脑肠轴与胃肠动力之间相关性的研究进展
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摘要
脑肠轴是中枢神经系统与胃肠道功能相互作用的双向调节轴,是联络中枢神经系统、肠神经系统、神经内分泌和免疫系统的双向作用通路,对胃肠动力的调节十分重要。有研究表明,在某些胃肠功能性疾病的发生发展过程中,脑肠轴的异常变化都与其密切相关,因此探索两者之间的相关性,这对于临床上胃肠道疾病的治疗和预防都具有一定的指导意义。目前,中医药对相关胃肠功能性疾病的防治发挥着重要作用,其对脑肠肽的调节机制也逐渐被证实,现就将有关脑肠轴理论与其对胃肠动力的指导作用作一综述。
There is a complex bidirectional adjusting shaft between the Brain and intestine, so it is called brain-gut axis. The brain-gut axis is the interactional two-way regulating shaft of the central nercous system and gastrointestinal function. It contacts not only the enteric nervous system and the central nervous system but also neuro, endocrine and immune system. As a result, it is very important for the regulation of gastrointestinal dunamics.Studies have shown that abnormal changes in the brain-gut axis are closely related to the development of certain types of gastrointestinal functional disorders. Therefore,the action of exploring the correlation has a certain guiding significance for the clinical treatment and prevention of clinical gastrointestinal diseases.Nowadays, the traditional Chinese medicine is playing an important role in regarding gastrointestinal disease, and it's regulatory mechanism of the brain gut peptide has been gradually confirmed. Now this article makes a brief summary of the gut axis theory and gastrointestinal motility.
There is a complex bidirectional adjusting shaft between the Brain and intestine, so it is called brain-gut axis. The brain-gut axis is the interactional two-way regulating shaft of the central nercous system and gastrointestinal function. It contacts not only the enteric nervous system and the central nervous system but also neuro, endocrine and immune system. As a result, it is very important for the regulation of gastrointestinal dunamics.Studies have shown that abnormal changes in the brain-gut axis are closely related to the development of certain types of gastrointestinal functional disorders. Therefore,the action of exploring the correlation has a certain guiding significance for the clinical treatment and prevention of clinical gastrointestinal diseases.Nowadays, the traditional Chinese medicine is playing an important role in regarding gastrointestinal disease, and it's regulatory mechanism of the brain gut peptide has been gradually confirmed. Now this article makes a brief summary of the gut axis theory and gastrointestinal motility.
引文
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[20]杜晓娟,汪龙德,刘俊宏,等.功能性消化不良与脑肠轴机制研究进展[J].辽宁中医药大学学报,2017,19(7):116-118.
[21]李娟,孙晓宁,刘保军,等.功能性消化不良患者血浆胃肠激素的变化[J].宁夏医学杂志,2001,39(1):11-12.
[22]刘松林,梅国强,赵映前,等.疏肝和胃汤对功能性消化不良大鼠血中血管活性肠肽和生长抑素的影响[J].湖北中医学院学报,2008,33(4):15-16.
[23]刘松林,梅国强,赵映前,等.疏肝和胃汤对功能性消化不良大鼠胃窦组织中VIP和SS的影响[J].中华中医药学刊,2009,43(6):1245-1246.
[24]覃佩兰,成泽东.基于脑肠轴学说探讨针灸对肠道菌群调节的思考[J].时珍国医国药,2015,26(11):2712-2714.
[25]燕李晨,张爱国.肠易激综合征与5-羟色胺相关性的研究进展[J].世界最新医学信息文摘,2017,17(92):27-28.
[26]周正华,马玲玲.肠易激综合征与神经-内分泌-免疫网络关系[J].中国中西医结合消化杂志,2013,21(2):106-109.
[27] Halder SL,Locke GR 3rd,Schleck CD,etal. Natural history of functional gastrointestinal disorders:a 12-year longitudinal population-based study[J]. Gastroenterology,2007,133(3):799-807.
[28]王朝晖,姜春萌,应力,等. 2型糖尿病胃动力障碍的临床研究[J].中国中西医结合消化杂志,2005,41(5):32-33.
[29]何健,赵永锋.糖尿病胃轻瘫30例胃动力检查分析[J].陕西医学杂志,2013,42(1):78-79.
[30]孙双喜,白小欣.从中医生理病理角度谈对脑肠轴的认识[J].陕西中医,2017,38(6):787-788.
[2] Talley NJ,Howell S,Poulton R.The irritable bowel syndrome andpsychiatric disorders in the community:is there a link[J].Am J Gastroenterol,2001,96(4):1072-1079.
[3]郭椿,贺平.脑肠轴及其研究进展[J].世界最新医学信息文摘,2017,17(95):89-91.
[4]祝捷,李宇航,王庆国,等.半夏泻心汤对功能性消化不良大鼠胃排空及血浆胃动素的影响[J].中华中医药杂志,2005,27(6):335-337.
