六味安神胶囊联合氟哌噻吨美利曲辛片治疗轻中度焦虑抑郁的临床研究
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摘要
目的探讨六味安神胶囊联合氟哌噻吨美利曲辛片治疗轻中度焦虑抑郁的临床效果及安全性。方法选择2015年1月～2017年12月重庆市精神卫生中心收治的105例轻中度焦虑抑郁症患者,按随机数字表法分为对照组(52例)和治疗组(53例)。对照组给予氟哌噻吨美利曲辛片治疗,治疗组在对照组治疗的基础上给予六味安神胶囊治疗,两组均连续给予治疗8个疗程。评价并比较两组临床疗效、两组治疗前后的焦虑自评量表(SAS)评分和抑郁自评量表(SDS)评分。检测并比较两组治疗前后血清髓过氧化物酶(MPO)、5-羟色胺(5-HT)、黄体生成素(LH)、卵泡刺激素(FSH)及雌激素(E_2)水平。记录并比较两组患者治疗过程中不良反应的发生情况。结果治疗组的总有效率高于对照组,差异有统计学意义(P <0.05)。两组治疗后焦虑自评量表(SAS)评分和抑郁自评量表(SDS)评分均明显低于治疗前,且治疗组SAS评分、SDS评分低于对照组,差异有统计学意义(P <0.05)。治疗后两组MPO、LH、FSH水平均明显低于治疗前,血清5-HT、E_2水平均明显高于治疗前,且治疗组血清MPO、LH、FSH水平明显低于对照组,5-HT、E_2水平明显高于对照组,差异有统计学意义(P <0.05)。两组治疗过程中均无严重的不良反应发生。结论六味安神胶囊联合氟哌噻吨美利曲辛片治疗轻中度焦虑抑郁的临床效果显著,能够明显减轻焦虑抑郁症状,改善血清MPO、5-HT和性激素水平,且安全性较好,值得在临床上推广应用。
Objective To explore the clinical efficacy and safety of Liuweianshen Capsules combined with Flupentixol and Melitracen Tablets in the treatment of mild and moderate anxiety depression. Methods From January 2015 to December 2017, in Chongqing Mental Health Center, 105 patients with mild and moderate anxiety depression were selected, according to the random indicator method, they were divided into control group(52 cases) and treatment group(53 cases). The control group was treated with Flupentixol and Melitracen Tablets, the treatment group was treated with Liuweianshen Capsules combined with Flupentixol and Melitracen Tablets, two groups were treated for 8 treatment periods. The clinical curative effect after treatment, the SAS scores, SDS scores and levels of serum MPO, 5-HT, LH, FSH,E2 in two groups before and after treatment were was detected and compared. The adverse reactions of the two groups during the treatment were compared. Results Total effective rate of treatment group was significantly higher than the control group, the difference was statistically significant(P < 0.05). After treatment, the SAS scores, SDS scores and levels of serum MPO, LH, FSH in the two groups were significantly lower than before treatment, the levels of serum 5-HT, E2 in the two groups were significantly higher than before treatment, and the SAS scores, SDS scores and levels of serum MPO, LH, FSH in the treatment group were significantly lower than the control group, the levels of serum 5-HT,E2 were significantly higher than the control group, the differences were statistically significant(P < 0.05). No serious adverse reactions occurred in the two groups during the treatment. Conclusion Liuweianshen Capsules combined with Flupentixol and Melitracen Tablets for the treatment of mild and moderate anxiety depression has good efficacy and low adverse reactions, it can reduce the anxiety depression symptoms, improve the serum MPO, 5-HT and sex hormone levels, and it is worthy clinical application.
