中药功效物质与靶向治疗策略
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摘要
中医药与靶向治疗分属两个不同的学科体系,二者既有差别,又有多重联系和潜在的融合空间。这主要体现在二者理论体系的相通性,作用目的的相向性和实践手段的互补性上。中药功效物质的靶向治疗可以从两个角度理解。一方面,很多来源于中药的活性成分存在成药性问题,可通过现代靶向技术制备靶向制剂,以实现增效、减毒的目的;另一方面,在中医药思维下,很多中药功效成分能赋予药物或制剂良好的定向作用,引导他们更多地分布于某些特定区域,发挥靶向治疗的效果。将从上述两个角度综述近年来相关研究进展,以便于理解和发现二者的内在联系和潜在开发价值,促进中医药与制剂学科的融合发展。
Chinese medicine and targeted therapy belong to two different disciplinary systems.They have both differences and multiple connections and potential for integration.This is mainly reflected in the interconnectedness of the theoretical system,the syntropy of the purpose and the complementarity of the practical means.Targeted treatment of functional substance of Chinese medicine can be understood from two perspectives.On the one hand,many active ingredients derived from Chinese medicine have difficulties in druggability,which can be solved using the modern targeted technology for enhancing the efficacy and reducing the side effects.On the other hand,under the guiding thought of Chinese medicine,many functional substances of Chinese medicine endow drugs or preparations orientation to the specific regions,leading to the improved therapeutic effect.In this review,we summarize the research progress in recent years from the above two aspects in order to understand and discover the intrinsic relationship between them and the potential value of development,which will promote the integration development of Chinese medicine and pharmaceutics.
Chinese medicine and targeted therapy belong to two different disciplinary systems.They have both differences and multiple connections and potential for integration.This is mainly reflected in the interconnectedness of the theoretical system,the syntropy of the purpose and the complementarity of the practical means.Targeted treatment of functional substance of Chinese medicine can be understood from two perspectives.On the one hand,many active ingredients derived from Chinese medicine have difficulties in druggability,which can be solved using the modern targeted technology for enhancing the efficacy and reducing the side effects.On the other hand,under the guiding thought of Chinese medicine,many functional substances of Chinese medicine endow drugs or preparations orientation to the specific regions,leading to the improved therapeutic effect.In this review,we summarize the research progress in recent years from the above two aspects in order to understand and discover the intrinsic relationship between them and the potential value of development,which will promote the integration development of Chinese medicine and pharmaceutics.
引文
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[19]王利萍,奉建芳,胡凯莉,等.芳香开窍中药对血脑屏障通透性的调节作用及其机制研究进展[J].中国中药杂志,2014,39(6):949-954.
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[21]王刚,曾南,王建,等.合成冰片影响血脑屏障开放促槲皮素脑吸收的研究[J].中药药理与临床,2012,28(1):65-68.
[22]喻斌,蒋宝平,阮鸣,等.川芎嗪和不同剂量冰片配伍对全脑缺血/再灌注大鼠脑区特异性保护作用研究[J].中国药理学通报,2017,33(4):589-591.
[23]喻斌,阮鸣,董小平,等.不同间隔时间冰片处理对大鼠栀子苷脑靶向效应的影响[J].中国药理学通报,2012,28(6):862-866.
[24]REN JG,ZOU MJ,GAO P,et al.Tissue distribution of borneol-modified ganciclovir-loaded solid lipid nanoparticles in mice after intravenous administration[J].Eur J Pharm Biopharm,2013,83(2):141-148.
[25]林彦君,章津铭.新议桔梗“引经报使”理论研究思路与方法[J].中药与临床,2011,2(2):50-52.
[26]刘敏,孙龙军,唐德才.引经药桔梗“载药上行”作用辨析[J].中国中医急症,2010,9(8):1331-1333.
[27]边涛,王建平,赵驻军,等.中药桔梗对替米考星在肺脏中药物浓度的影响[J].畜牧兽医学报,2013,44(6):980-984.
[28]ZHU X,TSEND-AYUSH A,YUAN Z,et al.Glycyrrhetinic acid-modified TPGS polymeric micelles for hepatocellular carcinoma-targeted therapy[J].Int J Pharm,2017,529(1/2):451-464.
[2]蔡少青,王璇,尚明英,等.中药“显效理论”或有助于阐释并弘扬中药特色优势[J].中国中药杂志,2015,40(17):3435-3443.
[3]祖先鹏,林璋,谢海胜,等.中药有效成分与肠道菌群相互作用的研究进展[J].中国中药杂志,2016,41(10):1766-1772.
[4]SHI J,KANTOFF PW,WOOSTER R,et al.Cancer nanomedicine:progress,challenges and opportunities[J].Nat Rev Cancer,2017,17(1):20-37.
