透明质酸联合A型肉毒毒素在面下部轮廓重塑中的临床分析
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摘要
目的探讨透明质酸填充联合A型肉毒毒素注射在面下部轮廓重塑中的效果、满意度及安全性。方法回顾2014年12月至2017年5月接受面下部轮廓重塑治疗的78例求美者,根据美容方案将接受A型肉毒毒素注射的41例作为对照组,接受透明质酸填充联合A型肉毒毒素注射的37例作为实验组。对比两组求美者术后1个月,面下部宽度(WLF)和面下部长度(LLF),计算LLF/WLF比值及其变化,以及满意度和并发症发生情况的差异。结果对照组术前WLF为(13.27±0.84)cm,术后为(12.21±0.71)cm;术前LLF为(7.60±0.64)cm,术后为(7.58±0.62)cm。实验组术前WLF为(13.21±0.72)cm,术后为(12.35±0.63)cm;术前LLF为(6.45±0.53)cm,术后为(7.49±0.44)cm。两组术前术后WLF、LLF/WLF差异均有统计学意义(P<0.05)。实验组术前、术后LLF/WLF比值高于对照组(P<0.05);实验组求美者的总满意度高于对照组(P<0.05)。术后1个月,两组求美者的双侧面部不对称、透明质酸过敏等并发症的发生率比较,其差异无统计学意义(P>0.05)。结论采用透明质酸填充联合A型肉毒毒素注射重塑面下部轮廓的效果较明显,求美者的满意度较高,而且不会增加相关并发症的发生率,具有良好的治疗安全性。
Objective To explore the efficacy, satisfaction, and safety of hyaluronic acid combined with botulinum toxin type A injection in the contour remolding of the lower one third of the face. Methods From December 2014 to May 2017, 78 patients underwent contour remolding of the lower one third of the face. Among all patients, 41 patients who received botulinum toxin type A injection served as the control group. Thirty-seven patients who underwent hyaluronic acid combined with botulinum toxin type A injection served as experimental group. One month after cosmetology, data of facial contour parameters such as width of the lower face(WLF), length of the lower face(LLF), ratio of LLF to WLF and its interactive change, as well as satisfaction and complications between the two groups were compared. Results The WLF of the control group before and after surgery was(13.21±0.72) cm and(12.35±0.63) cm, respectively. The LLF of the control group before and after the operation was(7.60±0.64) cm and(7.58±0.62) cm, respectively. The WLF of the experimental group before and after surgery was(13.21±0.72) cm and(12.35±0.63) cm, respectively. The LLF of the experimental group before and after the operation was(6.45±0.53) cm and(7.49±0.44) cm, respectively. There was statistical difference in the pre-and postoperative data of WLF and LLF/WLF(P<0.05). The D-value of LLF/WLF of the experimental group before and after the operation was higher than that of the control group(P<0.05). The total satisfaction of the experimental group was higher than that of the control group(P<0.05). One month after surgery, there was no significant difference in the incidence of bilateral facial asymmetry, hyaluronic acid hypersensitivity, or other complications between the two groups(P>0.05). Conclusion Application of hyaluronic acid combined with botulinum toxin type A injection in contour remolding of the lower one third of the face was more effective than application of botulinum toxin type A alone. Patient satisfaction was high, and the related complications did not increase. It is a safe and effective treatment.
Objective To explore the efficacy, satisfaction, and safety of hyaluronic acid combined with botulinum toxin type A injection in the contour remolding of the lower one third of the face. Methods From December 2014 to May 2017, 78 patients underwent contour remolding of the lower one third of the face. Among all patients, 41 patients who received botulinum toxin type A injection served as the control group. Thirty-seven patients who underwent hyaluronic acid combined with botulinum toxin type A injection served as experimental group. One month after cosmetology, data of facial contour parameters such as width of the lower face(WLF), length of the lower face(LLF), ratio of LLF to WLF and its interactive change, as well as satisfaction and complications between the two groups were compared. Results The WLF of the control group before and after surgery was(13.21±0.72) cm and(12.35±0.63) cm, respectively. The LLF of the control group before and after the operation was(7.60±0.64) cm and(7.58±0.62) cm, respectively. The WLF of the experimental group before and after surgery was(13.21±0.72) cm and(12.35±0.63) cm, respectively. The LLF of the experimental group before and after the operation was(6.45±0.53) cm and(7.49±0.44) cm, respectively. There was statistical difference in the pre-and postoperative data of WLF and LLF/WLF(P<0.05). The D-value of LLF/WLF of the experimental group before and after the operation was higher than that of the control group(P<0.05). The total satisfaction of the experimental group was higher than that of the control group(P<0.05). One month after surgery, there was no significant difference in the incidence of bilateral facial asymmetry, hyaluronic acid hypersensitivity, or other complications between the two groups(P>0.05). Conclusion Application of hyaluronic acid combined with botulinum toxin type A injection in contour remolding of the lower one third of the face was more effective than application of botulinum toxin type A alone. Patient satisfaction was high, and the related complications did not increase. It is a safe and effective treatment.
