鼠疫耶尔森氏菌基因转录调控的研究进展
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摘要
细菌基因转录调控是多种调控机制中研究最为广泛的一种模式。复杂而精细的基因转录调控网络有助于细菌应答外界环境压力,在病原菌致病与传播中均发挥着关键作用。本文以鼠疫耶尔森氏菌基因转录调控的相关研究进展为基础展开论述,重点阐述细菌的转录调控机制、转录调控的研究策略及鼠疫菌致病与传播中转录调控的作用,以期为深入研究鼠疫菌致病与传播中的基因转录调控分子机制提供新思路。
Bacterial gene transcriptional regulation is one of the most widely studied mechanisms.Complex, but precise gene transcription regulatory network helps bacteria respond to environmental changes and plays a key role in the pathogenesis and transmission of pathogens. This paper discussed research progress of Yersinia pestis gene transcriptional regulation, the transcriptional regulation mechanism, strategies for transcriptional regulation, and the function of transcriptional regulation in Yersinia pestis pathogenesis and transmission, to provide new ideas for further research.
Bacterial gene transcriptional regulation is one of the most widely studied mechanisms.Complex, but precise gene transcription regulatory network helps bacteria respond to environmental changes and plays a key role in the pathogenesis and transmission of pathogens. This paper discussed research progress of Yersinia pestis gene transcriptional regulation, the transcriptional regulation mechanism, strategies for transcriptional regulation, and the function of transcriptional regulation in Yersinia pestis pathogenesis and transmission, to provide new ideas for further research.
引文
[1]Hastie JL,Williams KB,Bohr LL,et al.The anti-sigma factor RsiV is a bacterial receptor for lysozyme:co-crystal structure determination and demonstration that binding of lysozyme to Rsi V is required forσactivation[J].PLoS Genetics,2016,12(9):e1006287
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[3]Perry RD,Craig SK,Abney J,et al.Manganese transporters Yfe and MntH are Fur-regulated and important for the virulence of Yersinia pestis[J].Microbiology,2012,158(3):804-815
[4]Zhang YQ,Gao H,Wang L,et al.Molecular characterization of transcriptional regulation of rovA by PhoP and RovA in Yersinia pestis[J].PLoS One,2011,6(9):e25484
[5]Ba?os RC,Pons JI,Madrid C,et al.A global modulatory role for the Yersinia enterocolitica H-NS protein[J].Microbiology,2008,154(5):1281-1289
[6]Vadyvaloo V,Viall AK,Jarrett CO,et al.Role of the PhoP-PhoQgene regulatory system in adaptation of Yersinia pestis to environmental stress in the flea digestive tract[J].Microbiology,2015,161(6):1198-1210
[7]Zhou D,Yang R.Global analysis of gene transcription regulation in prokaryotes[J].Cellular and Molecular Life Sciences,2006,63(19/20):2260-2290
[8]Kontur C,Kumar S,Lan X,et al.Whole genome sequencing identifies a novel factor required for secretory granule maturation in Tetrahymena thermophila[J].G3:Genes,Genomes,Genetics,2016,6(8):2505-2516
[9]Borrill P,Harrington SA,Uauy C.Genome-Wide sequence and expression analysis of the NAC transcription factor family in polyploid wheat[J].G3:Genes,Genomes,Genetics,2017,7(9):3019-3029
[10]Le?meier L,Alkhateeb RS,Schulte F,et al.Applying DNAaffinity chromatography to specifically screen for sucrose-related DNA-binding transcriptional regulators of Xanthomonas campestris[J].Journal of Biotechnology,2016,232:89-98
[11]Si HM,Zhang F,Wu AN,et al.DNA microarray of global transcription factor mutant reveals membrane-related proteins involved in n-butanol tolerance in Escherichia coli[J].Biotechnology for Biofuels,2016,9:114