[5]周艳.抗肿瘤药紫杉醇的不良反应及临床合理用药分析[J].中国现代药物应用,2017,11(9):138-139.
[6]PEI Q,HU XL,LIU S,et al.Paclitaxel dimers assembling nanomedicines for treatment of cervix carcinoma[J].J Control Release,2017,28(54):23-33.
[7]PALLABITA C,PRASHANTH N,SHEEMA K,et al.Development of polyvinylpyrrolidone/paclitaxel self-assemblies for breast cancer[J].Acta Pharmacol Sin B,2017:1-12.
[8]毕文杰,穆小静,祖丽皮艳·阿布力米特,等.姜黄素新型靶向制剂研究进展[J].中国药学杂志,2015,50(4):323-329.
[9]SUN D,ZHOU JK,ZHAO LS,et al.Novel curcumin liposome modified with hyaluronan targeting CD44plays an anti-leukemic role in acute myeloid leukemia in vitro and in vivo[J].ACS Appl Mater Interf,2017,9(20):16857-16868.
[10]项松涛,赵明,史现勋,等.RDP多肽修饰的姜黄素隐形脂质体脑靶向作用的研究[J].中国药理学通报,2015,31(8):1136-1141.
[11]QIAO HZ,FANG D,CHEN J,et al.Orally delivered polycurcumin responsive to bacterial reduction for targeted therapy of inflammatory bowel disease[J].Drug Deliv,2017,24(1):233-242.
[12]QIAO HZ,SUN MJ,SU ZG,et al.Kidney-specific drug delivery system for renal fibrosis based on coordination-driven assembly of catechol-derived chitosan[J].Biomaterials,2014,35(25):7157-7171.
[13]LI J,ZHANG CT,HE WM,et al.Coordination-driven assembly of catechol-modified chitosan for the kidney-specific delivery of salvianolic acid B to treat renal fibrosis[J].Biomater Sci,2017,6(1):179-188.
[14]CHEN J,HE CQ,LIN AH,et al.Thermosensitive liposomes with higher phase transition temperature for targeted drug delivery to tumor[J].Int J Pharm,2014,475(2):408-415.
[15]刘敏,唐德才.引经药桔梗-牛膝在血府逐瘀汤中的配伍意义管窥[J].辽宁中医杂志,2010,37(12):2326-2327.
[16]黄巍,熊伟,唐灿,等.血府逐瘀汤中桔梗和牛膝对芍药苷组织分布的影响[J].中国实验方剂学杂志,2015,21(18):85-88.
[17]王倩,王斌,秦旭华,等.三妙丸中牛膝的基原考证及其引经作用浅析[J].中药与临床,2017,8(3):62-64.
[18]王云飞,李淑娟,杨伟朋,等.四君子加川牛膝方对大鼠下肢难愈性创面组织成纤维细胞及相关细胞因子的影响[J].上海中医药大学学报,2017,31(2):80-83.
[19]王利萍,奉建芳,胡凯莉,等.芳香开窍中药对血脑屏障通透性的调节作用及其机制研究进展[J].中国中药杂志,2014,39(6):949-954.
[20]王宁生,梁美蓉,刘启德,等.冰片“佐使则有功”之实验研究[J].中医杂志,1994,35(1):46-47.
[21]王刚,曾南,王建,等.合成冰片影响血脑屏障开放促槲皮素脑吸收的研究[J].中药药理与临床,2012,28(1):65-68.
[22]喻斌,蒋宝平,阮鸣,等.川芎嗪和不同剂量冰片配伍对全脑缺血/再灌注大鼠脑区特异性保护作用研究[J].中国药理学通报,2017,33(4):589-591.
[23]喻斌,阮鸣,董小平,等.不同间隔时间冰片处理对大鼠栀子苷脑靶向效应的影响[J].中国药理学通报,2012,28(6):862-866.
[24]REN JG,ZOU MJ,GAO P,et al.Tissue distribution of borneol-modified ganciclovir-loaded solid lipid nanoparticles in mice after intravenous administration[J].Eur J Pharm Biopharm,2013,83(2):141-148.
[25]林彦君,章津铭.新议桔梗“引经报使”理论研究思路与方法[J].中药与临床,2011,2(2):50-52.
[26]刘敏,孙龙军,唐德才.引经药桔梗“载药上行”作用辨析[J].中国中医急症,2010,9(8):1331-1333.
[27]边涛,王建平,赵驻军,等.中药桔梗对替米考星在肺脏中药物浓度的影响[J].畜牧兽医学报,2013,44(6):980-984.
[28]ZHU X,TSEND-AYUSH A,YUAN Z,et al.Glycyrrhetinic acid-modified TPGS polymeric micelles for hepatocellular carcinoma-targeted therapy[J].Int J Pharm,2017,529(1/2):451-464.