生长抑素联合乌司他丁对急性胰腺炎患者临床症状及血清学指标的影响
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摘要
目的分析生长抑素联合乌司他丁对急性胰腺炎(AP)患者临床症状及血清学指标的影响。方法 76例AP患者,依据入院先后顺序将其分为观察组及对照组,各38例。对照组患者给予乌司他丁治疗,观察组患者在对照组治疗基础上应用生长抑素治疗。观察两组临床症状缓解时间及血清学指标水平。结果观察组临床症状缓解时间为(3.04±1.35)d,对照组临床症状缓解时间为(5.78±1.96)d,观察组临床症状缓解时间短于对照组,差异有统计学意义(t=7.097,P<0.05);治疗后,观察组白细胞(WBC)及血清淀粉酶(AMS)水平均低于对照组,差异有统计学意义(P<0.05)。结论 AP患者应用生长抑素与乌司他丁两药联合治疗效果理想,可有效改善患者血清指标及临床症状,加快其康复进程,值得临床进一步研究及应用。
Objective To analyze influence by somatostatin combined with ulinastatin on clinical symptoms and serological indexes in acute pancreatitis(AP) patients.Methods A total of 76 AP patients were divided by admission order into observation group and control group,with 38 cases in each group.The control group received ulinastatin for treatment,and the observation group received additional somatostatin to therapy in the control group.Observation was made on clinical symptoms remission time and serological indexes levels in the two groups.Results The observation group had clinical symptoms remission time as(3.04±1.35) d,and the control group had clinical symptoms remission time as(5.78±1.96) d.The observation group had shorter clinical symptoms remission time than the control group,and their difference had statistical significance(t=7.097,P<0.05).After treatment,the observation group had all lower levels of white blood cell(WBC) and serum amylase(AMS) than the control group,and their difference had statistical significance(P<0.05).Conclusion Implement of somatostatin and ulinastatin for combined treatment shows ideal curative effect for AP patients.This method can effectively improve serological indexes and clinical symptoms in patients and accelerate their rehabilitation process.It is worth further clinical research and application.
Objective To analyze influence by somatostatin combined with ulinastatin on clinical symptoms and serological indexes in acute pancreatitis(AP) patients.Methods A total of 76 AP patients were divided by admission order into observation group and control group,with 38 cases in each group.The control group received ulinastatin for treatment,and the observation group received additional somatostatin to therapy in the control group.Observation was made on clinical symptoms remission time and serological indexes levels in the two groups.Results The observation group had clinical symptoms remission time as(3.04±1.35) d,and the control group had clinical symptoms remission time as(5.78±1.96) d.The observation group had shorter clinical symptoms remission time than the control group,and their difference had statistical significance(t=7.097,P<0.05).After treatment,the observation group had all lower levels of white blood cell(WBC) and serum amylase(AMS) than the control group,and their difference had statistical significance(P<0.05).Conclusion Implement of somatostatin and ulinastatin for combined treatment shows ideal curative effect for AP patients.This method can effectively improve serological indexes and clinical symptoms in patients and accelerate their rehabilitation process.It is worth further clinical research and application.
引文
[1]潘林锋,张英杰,张国强,等.生长抑素对ERCP术后急性胰腺炎的预防作用研究.浙江医学,2016,38(17):1449-1450.
[2]吕昊泽,吕宁宁,刘仲祥.生长抑素联合乌司他丁应用于重症急性胰腺炎患者治疗对其血清炎性因子的影响.中国实验诊断学,2016,20(8):1315-1317.
[3]常江,王颖,王法.乌司他丁对重症急性胰腺炎并发急性肾损伤的临床干预观察.中国中西医结合肾病杂志,2016,17(5):425-426.
[4]宋奇峰,周建波,桑建忠,等.乌司他丁联合奥曲肽对急性胰腺炎的临床疗效及预后分析.中国生化药物杂志,2016,36(7):158-160.
[5]王丰平,张永龙.乌司他丁联合生长抑素治疗急性重症胰腺炎疗效观察.中国药师,2014,17(5):812-814.
[6]秦林燕,王国兴.乌司他丁联合生长抑素对重症急性胰腺炎大鼠血清炎性细胞因子的影响.临床和实验医学杂志,2015(15):1225-1228.