[12]Feng YW,Zheng M,Gan SJ,et al.Identification of potential gene targets in systemic vasculitis using DNA microarray analysis[J].Molecular Medicine Reports,2017,15(6):3665-3673
[13]Schmid CD,Bucher P.ChIP-Seq data reveal nucleosome architecture of human promoters[J].Cell,2007,131(5):831-832
[14]Bos KI,Herbig A,Sahl J,et al.Eighteenth century Yersinia pestis genomes reveal the long-term persistence of an historical plague focus[J].eLife,2016,5:e12994
[15]Perry RD,Fetherston JD.Yersinia pestis-etiologic agent of plague[J].Clinical Microbiology Reviews,1997,10(1):35-66
[16]Zhou DS,Yang RF.Formation and regulation of Yersinia biofilms[J].Protein&Cell,2011,2(3):173-179
[17]Fang N,Qu S,Yang HY,et al.HmsB enhances biofilm formation in Yersinia pestis[J].Frontiers in Microbiology,2014,5:685
[18]Bobrov AG,Kirillina O,Forman S,et al.Insights into Yersinia pestis biofilm development:topology and co-interaction of Hms inner membrane proteins involved in exopolysaccharide production[J].Environmental Microbiology,2008,10(6):1419-1432
[19]Bobrov AG,Kirillina O,Ryjenkov DA,et al.Systematic analysis of cyclic di-GMP signalling enzymes and their role in biofilm formation and virulence in Yersinia pestis[J].Molecular Microbiology,2011,79(2):533-551
[20]Ren GX,Fan S,Guo XP,et al.Differential regulation of c-di-GMP metabolic enzymes by environmental signals modulates biofilm formation in Yersinia pestis[J].Frontiers in Microbiology,2016,7:821
[21]Darby C,Ananth SL,Tan L,et al.Identification of gmhA,a Yersinia pestis gene required for flea blockage,by using a Caenorhabditis elegans biofilm system[J].Infection and Immunity,2005,73(11):7236-7242
[22]Tan L,Darby C.Yersinia pestis is viable with endotoxin composed of only lipid A[J].Journal of Bacteriology,2005,187(18):6599-6600
[23]Patel CN,Wortham BW,Lines JL,et al.Polyamines are essential for the formation of plague biofilm[J].Journal of Bacteriology,2006,188(7):2355-2363
[24]Majdalani N,Gottesman S.The Rcs phosphorelay:a complex signal transduction system[J].Annual Review of Microbiology,2005,59:379-405
[25]Sun YC,Guo XP,Hinnebusch BJ,et al.The Yersinia pestis Rcs phosphorelay inhibits biofilm formation by repressing transcription of the diguanylate cyclase gene hmsT[J].Journal of Bacteriology,2012,194(8):2020-2026
[26]Sun YC,Hinnebusch BJ,Darby C.Experimental evidence for negative selection in the evolution of a Yersinia pestis pseudogene[J].Proceedings of the National Academy of Sciences of the United States of America,2008,105(23):8097-8101
[27]Fang N,Yang HY,Fang HH,et al.RcsAB is a major repressor of Yersinia biofilm development through directly acting on hmsCDE,hmsT,and hmsHFRS[J].Scientific Reports,2015,5:9566
[28]Zhou DS,Qin L,Han YP,et al.Global analysis of iron assimilation and fur regulation in Yersinia pestis[J].FEMSMicrobiology Letters,2006,258(1):9-17
[29]Gao H,Zhou DS,Li YL,et al.The iron-responsive Fur regulon in Yersinia pestis[J].Journal of Bacteriology,2008,190(8):3063-3075
[30]Sun FJ,Gao H,Zhang YQ,et al.Fur is a repressor of biofilm formation in Yersinia pestis[J].PLoS One,2012,7(12):e52392
[31]Maddocks SE,Oyston PCF.Structure and function of the LysR-type transcriptional regulator(LTTR)family proteins[J].Microbiology,2008,154(Pt 12):3609-3623
[32]Heroven AK,Dersch P.RovM,a novel LysR-type regulator of the virulence activator gene rovA,controls cell invasion,virulence and motility of Yersinia pseudotuberculosis[J].Molecular Microbiology,2006,62(5):1469-1483
