针灸治疗过敏性鼻炎的疗效及对患者生活质量的影响
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摘要
目的观察针灸治疗过敏性鼻炎的疗效及对患者生活质量的影响。方法选择过敏性鼻炎患者72例,采用随机数字表法分为对照组和观察组,每组36例。对照组采用常规西药治疗,观察组采用针灸治疗,两组均连续治疗3个月,治疗完毕后对效果进行评估。采用酶联免疫吸附试验测定VCAM-1、白细胞介素-4(IL-4)、白细胞介素-6(IL-6)及白细胞介素-10(IL-10)水平;采用WHOQOl-BREF生活量表对两组生活质量进行评估,比较两组临床疗效及对患者生活质量的影响。结果观察组总有效率为97.2%,高于对照组的86.1%(P<0.05);两组治疗前VCAM-1、IL-4、IL-6及IL-10水平比较差异无统计学意义(P>0.05);观察组和对照组治疗后VCAM-1、IL-4、IL-6及IL-10水平均低于治疗前(P<0.05);观察组治疗后VCAM-1、IL-4、IL-6及IL-10水平均低于对照组(P<0.05);观察组和对照组治疗后生理健康、心理状态、社会关系、周围环境、独立能力评分均高于治疗前(P<0.05);观察组治疗后生理健康、心理状态、社会关系、周围环境、独立能力评分均高于对照组(P<0.05)。结论针灸治疗过敏性鼻炎疗效确切,能降低炎症因子水平,改善患者生活质量。
Objective To investigate the therapeutic effect of acupuncture and moxibustion on allergic rhinitis and its influence on the patients' quality of life. Method Seventy-two patients with allergic rhinitis were allocated,according to different protocols, to control and observation groups, 36 cases each. The control group received conventional Western drug treatment and the observation group, acupuncture and moxibustion. Both groups were treated for three consecutive months. The effects were evaluated after the completion of treatment. VCAM-1,interleukin-4(IL-4), interleukin-6(IL-6) and interleukin-10(IL-10) levels were measured using enzyme linked immunosorbent assay. The quality of life was assessed using the WHOQOL-BREF. The clinical therapeutic effects and the influences on the patients' quality of life were compared between the two groups. Result The total efficacy rate was 97.2% in the observation group, which was higher than 86.1% in the control group(P<0.05). There were no statistically significant pre-treatment differences in VCAM-1, IL-4, IL-6 and IL-10 levels between the two groups(P>0.05). After treatment, VCAM-1, IL-4, IL-6 and IL-10 levels decreased in both observation and control groups compared with before(P<0.05) and were lower in the observation group than in the control group(P<0.05). After treatment, the physical health, psychological health, social relationships, environment and independent ability scores increased in both observation and control groups compared with before(P<0.05) and were higher in the observation group than in the control group(P<0.05). Conclusion Acupuncture and moxibustion has a definite therapeutic effect on allergic rhinitis. It can reduce the levels of inflammatory factors and improve the patients' quality of life.
Objective To investigate the therapeutic effect of acupuncture and moxibustion on allergic rhinitis and its influence on the patients' quality of life. Method Seventy-two patients with allergic rhinitis were allocated,according to different protocols, to control and observation groups, 36 cases each. The control group received conventional Western drug treatment and the observation group, acupuncture and moxibustion. Both groups were treated for three consecutive months. The effects were evaluated after the completion of treatment. VCAM-1,interleukin-4(IL-4), interleukin-6(IL-6) and interleukin-10(IL-10) levels were measured using enzyme linked immunosorbent assay. The quality of life was assessed using the WHOQOL-BREF. The clinical therapeutic effects and the influences on the patients' quality of life were compared between the two groups. Result The total efficacy rate was 97.2% in the observation group, which was higher than 86.1% in the control group(P<0.05). There were no statistically significant pre-treatment differences in VCAM-1, IL-4, IL-6 and IL-10 levels between the two groups(P>0.05). After treatment, VCAM-1, IL-4, IL-6 and IL-10 levels decreased in both observation and control groups compared with before(P<0.05) and were lower in the observation group than in the control group(P<0.05). After treatment, the physical health, psychological health, social relationships, environment and independent ability scores increased in both observation and control groups compared with before(P<0.05) and were higher in the observation group than in the control group(P<0.05). Conclusion Acupuncture and moxibustion has a definite therapeutic effect on allergic rhinitis. It can reduce the levels of inflammatory factors and improve the patients' quality of life.
