β受体阻滞剂治疗射血分数保留性心力衰竭的网络meta分析
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摘要
目的采用网络meta分析方法评价不同的β受体阻滞剂对射血分数保留性心衰的治疗效果。方法计算机检索8个电子数据库中与射血分数保留性心力衰竭相关的随机对照试验,由2位评价员独立筛选文章、提取数据和评价纳入研究的风险偏倚后采用R 3.4.3软件Gemtc、Rjags包和STATA 14软件进行网络meta分析。结果共纳入50个随机对照试验,包括4 089例患者。与未使用β受体阻滞剂相比,使用β受体阻滞剂能显著提高临床有效率、降低心率(P<0.05);控制血压方面,美托洛尔、卡维地洛和阿罗洛尔效果优于未使用β受体阻滞剂(P<0.05);在改善E/A比值方面,美托洛尔、卡维地洛和比索洛尔的效果优于未使用β受体阻滞剂(P<0.05)。累计排名曲线下面积值对干预措施排序显示卡维地洛疗效最好。结论现有证据表明卡维地洛可能是应用前景较好的药物,但由于受纳入研究数量和质量的限制,本研究结论尚需开展更多高质量研究予以证实。
OBJECTIVE To evaluate the effect of different β-blockers for the efficacy of ejection fraction preserved heart failure by network meta-analysis. METHODS Eight databases were searched for randomized controlled trials(RCTs) of different β-blockers for patients with ejection fraction preserved heart failure. Two reviewers independently screened literature,extracted data and assessed the risk of bias of included studies. Statistical analysis was performed by STATA 14 software and R3.4.3 software, gemtc and rjags packages. RESULTS A total of 50 RCTs involving 4 089 patients were included. The results of network meta-analysis showed that compared with not use β-blockers, β-blockers could improve clinical efficacy, reduce heart rate(P<0.05). In the control of blood pressure, the effects of metoprolol, carvedilol, and arotinolol were better than those withoutβ-blockers(P<0.05). The results of area under the cumulative ranking curve which ranked effectiveness of all β-blockers showed that carvedilol had the best effectiveness. CONCLUSION The current evidence shows that carvedilol may be effective in heart failure with reduced ejection fraction treatment. Due to limited quality and quantity of the included studies, more high-quality studies are needed to verify the above conclusion.
OBJECTIVE To evaluate the effect of different β-blockers for the efficacy of ejection fraction preserved heart failure by network meta-analysis. METHODS Eight databases were searched for randomized controlled trials(RCTs) of different β-blockers for patients with ejection fraction preserved heart failure. Two reviewers independently screened literature,extracted data and assessed the risk of bias of included studies. Statistical analysis was performed by STATA 14 software and R3.4.3 software, gemtc and rjags packages. RESULTS A total of 50 RCTs involving 4 089 patients were included. The results of network meta-analysis showed that compared with not use β-blockers, β-blockers could improve clinical efficacy, reduce heart rate(P<0.05). In the control of blood pressure, the effects of metoprolol, carvedilol, and arotinolol were better than those withoutβ-blockers(P<0.05). The results of area under the cumulative ranking curve which ranked effectiveness of all β-blockers showed that carvedilol had the best effectiveness. CONCLUSION The current evidence shows that carvedilol may be effective in heart failure with reduced ejection fraction treatment. Due to limited quality and quantity of the included studies, more high-quality studies are needed to verify the above conclusion.
引文
[1]OWAN T E,HODGE D O,HERGES R M,et al.Trends in prevalence and outcome of heart failure with preserved ejection fraction[J].New Eng J Med,2006,355(3):251-259.
[2]DICKSTEIN K,COHEN-SOLAL A,FILIPPATOS G,et al.ESC Guidelines for the Diagnosis And Treatment of Acute And Chronic Heart Failure 2008:The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure2008 of the European Society of Cardiology.Developed in collaboration with the Heart Failure Association of the ESC(HFA)and endorsed by the European Society of Intensive Care Medicine(ESICM)[J].Revista Espa?ola de Cardiología(English Edition),2008,61(12):1329.
