桃红四物汤治疗Ⅱ型糖尿病的Meta分析
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摘要
目的 分析评价桃红四物汤治疗Ⅱ型糖尿病的临床疗效。方法 计算机检索CNKI、CBM、VIP、WANFANG数据库,纳入有关桃红四物汤治疗Ⅱ型糖尿病的随机对照试验与半随机对照试验,根据纳入、排除标准筛选文献,提取数据,采用RevMan5.3软件进行Meta分析。结果 共纳入7个对照试验,合计439例患者,包括试验组222例,对照组217例。Meta分析结果显示:试验组桃红四物汤与对照组常规西药在临床疗效方面有显著性差异(P<0.01);糖化血红蛋白(HbAlc)与空腹血糖(FBG)两个指标改善情况相当,差异均无统计学意义。结论 与常规西药相比,桃红四物汤治疗Ⅱ型糖尿病疗效显著,是一种良好的治疗Ⅱ型糖尿病的方法。然而,由于现有研究数量的限制和质量的影响,还需要更多高质量、多中心的对照试验加以证实。
Objective To analyze and evaluate the curative effect of Taohong Siwu Decoction and Western Medicine on type Ⅱ diabetes mellitus. Methods The computer retrieved CNKI, CBM, VIP, and Wanf and databases, and screened randomized controlled trials and semi-randomized controlled trials of Taohong Siwu Decoction in the treatment of type Ⅱ diabetes. Screening of documents and extraction of data according to inclusion criteria and exclusion criteria. Meta analysis was performed using RevMan5.3 software. Results A total of 7 controlled trials were included, totaling 439 patients, including 222 in the experimental group and 217 in the control group. The results of meta-analysis showed that there was a significant difference in the clinical efficacy between the experimental group Taohong Siwu Decoction and the control group(P<0.01). The improvement of glycosylated hemoglobin(HbAlc) and fasting blood glucose(FBG) was similar, and the difference was not statistically significant. Conclusion Taohong Siwu Decoction is effective in the treatment of type Ⅱ diabetes and is a good method for the treatment of type Ⅱ diabetes. However, due to the limitations of the number of existing studies and the quality, more high-quality, multi-center controlled trials are needed to confirm.
Objective To analyze and evaluate the curative effect of Taohong Siwu Decoction and Western Medicine on type Ⅱ diabetes mellitus. Methods The computer retrieved CNKI, CBM, VIP, and Wanf and databases, and screened randomized controlled trials and semi-randomized controlled trials of Taohong Siwu Decoction in the treatment of type Ⅱ diabetes. Screening of documents and extraction of data according to inclusion criteria and exclusion criteria. Meta analysis was performed using RevMan5.3 software. Results A total of 7 controlled trials were included, totaling 439 patients, including 222 in the experimental group and 217 in the control group. The results of meta-analysis showed that there was a significant difference in the clinical efficacy between the experimental group Taohong Siwu Decoction and the control group(P<0.01). The improvement of glycosylated hemoglobin(HbAlc) and fasting blood glucose(FBG) was similar, and the difference was not statistically significant. Conclusion Taohong Siwu Decoction is effective in the treatment of type Ⅱ diabetes and is a good method for the treatment of type Ⅱ diabetes. However, due to the limitations of the number of existing studies and the quality, more high-quality, multi-center controlled trials are needed to confirm.
引文
[1] 中华医学会糖尿病学分会.中国2型糖尿病防治指南(2017年版)[J].中国实用内科杂志,2018,38(4):292.
[2] 南平平.探讨瑞格列奈与甘精胰岛素用于2型糖尿病伴慢性肾功能不全患者治疗中的临床效果及不良反应[J].糖尿病新世界,2016,19(8):35.
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[6] 韩凤波.消渴症中医分期辩证与疗效评价方法探讨[J].糖尿病新世界,2018,21(2):47.
[7] 李江波,陈协辉,黄卫.2型糖尿病并高脂血症支持疗法的治疗及疗效评估[J].中国医药导刊,2017,19(1):27.
[8] 李双双,郭春燕.桃红四物汤化学成分及药理作用研究进展[J].神经药理学报,2016,6(4):42.
