患者血清CEA、CA724、CA199水平对胰腺癌的评估价值
|
摘要
目的探讨患者血清CEA、CA724、CA199水平对胰腺癌的评估价值。方法选取胰腺癌患者97例作为观察组,同期选取进行体检的健康者100例作为对照组。比较2组受试者及不同分期胰腺癌患者血清CEA、CA724、CA199的含量,并计算CEA、CA724、CA199单独检测及联合检测诊断胰腺癌的阳性率。结果观察组血清CEA、CA724、CA199水平均显著高于对照组(P <0. 05)。随着胰腺癌病理分期的增加,患者血清CEA、CA724、CA199水平也显著升高(P <0. 05)。胰腺癌患者CEA、CA724、CA199阳性率分别是59. 79%(58/97)、66. 04%(66/97)、84. 54%(82/97),CEA、CA724、CA199联合检测的阳性率是93. 81%(91/97),联合检测的阳性率显著高于单项检测(P <0. 05)。结论血清CEA、CA724、CA199联合检测有助于胰腺癌的诊断及病情评估,对于患者的治疗及预后具有积极意义,值得临床应用。
Objective To explore the evaluation value of serum CEA,CA724 and CA199 levels in patients with pancreatic cancer. Methods Selected 97 patients with pancreatic cancer admitted to our hospital from January 2015 to December 2017 were selected as observation group. In the same period,100 healthy people who had physical examination were selected as the control group. The serum CEA,CA724 and CA199 levels in two groups and different stage pancreatic cancer patients were detected and compared. The positive rate of CEA,CA724,CA199 alone and combined detection in the diagnosis of pancreatic cancer were calculated. Results The serum levels of CEA,CA724 and CA199 in the observation group were significantly higher than those in the control group( P < 0. 05). With the increase of the pathological stage of pancreatic cancer,the serum levels of CEA,CA724 and CA199 were also significantly increased( P < 0. 05). The positive rates of CEA,CA724,and CA199 in patients with pancreatic cancer were 59. 79%( 58/97),66. 04%( 66/97),and 84. 54%( 82/97) respectively. The positive rate of combined detection of CEA,CA724 and CA199 was 93. 81%( 91/97). The positive rate of combined detection was significantly higher than that of single detection( P < 0. 05). Conclusion Combined detection of serum CEA,CA724 and CA199 is helpful for the diagnosis and evaluation of pancreatic cancer. It is of positive significance for the treatment and prognosis of pancreatic cancer and is worthy of clinical application.
Objective To explore the evaluation value of serum CEA,CA724 and CA199 levels in patients with pancreatic cancer. Methods Selected 97 patients with pancreatic cancer admitted to our hospital from January 2015 to December 2017 were selected as observation group. In the same period,100 healthy people who had physical examination were selected as the control group. The serum CEA,CA724 and CA199 levels in two groups and different stage pancreatic cancer patients were detected and compared. The positive rate of CEA,CA724,CA199 alone and combined detection in the diagnosis of pancreatic cancer were calculated. Results The serum levels of CEA,CA724 and CA199 in the observation group were significantly higher than those in the control group( P < 0. 05). With the increase of the pathological stage of pancreatic cancer,the serum levels of CEA,CA724 and CA199 were also significantly increased( P < 0. 05). The positive rates of CEA,CA724,and CA199 in patients with pancreatic cancer were 59. 79%( 58/97),66. 04%( 66/97),and 84. 54%( 82/97) respectively. The positive rate of combined detection of CEA,CA724 and CA199 was 93. 81%( 91/97). The positive rate of combined detection was significantly higher than that of single detection( P < 0. 05). Conclusion Combined detection of serum CEA,CA724 and CA199 is helpful for the diagnosis and evaluation of pancreatic cancer. It is of positive significance for the treatment and prognosis of pancreatic cancer and is worthy of clinical application.
引文
[1]Hayakawa T,Kondo T,Shibata T,et al.Sensitive serum markers for detecting pancreatic cancer[J].Cancer,2015,61(9):1827-1831.