[3]HIGGINS J P T,GREEN S.Cochrane handbook for systematic reviews of interventions version 5.1.0[K/OL].The Cochrane Collaboration,2011.Available at:http://www.handbook.cochrane.org/.
[4]SALANTI G,ADES A E,IOANNIDIS J P.Graphical methods and numerical summaries for presenting results from multiple-treatment meta-analysis:an overview and tutorial[J].J Clin Epidemiol,2011,64(2):163-171.
[5]BERGSTROM A,ANDERSSON B,EDNER M,et al.Effect of carvedilol on diastolic function in patients with diastolic heart failure and preserved systolic function.Results of the Swedish Doppler-echocardiographic study(SWEDIC)[J].Eur J Heart Fail,2004,6(4):453-461.
[6]CONRAADS V M,METRA M,KAMP O,et al.Effects of the long-term administration of nebivolol on the clinical symptoms,exercise capacity,and left ventricular function of patients with diastolic dysfunction:results of the ELANDDstudy[J].Eur J Heart Fail,2012,14(2):219-225.
[7]GHIO S,MAGRINI G,SERIO A,et al.Effects of nebivolol in elderly heart failure patients with or without systolic left ventricular dysfunction:results of the SENIORSechocardiographic substudy[J].Eur Heart J,2006,27(5):562-568.
[8]KAMP O,SIESWERDA G T,VISSER C A.Comparison of effects on systolic and diastolic left ventricular function of nebivolol versus atenolol in patients with uncomplicated essential hypertension[J].Am J Cardiol,2003,92(3):344-348.
[9]NODARI S,METRA M,DEI CAS L.Beta-blocker treatment of patients with diastolic heart failure and arterial hypertension.A prospective,randomized,comparison of the long-term effects of atenolol vs.nebivolol[J].Eur J Heart Fail,2003,5(5):621-627.
[10]付红钢.倍他乐克片联合贝拉普利治疗左室射血分数正常心力衰竭的临床观察[J].中外医学研究,2016,14(30):16-17.
[11]高彦,潘娅萍,吕云.美托洛尔缓释片治疗原发性高血压并舒张性心力衰竭的疗效观察[J].中外医疗,2013,32(22):101+3.
[12]郜黎伟.倍他乐克治疗舒张性心力衰竭的疗效观察[J].中国交通医学杂志,2004,18(1):25-26.
[13]耿文学.比索洛尔对老年高血压患者舒张功能的影响[J].河北医药,2010,32(1):35-36.
[14]郝德靖,罗莉,何鹏,等.络活喜与阿替洛尔联合治疗舒张功能不全性心力衰竭[J].中国厂矿医学,2003,16(5):20-21.
[15]蒋永丰,刘小红,龙晓彬,等.贝那普利联合美托洛尔治疗左室射血分数正常心力衰竭的临床疗效[J].临床合理用药杂志,2015(36):41-42.
[16]李飞,袁勇,董剑廷,等.比索洛尔对高血压合并舒张性心力衰竭患者左心室舒张功能的影响[J].中华高血压杂志,2012,20(12):1178-1180.
[17]李骞,叶伟祥.美托洛尔缓释片治疗原发性高血压合并射血分数保留型心力衰竭的疗效观察[J].中国校医,2017,31(9):684-685.
[18]LI J W,LI H Y,LI G X,et al.Clinical efficacy of arotinolo in treaing elderly diastolic heart failur and the impact on cardiac function of patients[J].Chin J Clin Ration Drug Use,2017(24):3-5.
[19]LI W D.Study on clinical treatment of primary hypertension complicated with diastolic heart failure[J].China Health Standard Manage(中国卫生标准管理),2015(11):181-182.
[20]李晓杰,梁明,陈国俊.卡维地洛对老年慢性舒张性心力衰竭的影响[J].中华老年心脑血管病杂志,2009,11(9):734-735.
