中药治疗动脉粥样硬化的作用机制
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摘要
动脉粥样硬化是心血管系统中最常见的疾病。近年,对于动脉粥样硬化的研究进展十分迅速,中药因副作用小、效果好而备受关注。本文将从调节脂质代谢、抑制血管平滑肌细胞的增殖和迁移、抗血小板凝集、抗炎以及保护血管内皮的作用来综述中药治疗动脉粥样硬化的研究进展。
引文
[1]FENG X,NIE X B,SHI J P,et al.Quercetin inhibits LPS-induced inflammation and ox-LDL-induced lipid deposition[J].Front Pharmacol,2017,8:40.
[2]王姗姗.清热解毒中药干预动脉粥样硬化的研究进展[J].中西医结合心脑血管病杂志,2017,15(8):935-938.
[3]丁小朋,丁碧云.中医药对高LDL-C血症促动脉粥样硬化形成干预作用研究[J].中医药临床杂志,2017,29(10):1770-1773.
[4]吕文轩,范思佳,李文耀,等.参红通络颗粒对Apo E(-/-)小鼠动脉粥样硬化斑块内细胞凋亡的影响及其抗动脉粥样硬化作用机制[J].吉林大学学报(医学版),2016,42(5):882-886.
[5]YANG K,ZHANG H J,LUO Y,et al.Gypenoside XⅦprevents atherosclerosis by attenuating endothelial apoptosis and oxidative stress:insight into the ERα-mediated PI3K/Akt pathway[J].Int J Mol Sci,2017,18(2):77.
[6]ZHANG Z K,LI J,YAN D X,et al.Icaritin inhibits collagen degradation-related factors and facilitates collagen accumulation in atherosclerotic lesions:a potential action for plaque stabilization[J].Int J Mol Sci,2016,17(2):169.
[7]WANG D Q,ZHUANG Y,TIAN Y P,et al.Study of the effects of total flavonoids of astragalus on atherosclerosis formation and potential mechanisms[J].Oxid Med Cell Longev,2012,2012:282-383.
[8]客蕊,周婷,赵志成.中药复方治疗动脉粥样硬化机制研究进展[J].江苏中医药,2017,49(2):83-85.
[9]闫红梅,李覃,周欣,等.中医药抗动脉粥样硬化作用机制的研究进展[J].武警后勤学院学报(医学版),2016,25(9):760-763.
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[11]WU W Y,WANG Y P.Pharmacological actions and therapeutic applications of Salvia miltiorrhiza depside salt and its active components[J].Acta Pharmacol Sin,2012,33(9):1119-1130.
[12]喻志慧,陈煜森.血小板在动脉粥样硬化中作用的研究进展[J].医学综述,2015,21(5):799-801.
[13]DUAN L,XIONG X J,HU J Y,et al.Panax notoginseng saponins for treating coronary artery disease:a functional and mechanistic overview[J].Front Pharmacol,2017,8:702.
[14]LIU D S,WANG S L,LI J M,et al.Allicin improves carotid artery intima-media thickness in coronary artery disease patients with hyperhomocysteinemia[J].Exp Ther Med,2017,14(2):1722-1726.
[15]姜华,姜玉姬.3种不同治法的中药复方防治动脉粥样硬化的机制研究[J].中国中西医结合杂志,2015,35(10):1244-1248.
[16]周岚,李杨,汪典,等.利用基因芯片分析活血中药、破血中药对Apo E基因敲除小鼠动脉粥样硬化模型的差异表达基因[J].疑难病杂志,2017,16(1):18-22.
[17]胡刚,王道成,薛刚,等.通心痹合剂对实验性动脉粥样硬化家兔血清炎症标志物的影响[J].吉林中医药,2016,36(12):1251-1253.
[18]WU X L,ZHENG B,JIN L S,et al.Chinese medicine Tongxinluo reduces atherosclerotic lesion by attenuating oxidative stress and inflammation in microvascular endothelial cells[J].Int J Clin Exp Pathol,2015,8(6):6323-6333.
[19]CHENG L,PAN G F,ZHANG X D,et al.Yindanxinnaotong,a Chinese compound medicine,synergistically attenuates atherosclerosis progress[J].Sci Rep,2015,5:12333.
[20]REN Y,QIAO W,FU D L,et al.Traditional Chinese medicine protects against cytokine production as the potential immunosuppressive agents in atherosclerosis[J].J Immunol Res,2017,2017:7424307.
[21]孙续鹏,朱艳琴,高爱社.中药治疗动脉粥样硬化的研究进展[J].国医论坛,2016,31(3):66-68.
[22]李炳东,于开军,刘晓波,等脑心通胶囊对动脉粥样硬化家兔血管内皮功能的影响[J].辽宁中医杂志,2014,41(11):2481-2483.
