GARP复合体结构和功能的研究进展
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摘要
真核细胞中的物质交流是通过膜泡运输完成的。膜泡运输主要包括运输囊泡的出芽、定向移动、拴留、锚定和膜融合过程。其中,拴留过程是运输囊泡和靶膜最初的接触。在此过程中,有许多因子参与调控,如拴留因子、小GTPase、SNARE蛋白等。GARP(golgi-associated retrograde protein)复合体是内涵体到高尔基体反面网状结构(TGN)逆行运输过程中的拴留因子。目前,关于GARP复合体的组成和功能已经有了一定的了解,本文将对GARP复合体的最新研究进展进行概述。
In eukaryotic cells,the material communication is accomplished by vesicle transport. Vesicle transport includes the process of vesicle budding,directional transport,tethering,docking and fusion. Tethering process is the initial contact between transport vesicles and target membrane. In this process,there are many factors involved in regulation,such as tethering factors,small GTPases,SNAREs and so on. GARP(golgi-associated retrograde protein) complex is a tethering factor in endosome-to-TGN retrograde transport. Currently,there is a certain understanding about the structure and function of GARP. This review would summary the recent research progress of GARP complex.
In eukaryotic cells,the material communication is accomplished by vesicle transport. Vesicle transport includes the process of vesicle budding,directional transport,tethering,docking and fusion. Tethering process is the initial contact between transport vesicles and target membrane. In this process,there are many factors involved in regulation,such as tethering factors,small GTPases,SNAREs and so on. GARP(golgi-associated retrograde protein) complex is a tethering factor in endosome-to-TGN retrograde transport. Currently,there is a certain understanding about the structure and function of GARP. This review would summary the recent research progress of GARP complex.
引文
Abascal-Palaci os G.,Schindler C.,Rojas A.L.,Bonifacino J.S.,and Hierro A.,2013,Structural basis for the interaction of the golgi-associated retrograde protein complex with the T-snare syntaxin 6,Structure,21(9):1698-1706
Bonifacino J.S.,and Glick B.S.,2004,The mechanisms of vesicle budding and fusion,Cell,116(2):153-166
Bonifacino J.S.,and Hierro A.,2011,Transport according to GARP:receiving retrograde cargo at the Trans-Golgi network,Trends Cell Biol.,21(3):159-167
Cai H.Q.,Yu S.,Menon S.,Cai Y.Y.,Lazarova D.,Fu C.,Reinisch K.,Hay J.C.,and Ferro-Novick S.,2007,TRAPPⅠtethers COPⅡvesicles by binding the coat subunit Sec23,Nature,445(7130):941-944
Conibear E.,Cleck J.N.,and Stevens T.H.,2003,Vps51p mediates the association of the GARP(Vps52/53/54)complex with the late golgi t-SNARE Tlg1p,Molecular Biology of the Cell,14(4):1610-1623
Conibear E.,and Stevens T.H.,2000,Vps52p,Vps53p,and Vps54p form a novel multisubunit complex required for protein sorting at the yeast late Golgi,Molecular Biology of the Cell,11(1):305-323
Cottam N.P.,and Ungar D.,2012,Retrograde vesicle transport in the golgi,Protoplasma,249(4):943-955
Desfougères Y.,D'Agostino M.,and Mayer A.,2015,A modular tethering complex for endosomal recycling,Nature Cell Biology,17(5):540-541
Dotiwala F.,Eapen V.V.,Harrison J.C.,Arbel-Eden A.,Ranade V.,Yoshida S.,and Haber J.E.,2013,DNA damage checkpoint triggers autophagy to regulate the initiation of anaphase,Proc.Natl.Acad.Sci.USA,110(1):41-49
Eapen V.V.,and Haber J.E.,2013,DNA damage signaling triggers the cytoplasm-to-vacuole pathway of autophagy to regulate cell cycle progression,Autophagy,9(3):440-441
