硝苯地平与硫酸镁治疗早产的临床效果比较
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摘要
目的分析硫酸镁与硝苯地平治疗早产的临床效果、母婴结局及不良事件。方法回顾性分析2016年2月～2017年3月四川省宜宾市第一人民医院接收的98例先兆性早产孕妇资料,依据医治方案不同可分成两组,将行硝苯地平医治的49例患者设为研究组,行硫酸镁医治的49例患者设为对照组,对比两组临床疗效、母婴结局及不良反应状况。结果研究组孕龄延长≥7 d、孕龄延长≥2 d、保胎成功者占比高于对照组,显效时间短于对照组,不良反应总发生率低于对照组,差异均有统计学意义(P <0.05);两组新生儿体重、Apgar评分、分娩孕龄、初次用药后宫缩抑制的时间等母婴结局对比差异无统计学意义(P> 0.05)。结论先兆早产孕妇行硝苯地平医治可提高保胎成功率,延长孕龄,而且药物不良反应发生率较低,具一定临床应用与研究价值。
Objective To analyze clinical effects, maternal and infant outcomes and adverse events of magnesium sulfate and Nifedipine on premature delivery. Methods Clinical data of 98 preterm pregnant women from March 2017 to February 2016 in the First People′s Hospital of Yibin City in Sichuan Province were retrospectively analyzed, and they were divided into two groups according to the treatment scheme, 49 patients treated with Nifedipine were set up as the study group, 49 patients treated with Magnesium Sulfate were set up as the control group. The clinical curative effect, the maternal and infant outcome and the adverse reaction of the two groups were compared. Results In the study group, the proportion of pregnant women whose duration of gestational age longer than 7 d, gestational age longer than 2 d, and the success rate of fetus preservation were higher than those of control group, and the effective time was shorter than that of the control group, the total incidence of adverse reactions was lower than that of the control group, the differences were statistically significant(P < 0.05). There was no statistically difference in newborn weight, Apgar score, pregnancy week, and the time of uterine contraction after the first drug use between the two groups(P > 0.05). Conclusion Treatment with Nifedipine for preterm pregnant women can improve the success rate of pregnancy preservation and prolong the gestational weeks,and the incidence of adverse reactions of drug is low, with a certain clinical application and research value.
Objective To analyze clinical effects, maternal and infant outcomes and adverse events of magnesium sulfate and Nifedipine on premature delivery. Methods Clinical data of 98 preterm pregnant women from March 2017 to February 2016 in the First People′s Hospital of Yibin City in Sichuan Province were retrospectively analyzed, and they were divided into two groups according to the treatment scheme, 49 patients treated with Nifedipine were set up as the study group, 49 patients treated with Magnesium Sulfate were set up as the control group. The clinical curative effect, the maternal and infant outcome and the adverse reaction of the two groups were compared. Results In the study group, the proportion of pregnant women whose duration of gestational age longer than 7 d, gestational age longer than 2 d, and the success rate of fetus preservation were higher than those of control group, and the effective time was shorter than that of the control group, the total incidence of adverse reactions was lower than that of the control group, the differences were statistically significant(P < 0.05). There was no statistically difference in newborn weight, Apgar score, pregnancy week, and the time of uterine contraction after the first drug use between the two groups(P > 0.05). Conclusion Treatment with Nifedipine for preterm pregnant women can improve the success rate of pregnancy preservation and prolong the gestational weeks,and the incidence of adverse reactions of drug is low, with a certain clinical application and research value.
引文
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[11]Tsopanoglou SP,Davidson J,Goulart AL,et al.Functional capacity during exercise in very-low-birth-weight premature children[J].Pediatr Pulmonol,2013,49(1):91-98.
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[14]麦隽,綦巧雯,蔡琍璇.双水平正压通气和经鼻持续呼吸道正压通气在早产儿呼吸窘迫综合征初始治疗中应用比较[J].中国妇幼保健,2015,30(11):1690-1694.
[15]李旭芳,关瑞莲,程婷婷.不同通气方式对肺表面活性物质治疗呼吸窘迫综合征早产儿过程中脑氧代谢的影响[J].中华实用儿科杂志,2017,32(2):96-99.
[16]谷秋寒,毛红莉,马艳红,等.硫酸镁联合硝苯地平治疗妊娠期高血压患者的临床效果[J].中国生化药物杂志,2016,36(6):97-99.
