中国精神分裂症超高危人群认知功能的meta分析
|
摘要
目的通过meta分析探究中国精神分裂症超高危人群认知功能情况。方法在中国生物医学文献数据库、中国知网、万方、维普等中文数据库及Cochrane图书馆、Pubmed、Medline、Elsevier等英文数据库中搜集中国精神分裂症超高危人群认知功能相关病例对照研究,提取资料并评价偏倚风险,采用Rev Man 5.3软件进行meta分析。结果纳入14篇研究,466例研究对象。精神分裂症超高危人群在连线测验A(P=0.02)、符号编码测验(P<0.01)、语义流畅性测验(P=0.04)、持续操作测验(P<0.01)、空间广度测验(P<0.01)、霍普金斯词语学习测验(P=0.0003)、简易视觉记忆测验(P<0.01)、迷宫测验(P=0.007)、Stroop色-词试验(P<0.01)成绩均低于健康人群;情绪管理测验差异无统计学意义(P=0.33)。结论精神分裂症超高危人群存在相对广泛的认知功能损害,注意力与警觉性损害更严重。
Objective To investigate the cognitive function in Chinese ultra-high-risk schizophrenia group by meta-analysis. Methods Case-control studies of cognitive function in Chinese ultra-highrisk schizophrenia group were collected in CBM, CNKI, Wan Fang, VIP, Cochrane Library,Pubmed, Medline and Elsevie database. The risks of bias of included studies were assessed, and metaanalysis was performed by using Rev Man 5.3. Results Totally 14 studies were recruited, including466 samples. In the relative group, excepting Managing Emotions test(P=0.33), the results of Trail Marking test(P=0.02), Symbol Coding test(P<0.01), Verbal Fluency test(P=0.04), Continuous Performance test(P<0.01), Third Edition Spatial Span(P<0.01), Hopkins Verbal Leaning test-Revised(P=0.0003), Simple Visual Memory test-revised(P<0.01), Neuropsychological Assessment Battery Mazesedition(P=0.007) and Stroop Colorr-Word test(P<0.01) were worse than those in the control group. Conclusions The ultra-high-risk schizophrenia group has relatively widespread cognitive impairments range. There are more serious damages in attention and vigilance function.
Objective To investigate the cognitive function in Chinese ultra-high-risk schizophrenia group by meta-analysis. Methods Case-control studies of cognitive function in Chinese ultra-highrisk schizophrenia group were collected in CBM, CNKI, Wan Fang, VIP, Cochrane Library,Pubmed, Medline and Elsevie database. The risks of bias of included studies were assessed, and metaanalysis was performed by using Rev Man 5.3. Results Totally 14 studies were recruited, including466 samples. In the relative group, excepting Managing Emotions test(P=0.33), the results of Trail Marking test(P=0.02), Symbol Coding test(P<0.01), Verbal Fluency test(P=0.04), Continuous Performance test(P<0.01), Third Edition Spatial Span(P<0.01), Hopkins Verbal Leaning test-Revised(P=0.0003), Simple Visual Memory test-revised(P<0.01), Neuropsychological Assessment Battery Mazesedition(P=0.007) and Stroop Colorr-Word test(P<0.01) were worse than those in the control group. Conclusions The ultra-high-risk schizophrenia group has relatively widespread cognitive impairments range. There are more serious damages in attention and vigilance function.
引文
[1]Heinrichs RW,Zakzanis KK.Neurocognitive deficit in schizophrenia:a quantitative review of the evidence[J].Neuropsychology,1998,12(3):426-445.
[2]Miller TJ,Mcglashan TH,Woods SW,et al.Symptom assessment in schizophrenic prodromal states[J].Psychiatr Q,1999,70(4):273-287.
[3]Yung AR,Nelson B,Thompson A,et al.The psychosis threshold in Ultra High Risk(prodromal)research:is it valid[J].Schizophr Res,2010,120(1-3):1-6.
[4]Dickon H,Laurens KR,Cullen AE,et al.meta-analyses of cognitive and motor function in youth aged 16 years and younger who subsequently develop schizophrenia[J].Psychol Med,2012,42(4):743-755.
[5]宁玉萍,张璐璐.精神病风险综合征—诊断和随访手册[M].北京:人民卫生出版社,2012:144-145.
