颈动脉粥样硬化斑块的超声特征及其与血清脂联素、超敏C反应蛋白水平的相关性
|
摘要
目的分析颈动脉粥样硬化斑块的超声特征及其与血清脂联素、超敏C反应蛋白水平的相关性,并探讨脑梗死疾病的主要危险因素。方法选择2017年2月至2018年3月于我院神经内科就诊的60例脑梗死患者作为试验组,并选择同期60名体检健康者作为对照组。利用超声对受检者颈动脉粥样硬化斑块及斑块类型进行检测,并利用酶联免疫吸附法测定血清脂联素水平,通过免疫比浊法测定超敏C反应蛋白水平。分析斑块与血清脂联素、超敏C反应蛋白水平之间的相关性。结果试验组中具有饮酒史、高血压史、高血脂史、糖尿病史的患者占比明显高于对照组(P<0.05)。试验组的血清脂联素水平明显低于对照组,超敏C反应蛋白水平明显高于对照组(P<0.05)。试验组的斑块检出率明显高于对照组(P<0.05)。硬斑块患者血清脂联素水平明显高于软斑块患者,超敏C反应蛋白水平明显低于软斑块患者(P<0.05)。结论饮酒、高血压、高血脂及糖尿病等因素对颈动脉粥样硬化脑梗死疾病的发生、发展具有一定的影响。超声检测颈动脉情况及血清脂联素与超敏C反应蛋白水平检测在脑梗死等脑血管疾病的诊断中具有较高的临床应用价值
Objective To analyze the ultrasound characteristics of carotid atherosclerotic plaque and their correlationwith the levels of serum adiponectin and hypersensitive C-reactive protein, and to explore the main risk factors of cerebralinfarction. Methods Sixty patients with cerebral infarction treated in internal medicine-neurology department of our hospitalfrom February 2017 to March 2018 were selected as experimental group, and 60 healthy persons were selected as controlgroup during the same period. The carotid atherosclerotic plaques and plaque types were detected by ultrasound; the levelof serum adiponectin was determined by ELISA and the level of hypersensitive C-reactive protein was determined byimmunoturbidimetry. The correlation between plaque situation and levels of serum adiponectin and hypersensitive C-reactive protein was analyzed. Results The proportions of patients with history of drinking, hypertension, hyperlipidemia anddiabetes mellitus in the experimental group were significantly higher than those in the control group(P<0.05). The level ofserum adiponectin in the experimental group was significantly lower than that in the control group, and the level ofhypersensitive C-reactive protein was significantly higher than that in the control group(P <0.05). The detection rate ofplaque in the experimental group was significantly higher than that in the control group(P <0.05). The level of serumadiponectin in patients with hard plaque was significantly higher than that in patients with soft plaque, and the level ofhypersensitive C-reactive protein was significantly lower than that in patients with soft plaque(P <0.05). ConclusionDrinking, hypertension, hyperlipidemia and diabetes have certain effects on the occurrence and development of carotidatherosclerosis and cerebral infarction. Ultrasound detection of carotid artery condition and detection of levels of serumadiponectin and high-sensitivity C-reactive protein have high clinical application value in the diagnosis of cerebralinfarction and other cerebrovascular diseases.
Objective To analyze the ultrasound characteristics of carotid atherosclerotic plaque and their correlationwith the levels of serum adiponectin and hypersensitive C-reactive protein, and to explore the main risk factors of cerebralinfarction. Methods Sixty patients with cerebral infarction treated in internal medicine-neurology department of our hospitalfrom February 2017 to March 2018 were selected as experimental group, and 60 healthy persons were selected as controlgroup during the same period. The carotid atherosclerotic plaques and plaque types were detected by ultrasound; the levelof serum adiponectin was determined by ELISA and the level of hypersensitive C-reactive protein was determined byimmunoturbidimetry. The correlation between plaque situation and levels of serum adiponectin and hypersensitive C-reactive protein was analyzed. Results The proportions of patients with history of drinking, hypertension, hyperlipidemia anddiabetes mellitus in the experimental group were significantly higher than those in the control group(P<0.05). The level ofserum adiponectin in the experimental group was significantly lower than that in the control group, and the level ofhypersensitive C-reactive protein was significantly higher than that in the control group(P <0.05). The detection rate ofplaque in the experimental group was significantly higher than that in the control group(P <0.05). The level of serumadiponectin in patients with hard plaque was significantly higher than that in patients with soft plaque, and the level ofhypersensitive C-reactive protein was significantly lower than that in patients with soft plaque(P <0.05). ConclusionDrinking, hypertension, hyperlipidemia and diabetes have certain effects on the occurrence and development of carotidatherosclerosis and cerebral infarction. Ultrasound detection of carotid artery condition and detection of levels of serumadiponectin and high-sensitivity C-reactive protein have high clinical application value in the diagnosis of cerebralinfarction and other cerebrovascular diseases.
