鼻渊软胶囊联合糠酸莫米松鼻喷剂治疗慢性鼻炎临床观察
|
摘要
目的探讨鼻渊软胶囊联合糠酸莫米松鼻喷剂治疗慢性鼻炎的疗效及对血清白细胞介素17(IL-17)、免疫球蛋白E(IgE)水平的影响。方法选取莱芜市钢铁集团有限公司医院2016年10月至2018年2月收治的慢性鼻炎患者98例,按治疗方法的不同分为研究组和对照组,各49例。两组患者均予以糠酸莫米松鼻喷剂治疗,研究组患者加用鼻渊软胶囊。两组均连续治疗4周。结果研究组总有效率为93. 88%,明显高于对照组的75. 51%(χ2=34. 282,P <0. 01);与治疗前比较,两组患者治疗后鼻阻力,临床症状评分,以及IL-17和IgE水平均显著降低(P <0. 05),且研究组降幅更显著(P <0. 05);研究组患者不良反应发生率为6. 12%,明显低于对照组的18. 37%(χ~2=15. 882,P <0. 01)。结论鼻渊软胶囊联合糠酸莫米松鼻喷剂治疗慢性鼻炎疗效较好,可明显减轻炎性反应,且不增加不良反应。
Objective To investigate the clinical effect of Biyuan Soft Capsules combined with Mometasone Furoate Nasal Spray in the treatment of chronic rhinitis and its effect on the levels of serum interleukin-17( IL-17) and immunoglobulin E( IgE). Methods Totally 98 patients with chronic rhinitis admitted to Laiwu City Laigang Hospital from October 2016 to February 2018 were selected and divided into the study group and the control group according to different treatment methods,49 cases in each group. The patients in the two groups were treated with Mometasone Furoate Nasal Spray,on this basis,the patients in the study group were treated with Biyuan Soft Capsules. Both groups were treated continuously for 4 weeks. Results The total effective rate of the study group was 93. 88%,which was significantly higher than 75. 51% of the control group(χ~2 = 34. 282,P < 0. 001). Compared with before treatment,the nasal resistance,clinical symptom score,the levels of IL-17 and IgE in the two groups were significantly decreased after treatment( P <0. 05),and the decrease in the study group was more significant than that in the control group( P < 0. 05). The incidence of adverse reactions in the study group was 6. 12%,which was significantly lower than 18. 37% in the control group(χ~2 = 15. 882,P < 0. 01).Conclusion Biyuan Soft Capsules combined with Mometasone Furoate Nasal Spray are effective in the treatment of chronic rhinitis,which can reduce the inflammatory reaction without increasing the adverse reactions.
Objective To investigate the clinical effect of Biyuan Soft Capsules combined with Mometasone Furoate Nasal Spray in the treatment of chronic rhinitis and its effect on the levels of serum interleukin-17( IL-17) and immunoglobulin E( IgE). Methods Totally 98 patients with chronic rhinitis admitted to Laiwu City Laigang Hospital from October 2016 to February 2018 were selected and divided into the study group and the control group according to different treatment methods,49 cases in each group. The patients in the two groups were treated with Mometasone Furoate Nasal Spray,on this basis,the patients in the study group were treated with Biyuan Soft Capsules. Both groups were treated continuously for 4 weeks. Results The total effective rate of the study group was 93. 88%,which was significantly higher than 75. 51% of the control group(χ~2 = 34. 282,P < 0. 001). Compared with before treatment,the nasal resistance,clinical symptom score,the levels of IL-17 and IgE in the two groups were significantly decreased after treatment( P <0. 05),and the decrease in the study group was more significant than that in the control group( P < 0. 05). The incidence of adverse reactions in the study group was 6. 12%,which was significantly lower than 18. 37% in the control group(χ~2 = 15. 882,P < 0. 01).Conclusion Biyuan Soft Capsules combined with Mometasone Furoate Nasal Spray are effective in the treatment of chronic rhinitis,which can reduce the inflammatory reaction without increasing the adverse reactions.
引文
[1]沈莹,罗蜜,张建斌,等.丝裂霉素C治疗慢性鼻窦炎和鼻息肉鼻内镜术后鼻腔粘连疗效及安全性评价[J].中国药业,2016,25(15):60-62.
[2]邓建洪,黄河,彭利.丙酸氟替卡松联合克拉霉素治疗慢性鼻窦炎伴鼻息肉的疗效和安全性分析[J].中国药业,2015,24(11):20-21.
[3]刘向阳,曹慧芳,古小东.盐酸奥洛他定片治疗过敏性鼻炎的效果及对患者血清免疫球蛋白水平的影响[J].保健医学研究与实践,2017,14(3):64-66.
