基于药化设计性实验培养学生创新与科研能力
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摘要
药物化学是药学相关专业的核心课程,具有很强的实践性。实验教学是培养学生动手操作、理论运用及创新能力的重要环节。前药设计可有效改善化合物的类药特征,并避免相关不良反应,是药物分子设计中较为重要也是最为常见的一种改造方法。本教研室针对近几年在实验教学实践遇到的问题,对药化实验教学模式进行了改革,通过开展对乙酰氨基酚前药设计性实验,培养学生创新与科研能力。通过实践提高了学生的文献查阅与实践操作能力,进一步提高学生对药化课程的学习兴趣。
As one of the sole courses of Pharmacy,Medicinal Chemistry relies highly on practice. The practical teaching is the key segment in cultivating students' abilities of handling operation,theory usage and innovation. The prodrug strategy is important in improving the drug-likeness and avoiding side effect. Some reforms in practical education were carried out and the prodrug design of paracetamol was launched,with the aim of cultivating students' innovative and scientific ability. The accomplishment of this experiment raised students' abilities of literature searching and practical operation,and further promoted their interest in Medicinal Chemistry.
As one of the sole courses of Pharmacy,Medicinal Chemistry relies highly on practice. The practical teaching is the key segment in cultivating students' abilities of handling operation,theory usage and innovation. The prodrug strategy is important in improving the drug-likeness and avoiding side effect. Some reforms in practical education were carried out and the prodrug design of paracetamol was launched,with the aim of cultivating students' innovative and scientific ability. The accomplishment of this experiment raised students' abilities of literature searching and practical operation,and further promoted their interest in Medicinal Chemistry.
引文
[1]陈洪,黄思庆,谢建英.药物化学教学模式改革的探索与创新[J].科技视界,2016(17):48.
[2]朱玲娟,宋少江,高慧媛,等.以药学创新人才培养为导向的天然药物化学实践教学研究[J].教育教学论坛,2018(6):180-181.
[3]莫颖华.关于高职药物化学实践教学的改革[J].教育教学论坛,2016(3):49-50.
[4]纪慧.非甾体抗炎药的临床应用及不良反应分析[J].中国现代药物应用,2018,12(24):127-128.
[5]万志勇.肌内注射安乃近不良反应2例[J].人民军医,2014,57(12):1308.
[6]李静孟,周东,刘权兴,等.脓毒血症应用丙氨酰谷氨酰胺双肽强化早期肠内营养治疗[J].中国临床研究,2018,31(11):1441-1444.
[7]武锬洋,王朝明,付奔,等.盐酸丙帕他莫合成工艺改进[J].山东化工,2018,47(15):26-27,31.
[8]高雷雷,黄俊凯,何黎琴.香豆素-3-羧酸-烟酸前药的设计、合成及抗血小板聚集活性的研究[J].化学世界,2014,55(7):429-433.
[9]姬勋,王江,张磊,等.磷酸酯前药在药物研究中的应用[J].药学学报,2013,48(5):621-634.
[2]朱玲娟,宋少江,高慧媛,等.以药学创新人才培养为导向的天然药物化学实践教学研究[J].教育教学论坛,2018(6):180-181.
[3]莫颖华.关于高职药物化学实践教学的改革[J].教育教学论坛,2016(3):49-50.
[4]纪慧.非甾体抗炎药的临床应用及不良反应分析[J].中国现代药物应用,2018,12(24):127-128.
[5]万志勇.肌内注射安乃近不良反应2例[J].人民军医,2014,57(12):1308.
[6]李静孟,周东,刘权兴,等.脓毒血症应用丙氨酰谷氨酰胺双肽强化早期肠内营养治疗[J].中国临床研究,2018,31(11):1441-1444.
[7]武锬洋,王朝明,付奔,等.盐酸丙帕他莫合成工艺改进[J].山东化工,2018,47(15):26-27,31.
[8]高雷雷,黄俊凯,何黎琴.香豆素-3-羧酸-烟酸前药的设计、合成及抗血小板聚集活性的研究[J].化学世界,2014,55(7):429-433.
[9]姬勋,王江,张磊,等.磷酸酯前药在药物研究中的应用[J].药学学报,2013,48(5):621-634.