中药抗抑郁药对研究进展
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摘要
抑郁症是一种致病因素多样且严重影响人类身心健康的全球性疾病,在我国中医理论中属于"郁证"的范畴。目前,由于抗抑郁西药不良反应的日益凸显,抗抑郁中药大复方因其复杂性所致的在有效成分及配伍机制研究中存在的难题,使得抗抑郁中药药对成为抗抑郁药物研究领域的热点。药对是中药复方的核心,甚至有的方剂本身就是一个药对,对抗抑郁药对进行研究更有利于阐明抗抑郁中药之间配伍机制及药对共同对机体的作用机制。因此,本文从抗抑郁药对的物质基础研究、药物代谢动力学研究及功效作用研究方面,对抗抑郁中药药对展开系统的阐述,以期为抗抑郁药对配伍机制及抗抑郁中药新药的研究提供理论支持。
Depression, a global disease with various pathogenic factors, is seriously affecting human physical and mental health. In Chinese traditional medical theory, the disease belongs to the category of "Yu Zheng". At present, on the one hand, adverse reactions to antidepressant western medicine are becoming more and more prominent. On the other hand, the study of their antidepressant active ingredients and compatibility mechanisms has become a difficult field in the traditional Chinese medicine compounds due to their complexity. The Chinese antidepressant herb-pairs has become a hot topic in the field of antidepressant research. Herb-pair is the core of traditional Chinese medicine compound. In addition, the compound itself is a herb-pair. The study of traditional Chinese antidepressant herb-pairs is more conducive to clarify the compatibility mechanism of herb interaction and the mechanism of antidepressants on the body. Therefore, this paper systematically expounds antidepressant herb-pairs from the study of material, pharmacokinetics and efficacy, which aims at providing theoretical support for the compatibility mechanism of antidepressant herb-pairs and the research of new antidepressant drugs.
Depression, a global disease with various pathogenic factors, is seriously affecting human physical and mental health. In Chinese traditional medical theory, the disease belongs to the category of "Yu Zheng". At present, on the one hand, adverse reactions to antidepressant western medicine are becoming more and more prominent. On the other hand, the study of their antidepressant active ingredients and compatibility mechanisms has become a difficult field in the traditional Chinese medicine compounds due to their complexity. The Chinese antidepressant herb-pairs has become a hot topic in the field of antidepressant research. Herb-pair is the core of traditional Chinese medicine compound. In addition, the compound itself is a herb-pair. The study of traditional Chinese antidepressant herb-pairs is more conducive to clarify the compatibility mechanism of herb interaction and the mechanism of antidepressants on the body. Therefore, this paper systematically expounds antidepressant herb-pairs from the study of material, pharmacokinetics and efficacy, which aims at providing theoretical support for the compatibility mechanism of antidepressant herb-pairs and the research of new antidepressant drugs.
引文
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[11]Zhang Y,Huang X,Wang Y,et al.Ferulic acid-induced antidepression and prokinetics similar to Chaihu-Shugan-San via polypharmacology[J].Brain Res Bull,2011,86:222-228.
[12]Wang YT,Tan QR,Sun LL,et al.Possible therapeutic effect of a traditional Chinese medicine,Sinisan,on chronic restraint stress related disorders[J].Neurosci Lett,2009,449:215-219.
[13]Li ZY,Guo Z,Liu YM,et al.Neuroprotective effects of total Saikosaponins of Bupleurum yinchowense on corticosterone-in‐duced apoptosis in PC12 cells[J].J Ethnopharmacol,2013,148:794-803.
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[15]Mao QQ,Ip SP,Ko KM,et al.Peony glycosides produce antide‐pressant-like action in mice exposed to chronic unpredictable mild stress:effects on hypothalamic-pituitary-adrenal function and brain-derived neurotrophic factor[J].Prog Neuropsycho‐pharmacol Biol Psychiatry,2009,33:1211-1216.
[16]Wang Y.Extraction technology and anti-depression activity of Saponins from Liliumbrownii[J].China Pharm(中国药房),2014,25:602-604.