引文
[1]郑春梅,王薇,黄雪兰,等.颈动脉粥样硬化斑块与缺血性脑血管病的相关性[J].中国老年学,2016,36(18):4464-4465.
[2]李凤,朱余友,杨孙凤,等.血清五聚素3、超敏C反应蛋白、脂蛋白相关磷脂酶A2水平以及微栓子信号与大动脉粥样硬化型急性脑梗死患者颈动脉粥样硬化斑块稳定性的相关研究[J].临床神经病学杂志,2016,29(2):95-100.
[3]张作念,王志晔,顾伟,等.急性脑梗死患者血清炎症因子与颈动脉粥样硬化斑块性质关系的临床研究[J].重庆医学,2016,45(10)1375-1377.
[4]王新德.各类脑血管疾病诊断要点[J].中华神经科杂志,1996,29(6)379-380.
[5]王英歌,陈露,张新江,等.老年脑梗死患者血浆MMP-9、CD105和TIMP-1的表达水平及其与颈动脉粥样硬化斑块稳定性的相关性[J].中国老年学杂志,2017,37(12):2912-2913.
[6]王玮,王旭生,张帆,等.急性脑梗死患者颈动脉粥样硬化斑块稳定性与血清YKL-40水平的相关性研究[J].中风与神经疾病杂志2015,32(8):712-714.
[7]彭少华,王成伟.老年颈动脉粥样硬化斑块患者磁共振检查结果与临床症状的相关性[J].中国老年学杂志,2016,36(19):4749-4751.
[8]廖忠银,田力,邹小媚,等.高敏C反应蛋白及糖化血红蛋白与高血压脑出血患者颈动脉粥样硬化斑块的相关性[J].中国老年学杂志2017,37(15):3748-3750.
[9]刘逾前,李海波,张晓慧,等.不稳定性颈动脉粥样硬化斑块的相关因素[J].中国老年学杂志,2017,37(22):5597-5598.
[10]蔡秋琼,江怡,王颖,等.超声造影时间强度曲线技术预测颈动脉粥样硬化斑块新生血管的可行性分析[J].医学研究杂志,2015,44(6)76-79.
[11]王耀,朱启云,李光布.74例脑梗塞患者颈动脉粥样硬化斑块和血脂分析[J].中华全科医学,2015,13(5):854-856.
[12]王智明,李淮玉,李凤.颈动脉超声结合脂联素和超敏C反应蛋白在动脉粥样硬化脑梗死中的临床研究[J].实用医学杂志,2016,32(5):799-802.
[2]李凤,朱余友,杨孙凤,等.血清五聚素3、超敏C反应蛋白、脂蛋白相关磷脂酶A2水平以及微栓子信号与大动脉粥样硬化型急性脑梗死患者颈动脉粥样硬化斑块稳定性的相关研究[J].临床神经病学杂志,2016,29(2):95-100.
[3]张作念,王志晔,顾伟,等.急性脑梗死患者血清炎症因子与颈动脉粥样硬化斑块性质关系的临床研究[J].重庆医学,2016,45(10)1375-1377.
[4]王新德.各类脑血管疾病诊断要点[J].中华神经科杂志,1996,29(6)379-380.
[5]王英歌,陈露,张新江,等.老年脑梗死患者血浆MMP-9、CD105和TIMP-1的表达水平及其与颈动脉粥样硬化斑块稳定性的相关性[J].中国老年学杂志,2017,37(12):2912-2913.
[6]王玮,王旭生,张帆,等.急性脑梗死患者颈动脉粥样硬化斑块稳定性与血清YKL-40水平的相关性研究[J].中风与神经疾病杂志2015,32(8):712-714.
[7]彭少华,王成伟.老年颈动脉粥样硬化斑块患者磁共振检查结果与临床症状的相关性[J].中国老年学杂志,2016,36(19):4749-4751.
[8]廖忠银,田力,邹小媚,等.高敏C反应蛋白及糖化血红蛋白与高血压脑出血患者颈动脉粥样硬化斑块的相关性[J].中国老年学杂志2017,37(15):3748-3750.
[9]刘逾前,李海波,张晓慧,等.不稳定性颈动脉粥样硬化斑块的相关因素[J].中国老年学杂志,2017,37(22):5597-5598.
[10]蔡秋琼,江怡,王颖,等.超声造影时间强度曲线技术预测颈动脉粥样硬化斑块新生血管的可行性分析[J].医学研究杂志,2015,44(6)76-79.
[11]王耀,朱启云,李光布.74例脑梗塞患者颈动脉粥样硬化斑块和血脂分析[J].中华全科医学,2015,13(5):854-856.
[12]王智明,李淮玉,李凤.颈动脉超声结合脂联素和超敏C反应蛋白在动脉粥样硬化脑梗死中的临床研究[J].实用医学杂志,2016,32(5):799-802.