熊果酸调控细胞因子法治疗炎症疾病的临床观察
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摘要
熊果酸属于五环三萜类化合物,生物活性及药理作用相对广泛,如抗炎与抗变态反应、抗癌、抗氧化、镇静、降压、免疫调节、促进造血等。细胞因子作为免疫反应的调节者和炎症反应的中介者,在众多疾病发生发展过程中起着重要作用。本文将综述熊果酸作为具有抗炎作用的天然产物,对细胞因子IFN-γ、TGF-β1、IL-10、IL-6调节作用的研究,为研究开发新药和扩大熊果酸的临床应用范围提供理论参考。
Ursolic acid belongs to pentacyclic triterpene compounds and has a relatively wide range of biological activities and pharmacological activities. Such as anti-inflammatory and anti-allergic reaction, anti-cancer, anti-oxidation, sedation, hypotension,immune regulation, and promote hematopoiesis, etc. Cytokines, as mediators of immune response and inflammation, play an important role in the occurrence and development of many diseases.This article reviews ursolic acid as a natural product with anti-inflammatory effect, and studies on the regulation of cytokine IFN-γ, TGF-β1, IL-10 and IL-6, which provide theoretical reference for the research and development of new drugs and the expansion of ursolic acid's clinical application range.
Ursolic acid belongs to pentacyclic triterpene compounds and has a relatively wide range of biological activities and pharmacological activities. Such as anti-inflammatory and anti-allergic reaction, anti-cancer, anti-oxidation, sedation, hypotension,immune regulation, and promote hematopoiesis, etc. Cytokines, as mediators of immune response and inflammation, play an important role in the occurrence and development of many diseases.This article reviews ursolic acid as a natural product with anti-inflammatory effect, and studies on the regulation of cytokine IFN-γ, TGF-β1, IL-10 and IL-6, which provide theoretical reference for the research and development of new drugs and the expansion of ursolic acid's clinical application range.
引文
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[3]张明发,沈雅琴.齐墩果酸降血糖和抗糖尿病并发症作用的研究进展[J].抗感染药学,2015,12(6):801-806.
[4]张明发,沈雅琴.熊果酸降血糖药理作用及其机制的研究进展[J].抗感染药学,2016,13(2):247-251.
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[7]胡志芳,姜凤良.熊果酸对人外周血单个核细胞分泌Th1/Th2型细胞因子的影响[J].山西医科大学学报,2010,41(9):783-785.
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[13] Koczy-Baron E,Kasperska-Zajac A. The role of vascular endothelial growth factor in inflammatory processes. Postepy Hig Med Dosw(Online),2014,68:57-65.
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[15]张扬武,罗伟生,陈姗,等.枇杷叶熊果酸对大鼠肝星状细胞增殖抑制作用及对PPAR-γ、TGF-β1表达的影响[J].中国药理学通报,2017,33(4):517-521.
[16] Murakami S,Takashima H,Sato-Watanabe M,et al. Ursolic acid,an antagonist for transforming growth factor(TGF)-beta1[J]. FEBS Lett,2004,566(1-3):55-9.
[17] Yoshimura H,Sugawara K,Saito M,et al. In vitro TGF-beta1antagonistic activity of ursolic and oleanolic acids isolated from Clerodendranthus spicatus[J]. Planta Med,2003,69(7):673-675.
[18]林志民,李月婷,郑兴中,等.熊果酸含药血清对大鼠肾小球系膜细胞增殖及TGF-β1表达的影响[J].中国医院药学杂志,2017,10(37),938-941.
[19]郑晶晶,顾玉海.低氧条件下IL-6、IL-8、IL-10作用机制研究进展[J].国际呼吸杂志,2016,36(3):224-227.
[20]吴华仙,田广俊,陈曲波. IL-10+调节性B细胞在自身免疫性疾病中的研究进展[J].中国免疫学杂志,2016,32(7):1077-1079,1083.
