针灸干预围绝经期抑郁症的机制研究进展
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摘要
本文分析近年来大鼠实验研究中针灸干预围绝经期抑郁症的作用机制,认为针灸干预围绝经期抑郁症的机制与以下几点相关:针灸可通过调节神经内分泌网络功能、调节神经递质水平、协调相关信号转导通路表达以及抑制神经细胞凋亡等环节干预围绝经期抑郁症。
This paper analyzes the possible mechanisms of acupuncture intervention to perimenopausal depression in rats in recent years, which proposes that the mechanisms are closely correlated to the following aspects: acupuncture could intervene the perimenopausal depression by regulating the nerve-endocrine network function, harmonizing the neural transmitters contents, mediating the correlated signaling transductions and inhibiting the neuronal cellular apoptosis.
This paper analyzes the possible mechanisms of acupuncture intervention to perimenopausal depression in rats in recent years, which proposes that the mechanisms are closely correlated to the following aspects: acupuncture could intervene the perimenopausal depression by regulating the nerve-endocrine network function, harmonizing the neural transmitters contents, mediating the correlated signaling transductions and inhibiting the neuronal cellular apoptosis.
引文
[1]吴南顺.围绝经期抑郁激素替代疗法的研究进展[J].中国医药导报,2016,13(6):38-42.
[2]Dafopoulos KC,Kotsovassilis CP,Milingos SD,et al.FSHand LH responses to Gn RH after ovariectomy in postmenopausal women[J].Clin Endocrinol(Oxf),2004,60(1):120-124.
[3]Ng J,Chwalisz K,Carter DC,et al.Dose-Dependent Suppression of Gonadotropins and Ovarian Hormones by E-lagolix in Healthy Premenopausal Women[J].J Clin Endocrinol Metab,2017,102(5):1683-1691.
[4]Shi J,Li SX,Zhang XL,et al.Time-dependent neuroendocrine alterations and drug craving during the first month of abstinence in heroin addicts[J].Am J Drug Alcohol Abuse,2009,35(5):267-272.
[5]蒋希荣,任路.电针疗法对围绝经期抑郁症模型大鼠下丘脑-垂体-肾上腺轴及β-内啡肽的影响[J].中华中医药学刊,2016,34(8):1923-1925.
[6]Oh DR,Yoo JS,Kim Y,et al.Vaccinium bracteatum Leaf Extract Reverses Chronic Restraint Stress-Induced Depression-Like Behavior in Mice:Regulation of Hypothalamic-Pituitary-Adrenal Axis,Serotonin Turnover Systems,and ERK/Akt Phosphorylation[J].Front Pharmacol,2018,9:604.
[7]蒋希荣,任路,李春日.电针对围绝经期抑郁症大鼠下丘脑-垂体-卵巢轴的影响[J].针刺研究,2017,42(1):45-49.
[8]蒋希荣,任路,毛亮.以“肾脑相济”理论为指导的电针疗法对围绝经期抑郁症模型大鼠行为学及下丘脑-垂体-肾上腺影响[J].辽宁中医杂志,2016,43(8):1752-1754.
[9]申国明,许浩,胡光明,等.电针对雌性去势大鼠行为学和下丘脑室旁核c-fos表达的影响[J].中华中医药杂志,2011,26(9):2062-2064.
[10]王海颖,胡光民,刘艳,等.电针对雌性去势大鼠行为学及血清E2、FSH、LH的影响[J].云南中医中药杂志,2010,31(4):54-55.
[11]胡江珊,杨汝薇,淘敏芳.雌二醇、G蛋白耦联雌激素受体激动剂和抑制剂对去势大鼠5-羟色胺水平的影响[J].中华生殖与避孕杂志,2018,38(7):559-563.
[12]王铁枫,刘雁峰,辛明蔚,等.交通心肾中药对更年期大鼠性激素及神经递质的影响[J].中华中医药杂志,2018,33(4):1340-1343.
[13]Prommer E.Aripiprazole[J].Am J Hosp Palliat Care,2017,34(2):180-185.
[14]邓海峰,孙缦利,吴琼,等.毛蕊花糖苷通过调控BD-NF-Trk B信号通路改善CUMS大鼠的抑郁样行为[J].中国病理生理杂志,2018,34(9):1633-1637.
[15]李晶晶,唐苾芯,黄流波,等.中医药对围绝经期综合征妇女下丘脑-垂体-性腺轴影响的研究进展[J].上海中医药杂志,2013,47(12):90-92.
