调和冲任推拿手法治疗肝郁痰凝型乳腺增生患者的临床效果
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摘要
目的评价调和冲任推拿手法对肝郁痰凝型乳腺增生患者症状、激素水平和生活质量的影响。方法选择2017年1月～2018年1月于新疆维吾尔自治区中医医院就诊的肝郁痰凝型乳腺增生患者84例,按随机数字表法将其分为对照组(42例)和观察组(42例)。对照组采用乳癖消胶囊,观察组应用乳癖消胶囊联合调和冲任推拿手法,治疗2个疗程。比较两组患者的临床疗效、视觉模拟评分(VAS)、中医证候积分、激素水平和生活质量。结果观察组总有效率明显高于对照组(P <0.05)。治疗后,两组中医证候积分、VAS评分和雌二醇(E2)水平均较治疗前明显降低(P <0.05),孕酮水平、癌症患者生命质量测定量表(EORTC QLQ-C30)评分均较治疗前明显升高(P <0.05),且观察组上述指标的改善程度均优于对照组(P <0.05)。结论调和冲任推拿手法治疗肝郁痰凝型乳腺增生的效果较好,能够有效改善症状积分和激素水平,明显减轻疼痛,提高患者生活质量。
Objective To evaluate the effects of massage by coordinating Chong and Conception Channels on the symptoms, hormone levels and quality of life in hyperplasia of mammary glands patients with syndrome of stagnation of liver qi and coagulated phlegm. Methods Total 84 hyperplasia of mammary glands patients with syndrome of stagnation of liver qi and coagulated phlegm treated in Traditional Chinese Medicine Hospital of Xinjiang Uygur Autonomous Region from January 2017 to January 2018 were selected and randomly divided into control group(42 cases) and observation group(42 cases) by random number table method. The control group was treated with Rupixiao Capsules. The observation group was treated with Rupixiao Capsules combined with massage by coordinating Chong and Conception Channels, both were treated for 2 courses. The clinical efficacy, visual analogue scale(VAS), TCM syndrome score, hormone level and quality of life were compared between the two groups. Results The total effective rate of the observation group was significantly higher than that of the control group(P < 0.05). After treatment, the TCM syndrome scores, VAS and estradiol(E2) levels of the two groups were significantly lower than those before treatment(P < 0.05), the progesterone levels, the scores of European Organization for Reasearch and Treatment of Cancer(EORTC) quality of life questionnaire(QLQ-C30) of the two groups were significantly lower than those before treatment(P < 0.05). The improvement of the indices above in the observation group was better than that in the control group(P < 0.05). Conclusion The curative effect of massage by coordinating Chong and Conception Channels in the treatment of hyperplasia of mammary glands patients with syndrome of stagnation of liver qi and coagulated phlegm is good, which can significantly increase the symptom scores and hormone levels, relieve pain and improve the quality of life.
Objective To evaluate the effects of massage by coordinating Chong and Conception Channels on the symptoms, hormone levels and quality of life in hyperplasia of mammary glands patients with syndrome of stagnation of liver qi and coagulated phlegm. Methods Total 84 hyperplasia of mammary glands patients with syndrome of stagnation of liver qi and coagulated phlegm treated in Traditional Chinese Medicine Hospital of Xinjiang Uygur Autonomous Region from January 2017 to January 2018 were selected and randomly divided into control group(42 cases) and observation group(42 cases) by random number table method. The control group was treated with Rupixiao Capsules. The observation group was treated with Rupixiao Capsules combined with massage by coordinating Chong and Conception Channels, both were treated for 2 courses. The clinical efficacy, visual analogue scale(VAS), TCM syndrome score, hormone level and quality of life were compared between the two groups. Results The total effective rate of the observation group was significantly higher than that of the control group(P < 0.05). After treatment, the TCM syndrome scores, VAS and estradiol(E2) levels of the two groups were significantly lower than those before treatment(P < 0.05), the progesterone levels, the scores of European Organization for Reasearch and Treatment of Cancer(EORTC) quality of life questionnaire(QLQ-C30) of the two groups were significantly lower than those before treatment(P < 0.05). The improvement of the indices above in the observation group was better than that in the control group(P < 0.05). Conclusion The curative effect of massage by coordinating Chong and Conception Channels in the treatment of hyperplasia of mammary glands patients with syndrome of stagnation of liver qi and coagulated phlegm is good, which can significantly increase the symptom scores and hormone levels, relieve pain and improve the quality of life.
引文
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[11]刘侠,陈凯,刘琳,等.乳癖消丸联合他莫昔芬治疗乳腺增生的临床疗效观察[J].中国妇幼保健,2013,28(28):4623-4625.