[33]Vadyvaloo V,Hinz AK.A LysR-Type transcriptional regulator,RovM,senses nutritional cues suggesting that it is involved in metabolic adaptation of Yersinia pestis to the flea gut[J].PLoSOne,2015,10(9):e0137508
[34]Liu L,Fang HH,Yang HY,et al.Reciprocal regulation of Yersinia pestis biofilm formation and virulence by RovM and RovA[J].Open Biology,2016,6(3):150198
[35]Tam C,Demke O,Hermanas T,et al.YfbA,a Yersinia pestis regulator required for colonization and biofilm formation in the gut of cat fleas[J].Journal of Bacteriology,2014,196(6):1165-1173
[36]Marceau M.Transcriptional regulation in Yersinia:an update[J].Current Issues in Molecular Biology,2005,7(2):151-177
[37]Boolgakova EG,Krasnov YM,Sukhonosov IY,et al.Structural organization of intact and damaged by IS100 element porin genes adjacent to the PGM region in Yersinia pestis and Yersinia pseudotuberculosis strains[J].Molecular Genetics,Microbiology and Virology,2016,31(2):58-68
[38]Tencati M,Tapping RI.Resistance of mice of the 129 background to Yersinia pestis maps to multiple loci on chromosome 1[J].Infection and Immunity,2016,84(10):2904-2913
[39]Rempe KA,Hinz AK,Vadyvaloo V.Hfq regulates biofilm gut blockage that facilitates flea-Borne transmission of Yersinia pestis[J].Journal of Bacteriology,2012,194(8):2036-2040
[40]Zhang YQ,Wang L,Fang N,et al.Reciprocal regulation of pH 6antigen gene loci by PhoP and RovA in Yersinia pestis biovar Microtus[J].Future Microbiology,2013,8(2):271-280
[41]Bao R,Nair MKMN,Tang WK,et al.Structural basis for the specific recognition of dual receptors by the homopolymeric pH 6antigen(Psa)fimbriae of Yersinia pestis[J].Proceedings of the National Academy of Sciences of the United States of America,2013,110(3):1065-1070
[42]Weening EH,Cathelyn JS,Kaufman G,et al.The dependence of the Yersinia pestis capsule on pathogenesis is influenced by the mouse background[J].Infection and Immunity,2011,79(2):644-652
[43]Cathelyn JS,Crosby SD,Lathem WW,et al.RovA,a global regulator of Yersinia pestis,specifically required for bubonic plague[J].Proceedings of the National Academy of Sciences of the United States of America,2006,103(36):13514-13519
[44]Felek S,Tsang TM,Krukonis ES.Three Yersinia pestis adhesins facilitate Yop delivery to eukaryotic cells and contribute to plague virulence[J].Infection and Immunity,2010,78(10):4134-4150
[45]Huang XZ,Lindler LE.The pH 6 antigen is an antiphagocytic factor produced by Yersinia pestis independent of Yersinia outer proteins and capsule antigen[J].Infection and Immunity,2004,72(12):7212-7219
[46]Makoveichuk E,Cherepanov P,Lundberg S,et al.pH6 antigen of Yersinia pestis interacts with plasma lipoproteins and cell membranes[J].Journal of Lipid Research,2003,44(2):320-330
[47]Waller H,Ulusu Y,Lakey JH.Caf1 of Yersinia pestis forms complex highly stable protein polymers and hydrogel scaffolds[J].Biophysical Journal,2016,110(3):339a
[48]Hinnebusch BJ,Rudolph AE,Cherepanov P,et al.Role of Yersinia murine toxin in survival of Yersinia pestis in the midgut of the flea vector[J].Science,2002,296(5568):733-735
[49]Lathem WW,Price PA,Miller VL,et al.Aplasminogen-activating protease specifically controls the development of primary pneumonic plague[J].Science,2007,315(5811):509-513
[50]Zimbler DL,Schroeder JA,Eddy JL,et al.Early emergence of Yersinia pestis as a severe respiratory pathogen[J].Nature Communications,2015,6:7487
[51]Wilkinson SP,Grove A.Ligand-responsive transcriptional regulation by members of the MarR family of winged helix proteins[J].Current Issues in Molecular Biology,2006,8(1):51-62