Fabrizio J.J.,Hime G.,Lemmon S.K.,and Bazinet C.,1998,Genetic dissection of sperm individualization in Drosophila melanogaster,Development,125(10):1833-1843
Feinstein M.,Flusser H.,Lerman-Sagie T.,Ben-Zeev B.,Lev D.,Agamy O.,Cohen I.,Kadir R.,Sivan S.,Leshinsky-Silver E.,Markus B.,and Birk O.S.,2014,Vps53 mutations cause progressive cerebello-cerebral atrophy type 2(PCCA2),Journal of Medical Genetics,51(5):303-308
Fiedler T.A.,Karpova T.S.,Fleig U.,Young M.E.,Cooper J.A.,and Hegemann J.H.,2002,The vesicular transport protein Cgp1p/Vps54p/Tcs3p/Luv1p is required for the integrity of the actin cytoskeleton,Molecular Genetics and Genomics,268(2):190-205
Fridmann-Sirkis Y.,Kent H.M.,Lewis M.J.,Evans P.R.,and Pelham H.R.,2006,Structural analysis of the interaction between the snare Tlg1 and Vps51,Traffic,7(2):182-190
Frohlich F.,Petit C.,Kory N.,Christiano R.,Hannibal-Bach H.K.,Graham M.,Liu X.R.,Ejsing C.S.,Farese R.V.,and Walther T.C.,2015,The GARP complex is required for cellular sphingolipid homeostasis,Elife,4:8712
Guermonprez H.,Smertenko A.,Crosnier M.T.,Durandet M.,Vrielynck N.,Guerche P.,Hussey P.J.,Satiat-Jeunemaitre B.,and Bonhomme S.,2008,The Pok/Atvps52 protein localizes to several distinct post-golgi compartments in sporophytic and gametophytic cells,Journal of Experimental Botany,59(11):3087-3098
Heard W.,SklenáǐJ.,ToméD.F.A.,Robatzek S.,Jones A.M.E.,2015,Identification of regulatory and cargo proteins of endosomal and secretory pathways in Arabidopsis thaliana by proteomic dissection,Molecular&Cellular Proteomics,14(7):1796-1813
Hirata T.,Fujita M.,Nakamura S.,Gotoh K.,Motooka D.,Murakami Y.,Maeda Y.,and Kinoshita T.,2015,Post-golgi anterograde transport requires GARP-dependent endosome to TGN retrograde transport,Molecular Biology of the Cell,26(17):3071-3084
Ho S.Y.,Lorent K.,Pack M.,and Farber S.A.,2006,Zebrafish fat-free is required for intestinal lipid absorption and golgi apparatus structure,Cell Metab.,3(4):289-300
Hong W.J.,and Lev S.,2014,Tethering the assembly of SNAREcomplexes,Trends in Cell Biology,24(1):35-43
Jockusch H.,Holland A.,Staunton L.,Schmitt-John T.,Heimann P.,Dowling P.,and Ohlendieck K.,2014,Pathoproteomics of testicular tissue deficient in the GARP component VPS54:the wobbler mouse model of globozoospermia,Proteomics,14(7-8):839-852
Karlsson P.,Droce A.,Moser J.M.,Cuhlmann S.,Padilla C.O.,Heimann P.,Bartsch J.W.,Füchtbauer A.,Füchtbauer E.M.,and Schmitt-John T.,2013,Loss of Vps54 function leads to vesicle traffic impairment,protein mis-sorting and embryonic lethality,Int.J.Mol.Sci.,14(6):10908-10925
Koumandou V.L.,Dacks J.B.,Coulson R.M.R.,and Field M.C.,2007,Control systems for membrane fusion in the ancestral eukaryote;evolution of tethering complexes and SM proteins,BMC Evolutionary Biology,7(1):29
Lee C.F.,Pu H.Y.,Wang L.C.,Sayler R.J.,Yeh C.H.,and Wu S.J.,2006,Mutation in a homolog of yeast Vps53p accounts for the heat and osmotic hypersensitive phenotypes in Arabidopsis hit1-1 mutant,Planta,224(2):330-338
Li Z.F.,and Blissard G.,2014,The vacuolar protein sorting genes in insects:a comparative genome view,Insect Biochemistry and Molecular Biology,62:211-225