引文
[1]张治成,杨晓,杨晓刚.意守式针灸疗法联合枸地氯雷他定治疗中重度间歇性过敏性鼻炎临床疗效及预后分析[J].重庆医学,2016,45(25):3542-3544.
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[4]张桂桃,粱利伟,宋德锋.鼻渊通窍颗粒联合盐酸非索非那定治疗过敏性鼻炎的疗效、预后及血清炎症因子水平分析[J].中国现代医学杂志,2016,26(13):122-125.
[5]陈树煜,吴锡平,何熹,等.过敏性鼻炎对轻度支气管哮喘患者的影响[J].中华结核和呼吸杂志,2017,40(7):540-542.
[6]黄选兆,汪吉宝,孔维佳.实用耳鼻咽喉头颈外科学[M].北京:人民卫生出版社,2008:1328.
[7]陈盼碧,宣锦,史林威,等.热敏灸对过敏性鼻炎大鼠血清Ig E、IL-4含量的影响[J].中国现代医学杂志,2017,27(4):17-21.
[8]张成斌,杨旭平,黄毅岚,等.非索非那定与西替利嗪治疗过敏性鼻炎疗效及安全性的Meta分析[J].中国全科医学,2017,20(8):964-968.
[9]唐雪春,樊佳.运用益气温阳、平喘通窍法治疗成人过敏性鼻炎-哮喘综合征[J].中医杂志,2016,57(7):615-617.
[10]Koatz AM,Coe NA,Cicerán A,et al.Clinical and immunological benefits of OM-85 bacterial lysate in patients with allergic rhinitis,asthma,and copd and recurrent respiratory infections[J].Lung,2016,194(4):687-697.
[11]国家中医药管理局.中医病证诊断疗效标准[S].南京:南京大学出版社,1994:107.
[12]郭惟,何颖贤,张徐文,等.玉屏风散加减辅助治疗过敏性鼻炎的系统评价[J].中国药房,2017,28(21):2947-2950.
[13]朱正阳,戚凯明,宣丽华.不同穴位贴敷对变应性鼻炎患者生活质量影响的比较研究[J].上海针灸杂志,2017,36(12):1396-1400.
[14]Wallace DV,Dykewicz MS,Oppenheimer J,et al Pharmacologic treatment of seasonal allergic rhinitis:synopsis of guidance from the 2017 joint task force on practice parameters[J].Annals of Internal Medicine,2017,167(12):876-881.
[15]玛依努尔·木拉提.温针灸治疗过敏性鼻炎68例疗效观察[J].新疆中医药,2011,29(1):24-25.
[16]林周杰,李克明,梁伟英,等.针灸结合埋线治疗过敏性鼻炎57例临床观察[J].四川中医,2004,22(5):85-86.
[17]林艳霞,范丽英.针灸治疗急性发作期过敏性鼻炎的临床观察[J].海南医学院学报,2011,17(4):508-510.
[18]黄晓梅,贺云鹏,许元文.慢性阻塞性肺疾病-哮喘重叠综合征和COPD患者临床特征的差异性[J].实用医学杂志,2016,32(15):2491-2494.
[19]刘永平,陈蕴光,郑俊斌,等.变应性鼻炎鼻激发后鼻腔分泌物嗜酸性粒细胞增加与血清特异性Ig E水平正相关[J].细胞与分子免疫学杂志,2017,33(1):85-88.