[21]LI X Z,SONG S M.Effect of metoprolol to patients diastolic heart failure cardiac function[J].Guid China Med(中国医药指南),2016(4):27.
[22]李阳,王晓强,刘亚宁.倍他乐克片联合贝拉普利治疗左室射血分数正常心力衰竭的临床观察[J].社区医学杂志,2016,14(2):64-66.
[23]李咏梅,牛敬宪.2型糖尿病伴左室舒张功能不全患者使用比索洛尔后B型尿钠肽(BNP)与左室舒张功能的变化分析[J].中国保健营养,2016,26(17):403-404.
[24]LIU G,XIA Y,LU G S,et al.The efficacy of Bisoprolol on the diastolic heart failure in the elderly hypertensive patients[J].Chin J Cardiol(中华心血管病杂志),2004,32(z2):293-295.
[25]LIU R T.The curative effect of carvedilol compared with metoprolol on acute diastolic heart failure[J].Pract J Cardiac Cerebral Pneumal Vascul Dis(实用心脑肺血管病杂志),2012,20(3):441-442.
[26]刘小珍,杨友星.美托洛尔缓释片治疗原发性高血压并舒张性心力衰竭的疗效观察[J].当代医学,2011,17(6):140-141.
[27]马丹.福辛普利与比索洛尔联合治疗舒张性心力衰竭的疗效观察[J].现代中西医结合杂志,2011,20(17):2140-2141.
[28]NI J H.Study of Bisoprolol in treatment of hypertension intervention of left ventricular remodeling in chronic heart failure[J].Medical Innovation of China(中国医学创新),2013(16):30-31.
[29]钱彩珍,顾国清.卡维地洛治疗老年射血分数正常的心力衰竭疗效观察[J].浙江医学,2010,32(6):872-874.
[30]SANG G S,SUN B L,FENG Y X,et al.Clinical evaluation of bisoprolol for treatment of diastolic heart failure[J].J Bengbu Med Coll(蚌埠医学院学报),2002,27(6):496-498.
[31]SHI Y Y,LIU L,DAI W B.Curative effects of arotinoloon treatment for middle aged hypertensive with diastolic heart failure[J].J Pract Med Tech(实用医技杂志),2015(2):117-119.
[32]孙琳琳.美托洛尔缓释片治疗原发性高血压并舒张性心力衰竭的临床效果分析[J].当代医学,2016,22(24):153-154.
[33]孙卫东.美托洛尔缓释片治疗原发性高血压并舒张性心力衰竭的临床效果分析[J].中国农村卫生,2015(20):24-25.
[34]唐桂红.美托洛尔缓释片治疗原发性高血压并舒张性心力衰竭的临床疗效[J].中国现代药物应用,2015,9(20):113-114.
[35]王为风.倍他乐克治疗舒张性心力衰竭22例疗效分析[J].吉林医学,2011,32(30):6376.
[36]魏建国,杨巧芳,吴虹.比索洛尔治疗舒张性心力衰竭[J].医药论坛杂志,2005,26(16):59.
[37]吴礼泓,陈友良,梅凤莲,刘春燕.比索洛尔和培哚普利联合治疗舒张功能不全的疗效观察[J].兵团医学,2012(1):33-34.
[38]肖国辉,梁荷华.比索洛尔对高血压合并糖尿病患者左室舒张功能的影响[J].江西医药,2013,48(4):346-347.
[39]XIE Y,JIANG J f.Metoprolol extended-release tablets in treatment of heart failure with preserved ejection fraction[J].JTongji Univ(Med Sci),2012,33(4):78-82.
[40]徐涛.卡维地洛在舒张性心力衰竭患者中的应用[J].山东医药,2014(25):75-76.
[41]YANG Y H,HUANG Q N,YE J F,et al.Influence of Bisoprolol on brain natriuretic peptide and left ventricular diastolic function in patients with type 2 diabetes and left ventricular diastolic dysfunction[J].Chin Gen Pract(中国全科医学),2013,16(31):3683-3685.
