房颤心房重构与MicroRNA关系的最新研究进展
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摘要
心房颤动(atrial fibrillation,AF)是临床最常见的心律失常之一,其发病机制尚不完全清楚。心房重构包括电重构、结构重构和自主神经重构,在AF的发生、发展中起着关键作用。近年来研究发现,微小RNA(MicroRNA,miRNA)参与基因转录后水平的调控,与心房重构和AF的发生、发展密切相关。研究发现,miRNA在房颤心房重构中起重要作用,本文就AF心房重构与miRNA关系做一综述。
Atrial fibrillation( AF) is one of the commonly encountered clinical arrhythmia and the pathogenesis has not yet entirely clear.Atrial remodeling includes electrical remodeling,structural remodeling and autonomic nerve remodeling. It plays a key role in the occurrence and development of AF. In recent years,researches have found that microRNA( miRNA) had rapidly emerged as one of the key players in the gene expression regulatory. Studies have found that miRNA plays an important role in atrial remodeling of AF. This article focuses on recent progress in correlation between atrial remodeling of AF and miRNA.
Atrial fibrillation( AF) is one of the commonly encountered clinical arrhythmia and the pathogenesis has not yet entirely clear.Atrial remodeling includes electrical remodeling,structural remodeling and autonomic nerve remodeling. It plays a key role in the occurrence and development of AF. In recent years,researches have found that microRNA( miRNA) had rapidly emerged as one of the key players in the gene expression regulatory. Studies have found that miRNA plays an important role in atrial remodeling of AF. This article focuses on recent progress in correlation between atrial remodeling of AF and miRNA.
引文
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[11] Soeki T,Matsuura T,Bando S,et al. Relationship between local production of microRNA-328 and atrial substrate remodeling in atrial fibrillation[J].J Cardiol,2016,68(6):472-477.
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[14] Zhao Y,Yuan Y,Qiu C.Underexpression of CACNA1C Caused by Overexpression of microRNA-29a Underlies the Pathogenesis of Atrial Fibrillation[J].Med Sci Monit,2016,22:2175-2181.
[15] Barana A,Matamoros M,Dolz-Gaitón P,et al. Chronic atrial fibrillation increases microRNA-21 in human atrial myocytes decreasing L-type calcium current[J]. Circ Arrhythm Electrophysiol,2014,7(5):861-868.
[16] Zhu Y,Feng Z,Cheng W,et al. MicroRNA 34a mediates atrial fibrillation through regulation of Ankyrin B expression[J]. Mol Med Rep,2018,17(6):8457-8465.
[17] Chiang DY,Kongchan N,Beavers DL,et al. Loss of microRNA-106b-25 cluster promotes atrial fibrillation by enhancing ryanodine receptor type-2 expression and calcium release[J].Circ Arrhythm Electrophysiol,2014,7(6):1214-1222.
[18] Shan H,Zhang Y,Lu Y,et al. Downregulation of miR-133 and miR-590 contributes to nicotine-induced atrial remodelling in canines[J].Cardiovasc Res,2009,83(3):465-472.
[19] van Rooij E,Sutherland LB,Thatcher JE,et al. Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis[J]. Proc Natl Acad Sci USA,2008,105(35):13027-13032.
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[22] Li S,Jiang Z,Wen L,et al. MicroRNA-208a-3p contributes to connexin40 remolding in human chronic atrial fibrillation[J].Exp Ther Med,2017,14(6):5355-5362.
[23] Zhang K,Zhao L,Ma Z,et al. Doxycycline Attenuates Atrial Remodeling by Interfering with MicroRNA-21 and Downstream Phosphatase and Tensin Homolog(PTEN)/Phosphoinositide 3-Kinase(PI3K)Signaling Pathway[J]. Med Sci Monit,2018,24:5580-5587.
[24] Tao H,Zhang M,Yang JJ,et al.MicroRNA-21 via Dysregulation of WW Domain-Containing Protein 1 Regulate Atrial Fibrosis in Atrial Fibrillation[J].Heart Lung Circ,2018,27(1):104-113.
