参芪降糖颗粒治疗2型糖尿病的Meta分析
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摘要
目的评价参芪降糖颗粒治疗2型糖尿病的疗效。方法检索中国学术期刊全文数据库、中国生物医学文献数据库、中国科技期刊全文数据库、万方医学网,同时手工检索相关医学期刊、纳入相关的随机对照试验组,采用RevMan 5.3软件进行Meta分析。最后以相对危险系数(RR)、平均差(MD)以及95%CI表示。结果纳入的6个RCT研究,共有486例患者。Meta分析结果显示,参芪降糖颗粒试验组有效率优于对照组(RR=0.76,95%CI为0.62～0.93,P=0.008),在空腹血糖、餐后血糖和糖化血红蛋白方面,参芪降糖颗粒试验组均优于对照组(MD=-1.49,95%CI为-2.8～-0.18;MD=-2.21,95%CI为-3.09～-1.32;MD=-1.49,95%CI为-3.32～0.34)。结论参芪降糖颗粒能治疗或辅助治疗2型糖尿病。
Objective To evaluate the curative effect of Shenqi Hypoglycemic Granules in the treatment of type 2 diabetes.Methods China academic journal full-text database and Chinese biomedical literature database,science and technology of China journal full-text database,and ten thousand medical networks were retrieved through computer.Meanwhile,the related medical journals were retrieved manualy.The relevant random controlled trials(RCT) were included and analyzed by RevMan 5.3 software in relative risk(RR),the mean difference(MD),and 95% confidence interval(CI).Results 6 RCT studied were included,totally 486 patients.The Meta results showed that in terms of efficiency,ginseng and Shenqi Hypoglycemic Granules group were better than the control group(RR=0.76,95%CI 0.62-0.93,P=0.008),In fasting plasma glucose,postprandial blood glucose,glycosylated hemoglobin,ginseng and Shenqi Hypoglycemic Granules group were better than the control group(MD=-1.49,95%CI-2.8--0.18;MD=-2.21,95%CI-3.09--1.32;MD=-1.49,95%CI-3.32-0.34).Conclusion Shenqi Hypoglycemic Granules can treat or auxiliarily treat type 2 diabetes.
Objective To evaluate the curative effect of Shenqi Hypoglycemic Granules in the treatment of type 2 diabetes.Methods China academic journal full-text database and Chinese biomedical literature database,science and technology of China journal full-text database,and ten thousand medical networks were retrieved through computer.Meanwhile,the related medical journals were retrieved manualy.The relevant random controlled trials(RCT) were included and analyzed by RevMan 5.3 software in relative risk(RR),the mean difference(MD),and 95% confidence interval(CI).Results 6 RCT studied were included,totally 486 patients.The Meta results showed that in terms of efficiency,ginseng and Shenqi Hypoglycemic Granules group were better than the control group(RR=0.76,95%CI 0.62-0.93,P=0.008),In fasting plasma glucose,postprandial blood glucose,glycosylated hemoglobin,ginseng and Shenqi Hypoglycemic Granules group were better than the control group(MD=-1.49,95%CI-2.8--0.18;MD=-2.21,95%CI-3.09--1.32;MD=-1.49,95%CI-3.32-0.34).Conclusion Shenqi Hypoglycemic Granules can treat or auxiliarily treat type 2 diabetes.
引文
[1] 中华医学会糖尿病学分会.中国2型糖尿病防治指南(2010年版)[J].中国糖尿病杂志,2012,20(1):1-37.
[2] 文晓寰.门冬胰岛素30联合西格列汀治疗老年2型糖尿病的临床观察[J].西北药学杂志,2016,31(5):519-522.
[3] Xu Y,Wang L,He J,et al.Prevalence and control of diabetes in Chinese adults[J].JAMA,2013,310(9):948-959.
[4] Sacks D B.Amylin-a glucoregulatory hormone involved in the pathogenesis of diabetes mellitus[J].Clin Chem,1996,42(4):494-495.
[5] 陈玉鹏,黄芳.中药活性成分治疗糖尿病胰岛素抵抗的机制研究进展[J].药学进展,2016,40(3):197-204.
[6] 张意,王淼,何颂华,等.中医药治疗2型糖尿病胰岛素抵抗的研究进展[J].辽宁中医杂志,2015,42(6):1385-1388.
[7] 刘光宇,庞敬涛.中医药对糖尿病胰岛素抵抗的研究进展[J].四川中医,2014,32(2):168-170.
[8] 王月,王涛,吴建霞,等.金芪降糖片组分体外抗糖尿病的作用及机制[J].中国实验方剂学杂志,2015,21(16):105-109.
[9] 叶卓丁,吴钧俊.参芪降糖颗粒治疗2型糖尿病疗效分析[J].实用中医药杂志,2009,25(12):788-789.
[10] Gu Y,Zhang Y,Shi X,et al.Effect of traditional Chinese medicine berberine on type 2 diabetes based on comprehensive metabonomics[J].Talanta,2010,81(3):766-772.
[11] 马利.糖尿病中药治疗进展[J].淮海医药,2016,34(4):500-501.
