MiRNA调控EMT影响肝癌侵袭转移的研究进展
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摘要
肝细胞肝癌(hepatocellular carcinoma,HCC)在原发性肝癌中占比超过90%,由于其较高的复发和转移,HCC患者的总生存率较低。在过去几十年中,众多研究发现,许多微小RNA(miRNA)与肝癌密切相关。此外,miRNA通过抑制或促进HCC中的各种下游靶基因而发挥其功能性作用。上皮-间质转化(Epithelial-mesenchymal transition,EMT)已被认为是人类肿瘤侵袭转移的关键因素。miRNA可通过调节不同信号通路和转录因子影响HCC中的EMT。本综述总结了近年来miRNA通过EMT在HCC中的最新研究进展
Hepatocellular carcinoma(HCC) more than 90% of primary liver cancer,the patient with HCC have low overall survival rate beacause of high recurrence and metastasis. over the past decades, most study find that most microRNAs(miRNA) have been closely correlated with the development of HCC.Furthermore,miRNA exhibits its functional role by inhibiting or promoting various downstream target genes in HCC. Epithelial-mesenchymal transition(EMT) has been regarded as a crucial factor for the development of metastasis of human tumors.Dysregulation microRNA could influence EMT in HCC via modulating diferent pathways and transcription factors. This review summarizes the latest researches development of miRNA in HCC via EMT in recent years.
Hepatocellular carcinoma(HCC) more than 90% of primary liver cancer,the patient with HCC have low overall survival rate beacause of high recurrence and metastasis. over the past decades, most study find that most microRNAs(miRNA) have been closely correlated with the development of HCC.Furthermore,miRNA exhibits its functional role by inhibiting or promoting various downstream target genes in HCC. Epithelial-mesenchymal transition(EMT) has been regarded as a crucial factor for the development of metastasis of human tumors.Dysregulation microRNA could influence EMT in HCC via modulating diferent pathways and transcription factors. This review summarizes the latest researches development of miRNA in HCC via EMT in recent years.
引文
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[22]Sun,X.,S.Zhao,H.Li,et al.MicroRNA-30b Suppresses EpithelialMesenchymal Transition and Metastasis of Hepatoma Cells[J].J Cell Physiol,2017,232(3):625-634.
[23]Wei,E.K.,E.Giovannucci,C.S.Fuchs,et al.Low plasma adiponectin levels and risk of colorectal cancer in men:a prospective study[J].J Natl Cancer Inst,2005,97(22):1688-94.
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[25]Oba,S.,T.Mizutani,E.Suzuki,et al.A useful method of identifying of miRNAs which can down-regulate Zeb-2[J].BMC Res Notes,2013,6:470.
[26]He,C.,Z.Liu,L.Jin,et al.lncRNA TUG1-Mediated Mir-142-3p Downregulation Contributes to Metastasis and the Epithelial-to-Mesenchymal Transition of Hepatocellular Carcinoma by Targeting ZEB1[J].Cell Physiol Biochem,2018,48(5):1928-1941.
[27]Meng,X.M.,D.J.Nikolic-Paterson,and H.Y.Lan,TGF-beta:the master regulator of fibrosis[J].Nat Rev Nephrol,2016,12(6):325-38.
[28]Li,S.P.,H.X.Xu,Y.Yu,et al.LncRNA HULC enhances epithelialmesenchymal transition to promote tumorigenesis and metastasis of hepatocellular carcinoma via the miR-200a-3p/ZEB1 signaling pathway[J].Oncotarget,2016,7(27):42431-42446.
[29]Fan,F.,S.Samuel,K.W.Evans,et al.Overexpression of snail induces epithelial-mesenchymal transition and a cancer stem cell-like phenotype in human colorectal cancer cells[J].Cancer Med,2012,1(1):5-16.
[30]Jin,Y.,J.Wang,J.Han,et al.MiR-122 inhibits epithelial-mesenchymal transition in hepatocellular carcinoma by targeting Snail1 and Snail2 and suppressing WNT/β-cadherin signaling pathway[J].Experimental Cell Research,2017,360(2):210-217.
[31]Wang,Y.,B.Sun,X.Zhao,et al.Twist1-related miR-26b-5p suppresses epithelial-mesenchymal transition,migration and invasion by targeting SMAD1 in hepatocellular carcinoma[J].Oncotarget,2016,7(17):24383-401.
