氨谷乳膏治疗黄褐斑40例临床观察
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摘要
目的观察氨谷乳膏治疗黄褐斑的临床疗效。方法 80例黄褐斑患者随机分为两组。治疗组40例外涂6%氨谷乳膏2次/d,对照组40例外涂3%氢醌霜2次/d。两组患者同时口服维生素E 0. 1g/次,1次/d,维生素C 0. 2g/次,3次/d。两组患者均治疗3个月为1个疗程,疗程结束后比较两组患者的疗效、黄褐斑评分和满意度评价判定治疗效果。结果临床疗效比较对照组的有效率为65. 00%,治疗组为50. 00%,差异无统计学意义(P> 0. 05);两组患者治疗后黄褐斑的面积、黄褐斑的积分与治疗前比较,差异有统计学意义(P <0. 05);对照组患者的满意度为80. 00%,治疗组为67. 50%。结论局部外用氨谷乳膏也是治疗黄褐斑的有效方法之一。
Objective To observe the clinical efficacy of tranexamic acid and glutathione cream in the treatment of chloasmas. Methods Eighty cases of chloasma were randomly divided into two groups. In the treatment group,topical applicated with 6% tranexamic acid and glutathione cream,twice a day; the control group was treated with 3% hydroquinone cream,twice a day. Patients in both groups received oral vitamin E 0. 1 g/d.Vitamin C 0. 6 g/d. The efficacy and the chloasma score were compared after the treatment for 3 months. Results The total effective rate was 65. 00% in the control group,50. 00% in the treatment group,and there was no statistically significant difference(P > 0. 05). Compared with baseline,the area of chloasma and the score of chloasma were reduced,the difference was statistically significant(P < 0. 05). In the control group,the degree of satisfaction was 80. 00% and the treatment group was67. 50%. Conclusion The topical application of tranexamic acid and glutathione cream is one of the effective methods for the treatment of chloasma.
Objective To observe the clinical efficacy of tranexamic acid and glutathione cream in the treatment of chloasmas. Methods Eighty cases of chloasma were randomly divided into two groups. In the treatment group,topical applicated with 6% tranexamic acid and glutathione cream,twice a day; the control group was treated with 3% hydroquinone cream,twice a day. Patients in both groups received oral vitamin E 0. 1 g/d.Vitamin C 0. 6 g/d. The efficacy and the chloasma score were compared after the treatment for 3 months. Results The total effective rate was 65. 00% in the control group,50. 00% in the treatment group,and there was no statistically significant difference(P > 0. 05). Compared with baseline,the area of chloasma and the score of chloasma were reduced,the difference was statistically significant(P < 0. 05). In the control group,the degree of satisfaction was 80. 00% and the treatment group was67. 50%. Conclusion The topical application of tranexamic acid and glutathione cream is one of the effective methods for the treatment of chloasma.
引文
[1]中国中西医结合学会皮肤性病专业委员会色素病学组.中国黄褐斑治疗专家共识(2015)[J].中华皮肤科杂志,2016,49(8):529-532.
[2]钱晓莺,赵春华.氨甲环酸不同给药途径治疗黄褐斑的疗效观察[J].中华皮肤科杂志,2013,46(8):598-599.
[3]赵思佳,王光平.黄褐斑的治疗进展[J].国际皮肤性病学杂志,2017,43(1):17-20.
[4]Dunn CJ,Goa KL.Tranexamic acid:A review of its use in surgery and other indications[J].Drugs,1999,57(6):1005-1032.
[5]二条贞子.トラネキサ厶酸による肝斑の治疗[J].基础と临床,1979,13(9):3129-3131.
[6]Maeda K,Tomita Y.Mechanism of the inhibitory effect of tranexamic acid on melanogenesis in cultured human melanocytes in the presence of keratinocyte-conditioned medium[J].J Health Sci,2007,53(4):389-396.
[7]Lee JH,Park JG,Lim SH.Localized intradermal microinjection of tranexamic acid for treatment of melasma in Asian patients:a preliminary clinical trial[J].Dermatol Surg,2006,32(5):626-631.
[8]Wellington K.Tranexamic acid:a review of its use in the management of menorrhagia[J].Drugs,2003,63(13):456-471.
[9]杨晓霞,曹莫.氨甲环酸治疗黄褐斑[J].中国美容整形外科杂志,2016,27(3):170-172.
[2]钱晓莺,赵春华.氨甲环酸不同给药途径治疗黄褐斑的疗效观察[J].中华皮肤科杂志,2013,46(8):598-599.
[3]赵思佳,王光平.黄褐斑的治疗进展[J].国际皮肤性病学杂志,2017,43(1):17-20.
[4]Dunn CJ,Goa KL.Tranexamic acid:A review of its use in surgery and other indications[J].Drugs,1999,57(6):1005-1032.
[5]二条贞子.トラネキサ厶酸による肝斑の治疗[J].基础と临床,1979,13(9):3129-3131.
[6]Maeda K,Tomita Y.Mechanism of the inhibitory effect of tranexamic acid on melanogenesis in cultured human melanocytes in the presence of keratinocyte-conditioned medium[J].J Health Sci,2007,53(4):389-396.
[7]Lee JH,Park JG,Lim SH.Localized intradermal microinjection of tranexamic acid for treatment of melasma in Asian patients:a preliminary clinical trial[J].Dermatol Surg,2006,32(5):626-631.
[8]Wellington K.Tranexamic acid:a review of its use in the management of menorrhagia[J].Drugs,2003,63(13):456-471.
[9]杨晓霞,曹莫.氨甲环酸治疗黄褐斑[J].中国美容整形外科杂志,2016,27(3):170-172.