[2]方恒忠,陈炯.血清肿瘤标志物在胰腺癌早期诊断中的研究进展[J].国际外科学杂志,2015,42(9):642-645.
[3]张艳,袁军,解娟,等.磁共振DWI成像结合血清肿瘤标志物检测在胰腺癌诊断中的价值及相关性分析[J].陕西医学杂志,2017,46(7):862-864.
[4]Garrido-Laguna I,Hidalgo M.Pancreatic cancer:from stateof-the-art treatments to promising novel therapies[J].Nature Reviews Clinical Oncology,2015,12(6):319-334.
[5]方恒忠,陈炯,赵金钱,等.血清学肿瘤标志物与胰腺癌诊断及分期的关系[J].国际外科学杂志,2016,43(3):171-173.
[6]Kleeff J,Korc M,Apte M,et al.Pancreatic cancer[J].Current Treatment Options in Oncology,2016,2(5):16022.
[7]林文科,吴吉芳,郑志昂.多种肿瘤标志物在胰腺癌中的诊断价值及相关性研究[J].中国免疫学杂志,2017,33(1):120-125.
[8]向焰,龙天蓉,陈亮.肿瘤标志物CA199、CA242及CA50联合检测对胰腺癌早期诊断的价值[J].检验医学与临床,2017,14(A02):137-138.
[9]Chen XZ,Zhang WH,Chen HN,et al.Associations between serum CA724 and HER2 overexpression among stageⅡ~Ⅲresectable gastric cancer patients:an observational study[J].Oncotarget,2016,7(17):23647-23657.
[10]马学柱.血清CA199 CA125 CA242癌胚抗原表达水平与胰腺癌的早期诊断和预后转归的关联性研究[J].山西医药杂志,2016,45(13):1543-1545.
[11]Liu L,Xu H,Wang W,et al.A Preoperative serum signature of CEA(+)/CA125(+)/CA19-9≥1,000 U/m L indicates poor outcome to pancreatectomy for pancreatic cancer[J].International Journal of Cancer,2015,136(9):2216-2227.
[2]方恒忠,陈炯.血清肿瘤标志物在胰腺癌早期诊断中的研究进展[J].国际外科学杂志,2015,42(9):642-645.
[3]张艳,袁军,解娟,等.磁共振DWI成像结合血清肿瘤标志物检测在胰腺癌诊断中的价值及相关性分析[J].陕西医学杂志,2017,46(7):862-864.
[4]Garrido-Laguna I,Hidalgo M.Pancreatic cancer:from stateof-the-art treatments to promising novel therapies[J].Nature Reviews Clinical Oncology,2015,12(6):319-334.
[5]方恒忠,陈炯,赵金钱,等.血清学肿瘤标志物与胰腺癌诊断及分期的关系[J].国际外科学杂志,2016,43(3):171-173.
[6]Kleeff J,Korc M,Apte M,et al.Pancreatic cancer[J].Current Treatment Options in Oncology,2016,2(5):16022.
[7]林文科,吴吉芳,郑志昂.多种肿瘤标志物在胰腺癌中的诊断价值及相关性研究[J].中国免疫学杂志,2017,33(1):120-125.
[8]向焰,龙天蓉,陈亮.肿瘤标志物CA199、CA242及CA50联合检测对胰腺癌早期诊断的价值[J].检验医学与临床,2017,14(A02):137-138.
[9]Chen XZ,Zhang WH,Chen HN,et al.Associations between serum CA724 and HER2 overexpression among stageⅡ~Ⅲresectable gastric cancer patients:an observational study[J].Oncotarget,2016,7(17):23647-23657.
[10]马学柱.血清CA199 CA125 CA242癌胚抗原表达水平与胰腺癌的早期诊断和预后转归的关联性研究[J].山西医药杂志,2016,45(13):1543-1545.
[11]Liu L,Xu H,Wang W,et al.A Preoperative serum signature of CEA(+)/CA125(+)/CA19-9≥1,000 U/m L indicates poor outcome to pancreatectomy for pancreatic cancer[J].International Journal of Cancer,2015,136(9):2216-2227.