Objective To explore the clinical efficacy and safety of Liuweianshen Capsules combined with Flupentixol and Melitracen Tablets in the treatment of mild and moderate anxiety depression. Methods From January 2015 to December 2017, in Chongqing Mental Health Center, 105 patients with mild and moderate anxiety depression were selected, according to the random indicator method, they were divided into control group(52 cases) and treatment group(53 cases). The control group was treated with Flupentixol and Melitracen Tablets, the treatment group was treated with Liuweianshen Capsules combined with Flupentixol and Melitracen Tablets, two groups were treated for 8 treatment periods. The clinical curative effect after treatment, the SAS scores, SDS scores and levels of serum MPO, 5-HT, LH, FSH,E2 in two groups before and after treatment were was detected and compared. The adverse reactions of the two groups during the treatment were compared. Results Total effective rate of treatment group was significantly higher than the control group, the difference was statistically significant(P < 0.05). After treatment, the SAS scores, SDS scores and levels of serum MPO, LH, FSH in the two groups were significantly lower than before treatment, the levels of serum 5-HT, E2 in the two groups were significantly higher than before treatment, and the SAS scores, SDS scores and levels of serum MPO, LH, FSH in the treatment group were significantly lower than the control group, the levels of serum 5-HT,E2 were significantly higher than the control group, the differences were statistically significant(P < 0.05). No serious adverse reactions occurred in the two groups during the treatment. Conclusion Liuweianshen Capsules combined with Flupentixol and Melitracen Tablets for the treatment of mild and moderate anxiety depression has good efficacy and low adverse reactions, it can reduce the anxiety depression symptoms, improve the serum MPO, 5-HT and sex hormone levels, and it is worthy clinical application.
引文
[1]何小婷,孙宁,杜巧荣,等.抑郁症伴焦虑症状的影响因素分析[J].中国神经精神疾病杂志,2016,42(4):206-210.
[2]易志强,罗银花,万凤福,等.黛力新对冠心病伴焦虑抑郁症的疗效及生活质量的影响[J].现代医药卫生,2014,30(22):3441-3443.
[3]刘锦龙,刘涛,欧雨.六味安神胶囊治疗失眠症60例[J].中国药业,2013,22(24):84-85.
[4]中华医学会精神科分会.中国精神障碍分类与诊断标准[M].3版.济南:山东科学技术出版社,2001:50-51.
[5]张明园.精神科评定量表手册[M].2版.长沙:湖南科学技术出版社,1998:121.
[6]戴晓阳.常用心理评估量表手册[M].北京:人民军医出版社,2011.
[7]世界卫生组织.ICD-10精神与行为障碍分类[M].范肖冬,汪向东,于欣,等,译.北京:人民卫生出版社,1993.
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[9]严钧.度洛西汀治疗焦虑抑郁症疗效及安全性探究[J].临床医药文献电子杂志,2017,4(44):8685.
[10]伍少莺,邱柳霞.氟哌噻吨美利曲辛治疗心血管疾病伴焦虑抑郁的临床效果[J].北方药学,2018,15(5):103-104.
[11]李宇晨.柴胡疏肝汤联合氟哌噻吨美利曲辛片治疗围绝经期抑郁症临床疗效研究[J].黑龙江医药,2017,30(6):1280-1283.
[12]王凯丽,闫西鹏,赵颖颖,等.中医治疗焦虑抑郁症简况[J].实用中医内科杂志,2016,30(9):113-116.
[13]李开凤.中西医结合治疗焦虑抑郁症疗效观察[J].深圳中西医结合杂志,2015,25(21):33-34.
[14]闫西鹏,赵颖颖,王凯丽,等.安神解郁汤联合黛力新治疗轻、中度焦虑抑郁症随机平行对照研究[J].实用中医内科杂志,2017,31(2):47-49.
[15]杨琴,杜青,赵洪庆,等.百合疏肝安神汤对焦虑性抑郁症模型大鼠前额叶-边缘结构及GR/BDNF/NPY表达的影响[J].中国临床药理学与治疗学,2017,22(10):1090-1098.
[16]赵微,陈关征.疏肝健脾解郁汤联合氟哌噻吨美利曲辛片治疗轻中度焦虑抑郁症60例[J].中医研究,2018,31(4):30-32.