[21]徐启鹏,刘成.细胞因子与慢性非细菌性前列腺炎的研究进展[J].中华全科医学,2010,8(11):1446-1447.
[22]刘雁飞,韩盼,赖永继.熊果酸对慢性非细菌性前列腺炎模型大鼠的治疗作用[J].医药导报,2015,34(10):1292-1295.
[23]周宁,杨标.熊果酸对大鼠肠系膜缺血再灌注损伤的保护作用及机制研究[J].中药药理与临床,2015,31(4):106-110.
[24]童晓萍,蔡彦,王维亮,等.成人肺炎支原体肺炎中医证候分析及与炎症指标的关系[J].广东医学,2014,35(2):291-292.
[25]车颖悟,佟晓辉,黄晓娟.自拟中药方联合阿奇霉素治疗小儿支原体肺炎的疗效观察[J].中国药房,2013,15(20):1875-1876.
[26] Geboes K,Riddell R,Ost A,et al. A reproducible grading scale for histological assessment of inflammation in ulcerative colitis[J]. Gut,2000,47(3):404-409.
[27]曾璐,唐外姣,殷锦锦,等.熊果酸改善肝细胞脂肪变性的实验研究[J].中药材,2015,38(5):1049-1052.
[28]孙爱平,孙书明,张国俊,等.熊果酸减轻LPS诱导的THP-1细胞损伤[J].基础医学与临床,2014,34(1):88-92.
[29] Yang Y,Lv J,Jiang S,et al. The emerging role of Toll-like receptor 4 in myocardial inflammation.Cell Death Dis,2016,7:e2234.
[30]简磊,高明杰,夏旋.熊果酸减轻糖尿病大鼠心脏缺血再灌注损伤[J].天然产物研究与开发,2017,29(5):843-848.
[2] Anyanwu G O,Nisar-Ur-Rehman,Onyeneke CE,et al. Medicinal plants of the genus Anthocleista-A review of their ethnobotany,phytochemistry and pharmacology. J Ethnopharmacol,2015,175:648-667.
[3]张明发,沈雅琴.齐墩果酸降血糖和抗糖尿病并发症作用的研究进展[J].抗感染药学,2015,12(6):801-806.
[4]张明发,沈雅琴.熊果酸降血糖药理作用及其机制的研究进展[J].抗感染药学,2016,13(2):247-251.
[5] Shishodia S,Majumdar S,Banerjee S,et al. Ursolic acid inhibits nuclear factor-kappaB activation induced by carcinogenic agents through suppression of IkappaBalpha kinase and p65 phosphorylation:correlation with down-regulation of cyclooxygenase 2,matrix metalloprotei-nase 9,and cyclin D1. Cancer Res(2003)63:4375-4383.
[6] Hussein Y M,EL-Shal A S,Rezk N A,et al. Influence of interleukin-4gene polymorphisms and interleukin-4 Serum level on susceptibility and severity of rheumatoid arthritis in Egytian population[J]. Cytokine,2013,61(3):849-855.
[7]胡志芳,姜凤良.熊果酸对人外周血单个核细胞分泌Th1/Th2型细胞因子的影响[J].山西医科大学学报,2010,41(9):783-785.
[8] Chen X,Krakauer T,Oppenhein J J,et al. Yin Zhi Hunag,an injectable multieomponent Chinese herbal medicine,is a potent inhibitor of T-cell aetivation[J]. J Aletm Complement Med,2004,10:519-526.
[9]董兴高.熊果酸对人外周血淋巴细胞细胞因子表达的影响[D].武汉大学,2005.
[10] Huang X,Du H,Gu J,et al. An allopurinol-controlled,multicenter,randomized,doubleblind,parallel between-group,comparative study of febuxostat in Chinese patients with gout and hyperuricemia[J]. Internation Journal of Rheumatic Disease,2014,17:679-686.
