非小细胞肺癌不同调强放疗方案的剂量学效果
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摘要
目的研究非小细胞肺癌患者实施不同调强放疗的剂量学对比效果。方法选择2016年2月—2019年2月我院放疗的非小细胞肺癌患者80例作为研究对象。采用随机数字表法,将其分为试验组与参照组,每组均40例。其中,参照组采用静态调强放疗,试验组行容积旋转调强放疗,对比两组患者患侧肺、健侧肺相关参数计量学。结果两组患者患侧肺V3比较,差异无统计学意义(P> 0.05);与参照组相比,试验组患侧肺V10、V13、V15、V20、V25、V30、Dmean/Gy较低,组间比较,差异具有统计学意义(P <0.05)。两组患者健侧肺V13、V15、V20、V25、V30、Dmean/Gy比较,差异无统计学意义(P> 0.05);与参照组相较,试验组健侧肺V3、V10较低,差异具有统计学意义(P<0.05)。结论非小细胞肺癌患者采用容积旋转调强放疗能够降低患者双侧肺放疗剂量。
Objective To study the dosimetric comparison of different intensity-modulated radiotherapy for patients with non-small cell lung cancer. Methods 80 patients with NSCLC who received radiotherapy in our hospital from February 2016 to February 2019 were selected and divided into the experimental group and the reference group by random number table method, with 40 cases in each group. Among them, the reference group received static intensity-modulated radiotherapy, while the experimental group received volumetric rotational intensity-modulated radiotherapy, and the two groups were compared in terms of the relevant parameters of the affected and uninjured lung. Results There was no difference in V3 of the affected lung between the two groups(P>0.05). Compared with the control group, V10, V13, V15, V20, V25, V30, and Dmean/Gy of the affected lung were lower in the experimental group(P<0.05). There was no difference in V13, V15, V20, V25, V30 and Dmean/Gy between the two groups(P>0.05). Compared with the control group, the experimental group had lower V3 and V10 in the healthy side lung, indicating a significant difference(P<0.05). Conclusion In patients with non-small cell lung cancer, the use of volumetric rotation intensity modulated radiotherapy can reduce the dose of bilateral pulmonary radiotherapy.
Objective To study the dosimetric comparison of different intensity-modulated radiotherapy for patients with non-small cell lung cancer. Methods 80 patients with NSCLC who received radiotherapy in our hospital from February 2016 to February 2019 were selected and divided into the experimental group and the reference group by random number table method, with 40 cases in each group. Among them, the reference group received static intensity-modulated radiotherapy, while the experimental group received volumetric rotational intensity-modulated radiotherapy, and the two groups were compared in terms of the relevant parameters of the affected and uninjured lung. Results There was no difference in V3 of the affected lung between the two groups(P>0.05). Compared with the control group, V10, V13, V15, V20, V25, V30, and Dmean/Gy of the affected lung were lower in the experimental group(P<0.05). There was no difference in V13, V15, V20, V25, V30 and Dmean/Gy between the two groups(P>0.05). Compared with the control group, the experimental group had lower V3 and V10 in the healthy side lung, indicating a significant difference(P<0.05). Conclusion In patients with non-small cell lung cancer, the use of volumetric rotation intensity modulated radiotherapy can reduce the dose of bilateral pulmonary radiotherapy.
引文
[1]李俊青,林武华,樊婷.替吉奥同步调强放疗治疗老年Ⅲ期非小细胞肺癌的临床观察[J].中国老年保健医学,2018,12(6):52-53,56.
[2]雷新军,涂建飞,王慧梅,等.多模态CT检查联合肿瘤标志物评估塞来昔布联合调强放疗对晚期非小细胞肺癌的疗效[J].中国慢性病预防与控制,2018,26(12):936-938.
[3]戴美云,郭妹,董阳,等.同步推量调强放疗联合多西他赛化疗对晚期非小细胞肺癌有效性和安全性研究[J].交通医学,2018,32(6):589-591,594.
[4]孔祥虎,焦建峰.图像引导调强适形大分割放疗治疗老年性非小细胞肺癌的临床研究[J].内蒙古医学杂志,2018,50(8):900-903.
[5]陈泽慧,张跃强.调强放疗同步联合化疗治疗晚期非小细胞肺癌的疗效及安全性评价[J].国际医药卫生导报,2018,24(19):2988-2991.
[6]孙宇,尹群,孙祝,等.静态调强放疗与三维适形放疗对局部晚期非小细胞肺癌的临床疗效比较[J].安徽医学,2018,39(8):918-922.
