α硫辛酸联合麦地参肾消胶囊对绝经后女性2型糖尿病肾病患者疗效及GDF-15的影响
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  • 英文篇名:The effect of Alpha lipoic acid combined with maidishen Shenxiao Capsule on postmenopausal women with type 2 diabetic nephropathy patients and its influence on GDF-15
  • 作者:卞伟 ; 张思为 ; 陈玲玲 ; 李佑生
  • 英文作者:BIAN Wei;ZHANG Si-wei;CHEN Ling-ling;Department of Chinese Medicine,The People'sHospital of Shenzhen;
  • 关键词:2型糖尿病肾病 ; 绝经后女性 ; α硫辛酸 ; 麦地参肾消胶囊 ; GDF-15
  • 英文关键词:Type 2 diabetic nephropathy;;Postmenopausal women;;Alpha lipoic acid;;Maidishen Shenxiao capsule;;GDF-15
  • 中文刊名:SYLC
  • 英文刊名:Journal of Clinical and Experimental Medicine
  • 机构:深圳市人民医院中医科;
  • 出版日期:2017-03-10
  • 出版单位:临床和实验医学杂志
  • 年:2017
  • 期:v.16;No.237
  • 基金:深圳市科技研发资金项目(编号:JCYJ20130402092657779)
  • 语种:中文;
  • 页:SYLC201705010
  • 页数:4
  • CN:05
  • ISSN:11-4749/R
  • 分类号:37-40
摘要
目的探究采用α硫辛酸联合麦地参肾消胶囊对绝经后女性2型糖尿病肾病治疗效果及肾损害相关指标、生长分化因子15(GDF-15)的影响。方法选取2型糖尿病肾病绝经后女性患者67例,按随机对照原则分为两组,对照组采用α硫辛酸注射液治疗,研究组在此基础上配合麦地参肾消胶囊。收集两组患者性别、年龄、病程等基本资料,同时测定血压、糖脂指标,参照《中药新药临床研究指导原则》判定临床疗效,测定治疗前后肾损害相关指标,采用酶联免疫吸附试验检测各组患者血浆中GDF-15的浓度。结果研究组治疗有效率90.62%(29/32)高于对照组治疗有效率71.43%(25/35),差异有统计学意义(P<0.05);与治疗前比较,两组治疗后尿微量白蛋白、血浆GDF-15及24h尿蛋白定量显著降低(P<0.05),肾小球滤过率显著升高(P<0.05);组间治疗后比较,研究组肾损害相关指标及血浆GDF-15较对照组改善更明显,差异具有统计学意义(P<0.05)。结论采用α硫辛酸联合麦地参肾消胶囊对绝经后女性2型糖尿病肾病患者疗效显著,能减轻肾损害,降低GDF-15含量,值得临床推广应用。
        Objective To explore the effects of alpha lipoic acid combined with maidishen Shenxiao Capsule in the treatment of postmenopausal women with type 2 diabetic nephropathy and influences on renal damage index,GDF-15. Methods A total of 67 postmenopausal women with type 2 diabetic nephropathy were selected,and randomly divided into two groups. The control group were treated with alpha lipoic acid injection therapy,the study group were treated with the Medina ginseng Shenxiao capsule on the basis of alpha lipoic acid injection. The data of gender,age and course of disease and other basic information,and the blood pressure,lipid index were collected. Clinical efficacy was measured according to the " standard" guiding principles of clinical research on new drugs,and before and after treatment of renal damage index was measured too. The level of GDF-15 was measured by enzyme-linked immunosorbent assay in each group. Results The effective rate of the treatment group was90. 62%( 29 /32),higher than that of the control group( 71. 43%,25 /35). Compared with before treatment,urinary microalbumin,plasma GDF-15 and 24 h urinary protein after treatment were significantly decreased( P<0. 05),and Glomerular filtration rate was significantly increased( P<0. 05) in the two groups after treatment. Compared with the control group,the levels of GDF-15 in the study group were significantly higher than those in the control group( P<0. 05),and the differences were statistically significant. Conclusion The effect on alpha lipoic acid combined with Maidishen Shenxiao capsule in the treatment of postmenopausal women with type 2 diabetic nephropathy patients is significant,and it can reduce renal damage and the content of GDF-15. It is worthy of clinical promotion.
引文
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