光动力疗法微透镜光纤评估
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摘要
目的对光动力疗法微透镜光纤进行评估。方法检测欧美临床使用的两种微透镜光纤,一种长3 m不带宏弯(400μm),另一种长4m带两个宏弯(800μm);分析它们的扩束性能、光斑均匀性以及对不同波长光线的透过性。结果两种微透镜光纤均有明显的扩束效果,带宏弯光纤的均匀性较不带宏弯光纤更好,两种光纤对光动力常用波长的可见光均具有良好的透过性。结论微透镜光纤的设计及其质量可同时影响扩束效果和光斑均匀性,使用宏弯能够进一步改善PDT透镜光纤的光传输质量。
Objective The combination of diode laser and microlens fiber is a commonly used technique and approach in photodynamic therapy(PDT).Methods The design and quality of microlens fiber can affect both the beam expansion and beam uniformity. In this paper,two types of microlens fibers were tested: one is 3 meters long with a core diameter of 400μm,having no macrobending; and another is 4 meters long with a core diameter of 800μm,having 2 permanent macrobendings. Both were approved for clinical use in the Europe and North America. Their beam expansion properties,uniformity,and wavelength transmission were analyzed.Results Both fibers showed a significant beam expansion effect. The uniformity of macrobend fiber was better than that of the non-macrobend fiber. Both fibers showed a good transmission to light of 400-1 000 nm.Conclusions Apparently,utilizing the macrobending will further improve the optical transmission quality of microlens fiber in PDT application.
Objective The combination of diode laser and microlens fiber is a commonly used technique and approach in photodynamic therapy(PDT).Methods The design and quality of microlens fiber can affect both the beam expansion and beam uniformity. In this paper,two types of microlens fibers were tested: one is 3 meters long with a core diameter of 400μm,having no macrobending; and another is 4 meters long with a core diameter of 800μm,having 2 permanent macrobendings. Both were approved for clinical use in the Europe and North America. Their beam expansion properties,uniformity,and wavelength transmission were analyzed.Results Both fibers showed a significant beam expansion effect. The uniformity of macrobend fiber was better than that of the non-macrobend fiber. Both fibers showed a good transmission to light of 400-1 000 nm.Conclusions Apparently,utilizing the macrobending will further improve the optical transmission quality of microlens fiber in PDT application.
引文
[1]李黎波,李文敏,项蕾红,等.光动力疗法在中国的应用与临床研究[J].中国激光医学杂志,2012,21:278-307.
[2]黄正,詹振林,邱海霞,等.实用临床光动力疗法剂量学[J].中国激光医学杂志,2016,25:34-41.
[3]黎富尧.一种光动力激光传输点状光纤:CN,CN203244695U[P].2013.
[4]Jacques SL.Light dosimetry technique for endoscopic PDTusing microlens optical fiber[J].Proceedings of SPIE,1999,3601:455462.
[5]Cuenca RE,Allison RR,Sibata C,et al.Breast cancer with chest wall progression:treatment with photodynamic therapy[J].Annals of Surgical Oncology,2004,11:322-327.
[6]Huang Z,Xu H,Meyers AD,et al.Photodynamic therapy for treatment of solid tumors-potential and technical challenges[J].Technology in Cancer Research Treatment,2008,7:309.
[7]李登道,耿杰,王文涌.光纤的结构及其传输特性分析[J].山东科技大学学报(自然科学版),2004,23:39-42.
[8]Narciso HL,Doiron DR.Optical fiber microlens:US,US5231684[P].1993.
[9]Smith RW.Linear systems,fourier Transforms and optics[M].Linear systems,Fourier transforms,and optics/.Wiley,1978,88:836.
[10]Wach ML.Optical fiber with enhanced light collection and illumination and having highly controlled emission and acceptance patterns:US,US 5878178 A[P].1999.
[11]陈爽,冯莹,王玲.基于GLM的多模光纤放大器模式控制研究[J].激光技术,2010,34:128-131.
[12]Mordon S,Cochrane C,Baptiste T,et al.Light emitting fabric technologies for photodynamic therapy[J].Photodiagnosis Photodynamic Therapy,2015,12:1-8.
[13]Mordon SR,邱海霞,黄正.乳房外派杰氏病光动力疗法的技术进展[J].中国激光医学杂志,2018,27:61-68.
[14]徐明泉,张振远.光纤束透过率的测试研究[J].玻璃纤维,2007,30:10-14.
[15]Biel MA.Photodynamic therapy and the treatment of neoplastic diseases of the larynx[J].Laryngoscope,1994,104:399.
[16]张智慧,陈文晖.光照功率密度及照光方式对光动力疗法影响的研究进展[J].中国激光医学杂志,2017,26:34-38.
[17]Macaire L,Vandenbroucke N,Postaire J.Color image segmentation by analysis of subset connectedness and color homogeneity properties[J].Computer Vision and Image Understanding,2006,102:105-116.
[2]黄正,詹振林,邱海霞,等.实用临床光动力疗法剂量学[J].中国激光医学杂志,2016,25:34-41.
[3]黎富尧.一种光动力激光传输点状光纤:CN,CN203244695U[P].2013.
[4]Jacques SL.Light dosimetry technique for endoscopic PDTusing microlens optical fiber[J].Proceedings of SPIE,1999,3601:455462.
[5]Cuenca RE,Allison RR,Sibata C,et al.Breast cancer with chest wall progression:treatment with photodynamic therapy[J].Annals of Surgical Oncology,2004,11:322-327.
[6]Huang Z,Xu H,Meyers AD,et al.Photodynamic therapy for treatment of solid tumors-potential and technical challenges[J].Technology in Cancer Research Treatment,2008,7:309.
[7]李登道,耿杰,王文涌.光纤的结构及其传输特性分析[J].山东科技大学学报(自然科学版),2004,23:39-42.
[8]Narciso HL,Doiron DR.Optical fiber microlens:US,US5231684[P].1993.
[9]Smith RW.Linear systems,fourier Transforms and optics[M].Linear systems,Fourier transforms,and optics/.Wiley,1978,88:836.
[10]Wach ML.Optical fiber with enhanced light collection and illumination and having highly controlled emission and acceptance patterns:US,US 5878178 A[P].1999.
[11]陈爽,冯莹,王玲.基于GLM的多模光纤放大器模式控制研究[J].激光技术,2010,34:128-131.
[12]Mordon S,Cochrane C,Baptiste T,et al.Light emitting fabric technologies for photodynamic therapy[J].Photodiagnosis Photodynamic Therapy,2015,12:1-8.
[13]Mordon SR,邱海霞,黄正.乳房外派杰氏病光动力疗法的技术进展[J].中国激光医学杂志,2018,27:61-68.
[14]徐明泉,张振远.光纤束透过率的测试研究[J].玻璃纤维,2007,30:10-14.
[15]Biel MA.Photodynamic therapy and the treatment of neoplastic diseases of the larynx[J].Laryngoscope,1994,104:399.
[16]张智慧,陈文晖.光照功率密度及照光方式对光动力疗法影响的研究进展[J].中国激光医学杂志,2017,26:34-38.
[17]Macaire L,Vandenbroucke N,Postaire J.Color image segmentation by analysis of subset connectedness and color homogeneity properties[J].Computer Vision and Image Understanding,2006,102:105-116.