Academy of Sciences,107(32)14176-14181
Vasile E.,Oka T.,Ericsson M.,Nakamura N.,and Krieger M.2006,Intra Golgi distribution of the Conserved Oligomeri Golgi(COG)complex,Experimental Cell Research,312(16):3132-3141
Vukasinovic N.,and Zarsky V.,2016,Tethering complexes in the Arabidopsis endomembrane system,Frontiers in Cell and Developmental Biology,4:46
Whyte J.R.,and Munro S.,2001,The Sec34/35 Golgi transpor complex is related to the exocyst,defining a family of com plexes involved in multiple steps of membrane traffic,De velopmental Cell,1(4):527-537
Whyte J.R.,and Munro S.,2002,Vesicle tethering complexes in membrane traffic,J.Cell.Sci.,115(13):2627-2637
Willett R.,Blackburn J.B.,Climer L.,Pokrovskaya I.,Kudlyk T.Wang W.,and Lupashin V.,2016,COG lobe B sub-com plex engages v-SNARE GS15 and functions via regulated interaction with lobe A sub-complex,Scientific Reports,629139
Willett R.,Kudlyk T.,Pokrovskaya I.,Schonherr R.,Ungar D.Duden R.,and Lupashin V.,2013a,COG complexes form spatial landmarks for distinct SNARE complexes,Natur Communications,4:1553
Willett R.,Ungar D.,and Lupashin V.,2013b,The Golgi puppe master:COG complex at center stage of membrane trafficking interactions,Histochemistryand Cell Biology,140(3):271-283
Yu C.C.,Yang J.C.,Chang Y.C.,Chuang J.G.,Lin C.W.,Wu MS.,and Chow L.P.,2013,VCP phosphorylation-dependen interaction partners prevent apoptosis in Helicobacter py lori-infected gastric epithelial cells,PLo S One,8(1):e55724
Yu I.M.,and Hughson F.M.,2010,Tethering factors as organiz ers of intracellular vesicular traffic,Annual Review of Cel and Developmental Biology,26:137-156
Zhang X.,and Wang Y.,2016,Glycosylation quality control by the Golgi structure,Journal of Molecular Biology,428(16)3183-3193
Zolov S.N.,and Lupashin V.V.,2005,Cog3p depletion block vesicle-mediated Golgi retrograde trafficking in He La cells J.Cell.Biol.,168(5):747-759