[16]周胜红,孙付军,陈忠,等.补肾针刺法对围绝经期抑郁模型大鼠单胺类神经递质含量的调节[J].时珍国医国药,2015,26(9):2299-2301.
[17]李静,李丹,雷升,等.围绝经期抑郁症发病与体质相关性的针刺实验研究[J].中华中医药学刊,2013,31(4):781-783.
[18]彭晓涛,程凯,徐玲,等.电针三阴交对自然围绝经期大鼠雌二醇和大脑皮层神经递质的影响[J].中国临床保健杂志,2015,18(5):509-511.
[19]Lu Y,Ho CS,Mc Intyre RS,et al.Agomelatine-induced modulation of brain-derived neurotrophic factor(BDNF)in the rat hippocampus[J].Life Sci,2018,210:177-184.
[20]Wang SS,Mu RH,Li CF,et al.micro RNA-124 targets glucocorticoid receptor and is involved in depressionlike behaviors[J].Prog Neuropsychopharmacol Biol Psychiatry,2017,79(Pt B):417-425.
[21]Bocci F,Jolly MK,George JT,et al.A mechanism-based computational model to capture the interconnections among epithelial-mesenchymal transition,cancer stem cells and Notch-Jagged signaling[J].Oncotarget,2018,9(52):29906-29920.
[22]Ishibashi M.Molecular mechanisms for morphogenesis of the central nervous system in mammals[J].Anat Sci Int,2004,79(4):226-234.
[23]Sakisaka Y,Kanaya S,Nakamura T,et al.p38 MAP kinase is required for Wnt3a-mediated osterix expression independently of Wnt-LRP5/6-GSK3βsignaling axis in dental follicle cells[J].Biochem Biophys Res Commun,2016,478(2):527-532.
[24]Peng H,Wang HB,Wang L,et al.Gsk3βaggravates the depression symptoms in chronic stress mouse model[J].JIntegr Neurosci,2018,17(2):217-226.
[25]邓雪,任路,冷雪,等.补肾益脑灸法通过Wnt信号通路影响围绝经期抑郁症大鼠海马神经发生[J].中国中医基础医学杂志,2017,23(9):1288-1291.
[26]荆秦,林卉,任路.“肾脑相济”电针疗法对围绝经期抑郁症大鼠海马Wnt/β-catenin信号通路的影响[J].中华中医药学刊,2018,36(6):1347-1350.
[27]邓雪,任路.以肾脑相济理论为指导的电针疗法对围绝经期抑郁症大鼠海马Notch通路的影响[J].辽宁中医杂志,2017,44(3):595-601.
[28]王戈,任路.“肾脑相济”电针疗法对围绝经期抑郁症大鼠海马BDNF、CREB的影响[J].辽宁中医杂志,2016,43(4):858-860.
[29]傅沈康,姜开妍,王玉,等.“肾脑相济”灸法对围绝经期抑郁症大鼠海马Notch通路的作用机制[J].辽宁中医杂志,2018,45(3):454-458.
[30]Demirda?s A,Nazιro?lu M,?vey I S.Duloxetine Reduces Oxidative Stress,Apoptosis,and Ca2+Entry Through Modulation of TRPM2 and TRPV1 Channels in the Hippocampus and Dorsal Root Ganglion of Rats[J].Mol Neurobiol,2017,54(6):4683-4695.
[31]Zhang WY,Wang KY,Li YJ,et al.Chronic stress causes protein kinase C epsilon-aldehyde dehydrogenase 2 signaling pathway perturbation in the rat hippocampus and prefrontal cortex,but not in the myocardium[J].Neural Regen Res,2018,13(7):1225-1230.
[32]Tong J,Li J,Zhang QS,et al.Delayed cognitive deficits can be alleviated by calcium antagonist nimodipine by downregulation of apoptosis following whole brain radiotherapy[J].Oncol Lett,2018,16(2):2525-2532.
[33]Tong C,Liu Y,Zhang Y,et al.Shock waves increase pulmonary vascular leakage,inflammation,oxidative stress,and apoptosis in a mouse model[J].Exp Biol Med(Maywood),2018,243(11):934-944.
[34]荆秦,林卉,任路.电针对围绝经期抑郁症大鼠海马神经元凋亡的影响[J].中国中医基础医学杂志,2017,23(11):1607-1610.
[35]王戈,任路,贾连群.电针对围绝经期抑郁症大鼠海马Bcl-2和Bax的影响[J].中国中医基础医学杂志,2016,22(6):838-840.