引文
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[9]宋海金.A型肉毒素咬肌注射联合玻尿酸颏部注射填充微整形术重塑面下部1/3轮廓的临床手术效果观察[J].药品评价,2016,13(15):52-54.
[10]Tian L,You J,Wang H,et al.Comparison of two different grafts in nasal framework reconstruction of binder syndrome:cartilage and silicone[J].J Craniofac Surg,2017,28(6):1413-1417.
[11]Ghazouane R,Bertrand B,Philandrianos C,et al.What about the rheological properties of PRP/microfat mixtures in fat grafting procedure?[J].Aesthetic Plast Surg,2017,41(5):1217-1221.
[12]Bhandari M,Bannuru RR,Babins EM,et al.Intra-articular hyaluronic acid in the treatment of knee osteoarthritis:a canadian evidence-based perspective[J].Ther Adv Musculoskelet Dis,2017,9(9):231-246.
[13]Prager W,Agsten K,Kravtsov M,et al.Mid-face volumization with hyaluronic acid:injection technique and safety aspects from a controlled,randomized,double-blind clinical study[J].J Drugs Dermatol,2017,16(4):351-357.
[14]Parikh RP,Snyder-Warwick A,Naidoo S,et al.Impact of an event reporting system on resident complication reporting in plastic surgery training:addressing an ACGME and plastic surgery milestone project core competency[J].Plast Reconstr Surg,2017,140(5):736e-745e.
[15]Pessis R,Gianfermi M,Lacoeuilhe G,et al.Patient counselingin case of postoperative complication leading to emergency reintervention in plastic surgery.What is the current situation?How to improve?Retrospective study of counseling modalities and traceability in a series of 16 patients who needed emergency reintervention within a cohort of 402 patients[J].Ann Chir Plast Esthet,2015,60(4):291-298.
[2]Wong W,Motakef S,Gupta S.Reply:redefining the ideal buttocks:a population analysis[J].Plast Reconstr Surg,2017,139(4):1023e-1024e.
[3]徐威,袁伟,庞星原,等.A型肉毒毒素和卵磷脂注射溶脂联合应用修改面部轮廓[J].武汉大学学报(医学版),2011,32(4):520-522.
[4]Kumar H,Ha DH,Lee EJ,et al.Safety and tolerability of intradiscal implantation of combined autologous adipose-derived mesenchymal stem cells and hyaluronic acid in patients with chronic discogenic low back pain:1-year follow-up of a phase Istudy[J].Stem Cell Res Ther,2017,8(1):262.
[5]Inbal A,Lemelman BT,Millet E,et al.Tissue expansion using hyaluronic acid filler for single-stage ear reconstruction:a novel concept for difficult areas[J].Aesthet Surg J,2017,37(10):1085-1097.
[6]Bogari M,Tan A,Xin Y,et al.Treatment of gastrocnemius muscle hypertrophy with botulinum toxin injection followed by magnetic resonance imaging assessment and 3-dimensional evaluation[J].Aesthet Surg J,2017,37(10):1146-1156.
[7]李芸,田霞,勾庆芬,等.A型肉毒毒素咬肌内注射联合颊脂垫切除面部轮廓塑形[J].口腔医学研究,2013,29(10):968-969,972.
[8]张超,滕利,靳小雷,等.A型肉毒素咬肌注射联合玻尿酸颏部注射重塑面下部1/3轮廓的临床研究[J].现代医学,2014,42(5):477-481.
[9]宋海金.A型肉毒素咬肌注射联合玻尿酸颏部注射填充微整形术重塑面下部1/3轮廓的临床手术效果观察[J].药品评价,2016,13(15):52-54.
[10]Tian L,You J,Wang H,et al.Comparison of two different grafts in nasal framework reconstruction of binder syndrome:cartilage and silicone[J].J Craniofac Surg,2017,28(6):1413-1417.
[11]Ghazouane R,Bertrand B,Philandrianos C,et al.What about the rheological properties of PRP/microfat mixtures in fat grafting procedure?[J].Aesthetic Plast Surg,2017,41(5):1217-1221.
[12]Bhandari M,Bannuru RR,Babins EM,et al.Intra-articular hyaluronic acid in the treatment of knee osteoarthritis:a canadian evidence-based perspective[J].Ther Adv Musculoskelet Dis,2017,9(9):231-246.
[13]Prager W,Agsten K,Kravtsov M,et al.Mid-face volumization with hyaluronic acid:injection technique and safety aspects from a controlled,randomized,double-blind clinical study[J].J Drugs Dermatol,2017,16(4):351-357.
[14]Parikh RP,Snyder-Warwick A,Naidoo S,et al.Impact of an event reporting system on resident complication reporting in plastic surgery training:addressing an ACGME and plastic surgery milestone project core competency[J].Plast Reconstr Surg,2017,140(5):736e-745e.
[15]Pessis R,Gianfermi M,Lacoeuilhe G,et al.Patient counselingin case of postoperative complication leading to emergency reintervention in plastic surgery.What is the current situation?How to improve?Retrospective study of counseling modalities and traceability in a series of 16 patients who needed emergency reintervention within a cohort of 402 patients[J].Ann Chir Plast Esthet,2015,60(4):291-298.