[17]Ren LX.Studies on the Antidepressant Effect and Mechanisms of Total Timosaponin and Sarsasapogenin(知母总皂苷及萨尔萨皂苷元的抗抑郁作用及其机制研究)[D].Shenyang:Shenyang Pharmaceutical University,2007.
[18]Wang JM,Yang LH,Zhang YY,et al.BDNF and COX-2 partici‐pate in anti-depressive mechanisms of catalpol in rats undergo‐ing chronic unpredictable mild stress[J].Physiol Behav,2015,151:360-368.
[19]Zhao QD,Shu LX,Wang Y,et al.Experimental study on antide‐pressant effect of total flavonoids from Semen Ziziphi Spinosae[J].Tianjin J Tradit Chin Med(天津中医药),2011,28:335-337.
[20]Zhao QD,Shu LX,Wang Y,et al.Antidepressant effect of total saponins from Semen Ziziphi Spinosae[J].Cent South Pharm(中南药学),2011,9:489-491.
[21]Guo CF,Xia M,Yin SG,et al.Antidepressant effect by Albizzia Julibrissin Flower total flavonoids and its mechanism[J].Chin J Exp Tradit Med Form(中国实验方剂学杂志),2013,19:225-228.
[22]Zhao J.Berberine Elicits Antidepressant-Like Effect in the Ovariectomized Mice(小檗碱对卵巢摘除小鼠的抗抑郁作用及其机制研究)[D].Changchun:Northeast Normal University,2015.
[23]Wang YW,Chen X,Jiang ML.Use of evodiamine for antidepres‐sant.CN 103340872A[P].2013.
[24]Guo YH.Studies on Chemical Composition of Effective Frac‐tions from Rhizoma Atractylodis Macrocephalae of Xiaoyaosan(白术对逍遥散抗抑郁有效部位贡献成分研究)[D].Taiyuan:Shanxi University,2014.
[25]Chen YZ,Gu YJ,Wu XM,et al.Protective effect of Acantho‐panax Senticousus Saponins on glutamate-induced cortical neuron damage[J].J Brain Nerv Dis(脑与神经疾病杂志),2004,12:84-87.
[26]Han Y.Pharmacodynamic Material Basic of Zhizi Chi Decoction(栀子豉汤的药效物质基础研究)[D].Fuzhou:Fujian Universi‐ty of Traditional Chinese Medicine,2015.
[27]Yan QZ,Wu F,Xu XX,et al.Antidepression-like effect and mechanism of ferulic acid[J].Chin J Pharm Toxicol(中国药理学与毒理学杂志),2014,28:645.
[28]Lu H,Wu YX,Yang LJ,et al.Antidepressant effects of Citrus medica L.var.sarcodactylis swingle from Sichuan province[J].J Zhengzhou Univ(郑州大学学报),2011,46:220-222.
[29]Zhang WX,Chen L,Duan JY.Study on the antidepressant activities of polysaccharides from three herbs and their mech‐anism[J].J Shanxi Agirc Univ(山西农业大学学报),2017,37:905-912.
[30]Fan ZZ,Zhao WH,Guo J,et al.Antidepressant activities of flavonoids from Glycyrrhiza uralensis and its neurogenesis protective effect in rats[J].Acta Pharm Sin(药学学报),2012,47:1612-1617.
[31]Huang SJ.Application and research of Wolfberry Fruit in treatment of depression[J].Chin Arch Tradit Chin Med(中华中医药学刊),2014,32:1841-1843.
[32]Tong Y,Wu XQ.Experimental study on antidepressant effect of physcion[J].Pharmacol Clin Chin Mater Med(中药药理与临床),2013,29:60-62.
[33]Qu XS,YangYF,Zhang J,et al.Different extraction methods of Zhi-Zi-Hou-Pu decoction and the antidepressant profile-effect[J].Chin J Pharm(中国医药工业杂志),2014,45:424-428.
[34]Li YC,Shen JD,Liu YM,et al.Screening of antidepressant effects of four main flavonoids compounds from Scutellaria baicalensis[J].Chin J Exp Tradit Med Form(中国实验方剂学杂志),2012,18:166-169.
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