[5]高清华,吕文亮,高真国,等.清热燥湿合剂对小鼠胃肠动力、大鼠胃肠激素影响的实验研究[J].湖北中医杂志,2008,3(10):5-7.
[6]李华锋,吕文亮,崔江禹.清热燥湿合剂对大鼠血浆胃动素、血清胃泌素水平的影响[J].山东中医杂志,2007,39(10):704-705.
[7]刘松林,梅国强,赵映前,等.疏肝和胃汤对功能性消化不良大鼠血胃动素和胃泌素的影响[J].中国中西医结合消化杂志,2004,29(4):198-200.
[8] Sam AH,Troke RC,Tan TM,et al.he role of the gut-brain axis in modulating food intake[J].Neuropharmacology,2012,63(1):46-56.
[9] Sanger GJ,Lee K. Hormones of the gut-brain axis as targets for the treatment of upper gastrointestinal disorders[J].Nat Rev Drug Discov,2008,7(3):241-254.
[10]潘彤彤,徐彰,黄开宇,等.功能性消化不良患儿血浆ghrelin变化及其与胃排空的关系[J].临床儿科杂志,2009,(10):935-937.
[11]寻庆英,杨德治,窦国祥,等.通腑汤对胃肠动力障碍大鼠小肠肌间神经丛中5-HT、SP和VIP含量的影响[J].东南大学学报(医学版),2002,42(3):221-223.
[12]蔡光先,卜献春.四磨汤治疗功能性消化不良肝脾不和证的疗效及对血浆P物质、胃动素的影响[J].中华中医药杂志,2010,35(6):856-859.
[13]李晓菲.食积因素对KM小鼠肺、肠组织中SP、VIP水平的影响及其机制的实验研究[C].中华中医药学会,北京中医药大学,2014:5.
[14] Sikander A,Rana SV,Prasad KK. Role of serotonin in gastrointestinal motility and irritable bowel syndrome[J].Clin Chim Acta,2009,403(1-2):47-55.
[15]刘松林,梅国强,赵映前,等.疏肝和胃汤对功能性消化不良大鼠胃窦iNOS、5-HT及SP表达的影响[J].湖北中医学院学报,2010,32(4):3-5.
[16]黄凯裕,梁爽,傅淑平,等.基于脑肠轴理论探讨胃肠调理在针灸治疗脑病中的应用[J].中医杂志,2016,57(13):1099-1104.
[17]张思超.脑肠相通病机研究[D].济南:山东中医药大学,2002.
[18] Tian J,Li M,Zhao J,et al. Research on the traditional Chinese medicine treating gastrointestinal motility in diabetic rats by improving biomechanical remodeling and neuroendocrine regulation. Am J Transl Res,2017,2017,9(5):2219-2230.
[19]汪龙德,毛兰芳,杜晓娟,等.功能性消化不良的相关研究进展[J].世界华人消化杂志,2017,25(1):84-90.
[20]杜晓娟,汪龙德,刘俊宏,等.功能性消化不良与脑肠轴机制研究进展[J].辽宁中医药大学学报,2017,19(7):116-118.
[21]李娟,孙晓宁,刘保军,等.功能性消化不良患者血浆胃肠激素的变化[J].宁夏医学杂志,2001,39(1):11-12.
[22]刘松林,梅国强,赵映前,等.疏肝和胃汤对功能性消化不良大鼠血中血管活性肠肽和生长抑素的影响[J].湖北中医学院学报,2008,33(4):15-16.
[23]刘松林,梅国强,赵映前,等.疏肝和胃汤对功能性消化不良大鼠胃窦组织中VIP和SS的影响[J].中华中医药学刊,2009,43(6):1245-1246.
[24]覃佩兰,成泽东.基于脑肠轴学说探讨针灸对肠道菌群调节的思考[J].时珍国医国药,2015,26(11):2712-2714.
[25]燕李晨,张爱国.肠易激综合征与5-羟色胺相关性的研究进展[J].世界最新医学信息文摘,2017,17(92):27-28.
[26]周正华,马玲玲.肠易激综合征与神经-内分泌-免疫网络关系[J].中国中西医结合消化杂志,2013,21(2):106-109.
[27] Halder SL,Locke GR 3rd,Schleck CD,etal. Natural history of functional gastrointestinal disorders:a 12-year longitudinal population-based study[J]. Gastroenterology,2007,133(3):799-807.
[28]王朝晖,姜春萌,应力,等. 2型糖尿病胃动力障碍的临床研究[J].中国中西医结合消化杂志,2005,41(5):32-33.
[29]何健,赵永锋.糖尿病胃轻瘫30例胃动力检查分析[J].陕西医学杂志,2013,42(1):78-79.
[30]孙双喜,白小欣.从中医生理病理角度谈对脑肠轴的认识[J].陕西中医,2017,38(6):787-788.