[17]朱明洋,唐可清,季忠军,等.冠心病合并焦虑抑郁患者血清MPO和LXA水平的变化研究[J].临床和实验医学杂志,2015,14(10):824-826.
[18]赵文静,刘军委.舍曲林联合心理干预对老年冠心病患者介入治疗后焦虑抑郁症状的影响及与血清IL-18和髓过氧化物酶水平的相关性[J].中国老年学杂志,2017,37(11):2668-2670.
[19]许莉莉.5-HT1A受体及其与抑郁症相关性的研究进展[J].中国医药导报,2012,9(3):16-17,20.
[20]苑杰,贾娜娜,庞静娟,等.不孕不育患者抑郁焦虑情绪影响因素研究进展[J].中国医药导报,2016,13(15):48-51.
[2]易志强,罗银花,万凤福,等.黛力新对冠心病伴焦虑抑郁症的疗效及生活质量的影响[J].现代医药卫生,2014,30(22):3441-3443.
[3]刘锦龙,刘涛,欧雨.六味安神胶囊治疗失眠症60例[J].中国药业,2013,22(24):84-85.
[4]中华医学会精神科分会.中国精神障碍分类与诊断标准[M].3版.济南:山东科学技术出版社,2001:50-51.
[5]张明园.精神科评定量表手册[M].2版.长沙:湖南科学技术出版社,1998:121.
[6]戴晓阳.常用心理评估量表手册[M].北京:人民军医出版社,2011.
[7]世界卫生组织.ICD-10精神与行为障碍分类[M].范肖冬,汪向东,于欣,等,译.北京:人民卫生出版社,1993.
[8]程新强.焦虑抑郁症患者的健康教育和心理疏导护理的疗效评价[J].中国继续医学教育,2015,7(15):231-232.
[9]严钧.度洛西汀治疗焦虑抑郁症疗效及安全性探究[J].临床医药文献电子杂志,2017,4(44):8685.
[10]伍少莺,邱柳霞.氟哌噻吨美利曲辛治疗心血管疾病伴焦虑抑郁的临床效果[J].北方药学,2018,15(5):103-104.
[11]李宇晨.柴胡疏肝汤联合氟哌噻吨美利曲辛片治疗围绝经期抑郁症临床疗效研究[J].黑龙江医药,2017,30(6):1280-1283.
[12]王凯丽,闫西鹏,赵颖颖,等.中医治疗焦虑抑郁症简况[J].实用中医内科杂志,2016,30(9):113-116.
[13]李开凤.中西医结合治疗焦虑抑郁症疗效观察[J].深圳中西医结合杂志,2015,25(21):33-34.
[14]闫西鹏,赵颖颖,王凯丽,等.安神解郁汤联合黛力新治疗轻、中度焦虑抑郁症随机平行对照研究[J].实用中医内科杂志,2017,31(2):47-49.
[15]杨琴,杜青,赵洪庆,等.百合疏肝安神汤对焦虑性抑郁症模型大鼠前额叶-边缘结构及GR/BDNF/NPY表达的影响[J].中国临床药理学与治疗学,2017,22(10):1090-1098.
[16]赵微,陈关征.疏肝健脾解郁汤联合氟哌噻吨美利曲辛片治疗轻中度焦虑抑郁症60例[J].中医研究,2018,31(4):30-32.
[17]朱明洋,唐可清,季忠军,等.冠心病合并焦虑抑郁患者血清MPO和LXA水平的变化研究[J].临床和实验医学杂志,2015,14(10):824-826.
[18]赵文静,刘军委.舍曲林联合心理干预对老年冠心病患者介入治疗后焦虑抑郁症状的影响及与血清IL-18和髓过氧化物酶水平的相关性[J].中国老年学杂志,2017,37(11):2668-2670.
[19]许莉莉.5-HT1A受体及其与抑郁症相关性的研究进展[J].中国医药导报,2012,9(3):16-17,20.
[20]苑杰,贾娜娜,庞静娟,等.不孕不育患者抑郁焦虑情绪影响因素研究进展[J].中国医药导报,2016,13(15):48-51.