[7]任英霞,康惠贞.乌司他丁、生长抑素联合泮托拉唑钠对急性重症胰腺炎患者炎症因子的影响.中国医刊,2014(12):64-65.
[8]欧云崧,贾利猛,王明锋,等.生长抑素联合乌司他丁治疗急性重症胰腺炎患者的临床分析.中国医学前沿杂志电子版,2014,6(4):84-86.
[9]郑盛,杨涓,张帆,等.生长抑素联合乌司他丁治疗重症急性胰腺炎临床疗效及安全性分析.现代生物医学进展,2016,16(30):5941-5944.
[10]贾会文,冯延冰,刘向业,等.生长抑素联合乌司他丁对重症急性胰腺炎患者腹内压的影响.中国生化药物杂志,2014,34(8):43.
[11]朱国福.生长抑素联合乌司他丁治疗重症急性胰腺炎的疗效.实用临床医学,2015,16(5):9.
[12]王永.乌司他丁联合生长抑素治疗急性胰腺炎的临床研究.中国现代医生,2012,50(31):75-77.
[13]敖栋基.生长抑素联合乌司他丁治疗急性胰腺炎的疗效观察.现代诊断与治疗,2016,27(4):645-647.
[14]邓永胜,邓启亮,王李妮,等.联合使用生长抑素及乌司他丁在急性胰腺炎治疗中的疗效观察.医药前沿,2012,2(1):40.
[15]王素梅.生长抑素联合乌司他丁对重症急性胰腺炎的治疗效果分析.临床医药文献电子杂志,2014(4):620.
[16]张彦宏,朴熙绪.乌司他汀联合生长抑素治疗重症急性胰腺炎疗效观察.现代预防医学,2011,38(21):4548-4549.
[2]吕昊泽,吕宁宁,刘仲祥.生长抑素联合乌司他丁应用于重症急性胰腺炎患者治疗对其血清炎性因子的影响.中国实验诊断学,2016,20(8):1315-1317.
[3]常江,王颖,王法.乌司他丁对重症急性胰腺炎并发急性肾损伤的临床干预观察.中国中西医结合肾病杂志,2016,17(5):425-426.
[4]宋奇峰,周建波,桑建忠,等.乌司他丁联合奥曲肽对急性胰腺炎的临床疗效及预后分析.中国生化药物杂志,2016,36(7):158-160.
[5]王丰平,张永龙.乌司他丁联合生长抑素治疗急性重症胰腺炎疗效观察.中国药师,2014,17(5):812-814.
[6]秦林燕,王国兴.乌司他丁联合生长抑素对重症急性胰腺炎大鼠血清炎性细胞因子的影响.临床和实验医学杂志,2015(15):1225-1228.
[7]任英霞,康惠贞.乌司他丁、生长抑素联合泮托拉唑钠对急性重症胰腺炎患者炎症因子的影响.中国医刊,2014(12):64-65.
[8]欧云崧,贾利猛,王明锋,等.生长抑素联合乌司他丁治疗急性重症胰腺炎患者的临床分析.中国医学前沿杂志电子版,2014,6(4):84-86.
[9]郑盛,杨涓,张帆,等.生长抑素联合乌司他丁治疗重症急性胰腺炎临床疗效及安全性分析.现代生物医学进展,2016,16(30):5941-5944.
[10]贾会文,冯延冰,刘向业,等.生长抑素联合乌司他丁对重症急性胰腺炎患者腹内压的影响.中国生化药物杂志,2014,34(8):43.
[11]朱国福.生长抑素联合乌司他丁治疗重症急性胰腺炎的疗效.实用临床医学,2015,16(5):9.
[12]王永.乌司他丁联合生长抑素治疗急性胰腺炎的临床研究.中国现代医生,2012,50(31):75-77.
[13]敖栋基.生长抑素联合乌司他丁治疗急性胰腺炎的疗效观察.现代诊断与治疗,2016,27(4):645-647.
[14]邓永胜,邓启亮,王李妮,等.联合使用生长抑素及乌司他丁在急性胰腺炎治疗中的疗效观察.医药前沿,2012,2(1):40.
[15]王素梅.生长抑素联合乌司他丁对重症急性胰腺炎的治疗效果分析.临床医药文献电子杂志,2014(4):620.
[16]张彦宏,朴熙绪.乌司他汀联合生长抑素治疗重症急性胰腺炎疗效观察.现代预防医学,2011,38(21):4548-4549.