浅谈膝骨性关节炎的病因学研究现状
摘要
膝骨性关节炎(Knee osteoarthritis,KOA)是主要以膝骨关节软骨变形、骨质增生以及坏死等炎症性病变为特征的骨关节疾病,属于中医的"痹病"范畴。目前普遍认为KOA的发病是关节软骨磨损,进而出现骨质增生所致。本文通过对大量文献的解读、归纳分析KOA的病因,总结目前KOA病因学研究方面的现状,为KOA的防治提供可靠的理论依据。
引文
[1]中华医学会骨科学会分会关节外科学组.骨关节炎诊疗指南(2018年版)[S].中华骨科杂志,2018,12:001.
[2]Peffers MJ,Balaskas P,Smagul A.Osteoarthritis year in review 2017:genetics and epigenetics[J].Osteoarthritis Cartilage,2018,26(3):304-311.
[3]梁衍祥,罗立媛,刘海刚,等.膝骨性关节炎的治疗研究进展[J].中国医药指南,2014,12(5):80-81.
[4]王新军,沈明球,刘俊昌,等.膝关节骨性关节炎的病因研究现状[J].新疆中医药,2011,29(3):77-80.
[5]王开超.411例膝关节骨性关节炎患者的流行病学调查分析[D].济南:山东中医药大学,2015.
[6]陆佳,陶弘武.膝关节骨性关节炎的MRI特点与中医分型的关系[J].中华中医药学刊,2016,34(8):2038-2042.
[7]郭然.膝关节骨性关节炎中医证型与炎性因子的相关性研究[D].北京:北京中医药大学,2017.
[8]黄木全.膝关节骨性关节炎各期经筋辨证及相关证素研究[C].北京中医药大学,2012.
[9]陈庆真.膝骨性关节炎中医证候规范化的研究[D].广州:广州中医药大学,2008.
[10]何春红,谭妃英,谢小鸣,等.广州市越秀区126例老年人膝关节骨性关节炎患病危险因素:与121例老年组的病例-对照分析[J].中国组织工程研究与临床康复,2009,13(33):6581-6584.
[11]董天华.膝关节骨性关节炎的基础与临床研究[D].石家庄:河北医科大学,2016.
[12]Madry H,van Dijk CN,Mueller-Gerbl M.The basic science of the subchondral bone.Knee Surg Sports Traumatol Arthrosc,2010,18(4):419-433.
[13]Lories RJ,Luyten FP.The bone-cartilage unit in osteoarthritis.Nat Rev Rheumatol,2011,7(1):43-49.
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[15]秦迪,李石伦,郑占乐,等.膝关节骨关节炎病因与关节软骨磨损的相关性研究[J].河北医科大学学报,2016,37(2):227-229.
[16]洛佳.137例膝骨性关节炎的影响因素与中医证型相关性分析[D].沈阳:辽宁中医药大学,2016.
[17]Jorn W.-P.Michael,Klaus U Schvter-Brust,Peer Eysel.The Epidemiology,Etiology,Diagnosis,and Treatment of Osteoarthritis of the Knee.Continuing Medical Education,2010,107(9):152-162.
[18]廖德发.我国骨性关节炎流行病学调查现状[J].微创医学,2017,12(4):521-524.
[19]刘健民,陈新华.膝关节骨性关节炎的病因分析[J].人民军医,2008,51(7):410.
[20]Phinyomary A,Osis ST,Hettinga BA,ect.Gender differences in gait kinematics for patients with knee osteoarthritis.BMCmusculoskeletal disorders,2016,12(17):157.
[21]Linn S,Murtaugh B,Casey E,Role of sex hormones in the development of osteoarthritis.PM&R;The journal of injury,function,and rehabilitation,2012,4(5):169-173.
[22]Fang WH,Huang GS,Chang HF,et al.Gender differences between WOMAC index scores,health-related quality of life and physical performance in an elderly Taiwanese population with knee osteoarthritis[J].BMJ Open,2015,5(9):e008542.
[23]杨文斌,陈光熙.社区中老年人骨关节炎认知调查及分析[J].按摩与康复医学,2013,4(9):204-205.
[24]Bhatti FU,Mehmood A,Latief N,et al.Vitamin E protects rat mesenchymal stem cells against hydrogen peroxide-induced oxidative stress in vitro and improves their therapeutic potential in surgically-induced ratmodel of osteoarthritis[J].Osteoarthritis Cartilage,2017,25(2):321-331.
[25]张美瑜.膝关节骨性关节炎性别差异的蛋白质组学研究[D].南宁:广西医科大学,2018.
[26]Valdes AM,Spector TD.The contribution of genes to osteoarthritis.Rheumatic diseases clinics of North America,2008,34(3):581-603.
[27]洪俊毅,张小春,许冠华.膝骨性关节炎发病主要危险因素Meta分析[J].浙江中西医结合杂志,2016,26(11):1042-1045.
[28]于波,彭伟秋,李福明.导致膝关节骨性关节炎的常见危险因素[J].系统医学,2018,3(7):194-198.
[29]Shah NJ,Geiger BC,Quadir MA,et al.Synthetic nanoscale electrostatic particles as growth factor carriers for cartilage repair[J].Bioeng Transl Med.2016,1(3):347-356
[30]孙红,田文,廖伟华,等.社区居民膝关节骨性关节炎流行病学调查分析[J].海南医学,2013,24(7):1064-1066.
[31]区广鹏,肖军,郑佐勇,等.老年膝关节骨性关节炎患病危险因素的调查[J].中国组织工程研究,2012,16(50):9463-9470.