[42]YANG Y,FENG D H,WANG J X,et al.Therapeutic effect of Carvedilol on diastolic heart failure of elder patients[J].China Mod Med(中国当代医药),2012,19(18):90-91.
[43]YE B H,LI A Y,ZHU X Y.Carvedilol on the management of diastolic heart failure[J].Chin J Cardiovasc Rev(中国心血管病研究杂志),2005,3(11):43-45.
[44]于力,汤月霞,王崇屹.氨氯地平和美托洛尔联合治疗舒张功能不全性心力衰竭[J].心脏杂志,2002,14(2):177.
[45]张琮.比索洛尔联合常规综合治疗对左心室射血分数保留的心力衰竭患者心功能及神经内分泌因子的影响[J].中国老年学杂志,2016,36(12):2900-2902.
[46]ZHANG H T,SHAO H,ZHAO Y J,et al.Efficiency comparison between carvedilol and bisoprolol in senile patients with chronic diastolic heart failure[J].Clin Focus(临床荟萃),2014,29(2):171-174.
[47]ZHANG H L.Clinical study on treatment of primary hypertention combine with diastolic heart failure[J].China Health Standard Manage(中国卫生标准管理),2015(13):102-103.
[48]张青青,李欣.β受体阻滞剂治疗射血分数保留心衰的临床效果[J].安徽卫生职业技术学院学报,2016,15(5):52-53.
[49]ZHEN Y Z.Clinical trial of bisoprolol combined with trimetazidine in the treatment of heart failure with preserved left ventricular ejection fraction[J].Chin J Clin Pharmacol(中国临床药理学杂志),2016,32(19):1735-1737,1741.
[50]ZHEN Y Z,DENG Y D,DUAN L N,et al.The effects of bisoprolol on chromaffin grain protein A and cardiac function of heart failure patients with preserved left ventricular ejection fraction[J].Chin J Evid Based Cardiovasc Med(中国循证心血管医学杂志),2016,8(8):919-921.
[51]ZHEN Y Z,DENG Y D,LI L Z,et al.Effects of bisoprolol on neuroendocrine hormones in patients with heart failure with preserved left ventricular ejection fraction[J].Chin J Clin Pharmacol(中国临床药理学杂志),2015,31(15):1471-1474.
[52]ZHEN Y Z,DUAN L N,LIU C,et al.Curative observation of bisoprolol in heart failure patients with preserved left ventricular ejection fraction[J].Chin J Evid Based Cardiovasc Med d(中国循证心血管医学杂志),2016,8(4):442-444,447.
[53]ZHENG Y,MENG L,DONG J S,et al.Effect of carvedilol on heart function and glucolipometabolic in elder patients with diastolic heart failure[J].J Jilin Univ(Med Ed)(吉林大学学报:医学版),2009,35(6):1111-1114.
[54]ZHU H Z,CHEN J J,PAN Q M.Effects of bisoprolol on vascular endothelial function and left ventricular diastolic function in hypertension complicated with diastolic heart failure[J].China Pharm(中国药业),2015(11):38-39,40.
[55]GANDHI S K,POWERS J C,NOMEIR A M,et al.The pathogenesis of acute pulmonary edema associated with hypertension[J].New Engl J Med,2001,344(1):17-22.
[56]LAM C S,DONAL E,KRAIGHER-KRAINER E,et al.Epidemiology and clinical course of heart failure with preserved ejection fraction[J].Eur J Heart Fail,2011,13(1):18-28.
[57]LEVY D,LARSON M G,VASAN R S,et al.The progression from hypertension to congestive heart failure[J].Jama,1996,275(20):1557-1562.
[58]BAKER D W.Prevention of heart failure[J].J Card Fail,2002,8(5):333-346.
[59]KOBAYASHI M,MACHIDA N,TANAKA R,et al.Effects of beta-blocker on left ventricular remodeling in rats with volume overload cardiac failure[J].J Vet Med Sci,2008,70(11):1231-1237.
