中药防龋的研究进展
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摘要
龋病是人类最常见的口腔疾病,龋病发病率呈上升趋势。中药是中华民族的瑰宝,资源丰富,历史悠久,受到国内外学者的广泛关注。本文对龋齿的成因、中药防病健齿的古方及中药五倍子、厚朴、茶、蜂胶等防龋的现代研究及应用进行了综述,结合市场调研结果,认为目前中药应用于防龋及口腔护理具有科学理论基础及广阔的市场前景。
Dental caries is the most common oral diseas e in humans, and the incidence s is on the rise. Chinese medicine is a treasure of the Chinese nation, rich in resources and has a long history, which has attracted wide attention from scholars at home and abroad.This paper summarizes the causes of dental caries, the ancient prescription of traditional Chinese medicine such as tea, galla chinensis, magnolia officinalis, cortex, propolis, and the modern research on caries prevention. Combined the market research, it is concluded that the application of Chinese medicine in caries prevention and oral care has scientific theoretical foundation and broad market prospects.
Dental caries is the most common oral diseas e in humans, and the incidence s is on the rise. Chinese medicine is a treasure of the Chinese nation, rich in resources and has a long history, which has attracted wide attention from scholars at home and abroad.This paper summarizes the causes of dental caries, the ancient prescription of traditional Chinese medicine such as tea, galla chinensis, magnolia officinalis, cortex, propolis, and the modern research on caries prevention. Combined the market research, it is concluded that the application of Chinese medicine in caries prevention and oral care has scientific theoretical foundation and broad market prospects.
引文
[1]李刚.中国古代在龋病防治方面的伟大贡献[J].牙体牙髓牙周病学杂志,1991(2):124-125.
[2] Nakahara K,Kawabata S,Ono H,et al. Inhibitory effect of oolong tea polyphenols on glycosyltransferases of mutans Streptococci. Appl Environ Microbiol,1993,59:968-973.
[3] Hattori M,Kusumoto IT,Namba T,et al. Effect of tea poly-phenols on glucan synthesis by glucosyltransferase from strep-tococcus mutans.Chem Pharm Bull,1990,38:717-720.
[4]刘晓丹,石四箴.茶多酚防龋研究进展[J].上海医学,2005(9):813-814.
[5]肖悦,刘天佳,詹玲,等.茶多酚影响致龋菌在唾液获得性膜粘附的研究[J].华西口腔医学杂志,2000(18):336-339.
[6] Yu H,Yu LX,Oho T,et al. The effect of a tannin-fluoride mixture on human dental enamel.Caries Res,1993,27:161-168.
[7] Cheng L,Exterkate R A,Zhou X et al. Effect of Galla chinensis on growth and metabolism of microcosm biofilms[J]. Caries Res,2011,45(2):87-92.
[8]赵今,李继遥,朱晒,等.中药对口腔细菌生物膜作用的实验研究[J].中华口腔医学杂志,2007,42(10):585-589.
[9] Shao D,Li J,Li J,et al. Inhibition of gallic acid on the growth and biofilm formation of escherichia coli and Streptococcus mutans[J]. J Food Sci,2015,80(6):M1299-305.
[10] Huang X,Cheng L,Exterkate R A,et al. Effect of p H on Galla chinensis extract’s stability and anti-caries properties in vitro[J]. Arch Oral Biol,2012,57(8):1093-1099.
[11]刘玉梅,徐静舒.五倍子抗口腔致病菌活性物质筛选及其体外抑菌效果评价[J].实用口腔医学杂志,2017,33(4):437-441.
[12]郑兰娟,罗艳萍,汪玉娇,等.五倍子抗菌抗炎作用研究进展[J].中国病原生物学杂志,2011,6(11):868-869,847.
[13]褚敏,梁景平,朱彩莲.茶多酚、鞣酸抗细菌生长、粘附能力的研究[J].现代口腔医学杂志,2001(2):127-128.
[14] Xie Q,Li J,Zhou X. Anticaries effect of compounds extracted from Galla Chinensis in a multispecies biofilm model[J]. Oral Microbiol Immunol,2008,23:459-465.
[15] Ling Zou,Ling Lin Zhang,Ji Yao,et al. Effect of Galla chinensis extract and chemical fraction on demineralization of bovine enamel in vitro[J].journal of dentistry,2008,36(12):999-1004.
