摘要
目的探讨肠促胰腺素类降糖药物对2型糖尿病患者骨质代谢的影响。方法回顾性分析医院101例2型糖尿病患者的临床资料,根据其治疗方案的不同进行分组,其中行二甲双胍+二肽基肽酶4(DPP-4)抑制剂(西格列汀片)治疗的为A组(34例),进行二甲双胍+胰高血糖素样肽-1(GLP-1)受体激动剂治疗的为B组(31例),进行二甲双胍+甘精胰岛素治疗的为C组(36例)。结果 3组患者治疗前的性别、年龄、糖尿病病程、体质量指数(BMI)、糖化血红蛋白(HbA1C)、空腹血糖(FBG)比较均无显著差异(P>0.05);治疗后,A组体质量明显大于B组与C组(P<0.05),骨密度(BMD)、血清钙离子(Ca~(2+))浓度、磷酸盐和碱性磷酸酶(ALP)水平均明显高于B组与C组(P<0.05);B组BMD、血清Ca~(2+)、磷酸盐和ALP水平与C组比较均无显著性差异(P>0.05)。结论 DPP-4抑制剂与二甲双胍联合治疗2型糖尿病疗效显著,且对BMD和血清骨代谢标志物水平有更好的改善作用。
Objective To investigate the effect of incretin-like hypoglycemic drugs on bone metabolism in patients with type 2 diabetes mellitus( T2DM).Methods The clinical data of 101 patients with T2DM in our hospital were retrospectively analyzed.The patients were divided into 3 groups according to their treatment regimens:Group A( 34 cases) was treated with metformin and DPP-4 inhibitor( Sitagliptin Tablets),group B( 31 cases) was treated with metformin and GLP-1 receptor agonist,group C( 36 cases) was treated with metformin and insulin glargine.Results There was no significant difference in the gender,age,duration of diabetes,BMI,HbA1 Cand FBG among the three groups before treatment( P > 0.05).After treatment,the body weight in group A was significantly higher than those in group B and group C( P < 0.05).After treatment,the levels of bone mineral density( BMD),serum Ca~(2+) concentration,phosphate and alkaline phosphatase in group A were significantly higher than those group B and group C( P < 0.05),but there was no significant difference in the above indexes between group B and group C( P < 0.05).Conclusion DPP-4 inhibitor combined with metformin is effective in the treatment of T2DM,and it has a good improvement effect on the BMD and serum bone metabolism markers.
引文
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