Liewe n H.,Meinhold-Heerlein I.,Oliveira V.,Schwarzenbacher R.,Luo G.R.,Wadle A.,Jung M.,Pfreundschuh M.,and Stenner-Liewen F.,2005,Characterization of the Human GARP(golgi associated retrograde protein)complex,Experimental Cell Research,306(1):24-34
Lobstein E.,Guyon A.,Férault M.,Twell D.,Pelletier G.,and Bonhomme S.,2004,The putative Arabidopsis homolog of yeast Vps52p is required for pollen tube elongation,localizes to golgi,and might be involved in vesicle trafficking,Plant Physiology,135(3):1480-1490
Marcusson E.G.,Horazdovsky B.F.,Cereghino J.L.,Gharakhanian E.,and Emr S.D.,1994,The sorting receptor for yeast vacuolar carboxypeptidase Y is encoded by the VPS10 gene,Cell,77(4):579-586
Mc Dermott H.,and Kim K.,2015,Molecular dynamics at the endocytic portal and regulations ofendocytic and recycling traffics,European Journal of Cell Biology,94(6):235-248
Moser J.M.,Bigini P.,and Schmitt-John T.,2013,The wobbler mouse,an ALS animal model,Mol.Genet.Genomics,288(5):207-229
Munro S.,2011,The golgin coiled-coil proteins of the golgi apparatus,Cold Spring Harbor Perspectives in Biology,3(6):1-14
Otto G.P.,Razi M.,Morvan J.,Stenner F.,and Tooze S.A.,2010,A novel syntaxin 6-interacting protein,SHIP164,regulates syntaxin 6-dependent sorting from early endosomes,Traffic,11(5):688-705
Pahari S.,Cormark R.D.,Blackshaw M.T.,Liu C.,Erickson J.L.,and Schultz E.A.,2014,Arabidopsis UNHINGED encodes a VPS51 homolog and reveals a role for the GARPcomplex in leaf shape and vein patterning,Development,141(9):1894-1905
Panic B.,Whyte J.R.C.,and Munro S.,2003,The ARF-like GT-Pases Arl1p and Arl3p act in a pathway that interacts with vesicle-tethering factors at the golgi apparatus,Current Biology,13(5):405-410
Pérez-Victoria F.J.,Abascal-Palacios G.,Tascón I.,Kajava A.,Magadán J.G.,Pioro E.P.,Bonifacino J.S.,and Hierro A.,2010a,Structural basis for the wobbler mouse neurodegenerative disorder caused by mutation in the Vps54 subunit of the GARP complex,Proc.Natl.Acad.Sci.USA,107(29):12860-12865
Pérez-Victoria F.J.,and Bonifacino J.S.,2009,Dual roles of the mammalian GARP complex in tethering and SNARE complex assembly at the trans-Golgi network,Molecular and Cellular Biology,29(19):5251-5263
Pérez-Victoria F.J.,Mardones G.A.,and Bonifacino J.S.,2008,Requirement of the human GARP complex for mannose6-phosphate-receptor-dependent sorting of cathepsin D to lysosomes,Molecular Biology of the Cell,19(6):2350-2362
Pérez-Victoria F.J.,Schindler C.,Magadán J.G.,Mardones G.A.,Delevoye C.,Romao M.,Raposo G.,and Bonifacino J.S.,2010b,Ang2/fat-free is a conserved subunit of the golgi-associated retrograde protein complex,Molecular Biology of the Cell,21(19):3386-3395
Quenneville N.R.,Chao T.Y.,Mc Caffery J.M.,and Conibear E.,2006,Domains within the GARP subunit Vps54 confer separate functions in complex assembly and early endosome recognition,Molecular Biology of the Cell,17(4):1859-1870
Ramirez I.B.R.,and Lowe M.,2009,Golgins and GRASPs:hold ing the golgi together,Semin Cell Dev.Biol.,20(7):770-779
Rosa-Ferreira C.,Christis C.,Torres I.L.,and Munro S.,2015,The small G protein Arl5 contributes to endosome-to-Golgi traffic by aiding the recruitment of the GARP complex to the golgi,Biology Open,4(4):474-481