[16] Chu J P,Li J Y,Hao Y Q,et al. Effect of compounds of Galla chinensis on remineralisation of initital enamel carious lesions in vitro[J]. Journal of Dentistry,2007,35(5):383-387.
[17]赵朋朋.天然药物五倍子防治龋病的动物实验研究[D].四川大学,2006.
[18]林志彬.蜂胶的药理作用和临床应用[J].药学通报,1982,17(4):226.
[19]于倩,薛瑞,赵今,等.伊犁黑蜂蜂胶对口腔主要致龋细菌及生物膜生长的实验研究[J].中国微生态学杂志,2015,27(12):1403-1406,1410.
[20]于倩,林静,祖力卡尔江·阿合买提,等.伊犁黑蜂蜂胶对口腔主要致龋细菌生物膜作用的实验研究[J].华西口腔医学杂志,2015,33(4):343-346.
[21]侯晓薇,杨更森,刘春梅,等.在模拟口腔条件下对蜂胶防龋作用的研究[J].中国生物医学工程学报,2003(2):188-189,177.
[22]王晶,李玉晶,杨东梅,等.蜂胶防龋作用的研究[J].牙体牙髓牙周病学杂志,2002(6):323-325.
[23]冯瑾.天然药物厚朴防龋作用的药效学研究[D].四川大学,2007.
[24]乌爱菊,翁方敏,邵家珏,等.中药厚朴的防龋研究———厚朴活性成分的抗菌作用[J].口腔医学,1983(3):115-116.
[25]翁方敏,乌爱菊,邵家珏,等.中药厚朴的防龋研究(三)-厚朴活性成分的抗菌作用[J].口腔医学,1987(2):70-71.
[26]黄冰冰.厚朴活性成分的提取及抗龋机制研究[J].武汉大学,2005.
[27]汪春平,蓝海.中药厚朴的防龋研究[J].中医药导报,2015,21(3):37-40.
[28]王伟健,魏怡.抗菌斑药物牙膏的研究与进展[J].现代口腔医学杂志.1995,9(3):162-164.
[29]杨是,石四箴.口腔预防医学及儿童口腔医学[M]. 2版.北京:人民卫生出版社,1995:80-81.
[30]邓媛.蜂胶牙膏防龋的实验和临床研究[D].重庆:重庆医科大学,2007.
[31]张静明.厚朴防龋牙膏的试验[J].日用化学工业,1983(5):11-13.
[32]卢林,刘天佳,郭丽娟.茶多酚抗牙菌斑作用机理的体外研究[J].口腔医学纵横杂志,1998(14):140-143.
[33]陈璇.复方金银花中药漱口水的制备及其功效实验研究[D].广州:南方医科大学,2017.
[34]冯希平,刘艳玲,束陈斌.绿茶多酚涂膜临床防龋效果观察[J].上海口腔医学,1997(6):135-137.
[2] Nakahara K,Kawabata S,Ono H,et al. Inhibitory effect of oolong tea polyphenols on glycosyltransferases of mutans Streptococci. Appl Environ Microbiol,1993,59:968-973.
[3] Hattori M,Kusumoto IT,Namba T,et al. Effect of tea poly-phenols on glucan synthesis by glucosyltransferase from strep-tococcus mutans.Chem Pharm Bull,1990,38:717-720.
[4]刘晓丹,石四箴.茶多酚防龋研究进展[J].上海医学,2005(9):813-814.
[5]肖悦,刘天佳,詹玲,等.茶多酚影响致龋菌在唾液获得性膜粘附的研究[J].华西口腔医学杂志,2000(18):336-339.
[6] Yu H,Yu LX,Oho T,et al. The effect of a tannin-fluoride mixture on human dental enamel.Caries Res,1993,27:161-168.
[7] Cheng L,Exterkate R A,Zhou X et al. Effect of Galla chinensis on growth and metabolism of microcosm biofilms[J]. Caries Res,2011,45(2):87-92.
[8]赵今,李继遥,朱晒,等.中药对口腔细菌生物膜作用的实验研究[J].中华口腔医学杂志,2007,42(10):585-589.