[60]PFISTER R,ERDMANN E,SCHNEIDER C A.Association and prognostic impact of heart rate and micro-albuminuria in patients with type 2 diabetes and cardiovascular disease:results from the PROactive trial[J].J Atheroscler Thromb,2011,18(1):65-71.
[61]KAPOOR J R,HEIDENREICH P A.Heart rate predicts mortality in patients with heart failure and preserved systolic function[J].J Card Fail,2010,16(10):806-811.
[62]PARAKH N,BHARGAVA B.Rate control with ivabradine:angina pectoris and beyond[J].Am J Cardiovasc Drugs,2011,11(1):1-12.
[63]HERNANDEZ A F,HAMMILL B G,O’CONNOR C M,et al.Clinical effectiveness of beta-blockers in heart failure:findings from the OPTIMIZE-HF(Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with Heart Failure)Registry[J].J Am Coll Cardiol,2009,53(2):184-192.
[64]FLATHER M D,SHIBATA M C,COATS A J,et al.Randomized trial to determine the effect of nebivolol on mortality and cardiovascular hospital admission in elderly patients with heart failure(SENIORS)[J].Eur Heart J,2005,26(3):215-225.
[65]HORI M,KITABATAKE A,TSUTSUI H,et al.Rationale and design of a randomized trial to assess the effects of beta-blocker in diastolic heart failure;Japanese Diastolic Heart Failure Study(J-DHF)[J].J Card Fail,2005,11(7):542-547.
[66]WIYSONGE C S,BRADLEY H,MAYOSI B M,et al.Beta-blockers for hypertension[J].Cochrane Database Syst Rev,2017(1):CD002003.
[67]BAVISHI C,CHATTERJEE S,ATHER S,et al.Beta-blockers in heart failure with preserved ejection fraction:a meta-analysis[J].Heart Fail Rev,2015,20(2):193-201.
[2]DICKSTEIN K,COHEN-SOLAL A,FILIPPATOS G,et al.ESC Guidelines for the Diagnosis And Treatment of Acute And Chronic Heart Failure 2008:The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure2008 of the European Society of Cardiology.Developed in collaboration with the Heart Failure Association of the ESC(HFA)and endorsed by the European Society of Intensive Care Medicine(ESICM)[J].Revista Espa?ola de Cardiología(English Edition),2008,61(12):1329.
[3]HIGGINS J P T,GREEN S.Cochrane handbook for systematic reviews of interventions version 5.1.0[K/OL].The Cochrane Collaboration,2011.Available at:http://www.handbook.cochrane.org/.
[4]SALANTI G,ADES A E,IOANNIDIS J P.Graphical methods and numerical summaries for presenting results from multiple-treatment meta-analysis:an overview and tutorial[J].J Clin Epidemiol,2011,64(2):163-171.
[5]BERGSTROM A,ANDERSSON B,EDNER M,et al.Effect of carvedilol on diastolic function in patients with diastolic heart failure and preserved systolic function.Results of the Swedish Doppler-echocardiographic study(SWEDIC)[J].Eur J Heart Fail,2004,6(4):453-461.
[6]CONRAADS V M,METRA M,KAMP O,et al.Effects of the long-term administration of nebivolol on the clinical symptoms,exercise capacity,and left ventricular function of patients with diastolic dysfunction:results of the ELANDDstudy[J].Eur J Heart Fail,2012,14(2):219-225.
[7]GHIO S,MAGRINI G,SERIO A,et al.Effects of nebivolol in elderly heart failure patients with or without systolic left ventricular dysfunction:results of the SENIORSechocardiographic substudy[J].Eur Heart J,2006,27(5):562-568.
[8]KAMP O,SIESWERDA G T,VISSER C A.Comparison of effects on systolic and diastolic left ventricular function of nebivolol versus atenolol in patients with uncomplicated essential hypertension[J].Am J Cardiol,2003,92(3):344-348.
[9]NODARI S,METRA M,DEI CAS L.Beta-blocker treatment of patients with diastolic heart failure and arterial hypertension.A prospective,randomized,comparison of the long-term effects of atenolol vs.nebivolol[J].Eur J Heart Fail,2003,5(5):621-627.