Schmitt-John T.,Drepper C.,Mubmann A.,Hahn P.,Kuhlmann M.,Thiel C.,Hafner M.,Lengeling A.,Heimann P.,Jones J.M.,Meisler M.H.,and Jockusch H.,2005,Mutation of Vps54 causes motor neuron disease and defective spermiogenesis in the wobbler mouse,Nature Genetics,37(11):1213-1215
Shestakova A.,Suvorova E.,Pavliv O.,Khaidakova G.,and Lupashin V.,2007,Interaction of the conserved oligomeric Golgi complex with t-SNARE Syntaxin5a/Sed5 enhances intra-Golgi SNARE complex stability,The Journal of Cell Biology,179(6):1179-1192
Siniossoglou S.,and Pelham H.R.B.,2002,Vps51p links the VFTcomplex to the SNARE Tlg1p,The Journal of Biological Chemistry,277(50):48318-48324
Sun Y.,Shestakova A.,Hunt L.,Sehgal S.,Lupashin V.,and Storrie B.,2007,Rab6 regulates both ZW10/RINT-1-and conserved oligomeric golgi complex-dependent golgi trafficking and homeostasis,Molecular Biology of the Cell,18(10):4129-4142
Takagi K.,Iwamoto K.,Kobayashi S.,Horiuchi H.,Fukuda R.,and Ohta A.,2012,Involvement of golgi-associated retrograde protein complex in the recycling of the putative Dnf aminophospholipid flippases in yeast,Biochemical and Biophysical Research Communications,417(1):490-494
Thielsen K.D.,Moser J.M.,Schmitt-John T.,Jensen M.S.,Jensen K.,and Holm M.M.,2013,The wobbler mouse model of amyotrophic lateral sclerosis(ALS)displays hippocampal hyperexcitability,and reduced number of interneurons,but no presynaptic vesicle release impairments,PLo S One,8(12):82767
Ueno K.,Saito M.,Nagashima M.,Kojima A.,Nishinoaki S.,Toshima J.Y.,and Toshima J.,2014,V-Atpase-dependent luminal acidification is required for endocytic recycling of a yeast cell wall stress sensor,Wsc1p,Biochemical and Biophysical Research Communications,443(2):549-555
Vasan N.,Hutagalung A.,Novick P.,and Reinisch K.M.,2010,Structure of a C-terminal fragment of its Vps53 subunit suggests similarity of golgi-associated retrograde protein(GARP)complex to a family of tethering complexes,Proc.Natl.Acad.Sci.USA,107(32):14176-14181
Vasquez-Rifo A.,BosséG.D.,Rondeau E.L.,Jannot G.,Dallaire A.,and Simard M.J.,2013,A new role for the GARP complex in micro RNA-mediated gene regulation,PLo S Genet,9(11):1003961
Wang L.C.,Tsai M.C.,Chang K.Y.,Fan Y.S.,Yeh C.H.,and Wu S.J.,2011,Involvement of the Arabidopsis HIT1/At VPS53tethering protein homologue in the acclimation of the plasma membrane to heat stress,Journal of Experimental Botany,62(10):3609-3620
Yu I.M.,and Hughson F.M.,2010,Tethering factors as organizers of intracellular vesicular traffic,Annual Review of Cell and Developmental Biology,26:137-156
Bonifacino J.S.,and Glick B.S.,2004,The mechanisms of vesicle budding and fusion,Cell,116(2):153-166
Bonifacino J.S.,and Hierro A.,2011,Transport according to GARP:receiving retrograde cargo at the Trans-Golgi network,Trends Cell Biol.,21(3):159-167
Cai H.Q.,Yu S.,Menon S.,Cai Y.Y.,Lazarova D.,Fu C.,Reinisch K.,Hay J.C.,and Ferro-Novick S.,2007,TRAPPⅠtethers COPⅡvesicles by binding the coat subunit Sec23,Nature,445(7130):941-944
Conibear E.,Cleck J.N.,and Stevens T.H.,2003,Vps51p mediates the association of the GARP(Vps52/53/54)complex with the late golgi t-SNARE Tlg1p,Molecular Biology of the Cell,14(4):1610-1623
