“陆止于此,海始于斯”:机械灌注将成为供肝保存修复新常态
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摘要
2018年5月,国际肝移植协会年会在葡萄牙首都里斯本举行,来自世界各地的专家汇聚一堂,分享了肝移植领域的经验及进展。机械灌注相关内容格外受人瞩目,连续3年入选"Rising Star"部分,且相关主题大会论文投稿数量逐年增加。本文汇总此次年会机械灌注内容,从机械灌注保存修复边缘供肝、供肝质量评估、体外干预治疗及基础研究四个方面详细介绍其进展及应用。
The 2018 Joint International Congress of International Liver Transplantation Society( ILTS),The European Liver and Intestine Transplant Association( ELITA) and The Liver Intensive Care Group of Europe( LICAGE) were held in Lisbon,Portugal in May 2018. The experts from all over the world shared their experiences on liver transplantation. Machine perfusion is an attractive topic,the content of which increases every year. This editorial highlights the most innovative and impactfulpresentations in machine perfusion,containing liver graft preservation,graft quality evaluation,ex-situ intervention and basic research.
The 2018 Joint International Congress of International Liver Transplantation Society( ILTS),The European Liver and Intestine Transplant Association( ELITA) and The Liver Intensive Care Group of Europe( LICAGE) were held in Lisbon,Portugal in May 2018. The experts from all over the world shared their experiences on liver transplantation. Machine perfusion is an attractive topic,the content of which increases every year. This editorial highlights the most innovative and impactfulpresentations in machine perfusion,containing liver graft preservation,graft quality evaluation,ex-situ intervention and basic research.
引文
1 Kim WR,Lake JR,Smith JM,et al.OPTN/SRTR 2016 Annual Data Report:Liver[J].Am J Transplant,2018,18(Suppl 1):S172-S253.
2 Dubbeld J,van Hoek B,Ringers J,et al.Biliary complications after liver transplantation from donation after cardiac death donors:an analysis of risk factors and long-term outcome from a single center[J].Ann Surg,2015,261(3):e64.
3 Nasralla D,Coussios CC,Mergental H,et al.A randomized trial of normothermic preservation in liver transplantation[J].Nature,2018,557(7703):50-56.
4 Guarrera JV,Henry SD,Samstein B,et al.Hypothermic machine preservation in human liver transplantation:the first clinical series[J].Am J Transplant,2010,10(2):372-381.
5 Dutkowski P,Schlegel A,de Oliveira M,et al.HOPE for human liver grafts obtained from donors after cardiac death[J].J Hepatol,2014,60(4):765-772.
6 Dutkowski P,Polak WG,Muiesan P,et al.First comparison of hypothermic oxygenated perfusion versus static cold storage of human donation after cardiac death liver transplants:an internationalmatched case analysis[J].Ann Surg,2015,262(5):764-771.
7 Guarrera JV,Henry SD,Samstein B,et al.Hypothermic machine preservation facilitates successful transplantation of"orphan"extended criteria donor livers[J].Am J Transplant,2015,15(1):161-169.
8 van Rijn R,Karimian N,Matton APM,et al.Dual hypothermic oxygenated machine perfusion in liver transplants donated after circulatory death[J].Br J Surg,2017,104(7):907-917.
9 De Carlis R,Di Sandro S,Lauterio A,et al.Successful donation after cardiac death liver transplants with prolonged warm ischemia time using normothermic regional perfusion[J].Liver Transpl,2017,23(2):166-173.
10 Ravikumar R,Jassem W,Mergental H,et al.Liver transplantation after ex vivo normothermic machine preservation:a phase 1(first-inman)clinical trial[J].Am J Transplant,2016,16(6):1779-1787.
11 Mergental H,Perera MT,Laing RW,et al.Transplantation of declined liver allografts following normothermic ex-situ evaluation[J].Am J Transplant,2016,16(11):3235-3245.
12 Selzner M,Goldaracena N,Echeverri J,et al.Normothermic ex vivo liver perfusion using steen solution as perfusate for human liver transplantation:first North American results[J].Liver Transpl,2016,22(11):1501-1508.
13 Watson CJE,Kosmoliaptsis V,Randle LV,et al.Normothermic perfusion in the assessment and preservation of declined livers before transplantation:hyperoxia and vasoplegia-important lessons from the first 12 cases[J].Transplantation,2017,101(5):1084-1098.
14 Bral M,Gala-Lopez B,Bigam D,et al.Preliminary single-center Canadian experience of human normothermic ex vivo liver perfusion:results of a clinical trial[J].Am J Transplant,2017,17(4):1071-1080.
2 Dubbeld J,van Hoek B,Ringers J,et al.Biliary complications after liver transplantation from donation after cardiac death donors:an analysis of risk factors and long-term outcome from a single center[J].Ann Surg,2015,261(3):e64.
3 Nasralla D,Coussios CC,Mergental H,et al.A randomized trial of normothermic preservation in liver transplantation[J].Nature,2018,557(7703):50-56.
4 Guarrera JV,Henry SD,Samstein B,et al.Hypothermic machine preservation in human liver transplantation:the first clinical series[J].Am J Transplant,2010,10(2):372-381.
5 Dutkowski P,Schlegel A,de Oliveira M,et al.HOPE for human liver grafts obtained from donors after cardiac death[J].J Hepatol,2014,60(4):765-772.
6 Dutkowski P,Polak WG,Muiesan P,et al.First comparison of hypothermic oxygenated perfusion versus static cold storage of human donation after cardiac death liver transplants:an internationalmatched case analysis[J].Ann Surg,2015,262(5):764-771.
7 Guarrera JV,Henry SD,Samstein B,et al.Hypothermic machine preservation facilitates successful transplantation of"orphan"extended criteria donor livers[J].Am J Transplant,2015,15(1):161-169.
8 van Rijn R,Karimian N,Matton APM,et al.Dual hypothermic oxygenated machine perfusion in liver transplants donated after circulatory death[J].Br J Surg,2017,104(7):907-917.
9 De Carlis R,Di Sandro S,Lauterio A,et al.Successful donation after cardiac death liver transplants with prolonged warm ischemia time using normothermic regional perfusion[J].Liver Transpl,2017,23(2):166-173.
10 Ravikumar R,Jassem W,Mergental H,et al.Liver transplantation after ex vivo normothermic machine preservation:a phase 1(first-inman)clinical trial[J].Am J Transplant,2016,16(6):1779-1787.
11 Mergental H,Perera MT,Laing RW,et al.Transplantation of declined liver allografts following normothermic ex-situ evaluation[J].Am J Transplant,2016,16(11):3235-3245.
12 Selzner M,Goldaracena N,Echeverri J,et al.Normothermic ex vivo liver perfusion using steen solution as perfusate for human liver transplantation:first North American results[J].Liver Transpl,2016,22(11):1501-1508.
13 Watson CJE,Kosmoliaptsis V,Randle LV,et al.Normothermic perfusion in the assessment and preservation of declined livers before transplantation:hyperoxia and vasoplegia-important lessons from the first 12 cases[J].Transplantation,2017,101(5):1084-1098.
14 Bral M,Gala-Lopez B,Bigam D,et al.Preliminary single-center Canadian experience of human normothermic ex vivo liver perfusion:results of a clinical trial[J].Am J Transplant,2017,17(4):1071-1080.