神经电刺激治疗癫痫临床研究
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摘要
目的探究分析当前阶段神经电刺激治疗癫痫的临床效果。方法方便选取该院在2014年4月—2016年4月期间所收治的共计100例癫痫患者作为主要的研究对象。其中50例患者采用神经电刺激治疗方式作为观察组,另外50例患者采用常规药物治疗进行对照组。观察组患者在进行治疗的过程中采用VNS电刺激技术进行治疗,对照组患者采用常规的药物治疗方式进行。将两组患者在实际治疗过程中的临床效果进行总结对比。结果观察组患者在治疗完成之后发作频率总体低于75%;并且发作停止的比例相比于对照组来说更加显著,分别为30%、18%和12%。差异有统计学意义(P<0.05)。观察组患者在治疗完成之后Mc Hugh等级一级A与二级A的等级分别为52%和36%,显著高于对照组。采用VNS电刺激方式治疗的患者效果更加显著,显著的降低了癫痫发作的频率。结论在进行癫痫治疗的过程中,采用VNS电刺激治疗方式是一种有效的治疗手段,能够大大降低患者的痛苦,提升治疗效果。
Objective To study and analyze the clinical effect of neurostimulation in treatment of epilepsy. Methods 100 cases of patients with epilepsy admitted and treated in our hospital from April 2014 to April 2016 were convenient selected and divided into two groups with 50 cases in each, the observation group and the control group were respectively neurostimulation and routine drugs, and the clinical effect was compared and summarized. Results After treatment, the total attack frequency in the observation group was lower than 75%, and the attack stop cases were more obvious compared with that in the control group, respectively 30%,18%, 12%, and the difference was statistically significant(P<0.05), and the 1 A and 2 A of the Mc Hugh level in the observation group were respectively 52% and 36%, which were obviously higher than those in the control group,and the effect of VNS electrical stimulation method was more obvious, obviously decreasing the frequency of epilepsy attack. Conclusion The VNS electrical stimulation method is an effective treatment means in treatment of epilepsy, which can greatly reduce the pains of patients and improve the treatment effect.
Objective To study and analyze the clinical effect of neurostimulation in treatment of epilepsy. Methods 100 cases of patients with epilepsy admitted and treated in our hospital from April 2014 to April 2016 were convenient selected and divided into two groups with 50 cases in each, the observation group and the control group were respectively neurostimulation and routine drugs, and the clinical effect was compared and summarized. Results After treatment, the total attack frequency in the observation group was lower than 75%, and the attack stop cases were more obvious compared with that in the control group, respectively 30%,18%, 12%, and the difference was statistically significant(P<0.05), and the 1 A and 2 A of the Mc Hugh level in the observation group were respectively 52% and 36%, which were obviously higher than those in the control group,and the effect of VNS electrical stimulation method was more obvious, obviously decreasing the frequency of epilepsy attack. Conclusion The VNS electrical stimulation method is an effective treatment means in treatment of epilepsy, which can greatly reduce the pains of patients and improve the treatment effect.
引文
[1]徐层林.难治性颞叶癫痫形成中海马下托兴奋性神经元介导的机制研究及发作预测[D].杭州:浙江大学,2016.
[2]杨佃旭,王桂松,王丽丽,等.经皮迷走神经耳支刺激与迷走神经刺激对药物难治性癫痫大鼠治疗效果的比较[J].立体定向和功能性神经外科杂志,2015,28(5):261-265.
[3]于志鑫,杨小枫.脑深部电刺激在难治性癫痫治疗中的研究进展[J].临床神经外科杂志,2016,13(1):72-75.
[4]杨霄鹏,杨颜滋,杨瑞玲.重复经颅磁刺激治疗癫痫的临床疗效及安全性分析[J].中国实用神经疾病杂志,2016,19(12):85-86.
[5]曹腾波.迷走神经电刺激对肺缺血再灌注损伤的保护作用[J].上海医学,2016,39(4):229-232.
[6]杨海龙,乔丽娜,谭连红,等.耳穴区经皮电刺激对颞叶癫痫大鼠癫痫发作频率及海马区白介素-1β、肿瘤坏死因子-α表达的影响[J].针刺研究,2016,41(4):283-290.
[7]雷震.基于稳态分布的癫痫检测研究及在线预警系统开发[D].杭州:浙江大学,2016.
[8]蔡先惠.深部脑电刺激内侧隔核对小鼠颞叶癫痫的作用研究[D].杭州:浙江大学,2016.
[9]黄玉文.急性肺栓塞心下交感神经放电变化及颈部迷走神经刺激的实验研究[D].重庆:重庆医科大学,2016.
[10]蒋莹.电刺激迷走神经对急性脑缺血再灌注损伤的影响及机制研究[D].重庆:重庆医科大学,2015.
[11]蔡鸣凡,周亮.神经电刺激治疗反复癫痫的临床疗效探讨[J].医学综述,2015,21(11):2067-2069.
[12]Domenico Serino,Elena Freri,Francesca Ragona,et al.Focal seizures versus epileptic spasms in children with focal cortical dysplasia and epilepsy onset in the first year[J].Epilepsy Research,2015,109.
[13]Laura Ochoa-Gómez,Javier López-Pisón,Carlos Lapresta Moros,et al.A study of epilepsy according to the age at onset and monitored for 3 years in a regional reference paediatric neurology unit[J].Anales de Pediatría(English Edition),2017,86(1):11.
[2]杨佃旭,王桂松,王丽丽,等.经皮迷走神经耳支刺激与迷走神经刺激对药物难治性癫痫大鼠治疗效果的比较[J].立体定向和功能性神经外科杂志,2015,28(5):261-265.
[3]于志鑫,杨小枫.脑深部电刺激在难治性癫痫治疗中的研究进展[J].临床神经外科杂志,2016,13(1):72-75.
[4]杨霄鹏,杨颜滋,杨瑞玲.重复经颅磁刺激治疗癫痫的临床疗效及安全性分析[J].中国实用神经疾病杂志,2016,19(12):85-86.
[5]曹腾波.迷走神经电刺激对肺缺血再灌注损伤的保护作用[J].上海医学,2016,39(4):229-232.
[6]杨海龙,乔丽娜,谭连红,等.耳穴区经皮电刺激对颞叶癫痫大鼠癫痫发作频率及海马区白介素-1β、肿瘤坏死因子-α表达的影响[J].针刺研究,2016,41(4):283-290.
[7]雷震.基于稳态分布的癫痫检测研究及在线预警系统开发[D].杭州:浙江大学,2016.
[8]蔡先惠.深部脑电刺激内侧隔核对小鼠颞叶癫痫的作用研究[D].杭州:浙江大学,2016.
[9]黄玉文.急性肺栓塞心下交感神经放电变化及颈部迷走神经刺激的实验研究[D].重庆:重庆医科大学,2016.
[10]蒋莹.电刺激迷走神经对急性脑缺血再灌注损伤的影响及机制研究[D].重庆:重庆医科大学,2015.
[11]蔡鸣凡,周亮.神经电刺激治疗反复癫痫的临床疗效探讨[J].医学综述,2015,21(11):2067-2069.
[12]Domenico Serino,Elena Freri,Francesca Ragona,et al.Focal seizures versus epileptic spasms in children with focal cortical dysplasia and epilepsy onset in the first year[J].Epilepsy Research,2015,109.
[13]Laura Ochoa-Gómez,Javier López-Pisón,Carlos Lapresta Moros,et al.A study of epilepsy according to the age at onset and monitored for 3 years in a regional reference paediatric neurology unit[J].Anales de Pediatría(English Edition),2017,86(1):11.