[52]Dube PH,Handley SA,Revell PA,et al.The rovA mutant of Yersinia enterocolitica displays differential degrees of virulence depending on the route of infection[J].Infection and Immunity,2003,71(6):3512-3520
[53]Nagel G,Lahrz A,Dersch P.Environmental control of invasin expression in Yersinia pseudotuberculosis is mediated by regulation of RovA,a transcriptional activator of the SlyA/Hor family[J].Molecular Microbiology,2001,41(6):1249-1269
[54]Revell PA,Miller VL.A chromosomally encoded regulator is required for expression of the Yersinia enterocolitica inv gene and for virulence[J].Molecular Microbiology,2000,35(3):677-685
[55]Ellison DW,Lawrenz MB,Miller VL.Invasin and beyond:regulation of Yersinia virulence by RovA[J].Trends in Microbiology,2004,12(6):296-300
[56]Heroven AK,Nagel G,Tran HJ,et al.RovA is autoregulated and antagonizes H-NS-mediated silencing of invasin and rovAexpression in Yersinia pseudotuberculosis[J].Molecular Microbiology,2004,53(3):871-888
[57]Simonet M,Riot B,Fortineau N,et al.Invasin production by Yersinia pestis is abolished by insertion of an IS200-like element within the inv gene[J].Infection and Immunity,1996,64(1):375-379
[58]Derbise A,Chenal-Francisque V,Pouillot F,et al.A horizontally acquired filamentous phage contributes to the pathogenicity of the plague bacillus[J].Molecular Microbiology,2007,63(4):1145-1157
[59]Li YJ,Dai EH,Cui YJ,et al.Different region analysis for genotyping Yersinia pestis isolates from China[J].PLoS One,2008,3(5):e2166
[60]Zhan LJ,Han YP,Yang LP,et al.The cyclic AMP receptor protein,CRP,is required for both virulence and expression of the minimal CRP regulon in Yersinia pestis biovar Microtus[J].Infection and Immunity,2008,76(11):5028-5037
[61]Kim TJ,Chauhan S,Motin VL,et al.Direct transcriptional control of the plasminogen activator gene of Yersinia pestis by the cyclic AMP receptor protein[J].Journal of Bacteriology,2007,189(24):8890-8900
[62]Liu HH,Wang H,Qiu JF,et al.Transcriptional profiling of a mice plague model:insights into interaction between Yersinia pestis and its host[J].Journal of Basic Microbiology,2009,49(1):92-99
[63]Lathem WW,Schroeder JA,Bellows LE,et al.Posttranscriptional regulation of the Yersinia pestis cyclic AMP receptor protein Crp and impact on virulence[J].mBio,2014,5(1):e01038-13
[64]Liu L,Fang HH,Yang HY,et al.CRP is an activator of Yersinia pestis biofilm formation that operates via a mechanism involving gmhA and waaAE-coaD[J].Frontiers in Microbiology,2016,7:295
[65]Rebeil R,Jarrett CO,Driver JD,et al.Induction of the Yersinia pestis PhoP-PhoQ regulatory system in the flea and its role in producing a transmissible infection[J].Journal of Bacteriology,2013,195(9):1920-1930
[66]Liu L,Fang N,Sun YC,et al.Transcriptional regulation of the waaAE-coaD operon by PhoP and RcsAB in Yersinia pestis biovar Microtus[J].Protein&Cell,2014,5(12):940-944
[2]Davis MC,Kesthely CA,Franklin EA,et al.The essential activities of the bacterial sigma factor[J].Canadian Journal of Microbiology,2016,63(2):89-99
[3]Perry RD,Craig SK,Abney J,et al.Manganese transporters Yfe and MntH are Fur-regulated and important for the virulence of Yersinia pestis[J].Microbiology,2012,158(3):804-815
[4]Zhang YQ,Gao H,Wang L,et al.Molecular characterization of transcriptional regulation of rovA by PhoP and RovA in Yersinia pestis[J].PLoS One,2011,6(9):e25484
[5]Ba?os RC,Pons JI,Madrid C,et al.A global modulatory role for the Yersinia enterocolitica H-NS protein[J].Microbiology,2008,154(5):1281-1289
