依达拉奉联合尤瑞克林治疗对急性脑梗塞患者血液流变学与血管内皮细胞功能的影响
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摘要
目的:分析依达拉奉、尤瑞克林联合治疗对急性脑梗塞患者血液流变学与血管内皮细胞功能的影响。方法:选取2015年1月—2017年12月我院收治的急性脑梗死患者90例为研究对象,按照随机数字表法分为对照组与观察组,各45例。对照组采用依达拉奉(30 mg加入250 mL 0.9%氯化钠注射液中稀释后静脉滴注,bid)治疗,观察组在对照组基础上加用尤瑞克林(0.15 PNA单位溶于50 mL0.9%氯化钠注射液中,ivgtt,qd)治疗,比较两组血液流变学指标与血管内皮细胞功能情况。结果:治疗后两组血液流变学指标均低于治疗前,且观察组低于对照组,差异有统计学意义(P <0.05);治疗后观察组血管内皮生长因子(VEGF)、一氧化氮(NO)显著高于对照组,差异有统计学意义(P <0.05)。结论:依达拉奉联合尤瑞克林治疗急性脑梗塞可有效清除患者体内自由基,改善血液流变学指标及血管内皮功能,是个优良的治疗方案。
Objective: To analyze the effect of edaravone and urinary kallidinogenase combined therapy on hemorheology and vascular endothelial cell functions in patients with acute cerebral infarction. Methods: 90 patients with acute cerebral infarction admitted to our hospital from January 2015 to December 2017 were selected as subjects investigated and divided into a control group and an observation group according to the random number table method, 45 cases each. The patients in the control group were treated with edaravone(30 mg drug was diluted in 250 mL 0.9% sodium chloride injection, intravenous drip, bid), and the patients in the observation group were further treated with urinary kallidinogenase(0.15 PNA units were dissolved in 50 mL 0.9% sodium chloride injection, ivgtt, qd) on the basis of the control group. The hemorheological indexes and vascular endothelial cell functions were compared between the two groups. Results: The levels of hemorheological indexes in the two groups after treatment were lower than those before treatment, and the levels in the observation group were lower than those in the control group, with statistically significant differences(P<0.05). The levels of vascular endothelial growth factor(VEGF) and nitric oxide(NO) after treatment in the observation group were significantly higher than those in the control group, and the differences were statistically significant(P<0.05). Conclusion: Edaravone combined with urinary kallidinogenase for the treatment of acute cerebral infarction can effectively eliminate free radicals in patients, improve hemorheological indexes and vascular endothelial functions, which is an excellent treatment regimen.
Objective: To analyze the effect of edaravone and urinary kallidinogenase combined therapy on hemorheology and vascular endothelial cell functions in patients with acute cerebral infarction. Methods: 90 patients with acute cerebral infarction admitted to our hospital from January 2015 to December 2017 were selected as subjects investigated and divided into a control group and an observation group according to the random number table method, 45 cases each. The patients in the control group were treated with edaravone(30 mg drug was diluted in 250 mL 0.9% sodium chloride injection, intravenous drip, bid), and the patients in the observation group were further treated with urinary kallidinogenase(0.15 PNA units were dissolved in 50 mL 0.9% sodium chloride injection, ivgtt, qd) on the basis of the control group. The hemorheological indexes and vascular endothelial cell functions were compared between the two groups. Results: The levels of hemorheological indexes in the two groups after treatment were lower than those before treatment, and the levels in the observation group were lower than those in the control group, with statistically significant differences(P<0.05). The levels of vascular endothelial growth factor(VEGF) and nitric oxide(NO) after treatment in the observation group were significantly higher than those in the control group, and the differences were statistically significant(P<0.05). Conclusion: Edaravone combined with urinary kallidinogenase for the treatment of acute cerebral infarction can effectively eliminate free radicals in patients, improve hemorheological indexes and vascular endothelial functions, which is an excellent treatment regimen.
引文
[1]王世奇,蒋亚斌.尤瑞克林联合依达拉奉对急性脑梗死患者脑血管储备能力的改良与神经功能保护作用分析[J].山西医药杂志,2017,46(22):2707-2710.
[2]仇晨峰,冯学问,吴伟林,等.尤瑞克林和依达拉奉对急性脑梗死患者的疗效及作用机制探讨[J].中华全科医学,2016,14(8):1319-1321.
[3]李玉鹏,刘斌,邢成文.尤瑞克林联合依达拉奉治疗对急性脑梗死患者脑血流动力学的影响及其安全性[J].中国医药,2017,12(9):1348-1351.
[4]杜春艳,王庆广.尤瑞克林联合依达拉奉对急性脑梗死患者作用机制的研究[J].海南医学院学报,2017,23(3):429-432.
[5]刘畅,寇雨霏,罗德欣.尤瑞克林对急性脑梗死患者血小板的影响及临床效果[J].华南国防医学杂志,2015,29(1):26-28.
[6]王彦君.依达拉奉和尤瑞克林联合治疗53例急性脑梗死的疗效及其对血液流变学和血管内皮细胞功能的影响[J].中国医药科学,2015,5(17):101-103.
[7]刘向红,钟振洲,肖小六.尤瑞克林联合依达拉奉治疗急性脑梗塞的临床观察[J].医学信息(中旬刊),2010,5(5):1244-1245.
[8]寇幸福.依达拉奉与尤瑞克林联合治疗急性脑梗死疗效观察[J].中国实用神经疾病杂志, 2012,15(8):42-43.
[2]仇晨峰,冯学问,吴伟林,等.尤瑞克林和依达拉奉对急性脑梗死患者的疗效及作用机制探讨[J].中华全科医学,2016,14(8):1319-1321.
[3]李玉鹏,刘斌,邢成文.尤瑞克林联合依达拉奉治疗对急性脑梗死患者脑血流动力学的影响及其安全性[J].中国医药,2017,12(9):1348-1351.
[4]杜春艳,王庆广.尤瑞克林联合依达拉奉对急性脑梗死患者作用机制的研究[J].海南医学院学报,2017,23(3):429-432.
[5]刘畅,寇雨霏,罗德欣.尤瑞克林对急性脑梗死患者血小板的影响及临床效果[J].华南国防医学杂志,2015,29(1):26-28.
[6]王彦君.依达拉奉和尤瑞克林联合治疗53例急性脑梗死的疗效及其对血液流变学和血管内皮细胞功能的影响[J].中国医药科学,2015,5(17):101-103.
[7]刘向红,钟振洲,肖小六.尤瑞克林联合依达拉奉治疗急性脑梗塞的临床观察[J].医学信息(中旬刊),2010,5(5):1244-1245.
[8]寇幸福.依达拉奉与尤瑞克林联合治疗急性脑梗死疗效观察[J].中国实用神经疾病杂志, 2012,15(8):42-43.