[7]罗俊波,郑瑞锋,王彦威,等.调强放疗和三维适形放疗在局部晚期非小细胞肺癌患者中应用价值比较[J].肿瘤基础与临床,2018,31(4):316-318.
[8]蒋宗惠,董祥宁,薛松,等.调强适形放疗技术在非小细胞肺癌寡转移胸部原发灶区域的临床研究[J].中国辐射卫生,2018,27(4):354-356.
[9]牟安娜.非小细胞肺癌患者IMRT放疗后血清TGF-β1的变化及与T淋巴细胞亚群的关系研究[J].临床肺科杂志,2019,24(1):99-102.
[10]沈纲,李卓华,蒋娅莉.非小细胞肺癌中两种不同放疗技术的剂量学及临床疗效对比[J].肿瘤学杂志,2018,24(7):743-746.
[11]杨雯娟,曾彪,邱艳芳,等.局部晚期非小细胞肺癌同期整合推量调强放射治疗对正常组织影响的剂量学研究[J].中国医学装备,2017,14(7):63-68.
[12]宋明永,戴相昆,杜乐辉,等.3种调强放疗方式治疗非小细胞肺癌的剂量学比较[J].中国医学物理学杂志,2017,34(2):19-23,44.
[13]薛英波,冯志宇,邱冬,等.不同肺叶非小细胞肺癌三维适形放疗与调强放疗计划剂量学比较研究[J].肿瘤基础与临床,2017,30(2):149-152.
[14]解佳奇,蒋俊,任伟,等.非小细胞肺癌调强放疗与螺旋断层放疗剂量学的比较研究[J].实用癌症杂志,2017,32(3):479-483.
[15]蔡俊涛,陈凡,王财,等.非小细胞肺癌容积旋转调强与适形调强放疗的剂量学比较[J].中国医学物理学杂志,2018,35(4):389-393.
[2]雷新军,涂建飞,王慧梅,等.多模态CT检查联合肿瘤标志物评估塞来昔布联合调强放疗对晚期非小细胞肺癌的疗效[J].中国慢性病预防与控制,2018,26(12):936-938.
[3]戴美云,郭妹,董阳,等.同步推量调强放疗联合多西他赛化疗对晚期非小细胞肺癌有效性和安全性研究[J].交通医学,2018,32(6):589-591,594.
[4]孔祥虎,焦建峰.图像引导调强适形大分割放疗治疗老年性非小细胞肺癌的临床研究[J].内蒙古医学杂志,2018,50(8):900-903.
[5]陈泽慧,张跃强.调强放疗同步联合化疗治疗晚期非小细胞肺癌的疗效及安全性评价[J].国际医药卫生导报,2018,24(19):2988-2991.
[6]孙宇,尹群,孙祝,等.静态调强放疗与三维适形放疗对局部晚期非小细胞肺癌的临床疗效比较[J].安徽医学,2018,39(8):918-922.
[7]罗俊波,郑瑞锋,王彦威,等.调强放疗和三维适形放疗在局部晚期非小细胞肺癌患者中应用价值比较[J].肿瘤基础与临床,2018,31(4):316-318.
[8]蒋宗惠,董祥宁,薛松,等.调强适形放疗技术在非小细胞肺癌寡转移胸部原发灶区域的临床研究[J].中国辐射卫生,2018,27(4):354-356.
[9]牟安娜.非小细胞肺癌患者IMRT放疗后血清TGF-β1的变化及与T淋巴细胞亚群的关系研究[J].临床肺科杂志,2019,24(1):99-102.
[10]沈纲,李卓华,蒋娅莉.非小细胞肺癌中两种不同放疗技术的剂量学及临床疗效对比[J].肿瘤学杂志,2018,24(7):743-746.
[11]杨雯娟,曾彪,邱艳芳,等.局部晚期非小细胞肺癌同期整合推量调强放射治疗对正常组织影响的剂量学研究[J].中国医学装备,2017,14(7):63-68.
[12]宋明永,戴相昆,杜乐辉,等.3种调强放疗方式治疗非小细胞肺癌的剂量学比较[J].中国医学物理学杂志,2017,34(2):19-23,44.
[13]薛英波,冯志宇,邱冬,等.不同肺叶非小细胞肺癌三维适形放疗与调强放疗计划剂量学比较研究[J].肿瘤基础与临床,2017,30(2):149-152.
[14]解佳奇,蒋俊,任伟,等.非小细胞肺癌调强放疗与螺旋断层放疗剂量学的比较研究[J].实用癌症杂志,2017,32(3):479-483.
[15]蔡俊涛,陈凡,王财,等.非小细胞肺癌容积旋转调强与适形调强放疗的剂量学比较[J].中国医学物理学杂志,2018,35(4):389-393.