Conibear E.,and Stevens T.H.,2000,Vps52p,Vps53p,and Vps54p form a novel multisubunit complex required for protein sorting at the yeast late Golgi,Molecular Biology of the Cell,11(1):305-323
Cottam N.P.,and Ungar D.,2012,Retrograde vesicle transport in the golgi,Protoplasma,249(4):943-955
Desfougères Y.,D'Agostino M.,and Mayer A.,2015,A modular tethering complex for endosomal recycling,Nature Cell Biology,17(5):540-541
Dotiwala F.,Eapen V.V.,Harrison J.C.,Arbel-Eden A.,Ranade V.,Yoshida S.,and Haber J.E.,2013,DNA damage checkpoint triggers autophagy to regulate the initiation of anaphase,Proc.Natl.Acad.Sci.USA,110(1):41-49
Eapen V.V.,and Haber J.E.,2013,DNA damage signaling triggers the cytoplasm-to-vacuole pathway of autophagy to regulate cell cycle progression,Autophagy,9(3):440-441
Fabrizio J.J.,Hime G.,Lemmon S.K.,and Bazinet C.,1998,Genetic dissection of sperm individualization in Drosophila melanogaster,Development,125(10):1833-1843
Feinstein M.,Flusser H.,Lerman-Sagie T.,Ben-Zeev B.,Lev D.,Agamy O.,Cohen I.,Kadir R.,Sivan S.,Leshinsky-Silver E.,Markus B.,and Birk O.S.,2014,Vps53 mutations cause progressive cerebello-cerebral atrophy type 2(PCCA2),Journal of Medical Genetics,51(5):303-308
Fiedler T.A.,Karpova T.S.,Fleig U.,Young M.E.,Cooper J.A.,and Hegemann J.H.,2002,The vesicular transport protein Cgp1p/Vps54p/Tcs3p/Luv1p is required for the integrity of the actin cytoskeleton,Molecular Genetics and Genomics,268(2):190-205
Fridmann-Sirkis Y.,Kent H.M.,Lewis M.J.,Evans P.R.,and Pelham H.R.,2006,Structural analysis of the interaction between the snare Tlg1 and Vps51,Traffic,7(2):182-190
Frohlich F.,Petit C.,Kory N.,Christiano R.,Hannibal-Bach H.K.,Graham M.,Liu X.R.,Ejsing C.S.,Farese R.V.,and Walther T.C.,2015,The GARP complex is required for cellular sphingolipid homeostasis,Elife,4:8712
Guermonprez H.,Smertenko A.,Crosnier M.T.,Durandet M.,Vrielynck N.,Guerche P.,Hussey P.J.,Satiat-Jeunemaitre B.,and Bonhomme S.,2008,The Pok/Atvps52 protein localizes to several distinct post-golgi compartments in sporophytic and gametophytic cells,Journal of Experimental Botany,59(11):3087-3098
Heard W.,SklenáǐJ.,ToméD.F.A.,Robatzek S.,Jones A.M.E.,2015,Identification of regulatory and cargo proteins of endosomal and secretory pathways in Arabidopsis thaliana by proteomic dissection,Molecular&Cellular Proteomics,14(7):1796-1813
Hirata T.,Fujita M.,Nakamura S.,Gotoh K.,Motooka D.,Murakami Y.,Maeda Y.,and Kinoshita T.,2015,Post-golgi anterograde transport requires GARP-dependent endosome to TGN retrograde transport,Molecular Biology of the Cell,26(17):3071-3084
Ho S.Y.,Lorent K.,Pack M.,and Farber S.A.,2006,Zebrafish fat-free is required for intestinal lipid absorption and golgi apparatus structure,Cell Metab.,3(4):289-300
Hong W.J.,and Lev S.,2014,Tethering the assembly of SNAREcomplexes,Trends in Cell Biology,24(1):35-43
Jockusch H.,Holland A.,Staunton L.,Schmitt-John T.,Heimann P.,Dowling P.,and Ohlendieck K.,2014,Pathoproteomics of testicular tissue deficient in the GARP component VPS54:the wobbler mouse model of globozoospermia,Proteomics,14(7-8):839-852
Karlsson P.,Droce A.,Moser J.M.,Cuhlmann S.,Padilla C.O.,Heimann P.,Bartsch J.W.,Füchtbauer A.,Füchtbauer E.M.,and Schmitt-John T.,2013,Loss of Vps54 function leads to vesicle traffic impairment,protein mis-sorting and embryonic lethality,Int.J.Mol.Sci.,14(6):10908-10925