[6]Stroup DF,Berlin JA,Morton SC,et al.Meta-analysis of observational observational studies in epidemiology:a proposal for reporting.Meta-analysis Of Observational Studies in Epidemiology(MOOSE)group[J].J Am Med Assoc,2000,283(15):2008-2012.
[7]Wells GA,Shea BO,Connell D,et al.The NewcastleOttawa Scale(NOS)for assessing the quality of non-randomized studies in meta analyses[J].Appl Eng Agric,2013,7(5):2195-2207.
[8]鲍成,刘筠,刘得乐,等.精神分裂症超高危认知功能研究[J].现代诊断与治疗,2017,28(1):14-16.
[9]俞洋,徐彩霞,徐国洪,等.精神分裂症超高危人群认知功能研究[J].慢性病学杂志,2017,18(7):737-739。
[10]张哲,周福春,何凡,等.首发精神分裂症患者和精神病高危者的认知功能[J].中国心理卫生杂志,2017,31(5):345-349.
[11]Hou CL,Xiang YT,Wang ZL,et al.Cognitive functioning in individuals at ultra-high risk for psychosis,first-degree relatives of patients with psychosis and patients with first-episode schizophrenia[J].Schizophrenia Res,2016,174(1-3):71-76.
[12]陈清刚.精神分裂症超高危人群认知功能的对照研究[D].天津:天津医科大学,2014:5-30.
[13]范敏珍,吴逢春,郑洪波.精神分裂症超高危人群及首次发病患者的认知功能研究[J].临床精神医学杂志,2014,24(1):11-13.
[14]房茂胜,刘岩,周亚楠,等.精神分裂症超高危人群的认知功能对照研究[J].精神医学杂志,2016,29(4):249-252.
[15]韩汶洋,许鹏,姜忠东,等.某部新兵精神分裂症超高危人群认知功能分析[J].人民军医,2017,60(2):118-120.
[16]刘筠.精神分裂症超高危人群认知功能与氧化应激研究[D].南昌:南昌大学,2016:5-26.
[17]祁继鹏.首发精神分裂症及超高危人群的认知功能对照研究[D].新乡:新乡医学院,2015:6-30.
[18]肖垚南,范敏珍,吴逢春.精神分裂症超高危人群、首发患者认知功能与精神病理症状的相关性及帕利哌酮的干预作用[J].中国药业,2014,23(15):7-9.
[19]王中磊.精神病超高危人群认知功能和心理状况的比较研究[D].广州:南方医科大学,2015:8-37.
[20]张丽丽,张云淑,贾海,等.精神病超高危人群及精神分裂症一级亲属的认知功能研究[J].中华精神科杂志,2016,49(2):71-75.
[21]赵姗姗,张天宏,唐莺莹,等.精神病临床高危综合征与首发精神分裂症患者的神经认知功能比较研究[J].神经疾病与精神卫生,2014,14(2):131-133.
[22]Nuechterlein KH,Green MF,Kern RS,et al.The MATRICS Consensus Cognitive Battery,part 1:test selection,reliability,and validity[J].Am J Psychiatry,2008,165(2):203-213.
[23]崔界峰,王云辉,段京辉,等.MCCB中文版应用于中国精神分裂症患者认知功能评估的适用性[C].北京医学会精神病学分会2008年度学术会议论文集,2009:5-10.
[24]赵靖平,施慎逊.中国精神分裂症防治指南第二版[M].北京:中华医学电子音像出版社,2015:2-8.
[25]Correll CU,Hauser M,Auther AM,et al.Research in people with the psychosis risk syndrome:a review of the current evidence and future directions[J].J Child Psychol Psychiatry,2010,51(4):390-431.
[26]Fusar-Poli P,Bonoldi I,Yung AR,et al.Predicting psychosis:meta-analysis of transition outcomes in individuals at high clinical risk[J].Arch Gen Psychiatry,2012,69(3):220-229.
[27]Schvarcz A,Bearden CE.Early detection of psychosis:recent updates fromclinical high-risk research[J].Curr Behav Neurosci Rep,2015,2(2):90-101.
[28]Fusar-Poli P,Deste G,Smieskova R,et al.Cognitive functioning in prodromal psychosis:a meta-analysis[J].Arch Gen Psychiatry,2012,69(6):562-571.