[36]邓雪,任路,王旭.补肾健脑电针疗法对围绝经期抑郁症大鼠前额叶皮质神经细胞内尼氏小体及核仁影响的定量分析[J].辽宁中医杂志,2018,45(9):1797-1801,2013.
[37]皇甫伟玲,任路,林卉.“肾脑相济”电针疗法对围绝经期抑郁症模型大鼠海马及其内环境影响[J].辽宁中医药大学学报,2018,20(7):31-34.
[38]王玉,林卉,任路.电针疗法对围绝经期抑郁模型大鼠炎性细胞因子的影响[J].辽宁中医药大学学报,2017,19(12):72-75.
[2]Dafopoulos KC,Kotsovassilis CP,Milingos SD,et al.FSHand LH responses to Gn RH after ovariectomy in postmenopausal women[J].Clin Endocrinol(Oxf),2004,60(1):120-124.
[3]Ng J,Chwalisz K,Carter DC,et al.Dose-Dependent Suppression of Gonadotropins and Ovarian Hormones by E-lagolix in Healthy Premenopausal Women[J].J Clin Endocrinol Metab,2017,102(5):1683-1691.
[4]Shi J,Li SX,Zhang XL,et al.Time-dependent neuroendocrine alterations and drug craving during the first month of abstinence in heroin addicts[J].Am J Drug Alcohol Abuse,2009,35(5):267-272.
[5]蒋希荣,任路.电针疗法对围绝经期抑郁症模型大鼠下丘脑-垂体-肾上腺轴及β-内啡肽的影响[J].中华中医药学刊,2016,34(8):1923-1925.
[6]Oh DR,Yoo JS,Kim Y,et al.Vaccinium bracteatum Leaf Extract Reverses Chronic Restraint Stress-Induced Depression-Like Behavior in Mice:Regulation of Hypothalamic-Pituitary-Adrenal Axis,Serotonin Turnover Systems,and ERK/Akt Phosphorylation[J].Front Pharmacol,2018,9:604.
[7]蒋希荣,任路,李春日.电针对围绝经期抑郁症大鼠下丘脑-垂体-卵巢轴的影响[J].针刺研究,2017,42(1):45-49.
[8]蒋希荣,任路,毛亮.以“肾脑相济”理论为指导的电针疗法对围绝经期抑郁症模型大鼠行为学及下丘脑-垂体-肾上腺影响[J].辽宁中医杂志,2016,43(8):1752-1754.
[9]申国明,许浩,胡光明,等.电针对雌性去势大鼠行为学和下丘脑室旁核c-fos表达的影响[J].中华中医药杂志,2011,26(9):2062-2064.
[10]王海颖,胡光民,刘艳,等.电针对雌性去势大鼠行为学及血清E2、FSH、LH的影响[J].云南中医中药杂志,2010,31(4):54-55.
[11]胡江珊,杨汝薇,淘敏芳.雌二醇、G蛋白耦联雌激素受体激动剂和抑制剂对去势大鼠5-羟色胺水平的影响[J].中华生殖与避孕杂志,2018,38(7):559-563.
[12]王铁枫,刘雁峰,辛明蔚,等.交通心肾中药对更年期大鼠性激素及神经递质的影响[J].中华中医药杂志,2018,33(4):1340-1343.
[13]Prommer E.Aripiprazole[J].Am J Hosp Palliat Care,2017,34(2):180-185.
[14]邓海峰,孙缦利,吴琼,等.毛蕊花糖苷通过调控BD-NF-Trk B信号通路改善CUMS大鼠的抑郁样行为[J].中国病理生理杂志,2018,34(9):1633-1637.
[15]李晶晶,唐苾芯,黄流波,等.中医药对围绝经期综合征妇女下丘脑-垂体-性腺轴影响的研究进展[J].上海中医药杂志,2013,47(12):90-92.
[16]周胜红,孙付军,陈忠,等.补肾针刺法对围绝经期抑郁模型大鼠单胺类神经递质含量的调节[J].时珍国医国药,2015,26(9):2299-2301.
[17]李静,李丹,雷升,等.围绝经期抑郁症发病与体质相关性的针刺实验研究[J].中华中医药学刊,2013,31(4):781-783.
[18]彭晓涛,程凯,徐玲,等.电针三阴交对自然围绝经期大鼠雌二醇和大脑皮层神经递质的影响[J].中国临床保健杂志,2015,18(5):509-511.