[4]祝仁贵,叶少芬.氦氖激光联合鼻三针治疗过敏性鼻炎疗效及对血清特异性IgE抗体的影响[J].现代中西医结合杂志,2016,25(18):2002-2004.
[5]董艳玲.鼻渊软胶囊联合罗红霉素治疗慢性鼻窦炎的临床效果[J].湖北中医药大学学报,2016,18(2):77-79.
[6]GREENE LM,ROYAL KD,BRADLEY JM,et al.Severity of Nasal Inflammatory Disease Questionnaire for Canine Idiopathic Rhinitis Control:Instrument Development and Initial Validity Evidence[J].Journal of Veterinary Internal Medicine,2017,31(1):134-141.
[7]雷刚.孟鲁司特钠咀嚼片联合糠酸莫米松鼻喷雾剂治疗儿童过敏性鼻炎的临床研究[J].现代药物与临床,2015,30(4):425-428.
[8]李娟,程杰,何艳.鼻腔冲洗联合糠酸莫米松鼻喷雾剂治疗变应性鼻炎的疗效观察[J].重庆医学,2016,45(25):3506-3507.
[9]王俊,徐进敬,王洁,等.糠酸莫米松鼻喷雾剂联合玉屏风颗粒治疗季节性变应性鼻炎疗效分析[J].中国临床研究,2017,30(5):692-694.
[10]BENSON LM,MASON CJ,FRIEDMAN O,et al.Extensive fractionation and identification of proteins within nasal lavage fluids from allergic rhinitis and asthmatic chronic rhinosinusitis patients[J].Journal of Separation Science,2015,32(1):44-56.
[11]余晓燕,黄孟捷,徐浪.辛芩颗粒联合糠酸莫米松鼻喷雾剂治疗儿童变应性鼻炎的临床研究[J].现代药物与临床,2017,32(7):1289-1292.
[12]樊晖晖,王欣,王运红,等.鼻炎宁胶囊联合糠酸莫米松治疗慢性鼻炎的临床研究[J].现代药物与临床,2018,33(3):600-603.
[2]邓建洪,黄河,彭利.丙酸氟替卡松联合克拉霉素治疗慢性鼻窦炎伴鼻息肉的疗效和安全性分析[J].中国药业,2015,24(11):20-21.
[3]刘向阳,曹慧芳,古小东.盐酸奥洛他定片治疗过敏性鼻炎的效果及对患者血清免疫球蛋白水平的影响[J].保健医学研究与实践,2017,14(3):64-66.
[4]祝仁贵,叶少芬.氦氖激光联合鼻三针治疗过敏性鼻炎疗效及对血清特异性IgE抗体的影响[J].现代中西医结合杂志,2016,25(18):2002-2004.
[5]董艳玲.鼻渊软胶囊联合罗红霉素治疗慢性鼻窦炎的临床效果[J].湖北中医药大学学报,2016,18(2):77-79.
[6]GREENE LM,ROYAL KD,BRADLEY JM,et al.Severity of Nasal Inflammatory Disease Questionnaire for Canine Idiopathic Rhinitis Control:Instrument Development and Initial Validity Evidence[J].Journal of Veterinary Internal Medicine,2017,31(1):134-141.
[7]雷刚.孟鲁司特钠咀嚼片联合糠酸莫米松鼻喷雾剂治疗儿童过敏性鼻炎的临床研究[J].现代药物与临床,2015,30(4):425-428.
[8]李娟,程杰,何艳.鼻腔冲洗联合糠酸莫米松鼻喷雾剂治疗变应性鼻炎的疗效观察[J].重庆医学,2016,45(25):3506-3507.
[9]王俊,徐进敬,王洁,等.糠酸莫米松鼻喷雾剂联合玉屏风颗粒治疗季节性变应性鼻炎疗效分析[J].中国临床研究,2017,30(5):692-694.
[10]BENSON LM,MASON CJ,FRIEDMAN O,et al.Extensive fractionation and identification of proteins within nasal lavage fluids from allergic rhinitis and asthmatic chronic rhinosinusitis patients[J].Journal of Separation Science,2015,32(1):44-56.
[11]余晓燕,黄孟捷,徐浪.辛芩颗粒联合糠酸莫米松鼻喷雾剂治疗儿童变应性鼻炎的临床研究[J].现代药物与临床,2017,32(7):1289-1292.
[12]樊晖晖,王欣,王运红,等.鼻炎宁胶囊联合糠酸莫米松治疗慢性鼻炎的临床研究[J].现代药物与临床,2018,33(3):600-603.