奥美拉唑治疗老年溃疡性上消化道出血临床疗效研究
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摘要
目的探讨奥美拉唑治疗老年溃疡性上消化道出血的临床疗效。方法选取铜陵市人民医院自2014年6月至2017年6月收治的92例老年溃疡性上消化道出血患者为研究对象。随机将所有患者分为A、B两组,每组各46例。两组均给予常规治疗。A组患者在常规治疗的基础上使用奥美拉唑进行治疗,2次/d,每次40 mg;B组患者在常规治疗的基础上使用奥美拉唑进行治疗,每8 h进行一次用药,每次40 mg。比较两组患者的治疗总有效率、平均输血量、平均止血时间。结果 B组患者的治疗总有效率为95.7%(44/46),显著高于A组的82.6%(38/46),两组间比较,差异有统计学意义(P<0.05)。B组患者的平均输血量、平均止血时间显著优于A组,两组间比较,差异均有统计学意义(P<0.05)。结论奥美拉唑治疗老年溃疡性上消化道出血与其剂量具有显著相关性,每8 h进行一次用药,每次40 mg,临床疗效较为理想,各项指标得以快速恢复。
Objective To investigate the curative effect of omeprazole in the treatment of ulcerative upper gastrointestinal hemorrhage in elderly patients.Methods A retrospective study was performed on 92 cases of elderly patients with ulcerative upper gastrointestinal hemorrhage who were admitted from June 2014 to June 2017.Patients were randomly divided into the Group A and Group B,with 46 cases in each group.Both groups of patients were added omeprazole on the basis of conventional treatment.Patients in Group A were given omeprazole 2 times per day,each time 40 mg,the others in Group B were given omeprazole 1 time every 8 hours,each time 40 mg.The total effective rate,average transfusion volume and average hemostasis time of the two groups were compared.Results The total efficiency in Group B was 95.7%(44/46),which was significantly higher than 82.6%(38/46)in Group A(P<0.05).The average blood transfusion volume and hemostasis time of Group B were significantly better than those of Group A(P<0.05).Conclusion Omeprazole in treatment of elderly ulcer upper gastrointestinal hemorrhage and its dosage has significant correlation,the curative effect is ideal and the indicators can be quickly restored when drug administration in every 8 hours with 40 mg each time.
Objective To investigate the curative effect of omeprazole in the treatment of ulcerative upper gastrointestinal hemorrhage in elderly patients.Methods A retrospective study was performed on 92 cases of elderly patients with ulcerative upper gastrointestinal hemorrhage who were admitted from June 2014 to June 2017.Patients were randomly divided into the Group A and Group B,with 46 cases in each group.Both groups of patients were added omeprazole on the basis of conventional treatment.Patients in Group A were given omeprazole 2 times per day,each time 40 mg,the others in Group B were given omeprazole 1 time every 8 hours,each time 40 mg.The total effective rate,average transfusion volume and average hemostasis time of the two groups were compared.Results The total efficiency in Group B was 95.7%(44/46),which was significantly higher than 82.6%(38/46)in Group A(P<0.05).The average blood transfusion volume and hemostasis time of Group B were significantly better than those of Group A(P<0.05).Conclusion Omeprazole in treatment of elderly ulcer upper gastrointestinal hemorrhage and its dosage has significant correlation,the curative effect is ideal and the indicators can be quickly restored when drug administration in every 8 hours with 40 mg each time.
引文
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[6] 刘宁,许树长.奥美拉唑、泮托拉唑与兰索拉唑预防应激性溃疡疗效比较[J].中国药业,2014,23(23):21-22.
[7] 马建宁,陈燕,徐琴,等.奥美拉唑联合综合护理干预治疗上消化道出血48例[J].中国药业,2014,23(5):63-64.
[8] 徐象辉.三黄泻心汤联合西医治疗胃热炽盛型急性上消化道出血的临床疗效观察[J].河北中医,2017,39(5):702-705.
[9] 林昱,陈泽庭.奥曲肽联合凝血酶治疗肝硬化合并上消化道出血的疗效观察[J].河北医学,2017,23(5):809-812.
[10] 蒋丽琳,肖南平,陆俊伶.奥曲肽联合不同剂量垂体后叶素治疗血吸虫性肝硬化继发上消化道出血的应用研究[J].中国地方病防治杂志,2016,31(4):380-381.
[2] 王璐,赵伟,陈磊.大剂量奥美拉唑治疗溃疡性上消化道出血[J].中国现代普通外科进展,2017,20(2):150-151.
[3] 杨琴.大剂量奥美拉唑治疗溃疡性上消化道出血78例[J].中国药业,2015,24(3):83-84.
[4] 袁佳,薛挥,和水祥,等.15例无消化道出血史的肝硬化患者经颈静脉肝内门体静脉分流术后现状调查[J].中华消化杂志,2014,34(1):30-32.
[5] 孟海,程辉.血凝酶联合奥美拉唑治疗急性上消化道出血临床效果观察[J].南通大学学报(医学版),2017,37(2):160-161.
[6] 刘宁,许树长.奥美拉唑、泮托拉唑与兰索拉唑预防应激性溃疡疗效比较[J].中国药业,2014,23(23):21-22.
[7] 马建宁,陈燕,徐琴,等.奥美拉唑联合综合护理干预治疗上消化道出血48例[J].中国药业,2014,23(5):63-64.
[8] 徐象辉.三黄泻心汤联合西医治疗胃热炽盛型急性上消化道出血的临床疗效观察[J].河北中医,2017,39(5):702-705.
[9] 林昱,陈泽庭.奥曲肽联合凝血酶治疗肝硬化合并上消化道出血的疗效观察[J].河北医学,2017,23(5):809-812.
[10] 蒋丽琳,肖南平,陆俊伶.奥曲肽联合不同剂量垂体后叶素治疗血吸虫性肝硬化继发上消化道出血的应用研究[J].中国地方病防治杂志,2016,31(4):380-381.