[29]Niendam TA,Bearden CE,Zinberg J,et al.The course of neurocognition and social functioning in individuals at ultra high risk for psychosis[J].Schizophr Bull,2007,33(3):772-781.
[30]Broome MR,Matthiasson P,Fusar-Poli P,et al.Neural correlates of executive function and working memory in the'at-risk mental state'[J].Br J Psychiatry,2009,194(1):25-33.
[31]Velthorst E,Nieman DH,Becker HE,et al.Baseline differences in clinical symptomatology between ultra high risk subjects with and without a transition to psychosis[J].Schizophrenia Res,2009,109(1-3):60-65.
[32]Massuda R,Bücker J,Czepielewski LS,et al.Verbal memory impairment in healthy siblings of patients with schizophrenia[J].Schizophrenia Res,2013,150(2-3):580-582.
[33]Pukrop R,Klosterk?tter J.Neurocognitive indicators of clinical high-risk states for psychosis:a critical review of the evidence[J].Neurotoxicity Res,2010,18(3-4):272-286.
[34]Kim HS,Shin NY,Jang JH,et al.Social cognition and neurocognition as predictors of conversion to psychosis in individuals at ultra-high risk[J].Schizophrenia Res,2011,130(1-2):170-175.
[35]Lewandowski KE,Cohen BM,Ongur D.Evolution of neuropsychological dysfunction during the course of schizophrenia and bipolar disorder[J].Psychol Med,2011,41(2-3):225-241.
[36]Allott K,Liu P,Proffitt TM,et al.Cognition at illness onset as a predictor of later functional outcome in early psychosis:systematic review and methodological critique[J].Schizophrenia Res,2011,125(2-3):221-235.
[2]Miller TJ,Mcglashan TH,Woods SW,et al.Symptom assessment in schizophrenic prodromal states[J].Psychiatr Q,1999,70(4):273-287.
[3]Yung AR,Nelson B,Thompson A,et al.The psychosis threshold in Ultra High Risk(prodromal)research:is it valid[J].Schizophr Res,2010,120(1-3):1-6.
[4]Dickon H,Laurens KR,Cullen AE,et al.meta-analyses of cognitive and motor function in youth aged 16 years and younger who subsequently develop schizophrenia[J].Psychol Med,2012,42(4):743-755.
[5]宁玉萍,张璐璐.精神病风险综合征—诊断和随访手册[M].北京:人民卫生出版社,2012:144-145.
[6]Stroup DF,Berlin JA,Morton SC,et al.Meta-analysis of observational observational studies in epidemiology:a proposal for reporting.Meta-analysis Of Observational Studies in Epidemiology(MOOSE)group[J].J Am Med Assoc,2000,283(15):2008-2012.
[7]Wells GA,Shea BO,Connell D,et al.The NewcastleOttawa Scale(NOS)for assessing the quality of non-randomized studies in meta analyses[J].Appl Eng Agric,2013,7(5):2195-2207.
[8]鲍成,刘筠,刘得乐,等.精神分裂症超高危认知功能研究[J].现代诊断与治疗,2017,28(1):14-16.
[9]俞洋,徐彩霞,徐国洪,等.精神分裂症超高危人群认知功能研究[J].慢性病学杂志,2017,18(7):737-739。
[10]张哲,周福春,何凡,等.首发精神分裂症患者和精神病高危者的认知功能[J].中国心理卫生杂志,2017,31(5):345-349.
[11]Hou CL,Xiang YT,Wang ZL,et al.Cognitive functioning in individuals at ultra-high risk for psychosis,first-degree relatives of patients with psychosis and patients with first-episode schizophrenia[J].Schizophrenia Res,2016,174(1-3):71-76.
[12]陈清刚.精神分裂症超高危人群认知功能的对照研究[D].天津:天津医科大学,2014:5-30.
[13]范敏珍,吴逢春,郑洪波.精神分裂症超高危人群及首次发病患者的认知功能研究[J].临床精神医学杂志,2014,24(1):11-13.
[14]房茂胜,刘岩,周亚楠,等.精神分裂症超高危人群的认知功能对照研究[J].精神医学杂志,2016,29(4):249-252.