[12] 胡建国.参芪降糖颗粒治疗2型糖尿病102例临床观察[J].内蒙古中医药,2013,35(29):40-42.
[13] 刘佳,李丽静,崔一民,等.中药辅助治疗糖尿病酮症酸中毒疗效的系统评价[J].世界中医药,2015,10(6):924-927.
[14] 巫藤勇,杨晓霞,钟芳.参芪降糖颗粒治疗2型糖尿病临床疗效分析[J].中外医疗,2014,33(35):126-127.
[15] 李涛.参芪降糖颗粒治疗150例2型糖尿病患者的临床疗效[J].求医问药,2012,10(11):1010.
[16] 陈彦.参芪降糖颗粒治疗2型糖尿病的疗效观察[J].中外健康文摘,2013,(33):9-10.
[17] 晏洁,何柳瑜,何志坚.参芪降糖颗粒治疗2型糖尿病前期25例临床观察[J].广东医学院学报,2011,29(4):445-446.
[18] 韩旭亮,王晓雯,马永雯,等.2型糖尿病的药物治疗进展[J].西北药学杂志,2012,27(6):616-618.
[19] 李秋,胰岛素抵制在2型糖尿病发病机制中的作用[J].航空航天医学杂志,2014,25(3):379-380.
[20] 袁怡,张跃明.中医药治疗糖尿病脑病机理研究[J].吉林中医药,2008,28(12):867-868.
[21] 杨晶,杨继辉.黄芪注射液治疗糖尿病肾病的血液流变学观察[J].中国微循环,2002,6(2):113.
[22] 张黎明,高凌.炎症细胞因子在2型糖尿病发病机制中的研究进展[J].重庆医学,2016,45(8):1113-1115.
[2] 文晓寰.门冬胰岛素30联合西格列汀治疗老年2型糖尿病的临床观察[J].西北药学杂志,2016,31(5):519-522.
[3] Xu Y,Wang L,He J,et al.Prevalence and control of diabetes in Chinese adults[J].JAMA,2013,310(9):948-959.
[4] Sacks D B.Amylin-a glucoregulatory hormone involved in the pathogenesis of diabetes mellitus[J].Clin Chem,1996,42(4):494-495.
[5] 陈玉鹏,黄芳.中药活性成分治疗糖尿病胰岛素抵抗的机制研究进展[J].药学进展,2016,40(3):197-204.
[6] 张意,王淼,何颂华,等.中医药治疗2型糖尿病胰岛素抵抗的研究进展[J].辽宁中医杂志,2015,42(6):1385-1388.
[7] 刘光宇,庞敬涛.中医药对糖尿病胰岛素抵抗的研究进展[J].四川中医,2014,32(2):168-170.
[8] 王月,王涛,吴建霞,等.金芪降糖片组分体外抗糖尿病的作用及机制[J].中国实验方剂学杂志,2015,21(16):105-109.
[9] 叶卓丁,吴钧俊.参芪降糖颗粒治疗2型糖尿病疗效分析[J].实用中医药杂志,2009,25(12):788-789.
[10] Gu Y,Zhang Y,Shi X,et al.Effect of traditional Chinese medicine berberine on type 2 diabetes based on comprehensive metabonomics[J].Talanta,2010,81(3):766-772.
[11] 马利.糖尿病中药治疗进展[J].淮海医药,2016,34(4):500-501.
[12] 胡建国.参芪降糖颗粒治疗2型糖尿病102例临床观察[J].内蒙古中医药,2013,35(29):40-42.
[13] 刘佳,李丽静,崔一民,等.中药辅助治疗糖尿病酮症酸中毒疗效的系统评价[J].世界中医药,2015,10(6):924-927.
[14] 巫藤勇,杨晓霞,钟芳.参芪降糖颗粒治疗2型糖尿病临床疗效分析[J].中外医疗,2014,33(35):126-127.
[15] 李涛.参芪降糖颗粒治疗150例2型糖尿病患者的临床疗效[J].求医问药,2012,10(11):1010.
[16] 陈彦.参芪降糖颗粒治疗2型糖尿病的疗效观察[J].中外健康文摘,2013,(33):9-10.
[17] 晏洁,何柳瑜,何志坚.参芪降糖颗粒治疗2型糖尿病前期25例临床观察[J].广东医学院学报,2011,29(4):445-446.
[18] 韩旭亮,王晓雯,马永雯,等.2型糖尿病的药物治疗进展[J].西北药学杂志,2012,27(6):616-618.
[19] 李秋,胰岛素抵制在2型糖尿病发病机制中的作用[J].航空航天医学杂志,2014,25(3):379-380.
[20] 袁怡,张跃明.中医药治疗糖尿病脑病机理研究[J].吉林中医药,2008,28(12):867-868.
[21] 杨晶,杨继辉.黄芪注射液治疗糖尿病肾病的血液流变学观察[J].中国微循环,2002,6(2):113.
[22] 张黎明,高凌.炎症细胞因子在2型糖尿病发病机制中的研究进展[J].重庆医学,2016,45(8):1113-1115.