[6]Vadyvaloo V,Viall AK,Jarrett CO,et al.Role of the PhoP-PhoQgene regulatory system in adaptation of Yersinia pestis to environmental stress in the flea digestive tract[J].Microbiology,2015,161(6):1198-1210
[7]Zhou D,Yang R.Global analysis of gene transcription regulation in prokaryotes[J].Cellular and Molecular Life Sciences,2006,63(19/20):2260-2290
[8]Kontur C,Kumar S,Lan X,et al.Whole genome sequencing identifies a novel factor required for secretory granule maturation in Tetrahymena thermophila[J].G3:Genes,Genomes,Genetics,2016,6(8):2505-2516
[9]Borrill P,Harrington SA,Uauy C.Genome-Wide sequence and expression analysis of the NAC transcription factor family in polyploid wheat[J].G3:Genes,Genomes,Genetics,2017,7(9):3019-3029
[10]Le?meier L,Alkhateeb RS,Schulte F,et al.Applying DNAaffinity chromatography to specifically screen for sucrose-related DNA-binding transcriptional regulators of Xanthomonas campestris[J].Journal of Biotechnology,2016,232:89-98
[11]Si HM,Zhang F,Wu AN,et al.DNA microarray of global transcription factor mutant reveals membrane-related proteins involved in n-butanol tolerance in Escherichia coli[J].Biotechnology for Biofuels,2016,9:114
[12]Feng YW,Zheng M,Gan SJ,et al.Identification of potential gene targets in systemic vasculitis using DNA microarray analysis[J].Molecular Medicine Reports,2017,15(6):3665-3673
[13]Schmid CD,Bucher P.ChIP-Seq data reveal nucleosome architecture of human promoters[J].Cell,2007,131(5):831-832
[14]Bos KI,Herbig A,Sahl J,et al.Eighteenth century Yersinia pestis genomes reveal the long-term persistence of an historical plague focus[J].eLife,2016,5:e12994
[15]Perry RD,Fetherston JD.Yersinia pestis-etiologic agent of plague[J].Clinical Microbiology Reviews,1997,10(1):35-66
[16]Zhou DS,Yang RF.Formation and regulation of Yersinia biofilms[J].Protein&Cell,2011,2(3):173-179
[17]Fang N,Qu S,Yang HY,et al.HmsB enhances biofilm formation in Yersinia pestis[J].Frontiers in Microbiology,2014,5:685
[18]Bobrov AG,Kirillina O,Forman S,et al.Insights into Yersinia pestis biofilm development:topology and co-interaction of Hms inner membrane proteins involved in exopolysaccharide production[J].Environmental Microbiology,2008,10(6):1419-1432
[19]Bobrov AG,Kirillina O,Ryjenkov DA,et al.Systematic analysis of cyclic di-GMP signalling enzymes and their role in biofilm formation and virulence in Yersinia pestis[J].Molecular Microbiology,2011,79(2):533-551
[20]Ren GX,Fan S,Guo XP,et al.Differential regulation of c-di-GMP metabolic enzymes by environmental signals modulates biofilm formation in Yersinia pestis[J].Frontiers in Microbiology,2016,7:821
[21]Darby C,Ananth SL,Tan L,et al.Identification of gmhA,a Yersinia pestis gene required for flea blockage,by using a Caenorhabditis elegans biofilm system[J].Infection and Immunity,2005,73(11):7236-7242
[22]Tan L,Darby C.Yersinia pestis is viable with endotoxin composed of only lipid A[J].Journal of Bacteriology,2005,187(18):6599-6600
[23]Patel CN,Wortham BW,Lines JL,et al.Polyamines are essential for the formation of plague biofilm[J].Journal of Bacteriology,2006,188(7):2355-2363
[24]Majdalani N,Gottesman S.The Rcs phosphorelay:a complex signal transduction system[J].Annual Review of Microbiology,2005,59:379-405
[25]Sun YC,Guo XP,Hinnebusch BJ,et al.The Yersinia pestis Rcs phosphorelay inhibits biofilm formation by repressing transcription of the diguanylate cyclase gene hmsT[J].Journal of Bacteriology,2012,194(8):2020-2026