[23]LIU Y,HAO F,ZHANG H G,et al.Panax notoginseng saponins promote endothelial progenitor cell mobilization and attenuate atherosclerotic lesions in apolipoprotein Eknockout mice[J].Cell Physiol Biochem,2013,32(4):814-826.
[2]王姗姗.清热解毒中药干预动脉粥样硬化的研究进展[J].中西医结合心脑血管病杂志,2017,15(8):935-938.
[3]丁小朋,丁碧云.中医药对高LDL-C血症促动脉粥样硬化形成干预作用研究[J].中医药临床杂志,2017,29(10):1770-1773.
[4]吕文轩,范思佳,李文耀,等.参红通络颗粒对Apo E(-/-)小鼠动脉粥样硬化斑块内细胞凋亡的影响及其抗动脉粥样硬化作用机制[J].吉林大学学报(医学版),2016,42(5):882-886.
[5]YANG K,ZHANG H J,LUO Y,et al.Gypenoside XⅦprevents atherosclerosis by attenuating endothelial apoptosis and oxidative stress:insight into the ERα-mediated PI3K/Akt pathway[J].Int J Mol Sci,2017,18(2):77.
[6]ZHANG Z K,LI J,YAN D X,et al.Icaritin inhibits collagen degradation-related factors and facilitates collagen accumulation in atherosclerotic lesions:a potential action for plaque stabilization[J].Int J Mol Sci,2016,17(2):169.
[7]WANG D Q,ZHUANG Y,TIAN Y P,et al.Study of the effects of total flavonoids of astragalus on atherosclerosis formation and potential mechanisms[J].Oxid Med Cell Longev,2012,2012:282-383.
[8]客蕊,周婷,赵志成.中药复方治疗动脉粥样硬化机制研究进展[J].江苏中医药,2017,49(2):83-85.
[9]闫红梅,李覃,周欣,等.中医药抗动脉粥样硬化作用机制的研究进展[J].武警后勤学院学报(医学版),2016,25(9):760-763.
[10]SEO C S,KIM O S,KIM J H,et al.Simultaneous quantification and antiatherosclerosis effect of the traditional Korean medicine,Hwangryunhaedok-tang[J].BMC Complement Altern Med,2015,15:108.
[11]WU W Y,WANG Y P.Pharmacological actions and therapeutic applications of Salvia miltiorrhiza depside salt and its active components[J].Acta Pharmacol Sin,2012,33(9):1119-1130.
[12]喻志慧,陈煜森.血小板在动脉粥样硬化中作用的研究进展[J].医学综述,2015,21(5):799-801.
[13]DUAN L,XIONG X J,HU J Y,et al.Panax notoginseng saponins for treating coronary artery disease:a functional and mechanistic overview[J].Front Pharmacol,2017,8:702.
[14]LIU D S,WANG S L,LI J M,et al.Allicin improves carotid artery intima-media thickness in coronary artery disease patients with hyperhomocysteinemia[J].Exp Ther Med,2017,14(2):1722-1726.
[15]姜华,姜玉姬.3种不同治法的中药复方防治动脉粥样硬化的机制研究[J].中国中西医结合杂志,2015,35(10):1244-1248.
[16]周岚,李杨,汪典,等.利用基因芯片分析活血中药、破血中药对Apo E基因敲除小鼠动脉粥样硬化模型的差异表达基因[J].疑难病杂志,2017,16(1):18-22.
[17]胡刚,王道成,薛刚,等.通心痹合剂对实验性动脉粥样硬化家兔血清炎症标志物的影响[J].吉林中医药,2016,36(12):1251-1253.
[18]WU X L,ZHENG B,JIN L S,et al.Chinese medicine Tongxinluo reduces atherosclerotic lesion by attenuating oxidative stress and inflammation in microvascular endothelial cells[J].Int J Clin Exp Pathol,2015,8(6):6323-6333.
[19]CHENG L,PAN G F,ZHANG X D,et al.Yindanxinnaotong,a Chinese compound medicine,synergistically attenuates atherosclerosis progress[J].Sci Rep,2015,5:12333.
[20]REN Y,QIAO W,FU D L,et al.Traditional Chinese medicine protects against cytokine production as the potential immunosuppressive agents in atherosclerosis[J].J Immunol Res,2017,2017:7424307.
[21]孙续鹏,朱艳琴,高爱社.中药治疗动脉粥样硬化的研究进展[J].国医论坛,2016,31(3):66-68.
[22]李炳东,于开军,刘晓波,等脑心通胶囊对动脉粥样硬化家兔血管内皮功能的影响[J].辽宁中医杂志,2014,41(11):2481-2483.
[23]LIU Y,HAO F,ZHANG H G,et al.Panax notoginseng saponins promote endothelial progenitor cell mobilization and attenuate atherosclerotic lesions in apolipoprotein Eknockout mice[J].Cell Physiol Biochem,2013,32(4):814-826.