[15]韩汶洋,许鹏,姜忠东,等.某部新兵精神分裂症超高危人群认知功能分析[J].人民军医,2017,60(2):118-120.
[16]刘筠.精神分裂症超高危人群认知功能与氧化应激研究[D].南昌:南昌大学,2016:5-26.
[17]祁继鹏.首发精神分裂症及超高危人群的认知功能对照研究[D].新乡:新乡医学院,2015:6-30.
[18]肖垚南,范敏珍,吴逢春.精神分裂症超高危人群、首发患者认知功能与精神病理症状的相关性及帕利哌酮的干预作用[J].中国药业,2014,23(15):7-9.
[19]王中磊.精神病超高危人群认知功能和心理状况的比较研究[D].广州:南方医科大学,2015:8-37.
[20]张丽丽,张云淑,贾海,等.精神病超高危人群及精神分裂症一级亲属的认知功能研究[J].中华精神科杂志,2016,49(2):71-75.
[21]赵姗姗,张天宏,唐莺莹,等.精神病临床高危综合征与首发精神分裂症患者的神经认知功能比较研究[J].神经疾病与精神卫生,2014,14(2):131-133.
[22]Nuechterlein KH,Green MF,Kern RS,et al.The MATRICS Consensus Cognitive Battery,part 1:test selection,reliability,and validity[J].Am J Psychiatry,2008,165(2):203-213.
[23]崔界峰,王云辉,段京辉,等.MCCB中文版应用于中国精神分裂症患者认知功能评估的适用性[C].北京医学会精神病学分会2008年度学术会议论文集,2009:5-10.
[24]赵靖平,施慎逊.中国精神分裂症防治指南第二版[M].北京:中华医学电子音像出版社,2015:2-8.
[25]Correll CU,Hauser M,Auther AM,et al.Research in people with the psychosis risk syndrome:a review of the current evidence and future directions[J].J Child Psychol Psychiatry,2010,51(4):390-431.
[26]Fusar-Poli P,Bonoldi I,Yung AR,et al.Predicting psychosis:meta-analysis of transition outcomes in individuals at high clinical risk[J].Arch Gen Psychiatry,2012,69(3):220-229.
[27]Schvarcz A,Bearden CE.Early detection of psychosis:recent updates fromclinical high-risk research[J].Curr Behav Neurosci Rep,2015,2(2):90-101.
[28]Fusar-Poli P,Deste G,Smieskova R,et al.Cognitive functioning in prodromal psychosis:a meta-analysis[J].Arch Gen Psychiatry,2012,69(6):562-571.
[29]Niendam TA,Bearden CE,Zinberg J,et al.The course of neurocognition and social functioning in individuals at ultra high risk for psychosis[J].Schizophr Bull,2007,33(3):772-781.
[30]Broome MR,Matthiasson P,Fusar-Poli P,et al.Neural correlates of executive function and working memory in the'at-risk mental state'[J].Br J Psychiatry,2009,194(1):25-33.
[31]Velthorst E,Nieman DH,Becker HE,et al.Baseline differences in clinical symptomatology between ultra high risk subjects with and without a transition to psychosis[J].Schizophrenia Res,2009,109(1-3):60-65.
[32]Massuda R,Bücker J,Czepielewski LS,et al.Verbal memory impairment in healthy siblings of patients with schizophrenia[J].Schizophrenia Res,2013,150(2-3):580-582.
[33]Pukrop R,Klosterk?tter J.Neurocognitive indicators of clinical high-risk states for psychosis:a critical review of the evidence[J].Neurotoxicity Res,2010,18(3-4):272-286.
[34]Kim HS,Shin NY,Jang JH,et al.Social cognition and neurocognition as predictors of conversion to psychosis in individuals at ultra-high risk[J].Schizophrenia Res,2011,130(1-2):170-175.
[35]Lewandowski KE,Cohen BM,Ongur D.Evolution of neuropsychological dysfunction during the course of schizophrenia and bipolar disorder[J].Psychol Med,2011,41(2-3):225-241.
[36]Allott K,Liu P,Proffitt TM,et al.Cognition at illness onset as a predictor of later functional outcome in early psychosis:systematic review and methodological critique[J].Schizophrenia Res,2011,125(2-3):221-235.