[32]Deng,L.,J.Tang,H.Yang,et al.MTA1 modulated by miR-30e contributes to epithelial-to-mesenchymal transition in hepatocellular carcinoma through an ErbB2-dependent pathway[J].Oncogene,2017,36(28):3976-3985.
[33]Xu,Q.,Q.Zhu,Z.Zhou,et al.MicroRNA-876-5p inhibits epithelialmesenchymal transition and metastasis of hepatocellular carcinoma by targeting BCL6 corepressor like 1[J].Biomedicine&Pharmacotherapy,2018,103:645-652.
[2]Chen,W.,R.Zheng,P.D.Baade,et al.Cancer statistics in China,2015[J].CACancer J Clin,2016,66(2):115-32.
[3]Krol,J.,I.Loedige,and W.J.N.R.G.Filipowicz,The widespread regulation of microRNA biogenesis[J],function and decay,2010,11(9):597-610.
[4]Wang,R.,Z.Yu,F.Chen,et al.miR-300 regulates the epithelial-mesenchymal transition and invasion of hepatocellular carcinoma by targeting the FAK/PI3K/AKT signaling pathway[J].Biomed Pharmacother,2018,103:1632-1642.
[5]Chang,R.M.,J.F.Xu,F.Fang,et al.MicroRNA-130b promotes proliferation and EMT-induced metastasis via PTEN/p-AKT/HIF-1alpha signaling[J].Tumour Biol,2016,37(8):10609-19.
[6]Diaz-Lopez,A.,G.Moreno-Bueno,and A.Cano,Role of microRNA in epithelial to mesenchymal transition and metastasis and clinical perspectives[J].Cancer Manag Res,2014,6:205-16.
[7]McCarthy,J.B.,D.El-Ashry,and E.A.Turley,Hyaluronan,Cancer-Associated Fibroblasts and the Tumor Microenvironment in Malignant Progression[J].Front Cell Dev Biol,2018,6:48.
[8]Huang,X.H.,Q.Wang,J.S.Chen,et al.Bead-based microarray analysis of microRNA expression in hepatocellular carcinoma:miR-338 is downregulated[J].Hepatol Res,2009,39(8):786-94.
[9]Ebert,M.S.and P.A.Sharp,Roles for microRNAs in conferring robustness to biological processes[J].Cell,2012,149(3):515-24.
[10]Hornstein,E.and N.Shomron,Canalization of development by microRNAs[J].Nat Genet,2006,38:20-4.
[11]Wen,W.,J.Ding,W.Sun,et al.Cyclin G1-mediated epithelial-mesenchymal transition via phosphoinositide 3-kinase/Akt signaling facilitates liver cancer progression[J].Hepatology,2012,55(6):1787-98.
[12]Sliz,E.,M.Taipale,M.Welling,et al.TUFT1,a novel candidate gene for metatarsophalangeal osteoarthritis,plays a role in chondrogenesis on a calcium-related pathway[J].PLoS One,2017,12(4):0175474.
[13]Dou,C.,Z.Zhou,Q.Xu,et al.Hypoxia-induced TUFT1 promotes the growth and metastasis of hepatocellular carcinoma by activating the Ca(2+)/PI3K/AKT pathway[J].Oncogene,2018.
[14]Cui,S.,K.Zhang,C.Li,et al.Methylation-associated silencing of microRNA-129-3p promotes epithelial-mesenchymal transition,invasion and metastasis of hepatocelluar cancer by targeting Aurora-A[J].Oncotarget,2016,7(47):78009-78028.
[15]Janakiraman,H.,R.P.House,V.K.Gangaraju,et al.The Long(lncRNA)and Short(miRNA)of It:TGFbeta-Mediated Control of RNA-Binding Proteins and Noncoding RNAs[J].Mol Cancer Res,2018,16(4):567-579.
[16]Gulei,D.,N.Mehterov,H.Ling,et al.The“good-cop bad-cop”TGF-beta role in breast cancer modulated by non-coding RNAs[J].Biochim Biophys Acta Gen Subj,2017,1861(7):1661-1675.
