长链非编码RNA在精子发生与卵泡发育中的研究进展
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摘要
长链非编码RNA(Long noncoding RNA,lncRNA)是一类长度大于200 nt,对基因表达起调控作用的非蛋白质编码RNA,其中很多已经被证明在动物生理、病理方面起到重要作用,目前lncRNA在动物繁殖方面的生物学研究较少。本文主要对lncRNA作用机制及其在精子发生和卵泡发育中的作用展开论述,为深入探究动物繁殖调控机制提供参考。
Long noncoding RNA(lncRNA) is a non-protein-encoding RNA that is more than 200 nt in length and participates in various biological processes and regulates gene expression. Many of them have been shown to play an important role in animal physiology and pathology,the lncRNA in animal breeding biology research is less, so this article mainly discusses the lncRNA mechanism and its role in Spermatogenesis and Spermatogenesis, provide a reference for delving into animal reproduction regulatory mechanism.
Long noncoding RNA(lncRNA) is a non-protein-encoding RNA that is more than 200 nt in length and participates in various biological processes and regulates gene expression. Many of them have been shown to play an important role in animal physiology and pathology,the lncRNA in animal breeding biology research is less, so this article mainly discusses the lncRNA mechanism and its role in Spermatogenesis and Spermatogenesis, provide a reference for delving into animal reproduction regulatory mechanism.
引文
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[2]Ponting C P,Oliver P L,Reik W.Evolution and functions of long noncoding RNAs[J].Cell,2009,136(4):629-641.
[3]Wang K C,Chang H Y.Molecular mechanisms of long noncoding RNAs[J].Mol Cell,2011,43(6):904-914.
[4]Dinger M E,Amaral P P,Mercer T R,et al.Pervasive transcription of the eukaryotic genome:functional indices and conceptual implications[J].Brief Funct Genomic Proteomic,2009,8:407-423.
[5]Pang K C,Frith M C,Mattick J S.Rapid evolution of noncoding RNAs:lack of conservation does not mean lack of function[J].Trends Genet,2006,22:1-5.
[6]Rinn J L,Kertesz M,Wang J K,et al.Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs[J].Cell,2007,129(7):1311-1323.
[7]Sleutels F,Zwart R,Barlow D P.The non-coding Air RNA is required for silencing autosomal imprinted genes[J].Nature,2002,415(6873):810-813.
[8]Wang X,Arai S,Song X,et al.Induced ncRNAs allosterically modify rna binding proteins in cis to inhibit transcription[J].Nature,2008,454(7200):126-130.
[9]He Y,Vogeistein B,Velculescu V E,et al.The antisense transcriptomes of human cells[J].Science,2008,322(5909):1855-1857.
[10]Wang H,Iacoangeli A,Lin D,et al.Dendritic BC1 RNA in translational control mechanisms[J].J Cell Biol,2005,171(5):811-821.
[11]Lu Y J,Liu X,Xie M H,et al.The NF-κB-responsive long noncoding RNA FIRRE regulates posttranscriptional regulation of inflammatory gene expression through interacting with hnRNPU[J].J Immunol,2017,199(10):3571-3582.
[12]Willingham A T,Orth A P,Batalov S,et al.A strategy for probing the function of noncoding RNAs finds a repressor of NFAT[J].Science,2005,309(5740):1570-1573.
[13]Krawczyk M,Emerson B M.P50-associated COX-2 Extragenic RNA(pacer)activates human COX-2 gene expression by occluding repressive NF-κB p50 complexes[J].ELife,2014(3):e01776.
[14]Wolgemuth D J,Laurion E,Lele K M.Regulation of the mitotic and meiotic cell cycles in the male germ line[J].Recent Prog Horm Res,2002,57:75-101.
[15]JGarcia-Lopez L,Alonso D B,Cardenas,et al.Diversity and functional convergence of small noncoding RNAs in male germ cell differentiation and fertilization[J].RNA,2015,21:946-962.
[16]李世平,成姝婷,王正荣.非编码RNA调控精子发生的研究进展[J].四川生理科学杂志,2017,39(2):95-98.
[17]Liu K S,Li T P,Ton H.Advances of long noncoding RNAsmediated regulation in reproduction[J].Chin Med J(Engl),2018,131(2):226-234.
[18]Soumillon M,Necsulea A,Weier M,et al.Cellular source and mechanisms of high transcriptome complexity in the mammalian testis[J].Cell Rep,2013,3(6):2179-2190.
[19]Hong S H,Kwon J T,Kim J,et al.Profiling of testis-specific long noncoding RNAs in mice[J].BMC Genomics,2018,19(1):539.
[20]Ran M,Chen B,Li Z,et al.Systematic identification of long noncoding RNAs in immature and mature porcine testes[J].Biol Reprod,2016,94(4):77.
[21]Nakajima R,Sato T,Ogawa T,et al.A noncoding RNA containing a SINE-B1 motif associates with meiotic metaphase chromatin and has an indispensable function during spermatogenesis[J].PLoS One,2017,12(6):e0179585.
[22]Bao J,Wu J,Schuster A S,et al.Expression profiling reveals developmentally regulated lncRNA repertoire in the mouse male germline[J].Biol Reprod,2013,89(5):107.
[23]Akhade V S,Arun G,Donakonda S.Genome wide chromatin occupancy of mrhl RNA and its role in gene regulation in mouse spermatogonial cells[J].RNA Biol,2015,11(10):1262-1279.
[24]Akhade V S,Dighe S N,Kataruka S,et al.Mechanism of Wnt signaling induced down regulation of mrhl long non-coding RNA in mouse spermatogonial cells[J].Nucleic Acids Res,2015,44(1):387-401.
[25]Arun G,Akhade V S,Donakonda S,et al.mrhl RNA,a long noncoding RNA,negatively regulates Wnt signaling through its protein partner Ddx5/p68 in mouse spermatogonial cells[J].Mol Cell Biol,2012,32(15):3140-3152.
[26]Anguera M C,Ma W,Clift D,et al.Tsx produces a long noncoding RNA and has general functions in the germline,stem cells,and brain[J].PLoS Genet,2011,7(9):e1002248.
[27]ZhangL,Lu H,Xin D,et al.A novel ncRNA gene from mouse chromosome 5 trans-splices with Dmrt1 on chromosome 19[J].Biochem Biophys Res Commun,2010,400:696-700.
[28]Luk A C,Chan W Y,Rennert O M,et al.Long noncoding RNAs in spermatogenesis:insights from recent high-throughput transcriptome studies[J].Reproduction,2014,147(5):R131-R141.
[29]肖国宏.miRNA-133b调控卵泡发育的分子机制[D].衡阳:南华大学,2014.
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[32]李梦寻,黄涛,马力鹏,等.猪lnc RNA-ENSSSCT00000018610的克隆及其在猪卵泡中的表达[J].畜牧兽医学报,2018,49(9):1830-1839.
[33]李加宇.长链非编码RNA调控小鼠卵巢发育的初步研究[D].广州:华南农业大学,2016.
[34]York J P,Ren Y A,Zeng J,et al.Growth arrest specific 2(GAS2)is a critical mediator of germ cell cyst breakdown and folliculogenesis in mice[J].Sci Rep,2016,6:34956.