参七脑康胶囊联合奥扎格雷钠治疗急性脑梗死的临床研究
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摘要
目的探讨参七脑康胶囊联合奥扎格雷钠氯化钠注射液治疗急性脑梗死的临床疗效。方法选取2016年1月—2017年12月天津市宁河区医院收治的100例急性脑梗死患者作为研究对象,将患者随机分为对照组和治疗组,每组各50例。对照组患者静脉滴注奥扎格雷钠氯化钠注射液,250 mL/次,2次/d。治疗组在对照组治疗的基础上口服参七脑康胶囊,2 g/次,3次/d。2周为1个疗程,两组均治疗2个疗程。观察两组患者的临床疗效,同时比较两组治疗前后的美国国立卫生研究院卒中量表(NIHSS)评分、简易智力状态检查量表(MMSE)评分、Barthel指数和血液流变学指标。结果治疗后,治疗组的总有效率为92.00%,显著高于对照组的74.00%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者NIHSS评分显著降低,MMSE评分和Barthel指数显著升高,同组治疗前后比较差异具有统计学意义(P<0.05);治疗后,治疗组NIHSS评分明显低于对照组,MMSE评分和Barthel指数显著高于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者红细胞压积(HCT)、全血高切黏度(HBV)、全血低切黏度(LBV)、血浆比黏度(PV)和纤维蛋白原(FIB)水平均显著降低,同组治疗前后比较差异具有统计学意义(P<0.05);治疗后,治疗组患者血液流变学指标水平明显低于对照组,两组比较差异具有统计学意义(P<0.05)。结论参七脑康胶囊联合奥扎格雷钠氯化钠注射液治疗急性脑梗死的具有较好的临床疗效,可改善患者神经损伤情况和血液流变状态,安全性较高,具有一定的临床推广使用价值。
Objective To investigate the clinical effect of Shenqi Naokang Capsules combined with Sodium Ozagrel and Sodium Chloride Injection in treatment of acute cerebral infarction. Methods Patients(100 cases) with acute cerebral infarction in Tianjin Ninghe District Hospital from January 2016 to December 2017 were divided into control and treatment groups, and each group had 50 cases. Patients in the control group were iv administered with Sodium Ozagrel and Sodium Chloride Injection, 250 mL/time, twice daily. Patients in the treatment group were po administered with Shenqi Naokang Capsules on the basis of control group, 2 g/time,three times daily. A course of treatment had 2 weeks, and patients were treated for 2 courses. After treatment, the clinical efficacy was evaluated, and the NIHSS, MMSE scores, Barthel index, and hemorheology indexes in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the treatment group was 92.00%, which was significantly higher than74.00% in the control group, and there were differences between two groups(P < 0.05). After treatment, NIHSS in two groups were significantly decreased, but MMSE score and Barthel index were increased, and the difference was statistically significant in the same group(P < 0.05). After treatment, NIHSS in the treatment groups were significantly lower than that in the control group, but the MMSE score and Barthel index were higher than those in the control group, with significant difference between two groups(P <0.05). After treatment, HCT, HBV, LBV, PV, and FIB levels in two groups were significantly decreased, and the difference was statistically significant in the same group(P < 0.05). After treatment, the hemorheology indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups(P < 0.05). Conclusion Shenqi Naokang Capsules combined with Sodium Ozagrel and Sodium Chloride Injection has good clinical efficacy in treatment of acute cerebral infarction, can improve the nerve injury and hemorheological status, with high safety, which has a certain clinical application value.
Objective To investigate the clinical effect of Shenqi Naokang Capsules combined with Sodium Ozagrel and Sodium Chloride Injection in treatment of acute cerebral infarction. Methods Patients(100 cases) with acute cerebral infarction in Tianjin Ninghe District Hospital from January 2016 to December 2017 were divided into control and treatment groups, and each group had 50 cases. Patients in the control group were iv administered with Sodium Ozagrel and Sodium Chloride Injection, 250 mL/time, twice daily. Patients in the treatment group were po administered with Shenqi Naokang Capsules on the basis of control group, 2 g/time,three times daily. A course of treatment had 2 weeks, and patients were treated for 2 courses. After treatment, the clinical efficacy was evaluated, and the NIHSS, MMSE scores, Barthel index, and hemorheology indexes in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the treatment group was 92.00%, which was significantly higher than74.00% in the control group, and there were differences between two groups(P < 0.05). After treatment, NIHSS in two groups were significantly decreased, but MMSE score and Barthel index were increased, and the difference was statistically significant in the same group(P < 0.05). After treatment, NIHSS in the treatment groups were significantly lower than that in the control group, but the MMSE score and Barthel index were higher than those in the control group, with significant difference between two groups(P <0.05). After treatment, HCT, HBV, LBV, PV, and FIB levels in two groups were significantly decreased, and the difference was statistically significant in the same group(P < 0.05). After treatment, the hemorheology indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups(P < 0.05). Conclusion Shenqi Naokang Capsules combined with Sodium Ozagrel and Sodium Chloride Injection has good clinical efficacy in treatment of acute cerebral infarction, can improve the nerve injury and hemorheological status, with high safety, which has a certain clinical application value.
引文
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[6]全国第四届脑血管病学术会议.脑卒中患者临床神经功能缺损程度评分标准(1995)[J].中华神经科杂志,1996, 29(6):381-383.
[7]张继红,田开语,李雪松,等.MMSE量表联合Barthel指数在老年脑卒中患者认知障碍评价中的应用[J].中国伤残医学, 2012, 20(5):30-32.
[8]高社荣.奥扎格雷钠与低分子肝素联合治疗进展性脑梗死的疗效观察[J].临床神经病学杂志,2005,18(1):65-68.
[9]常玉荣,薄海美,孙尚帛,等.急性脑梗死患者血栓前状态实验室检测指标的临床意义[J].现代预防医学,2010, 37(20):3948-3949, 3955.
[2]杨新荣,王正银,龙景波,等.依达拉奉联合奥扎格雷钠治疗急性脑梗死[J].重庆医学,2010,39(11):1446-1447.
[3]吴云.参七脑康胶囊治疗脑外伤后综合征临床疗效观察[J].中国卫生产业, 2014(9):165-166.
[4]中华医学会第四届全国脑血管病学术会议.各类脑血管疾病诊断要点[J].中华神经科杂志,1996,29(6):379-380.
[5]郑筱萸.中药新药临床研究指导原则(试行)[M].北京:中国医药科技出版社, 2002:104.
[6]全国第四届脑血管病学术会议.脑卒中患者临床神经功能缺损程度评分标准(1995)[J].中华神经科杂志,1996, 29(6):381-383.
[7]张继红,田开语,李雪松,等.MMSE量表联合Barthel指数在老年脑卒中患者认知障碍评价中的应用[J].中国伤残医学, 2012, 20(5):30-32.
[8]高社荣.奥扎格雷钠与低分子肝素联合治疗进展性脑梗死的疗效观察[J].临床神经病学杂志,2005,18(1):65-68.
[9]常玉荣,薄海美,孙尚帛,等.急性脑梗死患者血栓前状态实验室检测指标的临床意义[J].现代预防医学,2010, 37(20):3948-3949, 3955.