[26]Sun YC,Hinnebusch BJ,Darby C.Experimental evidence for negative selection in the evolution of a Yersinia pestis pseudogene[J].Proceedings of the National Academy of Sciences of the United States of America,2008,105(23):8097-8101
[27]Fang N,Yang HY,Fang HH,et al.RcsAB is a major repressor of Yersinia biofilm development through directly acting on hmsCDE,hmsT,and hmsHFRS[J].Scientific Reports,2015,5:9566
[28]Zhou DS,Qin L,Han YP,et al.Global analysis of iron assimilation and fur regulation in Yersinia pestis[J].FEMSMicrobiology Letters,2006,258(1):9-17
[29]Gao H,Zhou DS,Li YL,et al.The iron-responsive Fur regulon in Yersinia pestis[J].Journal of Bacteriology,2008,190(8):3063-3075
[30]Sun FJ,Gao H,Zhang YQ,et al.Fur is a repressor of biofilm formation in Yersinia pestis[J].PLoS One,2012,7(12):e52392
[31]Maddocks SE,Oyston PCF.Structure and function of the LysR-type transcriptional regulator(LTTR)family proteins[J].Microbiology,2008,154(Pt 12):3609-3623
[32]Heroven AK,Dersch P.RovM,a novel LysR-type regulator of the virulence activator gene rovA,controls cell invasion,virulence and motility of Yersinia pseudotuberculosis[J].Molecular Microbiology,2006,62(5):1469-1483
[33]Vadyvaloo V,Hinz AK.A LysR-Type transcriptional regulator,RovM,senses nutritional cues suggesting that it is involved in metabolic adaptation of Yersinia pestis to the flea gut[J].PLoSOne,2015,10(9):e0137508
[34]Liu L,Fang HH,Yang HY,et al.Reciprocal regulation of Yersinia pestis biofilm formation and virulence by RovM and RovA[J].Open Biology,2016,6(3):150198
[35]Tam C,Demke O,Hermanas T,et al.YfbA,a Yersinia pestis regulator required for colonization and biofilm formation in the gut of cat fleas[J].Journal of Bacteriology,2014,196(6):1165-1173
[36]Marceau M.Transcriptional regulation in Yersinia:an update[J].Current Issues in Molecular Biology,2005,7(2):151-177
[37]Boolgakova EG,Krasnov YM,Sukhonosov IY,et al.Structural organization of intact and damaged by IS100 element porin genes adjacent to the PGM region in Yersinia pestis and Yersinia pseudotuberculosis strains[J].Molecular Genetics,Microbiology and Virology,2016,31(2):58-68
[38]Tencati M,Tapping RI.Resistance of mice of the 129 background to Yersinia pestis maps to multiple loci on chromosome 1[J].Infection and Immunity,2016,84(10):2904-2913
[39]Rempe KA,Hinz AK,Vadyvaloo V.Hfq regulates biofilm gut blockage that facilitates flea-Borne transmission of Yersinia pestis[J].Journal of Bacteriology,2012,194(8):2036-2040
[40]Zhang YQ,Wang L,Fang N,et al.Reciprocal regulation of pH 6antigen gene loci by PhoP and RovA in Yersinia pestis biovar Microtus[J].Future Microbiology,2013,8(2):271-280
[41]Bao R,Nair MKMN,Tang WK,et al.Structural basis for the specific recognition of dual receptors by the homopolymeric pH 6antigen(Psa)fimbriae of Yersinia pestis[J].Proceedings of the National Academy of Sciences of the United States of America,2013,110(3):1065-1070
[42]Weening EH,Cathelyn JS,Kaufman G,et al.The dependence of the Yersinia pestis capsule on pathogenesis is influenced by the mouse background[J].Infection and Immunity,2011,79(2):644-652
[43]Cathelyn JS,Crosby SD,Lathem WW,et al.RovA,a global regulator of Yersinia pestis,specifically required for bubonic plague[J].Proceedings of the National Academy of Sciences of the United States of America,2006,103(36):13514-13519
[44]Felek S,Tsang TM,Krukonis ES.Three Yersinia pestis adhesins facilitate Yop delivery to eukaryotic cells and contribute to plague virulence[J].Infection and Immunity,2010,78(10):4134-4150
