通窍鼻炎方对慢性鼻窦炎患者体内Foxa2、黏蛋白MUC5AC、HIF-1α水平的影响
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摘要
目的:探讨通窍鼻炎方对慢性鼻窦炎患者体内Foxa2、黏蛋白MUC5AC、HIF-1α水平的影响性。方法:选取116例慢性鼻窦炎患者作为研究对象,按入院先后顺序平均分成两组,均为58例。对照组常规治疗,研究组在对照组基础上加用通窍鼻炎方治疗,观察不同方法治疗后在临床症状、疗效、实验室指标和生活质量变化情况。结果:两组治疗前流脓、鼻塞、头昏头痛、嗅觉减退、黏膜充血肿胀积分和炎症指标IL-β、IL-5、TNF-α以及Foxa2、黏蛋白MUC5AC、HIF-1α比较差异不显著(P>0.05);对照组治疗前末在Foxa2、黏蛋白MUC5AC、HIF-1α水平比较差异无统计学意义(P>0.05);余治疗末较治疗前以上指标两组均显著下降,差异有统计学意义(P<0.05),治疗末研究组以上指标较对照组差异显著(P<0.05)。疗效上,对照组治愈率22.41%、总有效率81.03%;研究组治愈率36.21%、总有效率93.1%,研究组显著优于对照组,比较差异有统计学意义(P<0.05)。结论:通窍鼻炎方能抑制慢性鼻窦炎患者体内Foxa2、黏蛋白MUC5AC、HIF-1α表达,从而提高疗效,改善临床症状。
Objective:To investigate the effect of Tongqiao Biyan recipe on Foxa2 in patients with chronic sinusitis,and MUC5 AC protein levels of HIF-1 alpha.Methods:116 patients with chronic rhinosinusitis were selected as the research object and were divided into 2 groups according to the order of admission,all of which were 58 cases.The control group received routine treatment,research group in the control group based on the use of Tongqiao Biyan recipe treatment,observation of different treatment in the clinical symptoms,curative effect,laboratory index and quality of life changes.Results:The two groups before treatment,nasal congestion,dizziness,headache,pus hyposmia,mucosal hyperemia,swelling score and inflammation index of IL-beta,IL-5,TNF-,Foxa2,alpha HIF-1 alpha and MUC5 AC protein.There was no significant difference(P>0.05);the control group before treatment and at the end of Foxa2,the expression of MUC5 AC,no significant difference was found in HIF-1 alpha level difference(P>0.05);more than the end of treatment compared with before treatment,the above indexes of the two groups were significantly decreased,the difference was statistically significant(P< 0.05),the treatment in the research group the above indexes significantly compared with the control group(P< 0.05).In the control group,the cure rate was 22.41%and the total effective rate was 81.03%.The cure rate of the study group was 36.21%and the total effective rate was 93.1%.The difference between the study group and the control group was statistically significant(P<0.05).Conclusion:Tongqiao Biyan recipe can inhibit the expression of Foxa2 in patients with chronic sinusitis,the expression of MUC5 AC,HIF-1 alpha,so as to improve the curative effect,improve the clinical symptoms.
Objective:To investigate the effect of Tongqiao Biyan recipe on Foxa2 in patients with chronic sinusitis,and MUC5 AC protein levels of HIF-1 alpha.Methods:116 patients with chronic rhinosinusitis were selected as the research object and were divided into 2 groups according to the order of admission,all of which were 58 cases.The control group received routine treatment,research group in the control group based on the use of Tongqiao Biyan recipe treatment,observation of different treatment in the clinical symptoms,curative effect,laboratory index and quality of life changes.Results:The two groups before treatment,nasal congestion,dizziness,headache,pus hyposmia,mucosal hyperemia,swelling score and inflammation index of IL-beta,IL-5,TNF-,Foxa2,alpha HIF-1 alpha and MUC5 AC protein.There was no significant difference(P>0.05);the control group before treatment and at the end of Foxa2,the expression of MUC5 AC,no significant difference was found in HIF-1 alpha level difference(P>0.05);more than the end of treatment compared with before treatment,the above indexes of the two groups were significantly decreased,the difference was statistically significant(P< 0.05),the treatment in the research group the above indexes significantly compared with the control group(P< 0.05).In the control group,the cure rate was 22.41%and the total effective rate was 81.03%.The cure rate of the study group was 36.21%and the total effective rate was 93.1%.The difference between the study group and the control group was statistically significant(P<0.05).Conclusion:Tongqiao Biyan recipe can inhibit the expression of Foxa2 in patients with chronic sinusitis,the expression of MUC5 AC,HIF-1 alpha,so as to improve the curative effect,improve the clinical symptoms.
引文
[1]姚龙泉.通窍鼻炎颗粒治疗慢性鼻窦炎的疗效分析[J].心理医生,2017,23(23):53-54.
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[11]佘腊枝,鲁海涛,谢琼,等.缺氧诱导因子-1α和基质蛋白酶-9在鼻息肉嗜酸性粒细胞浸润过程中的作用[J].检验医学与临床,2017,(18):2553-2554,2556.
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[14]王靖涛,宋剑弘,奚丽婷,等.银尔通联合鼻渊通窍颗粒治疗小儿慢性鼻窦炎的疗效分析[J].现代诊断与治疗,2017,28(19):3585-3587.