[10]付红钢.倍他乐克片联合贝拉普利治疗左室射血分数正常心力衰竭的临床观察[J].中外医学研究,2016,14(30):16-17.
[11]高彦,潘娅萍,吕云.美托洛尔缓释片治疗原发性高血压并舒张性心力衰竭的疗效观察[J].中外医疗,2013,32(22):101+3.
[12]郜黎伟.倍他乐克治疗舒张性心力衰竭的疗效观察[J].中国交通医学杂志,2004,18(1):25-26.
[13]耿文学.比索洛尔对老年高血压患者舒张功能的影响[J].河北医药,2010,32(1):35-36.
[14]郝德靖,罗莉,何鹏,等.络活喜与阿替洛尔联合治疗舒张功能不全性心力衰竭[J].中国厂矿医学,2003,16(5):20-21.
[15]蒋永丰,刘小红,龙晓彬,等.贝那普利联合美托洛尔治疗左室射血分数正常心力衰竭的临床疗效[J].临床合理用药杂志,2015(36):41-42.
[16]李飞,袁勇,董剑廷,等.比索洛尔对高血压合并舒张性心力衰竭患者左心室舒张功能的影响[J].中华高血压杂志,2012,20(12):1178-1180.
[17]李骞,叶伟祥.美托洛尔缓释片治疗原发性高血压合并射血分数保留型心力衰竭的疗效观察[J].中国校医,2017,31(9):684-685.
[18]LI J W,LI H Y,LI G X,et al.Clinical efficacy of arotinolo in treaing elderly diastolic heart failur and the impact on cardiac function of patients[J].Chin J Clin Ration Drug Use,2017(24):3-5.
[19]LI W D.Study on clinical treatment of primary hypertension complicated with diastolic heart failure[J].China Health Standard Manage(中国卫生标准管理),2015(11):181-182.
[20]李晓杰,梁明,陈国俊.卡维地洛对老年慢性舒张性心力衰竭的影响[J].中华老年心脑血管病杂志,2009,11(9):734-735.
[21]LI X Z,SONG S M.Effect of metoprolol to patients diastolic heart failure cardiac function[J].Guid China Med(中国医药指南),2016(4):27.
[22]李阳,王晓强,刘亚宁.倍他乐克片联合贝拉普利治疗左室射血分数正常心力衰竭的临床观察[J].社区医学杂志,2016,14(2):64-66.
[23]李咏梅,牛敬宪.2型糖尿病伴左室舒张功能不全患者使用比索洛尔后B型尿钠肽(BNP)与左室舒张功能的变化分析[J].中国保健营养,2016,26(17):403-404.
[24]LIU G,XIA Y,LU G S,et al.The efficacy of Bisoprolol on the diastolic heart failure in the elderly hypertensive patients[J].Chin J Cardiol(中华心血管病杂志),2004,32(z2):293-295.
[25]LIU R T.The curative effect of carvedilol compared with metoprolol on acute diastolic heart failure[J].Pract J Cardiac Cerebral Pneumal Vascul Dis(实用心脑肺血管病杂志),2012,20(3):441-442.
[26]刘小珍,杨友星.美托洛尔缓释片治疗原发性高血压并舒张性心力衰竭的疗效观察[J].当代医学,2011,17(6):140-141.
[27]马丹.福辛普利与比索洛尔联合治疗舒张性心力衰竭的疗效观察[J].现代中西医结合杂志,2011,20(17):2140-2141.
[28]NI J H.Study of Bisoprolol in treatment of hypertension intervention of left ventricular remodeling in chronic heart failure[J].Medical Innovation of China(中国医学创新),2013(16):30-31.
[29]钱彩珍,顾国清.卡维地洛治疗老年射血分数正常的心力衰竭疗效观察[J].浙江医学,2010,32(6):872-874.
