四种抗感冒中成药的镇痛作用评价
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摘要
目的从药效学与药物经济学两个角度评价柴芩清宁胶囊、清开灵胶囊、清热解毒胶囊、疏风解毒胶囊的镇痛作用。方法采用醋酸扭体法和热板法进行各给药组的疗效及成本效果分析。结果各给药组均可在一定程度上抑制扭体反应,延长舔足反应痛阈值。与疏风解毒胶囊相比,柴芩清宁胶囊的最佳扭体抑制率效果较好且成本较低,最佳疼痛抑制率效果较好但成本较高;与清开灵胶囊、清热解毒胶囊相比,柴芩清宁胶囊的最佳镇痛效果较好,但成本较高。结论柴芩清宁胶囊、清开灵胶囊、清热解毒胶囊、疏风解毒胶囊均具有一定镇痛作用,但各药物发挥作用的特点不同,临床应用时可根据需求进行选择。
Objective To compare the analgesic effect of Chaiqin Qingning Capsule, Qingkailing capsule, Qingre Jiedu capsule and Shufeng Jiedu capsule from the perspectives of pharmacodynamics and pharmacoeconomics. Methods The efficacy and cost-effectiveness analysis of each group are assessed by writhing test and hot plate test. Results The different dose group can inhibit the writhing reaction and prolong the pain threshold to a certain extent. Compared with Shufeng Jiedu capsule, the best writhing inhibition rate of Chaiqin Qingning capsule is better and the cost is lower, the best pain inhibition rate of Chaiqin Qingning capsule is better but the cost is higher. Compared with Qingkailing capsule and Qingre Jiedu capsule, the best analgesic effect of Chaiqin Qingning capsule is better but the cost is higher. Conclusion Chaiqin Qingning capsule,Qingkailing capsule, Qingre Jiedu capsule and Shufeng Jiedu capsule all have certain analgesic effect, but the characteristics of each drug are different. Drugs can be selected according to different needs in clinical application.
Objective To compare the analgesic effect of Chaiqin Qingning Capsule, Qingkailing capsule, Qingre Jiedu capsule and Shufeng Jiedu capsule from the perspectives of pharmacodynamics and pharmacoeconomics. Methods The efficacy and cost-effectiveness analysis of each group are assessed by writhing test and hot plate test. Results The different dose group can inhibit the writhing reaction and prolong the pain threshold to a certain extent. Compared with Shufeng Jiedu capsule, the best writhing inhibition rate of Chaiqin Qingning capsule is better and the cost is lower, the best pain inhibition rate of Chaiqin Qingning capsule is better but the cost is higher. Compared with Qingkailing capsule and Qingre Jiedu capsule, the best analgesic effect of Chaiqin Qingning capsule is better but the cost is higher. Conclusion Chaiqin Qingning capsule,Qingkailing capsule, Qingre Jiedu capsule and Shufeng Jiedu capsule all have certain analgesic effect, but the characteristics of each drug are different. Drugs can be selected according to different needs in clinical application.
引文
[1]王新月.中医内科学[M].北京:中国中医药出版社,2013:45-51.
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[6]郑亚男,杜文杰,尹雪霏,等.独一味不同有效部位抗炎镇痛作用比较[J].时珍国医国药,2015,26(2):282-284.
[7]郭文贤,戴卫波,梅全喜,等.利尿合剂抗炎镇痛及体外抑菌作用研究[J].药物评价研究,2017,40(2):201-205.
[8]郭姗姗,马雪萍,高英杰,等.一叶抗流感胶囊解热、抗炎、镇痛的药效学研究[J].中国药物警戒,2014,11(9):513-515.
[9]罗友华,杨辉,黄亦琦,等.咽舒宁颗粒祛痰镇痛及抑菌作用[J].中国实验方剂学杂志,2013,19(1):287-290.
[10]王紫怡,丁选胜.抗感冒中成药药物经济学评价的文献研究[J].药物评价研究,2018,41(1):157-162.
[11]宗欣.药物经济学评价成本-效果阈值确定与应用研究[D].沈阳:沈阳药科大学,2013.
[2]中国医师协会呼吸医师分会.普通感冒规范诊治的专家共识[J].中华内科杂志,2012,51(4):330-333.
[3]刘雁.警惕感冒的并发症[J].科学之友:a版,2009(4):50.
[4]魏伟,吴希美,李元建.药理实验方法学(第四版)[M].北京:人民卫生出版社,2010.
[5]陈奇.中药药理研究方法学(第三版)[M].北京:人民卫生出版社,2011.
[6]郑亚男,杜文杰,尹雪霏,等.独一味不同有效部位抗炎镇痛作用比较[J].时珍国医国药,2015,26(2):282-284.
[7]郭文贤,戴卫波,梅全喜,等.利尿合剂抗炎镇痛及体外抑菌作用研究[J].药物评价研究,2017,40(2):201-205.
[8]郭姗姗,马雪萍,高英杰,等.一叶抗流感胶囊解热、抗炎、镇痛的药效学研究[J].中国药物警戒,2014,11(9):513-515.
[9]罗友华,杨辉,黄亦琦,等.咽舒宁颗粒祛痰镇痛及抑菌作用[J].中国实验方剂学杂志,2013,19(1):287-290.
[10]王紫怡,丁选胜.抗感冒中成药药物经济学评价的文献研究[J].药物评价研究,2018,41(1):157-162.
[11]宗欣.药物经济学评价成本-效果阈值确定与应用研究[D].沈阳:沈阳药科大学,2013.