输尿管下段结石体外冲击波碎石术后坦索罗辛联合索利那新辅助排石的疗效
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摘要
目的分析输尿管下段结石体外冲击波碎石术后坦索罗辛和索利那新辅助排石的治疗效果。方法选择我院2013年3月至2016年10月行输尿管下段结石体外冲击波碎石术治疗的100例患者作为研究对象,随机分为试验组及对照组,各50例。对照组行索利那新辅助排石,试验组行坦索罗辛联合索利那新辅助排石。对比两组患者的临床疗效。结果试验组患者的结石排净率为96.00%,明显高于对照组的80.00%(P<0.05);试验组患者的结石排出时间为(3.01±2.20)d,明显短于对照组的(6.50±2.20)d(P<0.05);试验组0、1、2级疼痛发生率均明显优于对照组(P<0.05);两组均未发生严重不良反应。结论输尿管下段结石患者体外冲击波碎石术后行坦索罗辛和索利那新辅助排石,可以提高排石成功率、加速排石,降低患者疼痛程度且无明显药物不良反应。
Objective To analyze the effect of tamsulosin combined with solifenacin on assisting remove calculus on distal ureteral calculus after extracorporeal shock wave lithotripsy(ESWL). Methods A total of 100 cases of patients with distal ureteral calculus underwent ESWL from March 2013 to October 2016 were selected as the study objects. They were randomly divided into experimental group and control group, with 50 cases in each group. The control group was treated with solifenacin and the experimental group was treated with tamsulosin and solifenacin to assisting remove urinary calculus. The clinical efficacy of the two groups were compared. Results The stone removal rate was 96.00% in the experimental group, which was significantly higher than 80.00% in the control group(P<0.05). The exclusion time of stones in the experimental group was(3.01±2.20) d, which was significantly shorter than(6.50 ±2.20) d in the control group(P<0.05). The incidences of pain at grade 0, grade 1 and grade 2 in the experimental group were significantly better than those in the control group(P<0.05); there was no serious adverse effect in the two groups. Conclusion For patients with distal ureteral calculus after ESWL, tamsulosin and solifenacin assisting remove calculus can reduce the success rate of stone removal, accelerate the row of stone, and reduce the pain degree, with no obvious adverse drug reaction.
Objective To analyze the effect of tamsulosin combined with solifenacin on assisting remove calculus on distal ureteral calculus after extracorporeal shock wave lithotripsy(ESWL). Methods A total of 100 cases of patients with distal ureteral calculus underwent ESWL from March 2013 to October 2016 were selected as the study objects. They were randomly divided into experimental group and control group, with 50 cases in each group. The control group was treated with solifenacin and the experimental group was treated with tamsulosin and solifenacin to assisting remove urinary calculus. The clinical efficacy of the two groups were compared. Results The stone removal rate was 96.00% in the experimental group, which was significantly higher than 80.00% in the control group(P<0.05). The exclusion time of stones in the experimental group was(3.01±2.20) d, which was significantly shorter than(6.50 ±2.20) d in the control group(P<0.05). The incidences of pain at grade 0, grade 1 and grade 2 in the experimental group were significantly better than those in the control group(P<0.05); there was no serious adverse effect in the two groups. Conclusion For patients with distal ureteral calculus after ESWL, tamsulosin and solifenacin assisting remove calculus can reduce the success rate of stone removal, accelerate the row of stone, and reduce the pain degree, with no obvious adverse drug reaction.
引文
[1]焦智勇,江世雄.坦索罗辛在输尿管下段结石体外冲击波碎石术后的排石作用[J].医学信息(中旬刊),2010,5(9):2520-2521.
[2]宫大鑫,姜振明,张哲,等.输尿管下段结石体外冲击波碎石术后坦索罗辛和索利那新辅助排石的疗效比较[J].中华泌尿外科杂志,2012,33(7):532-535.
[3]张哲,杨为民.坦索罗辛联合索利那新在输尿管下段结石体外冲击波碎石术后辅助排石中的应用[J].蚌埠医学院学报,2014,39(4):466-468.
[4]王明清,王旭光,高伯生,等.坦索罗辛对输尿管下段结石ESWL术后的辅助排石疗效研究[J].临床医药实践,2010,19(6):413-414.
[5]于峰.坦索罗辛在输尿管下段结石体外震波碎石术后辅助排石中的应用[J].实用药物与临床,2012,15(12):808-809.
[6]赵雪志,孙清,印荣,等.输尿管下段结石体外冲击波碎石术后盐酸坦索罗辛的应用观察[J].山东医药,2010,50(18):81-82.
[7]李冲,王娟,曹文娟,等.坦索罗辛和硝苯地平治疗输尿管下段结石疗效比较的荟萃分析[J].中华泌尿外科杂志,2015,36(11):847-853.
[8]仇军.对行碎石术的输尿管下段结石患者使用坦索罗辛和索利那新进行辅助排石的效果观察[J].当代医药论丛,2016,14(5):94-95.
[2]宫大鑫,姜振明,张哲,等.输尿管下段结石体外冲击波碎石术后坦索罗辛和索利那新辅助排石的疗效比较[J].中华泌尿外科杂志,2012,33(7):532-535.
[3]张哲,杨为民.坦索罗辛联合索利那新在输尿管下段结石体外冲击波碎石术后辅助排石中的应用[J].蚌埠医学院学报,2014,39(4):466-468.
[4]王明清,王旭光,高伯生,等.坦索罗辛对输尿管下段结石ESWL术后的辅助排石疗效研究[J].临床医药实践,2010,19(6):413-414.
[5]于峰.坦索罗辛在输尿管下段结石体外震波碎石术后辅助排石中的应用[J].实用药物与临床,2012,15(12):808-809.
[6]赵雪志,孙清,印荣,等.输尿管下段结石体外冲击波碎石术后盐酸坦索罗辛的应用观察[J].山东医药,2010,50(18):81-82.
[7]李冲,王娟,曹文娟,等.坦索罗辛和硝苯地平治疗输尿管下段结石疗效比较的荟萃分析[J].中华泌尿外科杂志,2015,36(11):847-853.
[8]仇军.对行碎石术的输尿管下段结石患者使用坦索罗辛和索利那新进行辅助排石的效果观察[J].当代医药论丛,2016,14(5):94-95.