[30]SANG G S,SUN B L,FENG Y X,et al.Clinical evaluation of bisoprolol for treatment of diastolic heart failure[J].J Bengbu Med Coll(蚌埠医学院学报),2002,27(6):496-498.
[31]SHI Y Y,LIU L,DAI W B.Curative effects of arotinoloon treatment for middle aged hypertensive with diastolic heart failure[J].J Pract Med Tech(实用医技杂志),2015(2):117-119.
[32]孙琳琳.美托洛尔缓释片治疗原发性高血压并舒张性心力衰竭的临床效果分析[J].当代医学,2016,22(24):153-154.
[33]孙卫东.美托洛尔缓释片治疗原发性高血压并舒张性心力衰竭的临床效果分析[J].中国农村卫生,2015(20):24-25.
[34]唐桂红.美托洛尔缓释片治疗原发性高血压并舒张性心力衰竭的临床疗效[J].中国现代药物应用,2015,9(20):113-114.
[35]王为风.倍他乐克治疗舒张性心力衰竭22例疗效分析[J].吉林医学,2011,32(30):6376.
[36]魏建国,杨巧芳,吴虹.比索洛尔治疗舒张性心力衰竭[J].医药论坛杂志,2005,26(16):59.
[37]吴礼泓,陈友良,梅凤莲,刘春燕.比索洛尔和培哚普利联合治疗舒张功能不全的疗效观察[J].兵团医学,2012(1):33-34.
[38]肖国辉,梁荷华.比索洛尔对高血压合并糖尿病患者左室舒张功能的影响[J].江西医药,2013,48(4):346-347.
[39]XIE Y,JIANG J f.Metoprolol extended-release tablets in treatment of heart failure with preserved ejection fraction[J].JTongji Univ(Med Sci),2012,33(4):78-82.
[40]徐涛.卡维地洛在舒张性心力衰竭患者中的应用[J].山东医药,2014(25):75-76.
[41]YANG Y H,HUANG Q N,YE J F,et al.Influence of Bisoprolol on brain natriuretic peptide and left ventricular diastolic function in patients with type 2 diabetes and left ventricular diastolic dysfunction[J].Chin Gen Pract(中国全科医学),2013,16(31):3683-3685.
[42]YANG Y,FENG D H,WANG J X,et al.Therapeutic effect of Carvedilol on diastolic heart failure of elder patients[J].China Mod Med(中国当代医药),2012,19(18):90-91.
[43]YE B H,LI A Y,ZHU X Y.Carvedilol on the management of diastolic heart failure[J].Chin J Cardiovasc Rev(中国心血管病研究杂志),2005,3(11):43-45.
[44]于力,汤月霞,王崇屹.氨氯地平和美托洛尔联合治疗舒张功能不全性心力衰竭[J].心脏杂志,2002,14(2):177.
[45]张琮.比索洛尔联合常规综合治疗对左心室射血分数保留的心力衰竭患者心功能及神经内分泌因子的影响[J].中国老年学杂志,2016,36(12):2900-2902.
[46]ZHANG H T,SHAO H,ZHAO Y J,et al.Efficiency comparison between carvedilol and bisoprolol in senile patients with chronic diastolic heart failure[J].Clin Focus(临床荟萃),2014,29(2):171-174.
[47]ZHANG H L.Clinical study on treatment of primary hypertention combine with diastolic heart failure[J].China Health Standard Manage(中国卫生标准管理),2015(13):102-103.
[48]张青青,李欣.β受体阻滞剂治疗射血分数保留心衰的临床效果[J].安徽卫生职业技术学院学报,2016,15(5):52-53.
[49]ZHEN Y Z.Clinical trial of bisoprolol combined with trimetazidine in the treatment of heart failure with preserved left ventricular ejection fraction[J].Chin J Clin Pharmacol(中国临床药理学杂志),2016,32(19):1735-1737,1741.
[50]ZHEN Y Z,DENG Y D,DUAN L N,et al.The effects of bisoprolol on chromaffin grain protein A and cardiac function of heart failure patients with preserved left ventricular ejection fraction[J].Chin J Evid Based Cardiovasc Med(中国循证心血管医学杂志),2016,8(8):919-921.