[25] Cao W,Shi P,Ge JJ.miR-21 enhances cardiac fibrotic remodeling and fibroblast proliferation via CADM1/STAT3 pathway[J]. BMC Cardiovasc Disord,2017,17(1):88.
[26] Zou T,Zhu M,Ma YC,et al.MicroRNA-410-5p exacerbates high-fat diet-induced cardiac remodeling in mice in an endocrine fashion[J].Sci Rep,2018,8(1):8780.
[27] Zhang Y,Zheng S,Geng Y,et al. MicroRNA profiling of atrial fibrillation in canines:miR-206 modulates intrinsic cardiac autonomic nerve remodeling by regulating SOD1[J]. PLoS One,2015,10(3):e0122674.
[28] Chen Y,Wakili R,Xiao J,et al. Detailed characterization of microRNA changes in a canine heart failure model:Relationship to arrhythmogenic structural remodeling[J]. J Mol Cell Cardiol,2014,77:113-124.
[29] Bernardo BC,Ooi JY,Matsumoto A,et al. Sex differences in response to miRNA-34a therapy in mouse models of cardiac disease:identification of sex-,disease-and treatment-regulated miRNAs[J].J Physiol,2016,594(20):5959-5974.
[2] Hawkins PG,Morris KV. RNA and transcriptional modulation of gene expression[J].Cell Cycle,2008,7(5):602-607.
[3] Pas quinelli AE. MicroRNAs and their targets:recognition,regulation and an emerging reciprocal relationship[J]. Nat Rev Genet,2012,13(4):271-282.
[4] Cheng HL,Fu CY,Kuo WC,et al. Detecting miRNA biomarkers from extracellular vesicles for cardiovascular disease with a microfluidic system[J].Lab Chip,2018,18(19):2917-2925.
[5] Zhuang YS,Liao YY,Liu BY,et al.MicroRNA-27a mediates the Wnt/β-catenin pathway to affect the myocardial fibrosis in rats with chronic heart failure[J].Cardiovasc Ther,2018:e12468.
[6] Wang CC,Shang BB,Yang CW,Liu YF,Li XD,Wang SY.MicroRNA-325 alleviates myocardial fibrosis after myocardial infarction via downregulating GLI1[J]. Eur Rev Med Pharmacol Sci.2018.22(16):5339-5346.
[7] Schmitz B,Brand SM. Commentary:MicroRNA-221/222 Family Counteracts Myocardial Fibrosis in Pressure Overload-Induced Heart Failure[J].Front Cardiovasc Med,2018,5:95.
[8] Xia YW,Wang SB.Microvesicles containing microRNA-21 induce myocardial fibrosis via AKT pathway[J].Eur Rev Med Pharmacol Sci,2018,22(14):4634-4641.
[9] Xue YM,Chen MG,Chen DW,et al.The effect of microRNA-21on myocardial fibrosis in mice with chronic viral myocarditis[J].Zhonghua Xin Xue Guan Bing Za Zhi,2018,46(6):450-457.
[10] Lu Y,Zhang Y,Wang N,et al. MicroRNA-328 contributes to adverse electrical remodeling in atrial fibrillation[J]. Circulation,2010,122(23):2378-2387.
[11] Soeki T,Matsuura T,Bando S,et al. Relationship between local production of microRNA-328 and atrial substrate remodeling in atrial fibrillation[J].J Cardiol,2016,68(6):472-477.
[12] Girmatsion Z,Biliczki P,Bonauer A,et al.Changes in microRNA-1 expression and IK1 up-regulation in human atrial fibrillation[J].Heart Rhythm,2009,6(12):1802-1809.
[13] Luo X,Pan Z,Shan H,et al.MicroRNA-26 governs profibrillatory inward-rectifier potassium current changes in atrial fibrillation[J].J Clin Invest,2013,123(5):1939-1951.