[17]方娟,魏宇峰.硫酸镁联合硝苯地平治疗妊娠期高血压疾病患者的临床效果及血清学指标分析[J].中国妇幼保健,2015,30(10):1528-1530.
[18]吴丽云.硝苯地平联合硫酸镁治疗妊娠高血压综合征的临床疗效[J].临床合理用药,2016,9(10):34-36.
[19]朱平.硝苯地平治疗先兆早产的效果观察[J].中国当代医药,2017,24(3):110-111,148.
[20]朱君.硫酸镁联合硝苯地平对妊娠期高血压患者血压控制及妊娠结局的影响[J].河南医学研究,2017,26(13):2448-2449.
[2]王静,吴兰芬,李苗.抗菌药物治疗妊娠中期阴道炎的疗效及与早产的关系探讨[J].中华医院感染学杂志,2014,24(11):2816-2817.
[3]陈璐,温弘,钱越,等.子宫颈锥切术对子宫颈管长度及早产的影响[J].中华妇产科杂志,2016,51(9):701-703.
[4]Taittonen L,Korhonen P,Palom覿ki O,et al.Opinions on the counselling,care and outcome of extremely premature birth among healthcare professionals in Finland[J].Acta Paediatr,2014,103(3):125-131.
[5]Pakrashi T,Defranco EA.The relative proportion of preterm births complicated by premature rupture of membranes in multifetal gestations:A population-based study[J].Am JPerinatol,30,23(1):23-29.
[6]伍冬,陈灵芝.多维度评估在早产儿NCPAP治疗下鼻中隔皮肤损伤中的应用效果[J].中华现代护理杂志,2017,23(5):701-705.
[7]刘鸽,田秀英,赵颖.不同剂量咖啡因治疗早产儿原发性呼吸暂停临床效果评估[J].中华儿科杂志,2016,54(1):33-36.
[8]潘涛,朱秋皎,肖志辉.双水平正压通气联合早期气管插管一肺表面活性物质-拔管策略治疗早产儿呼吸窘迫综合征的效果[J].中华围产医学杂志,2014,17(2):122-125.
[9]杨波,高翔羽,黑明燕.对乙酰氨基酚治疗早产儿症状性动脉导管未闭的研究进展[J].中华实用儿科杂志,2017,32(2):152-155.
[10]钱虎飞,魏嘉,刘瑜.早期脑室外引流术治疗早产儿或低出生体重儿生发基质-脑室内出血[J].中华神经外科杂志,2016,32(9):886-889.
[11]Tsopanoglou SP,Davidson J,Goulart AL,et al.Functional capacity during exercise in very-low-birth-weight premature children[J].Pediatr Pulmonol,2013,49(1):91-98.
[12]赵玉祥,武荣,韩良荣.改良气管插管-肺表面活性物质-拔管后鼻塞呼吸道正压通气方法治疗早产儿呼吸窘迫综合征的疗效[J].中华实用儿科杂志,2014,29(2):159-160.
[13]陈信,潘家华.无创通气在早产儿呼吸窘迫综合征中的应用进展[J].中国当代儿科杂志,2014,16(11):1177-1182.
[14]麦隽,綦巧雯,蔡琍璇.双水平正压通气和经鼻持续呼吸道正压通气在早产儿呼吸窘迫综合征初始治疗中应用比较[J].中国妇幼保健,2015,30(11):1690-1694.
[15]李旭芳,关瑞莲,程婷婷.不同通气方式对肺表面活性物质治疗呼吸窘迫综合征早产儿过程中脑氧代谢的影响[J].中华实用儿科杂志,2017,32(2):96-99.
[16]谷秋寒,毛红莉,马艳红,等.硫酸镁联合硝苯地平治疗妊娠期高血压患者的临床效果[J].中国生化药物杂志,2016,36(6):97-99.
[17]方娟,魏宇峰.硫酸镁联合硝苯地平治疗妊娠期高血压疾病患者的临床效果及血清学指标分析[J].中国妇幼保健,2015,30(10):1528-1530.
[18]吴丽云.硝苯地平联合硫酸镁治疗妊娠高血压综合征的临床疗效[J].临床合理用药,2016,9(10):34-36.
[19]朱平.硝苯地平治疗先兆早产的效果观察[J].中国当代医药,2017,24(3):110-111,148.
[20]朱君.硫酸镁联合硝苯地平对妊娠期高血压患者血压控制及妊娠结局的影响[J].河南医学研究,2017,26(13):2448-2449.