[19]Lu Y,Ho CS,Mc Intyre RS,et al.Agomelatine-induced modulation of brain-derived neurotrophic factor(BDNF)in the rat hippocampus[J].Life Sci,2018,210:177-184.
[20]Wang SS,Mu RH,Li CF,et al.micro RNA-124 targets glucocorticoid receptor and is involved in depressionlike behaviors[J].Prog Neuropsychopharmacol Biol Psychiatry,2017,79(Pt B):417-425.
[21]Bocci F,Jolly MK,George JT,et al.A mechanism-based computational model to capture the interconnections among epithelial-mesenchymal transition,cancer stem cells and Notch-Jagged signaling[J].Oncotarget,2018,9(52):29906-29920.
[22]Ishibashi M.Molecular mechanisms for morphogenesis of the central nervous system in mammals[J].Anat Sci Int,2004,79(4):226-234.
[23]Sakisaka Y,Kanaya S,Nakamura T,et al.p38 MAP kinase is required for Wnt3a-mediated osterix expression independently of Wnt-LRP5/6-GSK3βsignaling axis in dental follicle cells[J].Biochem Biophys Res Commun,2016,478(2):527-532.
[24]Peng H,Wang HB,Wang L,et al.Gsk3βaggravates the depression symptoms in chronic stress mouse model[J].JIntegr Neurosci,2018,17(2):217-226.
[25]邓雪,任路,冷雪,等.补肾益脑灸法通过Wnt信号通路影响围绝经期抑郁症大鼠海马神经发生[J].中国中医基础医学杂志,2017,23(9):1288-1291.
[26]荆秦,林卉,任路.“肾脑相济”电针疗法对围绝经期抑郁症大鼠海马Wnt/β-catenin信号通路的影响[J].中华中医药学刊,2018,36(6):1347-1350.
[27]邓雪,任路.以肾脑相济理论为指导的电针疗法对围绝经期抑郁症大鼠海马Notch通路的影响[J].辽宁中医杂志,2017,44(3):595-601.
[28]王戈,任路.“肾脑相济”电针疗法对围绝经期抑郁症大鼠海马BDNF、CREB的影响[J].辽宁中医杂志,2016,43(4):858-860.
[29]傅沈康,姜开妍,王玉,等.“肾脑相济”灸法对围绝经期抑郁症大鼠海马Notch通路的作用机制[J].辽宁中医杂志,2018,45(3):454-458.
[30]Demirda?s A,Nazιro?lu M,?vey I S.Duloxetine Reduces Oxidative Stress,Apoptosis,and Ca2+Entry Through Modulation of TRPM2 and TRPV1 Channels in the Hippocampus and Dorsal Root Ganglion of Rats[J].Mol Neurobiol,2017,54(6):4683-4695.
[31]Zhang WY,Wang KY,Li YJ,et al.Chronic stress causes protein kinase C epsilon-aldehyde dehydrogenase 2 signaling pathway perturbation in the rat hippocampus and prefrontal cortex,but not in the myocardium[J].Neural Regen Res,2018,13(7):1225-1230.
[32]Tong J,Li J,Zhang QS,et al.Delayed cognitive deficits can be alleviated by calcium antagonist nimodipine by downregulation of apoptosis following whole brain radiotherapy[J].Oncol Lett,2018,16(2):2525-2532.
[33]Tong C,Liu Y,Zhang Y,et al.Shock waves increase pulmonary vascular leakage,inflammation,oxidative stress,and apoptosis in a mouse model[J].Exp Biol Med(Maywood),2018,243(11):934-944.
[34]荆秦,林卉,任路.电针对围绝经期抑郁症大鼠海马神经元凋亡的影响[J].中国中医基础医学杂志,2017,23(11):1607-1610.
[35]王戈,任路,贾连群.电针对围绝经期抑郁症大鼠海马Bcl-2和Bax的影响[J].中国中医基础医学杂志,2016,22(6):838-840.
[36]邓雪,任路,王旭.补肾健脑电针疗法对围绝经期抑郁症大鼠前额叶皮质神经细胞内尼氏小体及核仁影响的定量分析[J].辽宁中医杂志,2018,45(9):1797-1801,2013.
[37]皇甫伟玲,任路,林卉.“肾脑相济”电针疗法对围绝经期抑郁症模型大鼠海马及其内环境影响[J].辽宁中医药大学学报,2018,20(7):31-34.
[38]王玉,林卉,任路.电针疗法对围绝经期抑郁模型大鼠炎性细胞因子的影响[J].辽宁中医药大学学报,2017,19(12):72-75.