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[10] 王凤,宋花玲,马燕云,等.中药复方治疗非增殖期糖尿病视网膜病变的Meta分析[J].中国实验方剂学杂志,2017,23(15):202.
[11] 张桂青.加味桃红四物汤对2型糖尿病患者血清HbAlc、APN水平变化的影响[J].北方药学,2018,15(4):40.
[12] 陈燕,徐娜.加味桃红四物汤联合罗格列酮对2型糖尿病患者胰岛β细胞功能及血清APN、FFA水平的影响[J].慢性病学杂志,2018,19(2):203.
[13] 于一江,洪兵,陈丽娟,等.桃红四物汤联合曲美他嗪对2型糖尿病阴虚血瘀证患者心肌病变及氧化应激的影响[J].吉林中医药,2016,36(2):131.
[14] 陈杰.应用加味桃红四物汤治疗2型糖尿病周围神经病变患者临床疗效观察40例[J].糖尿病新世界,2015,18(7):43.
[15] 郑海霞,李明波.桃红四物汤加减在治疗2型糖尿病中的临床观察[J].中国医药科学,2014,4(24):78.
[16] 张霞,苗林艳,孙钟海,等.加味桃红四物汤治疗2型糖尿病合并高尿酸血症30例[J].国际中医中药杂志,2012,34(1):76.
[17] 李树军,张志国.桃红四物汤加味联合甲钴胺治疗2型糖尿病周围神经病变[J].实用糖尿病杂志,2010,6(4):36.
[2] 南平平.探讨瑞格列奈与甘精胰岛素用于2型糖尿病伴慢性肾功能不全患者治疗中的临床效果及不良反应[J].糖尿病新世界,2016,19(8):35.
[3] 陈蕴博,马民,陈小平.2型糖尿病中医辨证论治研究综述[J].亚太传统医药,2017,13(15):42.
[4] 胡佳卉,谢晴宇,孟庆刚.从脾论治糖尿病及其并发症的文献计量分析[J].中华中医药杂志,2017,32(2):713.
[5] 张永鹏,刘静,李永民.中医药治疗糖尿病临床证治研究概况[J].中国实验方剂学杂志,2011,17(22):277.
[6] 韩凤波.消渴症中医分期辩证与疗效评价方法探讨[J].糖尿病新世界,2018,21(2):47.
[7] 李江波,陈协辉,黄卫.2型糖尿病并高脂血症支持疗法的治疗及疗效评估[J].中国医药导刊,2017,19(1):27.
[8] 李双双,郭春燕.桃红四物汤化学成分及药理作用研究进展[J].神经药理学报,2016,6(4):42.
[9] 吴芸,陈志鹏,蔡宝昌.桃红四物汤化学成分及药理作用的研究进展[J].中成药,2011,33(11):1965.
[10] 王凤,宋花玲,马燕云,等.中药复方治疗非增殖期糖尿病视网膜病变的Meta分析[J].中国实验方剂学杂志,2017,23(15):202.
[11] 张桂青.加味桃红四物汤对2型糖尿病患者血清HbAlc、APN水平变化的影响[J].北方药学,2018,15(4):40.
[12] 陈燕,徐娜.加味桃红四物汤联合罗格列酮对2型糖尿病患者胰岛β细胞功能及血清APN、FFA水平的影响[J].慢性病学杂志,2018,19(2):203.
[13] 于一江,洪兵,陈丽娟,等.桃红四物汤联合曲美他嗪对2型糖尿病阴虚血瘀证患者心肌病变及氧化应激的影响[J].吉林中医药,2016,36(2):131.
[14] 陈杰.应用加味桃红四物汤治疗2型糖尿病周围神经病变患者临床疗效观察40例[J].糖尿病新世界,2015,18(7):43.
[15] 郑海霞,李明波.桃红四物汤加减在治疗2型糖尿病中的临床观察[J].中国医药科学,2014,4(24):78.
[16] 张霞,苗林艳,孙钟海,等.加味桃红四物汤治疗2型糖尿病合并高尿酸血症30例[J].国际中医中药杂志,2012,34(1):76.
[17] 李树军,张志国.桃红四物汤加味联合甲钴胺治疗2型糖尿病周围神经病变[J].实用糖尿病杂志,2010,6(4):36.