Koumandou V.L.,Dacks J.B.,Coulson R.M.R.,and Field M.C.,2007,Control systems for membrane fusion in the ancestral eukaryote;evolution of tethering complexes and SM proteins,BMC Evolutionary Biology,7(1):29
Lee C.F.,Pu H.Y.,Wang L.C.,Sayler R.J.,Yeh C.H.,and Wu S.J.,2006,Mutation in a homolog of yeast Vps53p accounts for the heat and osmotic hypersensitive phenotypes in Arabidopsis hit1-1 mutant,Planta,224(2):330-338
Li Z.F.,and Blissard G.,2014,The vacuolar protein sorting genes in insects:a comparative genome view,Insect Biochemistry and Molecular Biology,62:211-225
Liewe n H.,Meinhold-Heerlein I.,Oliveira V.,Schwarzenbacher R.,Luo G.R.,Wadle A.,Jung M.,Pfreundschuh M.,and Stenner-Liewen F.,2005,Characterization of the Human GARP(golgi associated retrograde protein)complex,Experimental Cell Research,306(1):24-34
Lobstein E.,Guyon A.,Férault M.,Twell D.,Pelletier G.,and Bonhomme S.,2004,The putative Arabidopsis homolog of yeast Vps52p is required for pollen tube elongation,localizes to golgi,and might be involved in vesicle trafficking,Plant Physiology,135(3):1480-1490
Marcusson E.G.,Horazdovsky B.F.,Cereghino J.L.,Gharakhanian E.,and Emr S.D.,1994,The sorting receptor for yeast vacuolar carboxypeptidase Y is encoded by the VPS10 gene,Cell,77(4):579-586
Mc Dermott H.,and Kim K.,2015,Molecular dynamics at the endocytic portal and regulations ofendocytic and recycling traffics,European Journal of Cell Biology,94(6):235-248
Moser J.M.,Bigini P.,and Schmitt-John T.,2013,The wobbler mouse,an ALS animal model,Mol.Genet.Genomics,288(5):207-229
Munro S.,2011,The golgin coiled-coil proteins of the golgi apparatus,Cold Spring Harbor Perspectives in Biology,3(6):1-14
Otto G.P.,Razi M.,Morvan J.,Stenner F.,and Tooze S.A.,2010,A novel syntaxin 6-interacting protein,SHIP164,regulates syntaxin 6-dependent sorting from early endosomes,Traffic,11(5):688-705
Pahari S.,Cormark R.D.,Blackshaw M.T.,Liu C.,Erickson J.L.,and Schultz E.A.,2014,Arabidopsis UNHINGED encodes a VPS51 homolog and reveals a role for the GARPcomplex in leaf shape and vein patterning,Development,141(9):1894-1905
Panic B.,Whyte J.R.C.,and Munro S.,2003,The ARF-like GT-Pases Arl1p and Arl3p act in a pathway that interacts with vesicle-tethering factors at the golgi apparatus,Current Biology,13(5):405-410
Pérez-Victoria F.J.,Abascal-Palacios G.,Tascón I.,Kajava A.,Magadán J.G.,Pioro E.P.,Bonifacino J.S.,and Hierro A.,2010a,Structural basis for the wobbler mouse neurodegenerative disorder caused by mutation in the Vps54 subunit of the GARP complex,Proc.Natl.Acad.Sci.USA,107(29):12860-12865
Pérez-Victoria F.J.,and Bonifacino J.S.,2009,Dual roles of the mammalian GARP complex in tethering and SNARE complex assembly at the trans-Golgi network,Molecular and Cellular Biology,29(19):5251-5263
Pérez-Victoria F.J.,Mardones G.A.,and Bonifacino J.S.,2008,Requirement of the human GARP complex for mannose6-phosphate-receptor-dependent sorting of cathepsin D to lysosomes,Molecular Biology of the Cell,19(6):2350-2362
Pérez-Victoria F.J.,Schindler C.,Magadán J.G.,Mardones G.A.,Delevoye C.,Romao M.,Raposo G.,and Bonifacino J.S.,2010b,Ang2/fat-free is a conserved subunit of the golgi-associated retrograde protein complex,Molecular Biology of the Cell,21(19):3386-3395