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[13]马海涛,吴峰.王万林教授乳腺增生病诊治经验初探[J].中国中医药现代远程教育,2015,13(17):32-33.
[14]陈翠环,刘华.穴位贴敷配合健乳灵方治疗冲任不调型乳腺增生的效果与护理[J].中国医药导报,2014,11(20):124-126.
[15]朱琦,卞卫和,李永刚.乳腺增生病中医外治法研究进展[J].中医药导报,2011,17(12):79-81.
[16]王海龙.乳腺增生厥阴治之[J].中华养生保健,2013(12):67.
[17]Li HT,Liu HH,Yang YX,et al.Therapeutic Effects of a Traditional Chinese Medicine Formula Plus Tamoxifen vs.Tamoxifen for the Treatment of Mammary Gland Hyperplasia:A Meta-Analysis of Randomized Trials[J].Front Pharmacol,2018,9:45.
[18]肖嘉哲.自拟川玄消癖汤治疗乳腺增生病的疗效观察[J].中国医药科学,2018,8(1):66-68.
[19]郑享珍.针灸联合消癖汤治疗乳腺增生的疗效评价[J].临床医学研究与实践,2017,2(11):115-116.
[20]楚云杰.推拿结合针灸治疗乳腺增生30例[J].长春中医药大学学报,2012,28(4):670.
[21]李健,张雪岭,曲怡.推拿疏肝理气法治疗乳腺增生临床观察[J].世界中西医结合杂志,2011,6(4):310-312.
[2]张素燚,李德辉,廖锐,等.从情志方面探讨乳腺增生病因病机[J].时珍国医国药,2013,24(1):175-176.
[3]陈显春,蒋成刚,陈庆秋,等.675例乳腺增生女性患者的焦虑、抑郁情绪及其与生活事件和人格的关系研究[J].第三军医大学学报,2014,36(2):174-176.
[4]王钟富.现代实用乳房疾病诊疗学[M].郑州:郑州科技出版社,2000:15.
[5]国家药品食品监督管理局.中药新药临床研究指导原则(试行)[M].北京:中国医药科技出版社,2002:366-368.
[6]林毅,唐汉钧.现代中医乳房病学[M].北京:人民卫生出版社,2003:101-103.
[7]Rausch M,Zehetleitner M.A comparison between a visual analogue scale and a four point scale as measures of conscious experience of motion[J].Conscious Cogn,2014,28(6):126-140.
[8]Fayers PM.Interpreting quality of life data:populationbased reference data for the EORTC QLQ-C30[J].Eur JCancer,2001,37(11):1331-1334.
[9]钟文莲,吴双,史晓蓉,等.已婚妇女乳腺增生危险因素分析[J].中国妇幼保健,2014,29(2):205-207.
[10]王景诗.秦皇岛地区5年间城市妇女乳腺增生的患病率及其影响因素调查研究[J].中国妇幼保健,2016,31(18):3812-3814.
[11]刘侠,陈凯,刘琳,等.乳癖消丸联合他莫昔芬治疗乳腺增生的临床疗效观察[J].中国妇幼保健,2013,28(28):4623-4625.
[12]苏柏栓.针灸联合消癖汤治疗乳腺增生临床研究[J].中医学报,2012,27(8):1073-1074.
[13]马海涛,吴峰.王万林教授乳腺增生病诊治经验初探[J].中国中医药现代远程教育,2015,13(17):32-33.
[14]陈翠环,刘华.穴位贴敷配合健乳灵方治疗冲任不调型乳腺增生的效果与护理[J].中国医药导报,2014,11(20):124-126.
[15]朱琦,卞卫和,李永刚.乳腺增生病中医外治法研究进展[J].中医药导报,2011,17(12):79-81.
[16]王海龙.乳腺增生厥阴治之[J].中华养生保健,2013(12):67.
[17]Li HT,Liu HH,Yang YX,et al.Therapeutic Effects of a Traditional Chinese Medicine Formula Plus Tamoxifen vs.Tamoxifen for the Treatment of Mammary Gland Hyperplasia:A Meta-Analysis of Randomized Trials[J].Front Pharmacol,2018,9:45.
[18]肖嘉哲.自拟川玄消癖汤治疗乳腺增生病的疗效观察[J].中国医药科学,2018,8(1):66-68.
[19]郑享珍.针灸联合消癖汤治疗乳腺增生的疗效评价[J].临床医学研究与实践,2017,2(11):115-116.
[20]楚云杰.推拿结合针灸治疗乳腺增生30例[J].长春中医药大学学报,2012,28(4):670.
[21]李健,张雪岭,曲怡.推拿疏肝理气法治疗乳腺增生临床观察[J].世界中西医结合杂志,2011,6(4):310-312.