[15]陈永禄,吕细华,伍岚,等.中医序贯疗法联合FESS治疗慢性鼻窦炎的临床效果观察[J].中国现代药物应用,2017,11(16):85-86.
[16]马世明.苍耳子散加减治疗难治性慢性鼻窦炎169例疗效观察[J].内蒙古医学杂志,2017,49(6):690-691.
[17]熊静,周振峰,吴婷,等.龙胆通窍丸对湿热型慢性鼻窦炎患者血清IL-6和IL-8水平的影响[J].中国中西医结合耳鼻咽喉科杂志,2017,25(4):241-243,249.
[18]Tang,Yunneng,Shu Guangwen,Yuan Xinwang.FOXA2functions as a suppressor of tumor metastasis by inhibition of epithelial-to-mesenchymal transition in human lung cancers[J].Cell Res,2016,7(3);787-789.
[19]白晶,苗北平,夏文彤,等.白细胞介素-17A对鼻黏膜上皮细胞表达黏蛋白MUC5AC的刺激作用及分子机制[J].中国耳鼻咽喉头颈外科,2015,20(6):319-322.
[20]Jun I.,Kaori H.,Yuho I.,et al.Regulation of MUC5AC mucin production by the cell attachment dependent pathway involving integrinβ1in NCIH292human lung epithelial cells[J].Advances in Biological Chemistry,2013,3(1):33-35.
[2]向承仕.通窍鼻炎胶囊治疗鼻窦炎的临床分析与观察[J].大家健康(中旬版),2016,10(3):184-185.
[3]Yudoh,Kaz4uo,Nakamura,et al.Catabolic stress induces expression of hypoxia-inducible factor(HIF)-1αin articular chondrocytes:involvement of HIF-1αin the pathogenesis of osteoarthritis[J].Arthritis Res Ther,2015,9(1):11-14.
[4]Legendre,Claire,Reen,et al.Pseudomonas aeruginosa Alkyl Quinolones repress hypoxia-inducible factor 1(hif-1)signaling through hif-1αdegradation[J].Infect Immun,2013,6(5):34-35.
[5]叶上珠.慢性鼻窦炎中西医结合治疗的疗效和生活质量的临床研究[J].中国医学创新,2017,14(2):75-78.
[6]李萍.小儿慢性鼻窦炎临床分析及综合疗法的疗效观察[J].中国药物经济学,2017,12(7):91-93.
[7]陈家麟.中医序贯疗法治疗慢性鼻窦炎的效果分析[J].医学理论与实践,2016,29(17):3080-3081.
[8]李春杰.中西医联合治疗慢性鼻窦炎的临床疗效[J].中医临床研究,2016,8(6):90-92.
[9]邓婧,彭成.麻杏石甘汤加味治疗慢性鼻窦炎的近期临床疗效观察[J].医学信息,2016,9(2):354-355.
[10]罗庆,金雪玲,冯琨,等.慢性鼻窦炎中FoxA2与HIF-1α的表达及与黏蛋白MUC5AC的关系[C].2014,3(4):96-96.
[11]佘腊枝,鲁海涛,谢琼,等.缺氧诱导因子-1α和基质蛋白酶-9在鼻息肉嗜酸性粒细胞浸润过程中的作用[J].检验医学与临床,2017,(18):2553-2554,2556.
[12]江德鹏,Victor P,Juliy M,等.白介素13通过FOXA2调控气道上皮细胞粘液分泌[J].中国免疫学杂志,2015,27(2):99-102.
[13]Rausa,Francisco M,Tan,et al.Association between Hepatocyte Nuclear Factor 6(HNF-6)and FoxA2DNA binding domains stimulates foxa2transcriptional activity but inhibits hnf-6dna binding[J].Mol Cell Bio,2015,4(3):45-47.
[14]王靖涛,宋剑弘,奚丽婷,等.银尔通联合鼻渊通窍颗粒治疗小儿慢性鼻窦炎的疗效分析[J].现代诊断与治疗,2017,28(19):3585-3587.
[15]陈永禄,吕细华,伍岚,等.中医序贯疗法联合FESS治疗慢性鼻窦炎的临床效果观察[J].中国现代药物应用,2017,11(16):85-86.
[16]马世明.苍耳子散加减治疗难治性慢性鼻窦炎169例疗效观察[J].内蒙古医学杂志,2017,49(6):690-691.
[17]熊静,周振峰,吴婷,等.龙胆通窍丸对湿热型慢性鼻窦炎患者血清IL-6和IL-8水平的影响[J].中国中西医结合耳鼻咽喉科杂志,2017,25(4):241-243,249.
[18]Tang,Yunneng,Shu Guangwen,Yuan Xinwang.FOXA2functions as a suppressor of tumor metastasis by inhibition of epithelial-to-mesenchymal transition in human lung cancers[J].Cell Res,2016,7(3);787-789.
[19]白晶,苗北平,夏文彤,等.白细胞介素-17A对鼻黏膜上皮细胞表达黏蛋白MUC5AC的刺激作用及分子机制[J].中国耳鼻咽喉头颈外科,2015,20(6):319-322.
[20]Jun I.,Kaori H.,Yuho I.,et al.Regulation of MUC5AC mucin production by the cell attachment dependent pathway involving integrinβ1in NCIH292human lung epithelial cells[J].Advances in Biological Chemistry,2013,3(1):33-35.