咽后间隙高分化脂肪肉瘤1例
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摘要
<正>1 病例报告患者,女,60岁,因平卧时呼吸不畅1年于2018年7月10日入院。患者于1年前平卧时自觉呼吸不畅,伴颈部压迫感;伴进食梗塞感,尤以进食固体食物为甚,无咽痛及呼吸困难。曾就诊于外院行颈部超声及甲状腺功能检查,考虑桥本甲状腺炎,给予药物治疗后症状无好转遂就诊于我院。患者既往体健。体格检查:生命体征平稳,心肺腹未见明显异常;专科检查:咽部黏膜慢性充血,咽后壁肿物前突、遮挡喉腔后部,导致喉咽腔狭窄,双侧梨状窝未窥及(图1);颈部
Liposarcomas represent a significant proportion of softtissue sarcomas. However, rare cases of primary liposarcoma of the throat have been reported in the literature and they are exceedingly rare in the retropharyngeal space. The present study report a case of a 60 year old patient with retropharyngeal liposarcoma. Uniquely, because the patient has a hashimoto's thyroiditis, therefore the patient presented with typically worsening poor breathing.
Liposarcomas represent a significant proportion of softtissue sarcomas. However, rare cases of primary liposarcoma of the throat have been reported in the literature and they are exceedingly rare in the retropharyngeal space. The present study report a case of a 60 year old patient with retropharyngeal liposarcoma. Uniquely, because the patient has a hashimoto's thyroiditis, therefore the patient presented with typically worsening poor breathing.
引文
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[4]BRISKI L M,JORNS J M.Primary breast atypical lipomatous tumor/well-differentiated liposarcoma and dedifferentiated liposarcoma[J].Arch Pathol Lab Med,2018,142:268-274.
[5]CAROLINE L B,COINDRE J M,FERREIR C.The CDKN2A/CDKN2B/CDK4/CCND1pathway is pivotal in well-differentiated and dedifferentiated liposarcoma oncogenesis:an analysis of 104tumors[J].Genes Chromosomes Cancer,2011,50:896-907.
[6]ABDUL-GHAFAR J,AHMAD Z,USMAN TARIQM.Lipoblastoma:a clinicopathologic review of 23cases from a major tertiary care center plus detailed review of literature[J].BMC Res Notes,2018,42:1-6.
[7]CRAGO A M,SINGER S.Clinical and molecular approaches to well differentiated and dedifferentiated liposarcoma[J].Curr Opin Oncol,2011,23:373-376.
[8]HE J,JIANG H,YANG B.Liposarcoma of the retropharyngeal space with rapidly worsening dyspnea:Acase report and review of the literature[J].Oncol Lett,2013,5:1939-1942.
[9]THWAY K,JONES R L,NOUJAIM J.Dedifferentiated liposarcoma:updates on morphology,genetics,and therapeutic strategies[J].Adv Anat Pathol,2016,23:30-40.
[2]YUEH B,BASSEWITZ H L,EISELE D W.Retropharyngeal liposarcoma[J].Am J Otolaryngol,1995,16:331-340.
[3]JO V,FLETCHER C.WHO classification of soft tissue tumours[J].Pathology,2013,46:2013-2015.
[4]BRISKI L M,JORNS J M.Primary breast atypical lipomatous tumor/well-differentiated liposarcoma and dedifferentiated liposarcoma[J].Arch Pathol Lab Med,2018,142:268-274.
[5]CAROLINE L B,COINDRE J M,FERREIR C.The CDKN2A/CDKN2B/CDK4/CCND1pathway is pivotal in well-differentiated and dedifferentiated liposarcoma oncogenesis:an analysis of 104tumors[J].Genes Chromosomes Cancer,2011,50:896-907.
[6]ABDUL-GHAFAR J,AHMAD Z,USMAN TARIQM.Lipoblastoma:a clinicopathologic review of 23cases from a major tertiary care center plus detailed review of literature[J].BMC Res Notes,2018,42:1-6.
[7]CRAGO A M,SINGER S.Clinical and molecular approaches to well differentiated and dedifferentiated liposarcoma[J].Curr Opin Oncol,2011,23:373-376.
[8]HE J,JIANG H,YANG B.Liposarcoma of the retropharyngeal space with rapidly worsening dyspnea:Acase report and review of the literature[J].Oncol Lett,2013,5:1939-1942.
[9]THWAY K,JONES R L,NOUJAIM J.Dedifferentiated liposarcoma:updates on morphology,genetics,and therapeutic strategies[J].Adv Anat Pathol,2016,23:30-40.