[11] Wang Y,Wang L,Li E,et al. Chuanhu anti-gout mixture versus colchicine for acute gouty arthritis:a randomized,doubleblind,doubledummy,non-inferiority trial[J]. Int J Med Sci,2014,11(9):880-885.
[12] Ahmad SF,Khan B,Banis,et al. Amelioration of adjuvant-induced arthritis by ursolic acid through altered Th1/Th2 cytokine production[J].Pharmacol Res,2006,53(3):233-240.
[13] Koczy-Baron E,Kasperska-Zajac A. The role of vascular endothelial growth factor in inflammatory processes. Postepy Hig Med Dosw(Online),2014,68:57-65.
[14] Yang Y C,Zhang N,Van Crombruggen K,et al. Transforming growth factor beta1 in inflammatory airway disease:a key for understanding inflammation and remodeling[J]. Allergy,2012,67(10):1193-1202.
[15]张扬武,罗伟生,陈姗,等.枇杷叶熊果酸对大鼠肝星状细胞增殖抑制作用及对PPAR-γ、TGF-β1表达的影响[J].中国药理学通报,2017,33(4):517-521.
[16] Murakami S,Takashima H,Sato-Watanabe M,et al. Ursolic acid,an antagonist for transforming growth factor(TGF)-beta1[J]. FEBS Lett,2004,566(1-3):55-9.
[17] Yoshimura H,Sugawara K,Saito M,et al. In vitro TGF-beta1antagonistic activity of ursolic and oleanolic acids isolated from Clerodendranthus spicatus[J]. Planta Med,2003,69(7):673-675.
[18]林志民,李月婷,郑兴中,等.熊果酸含药血清对大鼠肾小球系膜细胞增殖及TGF-β1表达的影响[J].中国医院药学杂志,2017,10(37),938-941.
[19]郑晶晶,顾玉海.低氧条件下IL-6、IL-8、IL-10作用机制研究进展[J].国际呼吸杂志,2016,36(3):224-227.
[20]吴华仙,田广俊,陈曲波. IL-10+调节性B细胞在自身免疫性疾病中的研究进展[J].中国免疫学杂志,2016,32(7):1077-1079,1083.
[21]徐启鹏,刘成.细胞因子与慢性非细菌性前列腺炎的研究进展[J].中华全科医学,2010,8(11):1446-1447.
[22]刘雁飞,韩盼,赖永继.熊果酸对慢性非细菌性前列腺炎模型大鼠的治疗作用[J].医药导报,2015,34(10):1292-1295.
[23]周宁,杨标.熊果酸对大鼠肠系膜缺血再灌注损伤的保护作用及机制研究[J].中药药理与临床,2015,31(4):106-110.
[24]童晓萍,蔡彦,王维亮,等.成人肺炎支原体肺炎中医证候分析及与炎症指标的关系[J].广东医学,2014,35(2):291-292.
[25]车颖悟,佟晓辉,黄晓娟.自拟中药方联合阿奇霉素治疗小儿支原体肺炎的疗效观察[J].中国药房,2013,15(20):1875-1876.
[26] Geboes K,Riddell R,Ost A,et al. A reproducible grading scale for histological assessment of inflammation in ulcerative colitis[J]. Gut,2000,47(3):404-409.
[27]曾璐,唐外姣,殷锦锦,等.熊果酸改善肝细胞脂肪变性的实验研究[J].中药材,2015,38(5):1049-1052.
[28]孙爱平,孙书明,张国俊,等.熊果酸减轻LPS诱导的THP-1细胞损伤[J].基础医学与临床,2014,34(1):88-92.
[29] Yang Y,Lv J,Jiang S,et al. The emerging role of Toll-like receptor 4 in myocardial inflammation.Cell Death Dis,2016,7:e2234.
[30]简磊,高明杰,夏旋.熊果酸减轻糖尿病大鼠心脏缺血再灌注损伤[J].天然产物研究与开发,2017,29(5):843-848.