[45]Huang XZ,Lindler LE.The pH 6 antigen is an antiphagocytic factor produced by Yersinia pestis independent of Yersinia outer proteins and capsule antigen[J].Infection and Immunity,2004,72(12):7212-7219
[46]Makoveichuk E,Cherepanov P,Lundberg S,et al.pH6 antigen of Yersinia pestis interacts with plasma lipoproteins and cell membranes[J].Journal of Lipid Research,2003,44(2):320-330
[47]Waller H,Ulusu Y,Lakey JH.Caf1 of Yersinia pestis forms complex highly stable protein polymers and hydrogel scaffolds[J].Biophysical Journal,2016,110(3):339a
[48]Hinnebusch BJ,Rudolph AE,Cherepanov P,et al.Role of Yersinia murine toxin in survival of Yersinia pestis in the midgut of the flea vector[J].Science,2002,296(5568):733-735
[49]Lathem WW,Price PA,Miller VL,et al.Aplasminogen-activating protease specifically controls the development of primary pneumonic plague[J].Science,2007,315(5811):509-513
[50]Zimbler DL,Schroeder JA,Eddy JL,et al.Early emergence of Yersinia pestis as a severe respiratory pathogen[J].Nature Communications,2015,6:7487
[51]Wilkinson SP,Grove A.Ligand-responsive transcriptional regulation by members of the MarR family of winged helix proteins[J].Current Issues in Molecular Biology,2006,8(1):51-62
[52]Dube PH,Handley SA,Revell PA,et al.The rovA mutant of Yersinia enterocolitica displays differential degrees of virulence depending on the route of infection[J].Infection and Immunity,2003,71(6):3512-3520
[53]Nagel G,Lahrz A,Dersch P.Environmental control of invasin expression in Yersinia pseudotuberculosis is mediated by regulation of RovA,a transcriptional activator of the SlyA/Hor family[J].Molecular Microbiology,2001,41(6):1249-1269
[54]Revell PA,Miller VL.A chromosomally encoded regulator is required for expression of the Yersinia enterocolitica inv gene and for virulence[J].Molecular Microbiology,2000,35(3):677-685
[55]Ellison DW,Lawrenz MB,Miller VL.Invasin and beyond:regulation of Yersinia virulence by RovA[J].Trends in Microbiology,2004,12(6):296-300
[56]Heroven AK,Nagel G,Tran HJ,et al.RovA is autoregulated and antagonizes H-NS-mediated silencing of invasin and rovAexpression in Yersinia pseudotuberculosis[J].Molecular Microbiology,2004,53(3):871-888
[57]Simonet M,Riot B,Fortineau N,et al.Invasin production by Yersinia pestis is abolished by insertion of an IS200-like element within the inv gene[J].Infection and Immunity,1996,64(1):375-379
[58]Derbise A,Chenal-Francisque V,Pouillot F,et al.A horizontally acquired filamentous phage contributes to the pathogenicity of the plague bacillus[J].Molecular Microbiology,2007,63(4):1145-1157
[59]Li YJ,Dai EH,Cui YJ,et al.Different region analysis for genotyping Yersinia pestis isolates from China[J].PLoS One,2008,3(5):e2166
[60]Zhan LJ,Han YP,Yang LP,et al.The cyclic AMP receptor protein,CRP,is required for both virulence and expression of the minimal CRP regulon in Yersinia pestis biovar Microtus[J].Infection and Immunity,2008,76(11):5028-5037
[61]Kim TJ,Chauhan S,Motin VL,et al.Direct transcriptional control of the plasminogen activator gene of Yersinia pestis by the cyclic AMP receptor protein[J].Journal of Bacteriology,2007,189(24):8890-8900
[62]Liu HH,Wang H,Qiu JF,et al.Transcriptional profiling of a mice plague model:insights into interaction between Yersinia pestis and its host[J].Journal of Basic Microbiology,2009,49(1):92-99
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