[9] Shao D,Li J,Li J,et al. Inhibition of gallic acid on the growth and biofilm formation of escherichia coli and Streptococcus mutans[J]. J Food Sci,2015,80(6):M1299-305.
[10] Huang X,Cheng L,Exterkate R A,et al. Effect of p H on Galla chinensis extract’s stability and anti-caries properties in vitro[J]. Arch Oral Biol,2012,57(8):1093-1099.
[11]刘玉梅,徐静舒.五倍子抗口腔致病菌活性物质筛选及其体外抑菌效果评价[J].实用口腔医学杂志,2017,33(4):437-441.
[12]郑兰娟,罗艳萍,汪玉娇,等.五倍子抗菌抗炎作用研究进展[J].中国病原生物学杂志,2011,6(11):868-869,847.
[13]褚敏,梁景平,朱彩莲.茶多酚、鞣酸抗细菌生长、粘附能力的研究[J].现代口腔医学杂志,2001(2):127-128.
[14] Xie Q,Li J,Zhou X. Anticaries effect of compounds extracted from Galla Chinensis in a multispecies biofilm model[J]. Oral Microbiol Immunol,2008,23:459-465.
[15] Ling Zou,Ling Lin Zhang,Ji Yao,et al. Effect of Galla chinensis extract and chemical fraction on demineralization of bovine enamel in vitro[J].journal of dentistry,2008,36(12):999-1004.
[16] Chu J P,Li J Y,Hao Y Q,et al. Effect of compounds of Galla chinensis on remineralisation of initital enamel carious lesions in vitro[J]. Journal of Dentistry,2007,35(5):383-387.
[17]赵朋朋.天然药物五倍子防治龋病的动物实验研究[D].四川大学,2006.
[18]林志彬.蜂胶的药理作用和临床应用[J].药学通报,1982,17(4):226.
[19]于倩,薛瑞,赵今,等.伊犁黑蜂蜂胶对口腔主要致龋细菌及生物膜生长的实验研究[J].中国微生态学杂志,2015,27(12):1403-1406,1410.
[20]于倩,林静,祖力卡尔江·阿合买提,等.伊犁黑蜂蜂胶对口腔主要致龋细菌生物膜作用的实验研究[J].华西口腔医学杂志,2015,33(4):343-346.
[21]侯晓薇,杨更森,刘春梅,等.在模拟口腔条件下对蜂胶防龋作用的研究[J].中国生物医学工程学报,2003(2):188-189,177.
[22]王晶,李玉晶,杨东梅,等.蜂胶防龋作用的研究[J].牙体牙髓牙周病学杂志,2002(6):323-325.
[23]冯瑾.天然药物厚朴防龋作用的药效学研究[D].四川大学,2007.
[24]乌爱菊,翁方敏,邵家珏,等.中药厚朴的防龋研究———厚朴活性成分的抗菌作用[J].口腔医学,1983(3):115-116.
[25]翁方敏,乌爱菊,邵家珏,等.中药厚朴的防龋研究(三)-厚朴活性成分的抗菌作用[J].口腔医学,1987(2):70-71.
[26]黄冰冰.厚朴活性成分的提取及抗龋机制研究[J].武汉大学,2005.
[27]汪春平,蓝海.中药厚朴的防龋研究[J].中医药导报,2015,21(3):37-40.
[28]王伟健,魏怡.抗菌斑药物牙膏的研究与进展[J].现代口腔医学杂志.1995,9(3):162-164.
[29]杨是,石四箴.口腔预防医学及儿童口腔医学[M]. 2版.北京:人民卫生出版社,1995:80-81.
[30]邓媛.蜂胶牙膏防龋的实验和临床研究[D].重庆:重庆医科大学,2007.
[31]张静明.厚朴防龋牙膏的试验[J].日用化学工业,1983(5):11-13.
[32]卢林,刘天佳,郭丽娟.茶多酚抗牙菌斑作用机理的体外研究[J].口腔医学纵横杂志,1998(14):140-143.
[33]陈璇.复方金银花中药漱口水的制备及其功效实验研究[D].广州:南方医科大学,2017.
[34]冯希平,刘艳玲,束陈斌.绿茶多酚涂膜临床防龋效果观察[J].上海口腔医学,1997(6):135-137.