[32]苏阳,朱志刚,蔡裕兴,等.广州地区中老年人症状性膝关节骨关节炎流行病学的调查研究[J].中华关节外科杂志(电子版),2010,4(4):2-6.
[2]Peffers MJ,Balaskas P,Smagul A.Osteoarthritis year in review 2017:genetics and epigenetics[J].Osteoarthritis Cartilage,2018,26(3):304-311.
[3]梁衍祥,罗立媛,刘海刚,等.膝骨性关节炎的治疗研究进展[J].中国医药指南,2014,12(5):80-81.
[4]王新军,沈明球,刘俊昌,等.膝关节骨性关节炎的病因研究现状[J].新疆中医药,2011,29(3):77-80.
[5]王开超.411例膝关节骨性关节炎患者的流行病学调查分析[D].济南:山东中医药大学,2015.
[6]陆佳,陶弘武.膝关节骨性关节炎的MRI特点与中医分型的关系[J].中华中医药学刊,2016,34(8):2038-2042.
[7]郭然.膝关节骨性关节炎中医证型与炎性因子的相关性研究[D].北京:北京中医药大学,2017.
[8]黄木全.膝关节骨性关节炎各期经筋辨证及相关证素研究[C].北京中医药大学,2012.
[9]陈庆真.膝骨性关节炎中医证候规范化的研究[D].广州:广州中医药大学,2008.
[10]何春红,谭妃英,谢小鸣,等.广州市越秀区126例老年人膝关节骨性关节炎患病危险因素:与121例老年组的病例-对照分析[J].中国组织工程研究与临床康复,2009,13(33):6581-6584.
[11]董天华.膝关节骨性关节炎的基础与临床研究[D].石家庄:河北医科大学,2016.
[12]Madry H,van Dijk CN,Mueller-Gerbl M.The basic science of the subchondral bone.Knee Surg Sports Traumatol Arthrosc,2010,18(4):419-433.
[13]Lories RJ,Luyten FP.The bone-cartilage unit in osteoarthritis.Nat Rev Rheumatol,2011,7(1):43-49.
[14]宋伟.膝关节骨性关节炎骨软骨结构病理学观察和形态计量学研究[D].重庆:第三军医大学,2012.
[15]秦迪,李石伦,郑占乐,等.膝关节骨关节炎病因与关节软骨磨损的相关性研究[J].河北医科大学学报,2016,37(2):227-229.
[16]洛佳.137例膝骨性关节炎的影响因素与中医证型相关性分析[D].沈阳:辽宁中医药大学,2016.
[17]Jorn W.-P.Michael,Klaus U Schvter-Brust,Peer Eysel.The Epidemiology,Etiology,Diagnosis,and Treatment of Osteoarthritis of the Knee.Continuing Medical Education,2010,107(9):152-162.
[18]廖德发.我国骨性关节炎流行病学调查现状[J].微创医学,2017,12(4):521-524.
[19]刘健民,陈新华.膝关节骨性关节炎的病因分析[J].人民军医,2008,51(7):410.
[20]Phinyomary A,Osis ST,Hettinga BA,ect.Gender differences in gait kinematics for patients with knee osteoarthritis.BMCmusculoskeletal disorders,2016,12(17):157.
[21]Linn S,Murtaugh B,Casey E,Role of sex hormones in the development of osteoarthritis.PM&R;The journal of injury,function,and rehabilitation,2012,4(5):169-173.
[22]Fang WH,Huang GS,Chang HF,et al.Gender differences between WOMAC index scores,health-related quality of life and physical performance in an elderly Taiwanese population with knee osteoarthritis[J].BMJ Open,2015,5(9):e008542.
[23]杨文斌,陈光熙.社区中老年人骨关节炎认知调查及分析[J].按摩与康复医学,2013,4(9):204-205.
[24]Bhatti FU,Mehmood A,Latief N,et al.Vitamin E protects rat mesenchymal stem cells against hydrogen peroxide-induced oxidative stress in vitro and improves their therapeutic potential in surgically-induced ratmodel of osteoarthritis[J].Osteoarthritis Cartilage,2017,25(2):321-331.
[25]张美瑜.膝关节骨性关节炎性别差异的蛋白质组学研究[D].南宁:广西医科大学,2018.
[26]Valdes AM,Spector TD.The contribution of genes to osteoarthritis.Rheumatic diseases clinics of North America,2008,34(3):581-603.
[27]洪俊毅,张小春,许冠华.膝骨性关节炎发病主要危险因素Meta分析[J].浙江中西医结合杂志,2016,26(11):1042-1045.
[28]于波,彭伟秋,李福明.导致膝关节骨性关节炎的常见危险因素[J].系统医学,2018,3(7):194-198.
[29]Shah NJ,Geiger BC,Quadir MA,et al.Synthetic nanoscale electrostatic particles as growth factor carriers for cartilage repair[J].Bioeng Transl Med.2016,1(3):347-356
[30]孙红,田文,廖伟华,等.社区居民膝关节骨性关节炎流行病学调查分析[J].海南医学,2013,24(7):1064-1066.
[31]区广鹏,肖军,郑佐勇,等.老年膝关节骨性关节炎患病危险因素的调查[J].中国组织工程研究,2012,16(50):9463-9470.
[32]苏阳,朱志刚,蔡裕兴,等.广州地区中老年人症状性膝关节骨关节炎流行病学的调查研究[J].中华关节外科杂志(电子版),2010,4(4):2-6.