Quenneville N.R.,Chao T.Y.,Mc Caffery J.M.,and Conibear E.,2006,Domains within the GARP subunit Vps54 confer separate functions in complex assembly and early endosome recognition,Molecular Biology of the Cell,17(4):1859-1870
Ramirez I.B.R.,and Lowe M.,2009,Golgins and GRASPs:hold ing the golgi together,Semin Cell Dev.Biol.,20(7):770-779
Rosa-Ferreira C.,Christis C.,Torres I.L.,and Munro S.,2015,The small G protein Arl5 contributes to endosome-to-Golgi traffic by aiding the recruitment of the GARP complex to the golgi,Biology Open,4(4):474-481
Schmitt-John T.,Drepper C.,Mubmann A.,Hahn P.,Kuhlmann M.,Thiel C.,Hafner M.,Lengeling A.,Heimann P.,Jones J.M.,Meisler M.H.,and Jockusch H.,2005,Mutation of Vps54 causes motor neuron disease and defective spermiogenesis in the wobbler mouse,Nature Genetics,37(11):1213-1215
Shestakova A.,Suvorova E.,Pavliv O.,Khaidakova G.,and Lupashin V.,2007,Interaction of the conserved oligomeric Golgi complex with t-SNARE Syntaxin5a/Sed5 enhances intra-Golgi SNARE complex stability,The Journal of Cell Biology,179(6):1179-1192
Siniossoglou S.,and Pelham H.R.B.,2002,Vps51p links the VFTcomplex to the SNARE Tlg1p,The Journal of Biological Chemistry,277(50):48318-48324
Sun Y.,Shestakova A.,Hunt L.,Sehgal S.,Lupashin V.,and Storrie B.,2007,Rab6 regulates both ZW10/RINT-1-and conserved oligomeric golgi complex-dependent golgi trafficking and homeostasis,Molecular Biology of the Cell,18(10):4129-4142
Takagi K.,Iwamoto K.,Kobayashi S.,Horiuchi H.,Fukuda R.,and Ohta A.,2012,Involvement of golgi-associated retrograde protein complex in the recycling of the putative Dnf aminophospholipid flippases in yeast,Biochemical and Biophysical Research Communications,417(1):490-494
Thielsen K.D.,Moser J.M.,Schmitt-John T.,Jensen M.S.,Jensen K.,and Holm M.M.,2013,The wobbler mouse model of amyotrophic lateral sclerosis(ALS)displays hippocampal hyperexcitability,and reduced number of interneurons,but no presynaptic vesicle release impairments,PLo S One,8(12):82767
Ueno K.,Saito M.,Nagashima M.,Kojima A.,Nishinoaki S.,Toshima J.Y.,and Toshima J.,2014,V-Atpase-dependent luminal acidification is required for endocytic recycling of a yeast cell wall stress sensor,Wsc1p,Biochemical and Biophysical Research Communications,443(2):549-555
Vasan N.,Hutagalung A.,Novick P.,and Reinisch K.M.,2010,Structure of a C-terminal fragment of its Vps53 subunit suggests similarity of golgi-associated retrograde protein(GARP)complex to a family of tethering complexes,Proc.Natl.Acad.Sci.USA,107(32):14176-14181
Vasquez-Rifo A.,BosséG.D.,Rondeau E.L.,Jannot G.,Dallaire A.,and Simard M.J.,2013,A new role for the GARP complex in micro RNA-mediated gene regulation,PLo S Genet,9(11):1003961
Wang L.C.,Tsai M.C.,Chang K.Y.,Fan Y.S.,Yeh C.H.,and Wu S.J.,2011,Involvement of the Arabidopsis HIT1/At VPS53tethering protein homologue in the acclimation of the plasma membrane to heat stress,Journal of Experimental Botany,62(10):3609-3620
Yu I.M.,and Hughson F.M.,2010,Tethering factors as organizers of intracellular vesicular traffic,Annual Review of Cell and Developmental Biology,26:137-156