桂芍祛湿汤治疗阳虚型T2DM周围神经病变临床研究
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摘要
目的:研究自拟桂芍祛湿汤治疗阳虚型2型糖尿病(T2DM)周围神经病变的临床疗效。方法:选取82例T2DM周围神经病变患者作为对比研究资料,将入选病例均分后分别纳入对照组与观察组,对照组采取西药治疗,观察组在对照组疗法的基础上给予自拟桂芍祛湿汤治疗,1疗程后评估两组临床疗效,观察治疗前、治疗1疗程后两组患者的神经传导速度变化情况以及多伦多临床评分(TCSS)及中医证候积分变化情况。结果:对照组总有效率为51.22%,观察组总有效率为87.80%,观察组疗效较对照组良好,差异有统计学意义(P<0.05)。治疗后观察组MCV、SCV均可见改善,组内对比差异有统计学意义(P<0.05);治疗后观察组MCV、SCV优于对照组,组间对比差异有统计学意义(P<0.05)。治疗后两组中医证候积分与TCSS评分均较前改善,组内对比差异有统计学意义(P<0.05);治疗后观察组中医证候积分与TCSS评分均优于对照组,组间对比差异有统计学意义(P<0.05)。结论:桂芍祛湿汤治疗阳虚型2型糖尿病周围神经病变疗效更为理想,能够有效改善患者神经传导速度。
Objective:To study the parallel comparison method of Guishao Qushi decoction on the treatment of Yang deficiency in type 2 diabetes mellitus(T2 DM)clinical curative effect of peripheral neuropathy.Methods:82 cases of T2 DM patients with peripheral neuropathy were compared as research materials,the selected patients were divided respectively into control group and observation group,the control group took western medicine treatment,the observation group was given self-made Guishao Qushi decoction based on the control group therapy on the clinical efficacy of the two groups the evaluation after a course of treatment,observed before treatment,the nerve conduction velocity of two groups of patients after treatment and the clinical score of Toronto(TCSS)and TCM syndrome score changes.Results:The total effective rate of the control group was 51.22%,the total effective rate of the observation group was 87.80%,and the effect of the observation group was better than that of the control group(P<0.05).After treatment,both MCV and SCV were improved and was statistically significant compared in the group.After treatment,the observation group was superior to the control group in MCV and SCV,and the contrast between the groups was statistically significant(P<0.05).After treatment,the two groups of TCM syndrome scores and TCSS scores were improved compared with those before,compared with the group was statistically significant.After treatment,the TCM syndrome score and TCSS score in the observation group were better than those in the control group,and the difference between the two groups was statistically significant(P<0.05).Conclusion:The curative effect of peripheral neuropathy Guishao Qushi decoction in the treatment of Yang deficiency type 2 diabetes is more ideal,can effectively improve the patients with nerve conduction velocity,and has wide application value.
Objective:To study the parallel comparison method of Guishao Qushi decoction on the treatment of Yang deficiency in type 2 diabetes mellitus(T2 DM)clinical curative effect of peripheral neuropathy.Methods:82 cases of T2 DM patients with peripheral neuropathy were compared as research materials,the selected patients were divided respectively into control group and observation group,the control group took western medicine treatment,the observation group was given self-made Guishao Qushi decoction based on the control group therapy on the clinical efficacy of the two groups the evaluation after a course of treatment,observed before treatment,the nerve conduction velocity of two groups of patients after treatment and the clinical score of Toronto(TCSS)and TCM syndrome score changes.Results:The total effective rate of the control group was 51.22%,the total effective rate of the observation group was 87.80%,and the effect of the observation group was better than that of the control group(P<0.05).After treatment,both MCV and SCV were improved and was statistically significant compared in the group.After treatment,the observation group was superior to the control group in MCV and SCV,and the contrast between the groups was statistically significant(P<0.05).After treatment,the two groups of TCM syndrome scores and TCSS scores were improved compared with those before,compared with the group was statistically significant.After treatment,the TCM syndrome score and TCSS score in the observation group were better than those in the control group,and the difference between the two groups was statistically significant(P<0.05).Conclusion:The curative effect of peripheral neuropathy Guishao Qushi decoction in the treatment of Yang deficiency type 2 diabetes is more ideal,can effectively improve the patients with nerve conduction velocity,and has wide application value.
引文
[1]李航,李会琪.糖尿病周围神经病变的治疗[J].陕西医学杂志,2014,43(6):764-765.
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[8]王平,崔鹏,洪杨洋.“当归四逆汤”治疗寒凝血瘀型糖尿病周围神经病变优效性的临床观察[J].中华中医药学刊,2017,35(3):661-664.
[9]许美娟.甲钴胺联合前列地尔注射液治疗2型糖尿病周围神经病变患者效果分析[J].深圳中西医结合杂志,2015,25(16):25-27.
[10]王春风,李新兵.α-硫辛酸与甲钴胺治疗2型糖尿病周围神经病变临床效果对比分析[J].糖尿病新世界,2016,19(11):12-13.
[11]马艳锋,董长河.为糖尿病周围神经病变患者联用皮痹复仁汤与甲钴胺进行治疗的效果分析[J].当代医药论丛,2016,14(5):19-20.
[12]李跃祥.联用化湿活血汤和甲钴胺治疗糖尿病下肢周围神经病变的效果分析[J].当代医药论丛,2016,15(15):143-144.
[2]刘兰花.黄芪桂枝五物汤联合西医护理治疗糖尿病周围神经病变27例临床观察[J].实用中医内科杂志,2013,27(10s):53-54.
[3]中华中医药学会糖尿病分会.糖尿病周围神经病变中医临床诊疗指南(2016年版)[J].中医杂志,2017,58(7):625-629.
[4]中华医学会糖尿病分会.中国2型糖尿病防治指南(2013年版)[J].中华糖尿病杂志,2014,6(7):447-498.
[5]刘坚鹏,连晓玲,郑汉龙.加味桂枝芍药知母汤联合甲钴胺治疗阳虚湿瘀互结型糖尿病周围神经病变的效果分析[J].慢性病学杂志,2017,18(3):342-343,346.
[6]国家食品药品监督管理总局.中药新药临床研究指导原则[Z].北京:中国医药科技出版社,2002:233-237.
[7]彭永梅,庞利娟.鼠神经生长因子联合维生素D及甲钴胺治疗糖尿病周围神经病变疗效观察[J].中华实用诊断与治疗杂志,2017,31(3):281-283.
[8]王平,崔鹏,洪杨洋.“当归四逆汤”治疗寒凝血瘀型糖尿病周围神经病变优效性的临床观察[J].中华中医药学刊,2017,35(3):661-664.
[9]许美娟.甲钴胺联合前列地尔注射液治疗2型糖尿病周围神经病变患者效果分析[J].深圳中西医结合杂志,2015,25(16):25-27.
[10]王春风,李新兵.α-硫辛酸与甲钴胺治疗2型糖尿病周围神经病变临床效果对比分析[J].糖尿病新世界,2016,19(11):12-13.
[11]马艳锋,董长河.为糖尿病周围神经病变患者联用皮痹复仁汤与甲钴胺进行治疗的效果分析[J].当代医药论丛,2016,14(5):19-20.
[12]李跃祥.联用化湿活血汤和甲钴胺治疗糖尿病下肢周围神经病变的效果分析[J].当代医药论丛,2016,15(15):143-144.