bFSH、T、AMH与卵巢储备功能之间关系的探讨
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摘要
目的分析基础卵泡刺激素(bFSH)、基础睾酮水平(T)和抗苗勒氏管激素(AMH)与卵巢储备功能之间的关系。方法在江门市新会人民医院2015年1月-2018年1月正常妇科体检患者中随机选取200例,依照患者年龄分成三组,分别是20~34岁组75例,35~40岁组75例和>40岁组50例,比较三组患者的bFSH、T以及AMH表达变化和患者卵巢储备功能。结果和>40岁组及35~40岁组比较,20~34岁组的bFSH明显偏低,T和AMH明显偏高,差异有统计学意义(P<0.05);和20~34岁组比较,其余两组患者的卵巢功能明显偏低,b FSH和卵巢功能呈负相关,T以及AMH和卵巢功能呈正相关。结论随着女性年龄的增长,卵巢储备功能会出现明显下降,尤其是在35岁以后,通过检测bFSH、T以及AMH表达变化,能够对患者卵巢功能进行一定的预测。
Objective To analyze the relationship between basal follicle stimulating hormone(bFSH), basal testosterone level(T) and anti Mullerian hormone(AMH) and ovarian reserve function. Methods 200 cases of normal gynecological examination patients in Jiangmen Xinhui People's Hospital from January2015 to January 2018 were randomly selected and divided into three groups according to the age of patients: 20-34 years old group with 75 cases, 35-40 years old group with 75 cases and >40 years old group with 50 cases. The changes of the expression of bFSH, T, AMH and the ovarian reserve function of the patients were compared and analyzed. Results Compared with the >40 years old group and the35-40 years old group, the bFSH of the 20-34 years old group was significantly lower, the T value and AMH were obviously higher, and the differences were statistically significant(P<0.05). Compared with the 20-34 years old group, the ovarian functions of the other two groups were significantly lower. The bFSH and ovarian function were negatively correlated, T and AMH were positively correlated with ovarian function. Conclusion With the increase of women's age, ovarian reserve function can be significantly decreased, especially after 35 years of age. By detecting the changqes of bFSH, T and AMH expression,the ovarian function can be predicted.
Objective To analyze the relationship between basal follicle stimulating hormone(bFSH), basal testosterone level(T) and anti Mullerian hormone(AMH) and ovarian reserve function. Methods 200 cases of normal gynecological examination patients in Jiangmen Xinhui People's Hospital from January2015 to January 2018 were randomly selected and divided into three groups according to the age of patients: 20-34 years old group with 75 cases, 35-40 years old group with 75 cases and >40 years old group with 50 cases. The changes of the expression of bFSH, T, AMH and the ovarian reserve function of the patients were compared and analyzed. Results Compared with the >40 years old group and the35-40 years old group, the bFSH of the 20-34 years old group was significantly lower, the T value and AMH were obviously higher, and the differences were statistically significant(P<0.05). Compared with the 20-34 years old group, the ovarian functions of the other two groups were significantly lower. The bFSH and ovarian function were negatively correlated, T and AMH were positively correlated with ovarian function. Conclusion With the increase of women's age, ovarian reserve function can be significantly decreased, especially after 35 years of age. By detecting the changqes of bFSH, T and AMH expression,the ovarian function can be predicted.
引文
[1] Pang RD,Liautaud MM,Leventhal AM,et al.Ovarian Hormones and Tra nsdermal Nicotine Administration Independently and Synergistically Suppress Tobacco Withdrawal Symptoms and Smoking Reinstatement in the Human Laboratory[J].Neuropsychopharmacology:official publication of the American College of Neuropsychopharmacology,2018,43(4):828-837.
[2] Boivin JR.,Piekarski DJ,Wahlberg JK,et al.Age,sex,and gonadal hormones differently influence anxiety-and depression-related behavior during puberty in mice[J].Psychoneuroendocrinology:An International Journal,2017(85):78-87.
[3]李曼,温冬梅,王伟佳,等.AMH、FSH、LH、E2联合检测在不孕症患者卵巢储备功能中的预测价值[J].检验医学与临床,2017(12):1729-1731.
[4]苏占营,吴成亮,辜敏,等.抗苗勒管激素结合性激素、窦卵泡数评估卵巢储备功能应用探讨[J].实验与检验医学,2018,36(5):657-659.
[5]李冰,胡清.腹腔镜辅助卵巢巧克力囊肿剥除术对患者卵巢储备功能的影响[J].中国民康医学,2016(23):8-10.
[6]刘玉兰,宋春侠,暴宏伶,等.益肾化瘀方治疗卵巢储备功能降低临床研究[J].中国中医药信息杂志,2017(3):30-33.
[7]李凤琼,冯琳,韩倩倩.AMH、性激素、AFC联合年龄对不孕症患者卵巢储备功能预测的意义[J].实用妇科内分泌电子杂志,2018,5(14):30-31.
[8]龚衍,曾玖芝,刘伟信,等.年龄、窦卵泡数及相关性激素预测卵巢储备功能正常患者卵巢反应性的价值[J].中国妇幼保健,2017(13):2984-2987.
[2] Boivin JR.,Piekarski DJ,Wahlberg JK,et al.Age,sex,and gonadal hormones differently influence anxiety-and depression-related behavior during puberty in mice[J].Psychoneuroendocrinology:An International Journal,2017(85):78-87.
[3]李曼,温冬梅,王伟佳,等.AMH、FSH、LH、E2联合检测在不孕症患者卵巢储备功能中的预测价值[J].检验医学与临床,2017(12):1729-1731.
[4]苏占营,吴成亮,辜敏,等.抗苗勒管激素结合性激素、窦卵泡数评估卵巢储备功能应用探讨[J].实验与检验医学,2018,36(5):657-659.
[5]李冰,胡清.腹腔镜辅助卵巢巧克力囊肿剥除术对患者卵巢储备功能的影响[J].中国民康医学,2016(23):8-10.
[6]刘玉兰,宋春侠,暴宏伶,等.益肾化瘀方治疗卵巢储备功能降低临床研究[J].中国中医药信息杂志,2017(3):30-33.
[7]李凤琼,冯琳,韩倩倩.AMH、性激素、AFC联合年龄对不孕症患者卵巢储备功能预测的意义[J].实用妇科内分泌电子杂志,2018,5(14):30-31.
[8]龚衍,曾玖芝,刘伟信,等.年龄、窦卵泡数及相关性激素预测卵巢储备功能正常患者卵巢反应性的价值[J].中国妇幼保健,2017(13):2984-2987.