[20]陈勇,汪泽栋,丛文杰.三伏天贴敷治疗过敏性鼻炎随机对照研究[J].上海针灸杂志,2016,35(6):700-703.
[2]唐述权,张乾淑.中医药辅助治疗哮喘合并过敏性鼻炎的疗效观察[J].中国药房,2016,27(23):3255-3256.
[3]Asaria M,Dhami S,Ree RV,et al.Health economic analysis of allergen immunotherapy(AIT)for the management of allergic rhinitis,asthma,food allergy and venom allergy:A systematic overview[J].Allergy,2017,73(2):269.
[4]张桂桃,粱利伟,宋德锋.鼻渊通窍颗粒联合盐酸非索非那定治疗过敏性鼻炎的疗效、预后及血清炎症因子水平分析[J].中国现代医学杂志,2016,26(13):122-125.
[5]陈树煜,吴锡平,何熹,等.过敏性鼻炎对轻度支气管哮喘患者的影响[J].中华结核和呼吸杂志,2017,40(7):540-542.
[6]黄选兆,汪吉宝,孔维佳.实用耳鼻咽喉头颈外科学[M].北京:人民卫生出版社,2008:1328.
[7]陈盼碧,宣锦,史林威,等.热敏灸对过敏性鼻炎大鼠血清Ig E、IL-4含量的影响[J].中国现代医学杂志,2017,27(4):17-21.
[8]张成斌,杨旭平,黄毅岚,等.非索非那定与西替利嗪治疗过敏性鼻炎疗效及安全性的Meta分析[J].中国全科医学,2017,20(8):964-968.
[9]唐雪春,樊佳.运用益气温阳、平喘通窍法治疗成人过敏性鼻炎-哮喘综合征[J].中医杂志,2016,57(7):615-617.
[10]Koatz AM,Coe NA,Cicerán A,et al.Clinical and immunological benefits of OM-85 bacterial lysate in patients with allergic rhinitis,asthma,and copd and recurrent respiratory infections[J].Lung,2016,194(4):687-697.
[11]国家中医药管理局.中医病证诊断疗效标准[S].南京:南京大学出版社,1994:107.
[12]郭惟,何颖贤,张徐文,等.玉屏风散加减辅助治疗过敏性鼻炎的系统评价[J].中国药房,2017,28(21):2947-2950.
[13]朱正阳,戚凯明,宣丽华.不同穴位贴敷对变应性鼻炎患者生活质量影响的比较研究[J].上海针灸杂志,2017,36(12):1396-1400.
[14]Wallace DV,Dykewicz MS,Oppenheimer J,et al Pharmacologic treatment of seasonal allergic rhinitis:synopsis of guidance from the 2017 joint task force on practice parameters[J].Annals of Internal Medicine,2017,167(12):876-881.
[15]玛依努尔·木拉提.温针灸治疗过敏性鼻炎68例疗效观察[J].新疆中医药,2011,29(1):24-25.
[16]林周杰,李克明,梁伟英,等.针灸结合埋线治疗过敏性鼻炎57例临床观察[J].四川中医,2004,22(5):85-86.
[17]林艳霞,范丽英.针灸治疗急性发作期过敏性鼻炎的临床观察[J].海南医学院学报,2011,17(4):508-510.
[18]黄晓梅,贺云鹏,许元文.慢性阻塞性肺疾病-哮喘重叠综合征和COPD患者临床特征的差异性[J].实用医学杂志,2016,32(15):2491-2494.
[19]刘永平,陈蕴光,郑俊斌,等.变应性鼻炎鼻激发后鼻腔分泌物嗜酸性粒细胞增加与血清特异性Ig E水平正相关[J].细胞与分子免疫学杂志,2017,33(1):85-88.
[20]陈勇,汪泽栋,丛文杰.三伏天贴敷治疗过敏性鼻炎随机对照研究[J].上海针灸杂志,2016,35(6):700-703.