[51]ZHEN Y Z,DENG Y D,LI L Z,et al.Effects of bisoprolol on neuroendocrine hormones in patients with heart failure with preserved left ventricular ejection fraction[J].Chin J Clin Pharmacol(中国临床药理学杂志),2015,31(15):1471-1474.
[52]ZHEN Y Z,DUAN L N,LIU C,et al.Curative observation of bisoprolol in heart failure patients with preserved left ventricular ejection fraction[J].Chin J Evid Based Cardiovasc Med d(中国循证心血管医学杂志),2016,8(4):442-444,447.
[53]ZHENG Y,MENG L,DONG J S,et al.Effect of carvedilol on heart function and glucolipometabolic in elder patients with diastolic heart failure[J].J Jilin Univ(Med Ed)(吉林大学学报:医学版),2009,35(6):1111-1114.
[54]ZHU H Z,CHEN J J,PAN Q M.Effects of bisoprolol on vascular endothelial function and left ventricular diastolic function in hypertension complicated with diastolic heart failure[J].China Pharm(中国药业),2015(11):38-39,40.
[55]GANDHI S K,POWERS J C,NOMEIR A M,et al.The pathogenesis of acute pulmonary edema associated with hypertension[J].New Engl J Med,2001,344(1):17-22.
[56]LAM C S,DONAL E,KRAIGHER-KRAINER E,et al.Epidemiology and clinical course of heart failure with preserved ejection fraction[J].Eur J Heart Fail,2011,13(1):18-28.
[57]LEVY D,LARSON M G,VASAN R S,et al.The progression from hypertension to congestive heart failure[J].Jama,1996,275(20):1557-1562.
[58]BAKER D W.Prevention of heart failure[J].J Card Fail,2002,8(5):333-346.
[59]KOBAYASHI M,MACHIDA N,TANAKA R,et al.Effects of beta-blocker on left ventricular remodeling in rats with volume overload cardiac failure[J].J Vet Med Sci,2008,70(11):1231-1237.
[60]PFISTER R,ERDMANN E,SCHNEIDER C A.Association and prognostic impact of heart rate and micro-albuminuria in patients with type 2 diabetes and cardiovascular disease:results from the PROactive trial[J].J Atheroscler Thromb,2011,18(1):65-71.
[61]KAPOOR J R,HEIDENREICH P A.Heart rate predicts mortality in patients with heart failure and preserved systolic function[J].J Card Fail,2010,16(10):806-811.
[62]PARAKH N,BHARGAVA B.Rate control with ivabradine:angina pectoris and beyond[J].Am J Cardiovasc Drugs,2011,11(1):1-12.
[63]HERNANDEZ A F,HAMMILL B G,O’CONNOR C M,et al.Clinical effectiveness of beta-blockers in heart failure:findings from the OPTIMIZE-HF(Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with Heart Failure)Registry[J].J Am Coll Cardiol,2009,53(2):184-192.
[64]FLATHER M D,SHIBATA M C,COATS A J,et al.Randomized trial to determine the effect of nebivolol on mortality and cardiovascular hospital admission in elderly patients with heart failure(SENIORS)[J].Eur Heart J,2005,26(3):215-225.
[65]HORI M,KITABATAKE A,TSUTSUI H,et al.Rationale and design of a randomized trial to assess the effects of beta-blocker in diastolic heart failure;Japanese Diastolic Heart Failure Study(J-DHF)[J].J Card Fail,2005,11(7):542-547.
[66]WIYSONGE C S,BRADLEY H,MAYOSI B M,et al.Beta-blockers for hypertension[J].Cochrane Database Syst Rev,2017(1):CD002003.
[67]BAVISHI C,CHATTERJEE S,ATHER S,et al.Beta-blockers in heart failure with preserved ejection fraction:a meta-analysis[J].Heart Fail Rev,2015,20(2):193-201.