[17]Zhang,T.,W.Liu,W.Meng,et al.Downregulation of miR-542-3p promotes cancer metastasis through activating TGF-beta/Smad signaling in hepatocellular carcinoma[J].Onco Targets Ther,2018,11:1929-1939.
[18]Zhou,S.J.,F.Y.Liu,A.H.Zhang,et al.MicroRNA-199b-5p attenuates TGF-beta1-induced epithelial-mesenchymal transition in hepatocellular carcinoma[J].Br J Cancer,2017,117(2):233-244.
[19]Guo,C.,D.Zhao,Q.Zhang,et al.miR-429 suppresses tumor migration and invasion by targeting CRKL in hepatocellular carcinoma via inhibiting Raf/MEK/ERK pathway and epithelial-mesenchymal transition[J].Sci Rep,2018,8(1):2375.
[20]Sun,W.,Z.Zhang,J.Wang,et al.MicroRNA-150 suppresses cell proliferation and metastasis in hepatocellular carcinoma by inhibiting the GAB1-ERK axis[J].Oncotarget,2016,7(10):11595-608.
[21]Wang,Q.,Y.Zhou,P.Rychahou,et al.Ketogenesis contributes to intestinal cell differentiation[J].Cell Death Differ,2017,24(3):458-468.
[22]Sun,X.,S.Zhao,H.Li,et al.MicroRNA-30b Suppresses EpithelialMesenchymal Transition and Metastasis of Hepatoma Cells[J].J Cell Physiol,2017,232(3):625-634.
[23]Wei,E.K.,E.Giovannucci,C.S.Fuchs,et al.Low plasma adiponectin levels and risk of colorectal cancer in men:a prospective study[J].J Natl Cancer Inst,2005,97(22):1688-94.
[24]Liu,C.,Y.Li,M.Semenov,et al.Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism[J].Cell,2002,108(6):837-47.
[25]Oba,S.,T.Mizutani,E.Suzuki,et al.A useful method of identifying of miRNAs which can down-regulate Zeb-2[J].BMC Res Notes,2013,6:470.
[26]He,C.,Z.Liu,L.Jin,et al.lncRNA TUG1-Mediated Mir-142-3p Downregulation Contributes to Metastasis and the Epithelial-to-Mesenchymal Transition of Hepatocellular Carcinoma by Targeting ZEB1[J].Cell Physiol Biochem,2018,48(5):1928-1941.
[27]Meng,X.M.,D.J.Nikolic-Paterson,and H.Y.Lan,TGF-beta:the master regulator of fibrosis[J].Nat Rev Nephrol,2016,12(6):325-38.
[28]Li,S.P.,H.X.Xu,Y.Yu,et al.LncRNA HULC enhances epithelialmesenchymal transition to promote tumorigenesis and metastasis of hepatocellular carcinoma via the miR-200a-3p/ZEB1 signaling pathway[J].Oncotarget,2016,7(27):42431-42446.
[29]Fan,F.,S.Samuel,K.W.Evans,et al.Overexpression of snail induces epithelial-mesenchymal transition and a cancer stem cell-like phenotype in human colorectal cancer cells[J].Cancer Med,2012,1(1):5-16.
[30]Jin,Y.,J.Wang,J.Han,et al.MiR-122 inhibits epithelial-mesenchymal transition in hepatocellular carcinoma by targeting Snail1 and Snail2 and suppressing WNT/β-cadherin signaling pathway[J].Experimental Cell Research,2017,360(2):210-217.
[31]Wang,Y.,B.Sun,X.Zhao,et al.Twist1-related miR-26b-5p suppresses epithelial-mesenchymal transition,migration and invasion by targeting SMAD1 in hepatocellular carcinoma[J].Oncotarget,2016,7(17):24383-401.
[32]Deng,L.,J.Tang,H.Yang,et al.MTA1 modulated by miR-30e contributes to epithelial-to-mesenchymal transition in hepatocellular carcinoma through an ErbB2-dependent pathway[J].Oncogene,2017,36(28):3976-3985.
[33]Xu,Q.,Q.Zhu,Z.Zhou,et al.MicroRNA-876-5p inhibits epithelialmesenchymal transition and metastasis of hepatocellular carcinoma by targeting BCL6 corepressor like 1[J].Biomedicine&Pharmacotherapy,2018,103:645-652.