[14] Zhao Y,Yuan Y,Qiu C.Underexpression of CACNA1C Caused by Overexpression of microRNA-29a Underlies the Pathogenesis of Atrial Fibrillation[J].Med Sci Monit,2016,22:2175-2181.
[15] Barana A,Matamoros M,Dolz-Gaitón P,et al. Chronic atrial fibrillation increases microRNA-21 in human atrial myocytes decreasing L-type calcium current[J]. Circ Arrhythm Electrophysiol,2014,7(5):861-868.
[16] Zhu Y,Feng Z,Cheng W,et al. MicroRNA 34a mediates atrial fibrillation through regulation of Ankyrin B expression[J]. Mol Med Rep,2018,17(6):8457-8465.
[17] Chiang DY,Kongchan N,Beavers DL,et al. Loss of microRNA-106b-25 cluster promotes atrial fibrillation by enhancing ryanodine receptor type-2 expression and calcium release[J].Circ Arrhythm Electrophysiol,2014,7(6):1214-1222.
[18] Shan H,Zhang Y,Lu Y,et al. Downregulation of miR-133 and miR-590 contributes to nicotine-induced atrial remodelling in canines[J].Cardiovasc Res,2009,83(3):465-472.
[19] van Rooij E,Sutherland LB,Thatcher JE,et al. Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis[J]. Proc Natl Acad Sci USA,2008,105(35):13027-13032.
[20] Duisters RF,Tijsen AJ,Schroen B,et al.miR-133 and miR-30regulate connective tissue growth factor:implications for a role of microRNAs in myocardial matrix remodeling[J]. Circ Res. 2009.104(2):170-178.
[21] van Rooij E,Sutherland LB,Qi X,et al. Control of stressdependent cardiac growth and gene expression by a microRNA[J].Science,2007,316(5824):575-579.
[22] Li S,Jiang Z,Wen L,et al. MicroRNA-208a-3p contributes to connexin40 remolding in human chronic atrial fibrillation[J].Exp Ther Med,2017,14(6):5355-5362.
[23] Zhang K,Zhao L,Ma Z,et al. Doxycycline Attenuates Atrial Remodeling by Interfering with MicroRNA-21 and Downstream Phosphatase and Tensin Homolog(PTEN)/Phosphoinositide 3-Kinase(PI3K)Signaling Pathway[J]. Med Sci Monit,2018,24:5580-5587.
[24] Tao H,Zhang M,Yang JJ,et al.MicroRNA-21 via Dysregulation of WW Domain-Containing Protein 1 Regulate Atrial Fibrosis in Atrial Fibrillation[J].Heart Lung Circ,2018,27(1):104-113.
[25] Cao W,Shi P,Ge JJ.miR-21 enhances cardiac fibrotic remodeling and fibroblast proliferation via CADM1/STAT3 pathway[J]. BMC Cardiovasc Disord,2017,17(1):88.
[26] Zou T,Zhu M,Ma YC,et al.MicroRNA-410-5p exacerbates high-fat diet-induced cardiac remodeling in mice in an endocrine fashion[J].Sci Rep,2018,8(1):8780.
[27] Zhang Y,Zheng S,Geng Y,et al. MicroRNA profiling of atrial fibrillation in canines:miR-206 modulates intrinsic cardiac autonomic nerve remodeling by regulating SOD1[J]. PLoS One,2015,10(3):e0122674.
[28] Chen Y,Wakili R,Xiao J,et al. Detailed characterization of microRNA changes in a canine heart failure model:Relationship to arrhythmogenic structural remodeling[J]. J Mol Cell Cardiol,2014,77:113-124.
[29] Bernardo BC,Ooi JY,Matsumoto A,et al. Sex differences in response to miRNA-34a therapy in mouse models of cardiac disease:identification of sex-,disease-and treatment-regulated miRNAs[J].J Physiol,2016,594(20):5959-5974.