从《内经》“五脏皆柔弱,善病消瘅”理论探讨2型糖尿病防治策略
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摘要
从《内经》中"五脏皆柔弱,善病消瘅"理论认识出发,探讨防治2型糖尿病的策略。"五脏皆柔弱"是导致2型糖尿病发生、发展及转归的根本病因病机,由于五脏柔弱,内在之脏先天真阴真阳不足,而使脏腑之阴津阳气输布运行失常,津伤则化燥,气运失司则气机失衡,则代谢失司而发为消渴。久则瘀血、痰饮等诸多病理产物互相为患,形成恶性病理循环,从而导致糖尿病诸多并发症如糖尿病肾病、视网膜病变、血管病变等发生和进一步恶化。因此,该文从《内经》"五脏皆柔弱,善病消瘅"的思想认识进行发挥,围绕这一理论探究防治2型糖尿病的策略。
From Inner Canon of Huangdi"those with delicate weakness of five Zang organs are easily involved with diabetes"theory perspective,to explore strategies for the prevention and treatment of type 2 diabetes."Delicate weakness of five Zang organs"is leading to type 2 diabetes occurrence,development and outcome of etiology and pathogenesis,due to the five Zang-organs vulnerability,inner dirty first naive Yin and naive Yang deficiency,and make the viscera dysfunction of Yinjin and Yangqi,Jin injury is dry,lost fate is angry machine imbalance,the metabolism of division and for diabetes. Blood stasis,phlegm retention,inflammation,and many other pathogenic products with each other,a vicious pathologic circulation,which can lead to diabetes complications such as diabetic nephropathy,retinopathy,vascular lesions such as root cause of the occurrence and further deterioration. Therefore,this article from Inner Canon of Huangdi"those with delicate weakness of five Zang organs are easily involved with diabetes"the ideological understanding of play,around this theory to explore the strategy for the prevention and treatment of type 2 diabetes.
From Inner Canon of Huangdi"those with delicate weakness of five Zang organs are easily involved with diabetes"theory perspective,to explore strategies for the prevention and treatment of type 2 diabetes."Delicate weakness of five Zang organs"is leading to type 2 diabetes occurrence,development and outcome of etiology and pathogenesis,due to the five Zang-organs vulnerability,inner dirty first naive Yin and naive Yang deficiency,and make the viscera dysfunction of Yinjin and Yangqi,Jin injury is dry,lost fate is angry machine imbalance,the metabolism of division and for diabetes. Blood stasis,phlegm retention,inflammation,and many other pathogenic products with each other,a vicious pathologic circulation,which can lead to diabetes complications such as diabetic nephropathy,retinopathy,vascular lesions such as root cause of the occurrence and further deterioration. Therefore,this article from Inner Canon of Huangdi"those with delicate weakness of five Zang organs are easily involved with diabetes"the ideological understanding of play,around this theory to explore the strategy for the prevention and treatment of type 2 diabetes.
引文
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[14]庞博,赵进喜,王颖辉,等.糖尿病清热解毒治法探讨[J].中华中医药杂志,2011,26(7):1471-1474.
[15]柴可夫,王亚丽.从痰瘀论治胰岛素抵抗[J].中华中医药杂志,2005(9):542-543.
[16]杜丽坤,徐洪涛,王冰梅.益气养阴、化瘀涤痰法改善2型糖尿病胰岛素抵抗机制研究[J].哈尔滨医科大学学报,2014,48(2):149-151.
[17]单亮亮,邓小敏,郭超峰,等.五味消渴方治疗气阴两虚证2型糖尿病患者临床观察[J].中国实验方剂学杂志,2017,23(24):170-174.
[18]谢君艳,王振刚,邓小敏.自拟五味消渴方加减治疗2型糖尿病30例临床观察[J].湖南中医杂志,2018,34(1):60-62.
[19]单亮亮,邓小敏,郭超峰,等.邓小敏应用五味消渴方治疗糖尿病经验[J].中医药临床杂志,2017,29(5):631-633.
[20]Chen L,Magliano DJ,Zimmet PZ. The world wide epidemiologyof type 2 diabetes mellitus present and future perspectives[J].Nat Rev Endocrinol,2012,8(4):228-236.
[21]周方圆,陈璇.糖尿病中医体质研究现状[J].中医学报,2015,30(3):343-345.
[22]贾伟平,陆菊明,纪立农,等.中国2型糖尿病防治指南(2017年版)[J].中国实用内科杂志,2018,38(4):292-344.
[2]佚名.黄帝内经·素问[M].田代华,整理.北京:人民卫生出版社,2005:12-13.
[3]文颖娟.《内经》消渴病症探微[J].辽宁中医杂志,2015,42(2):276-277.
[4]胡晓菡,张葵.胰岛β细胞炎症与2型糖尿病[J].现代生物医学进展,2012,12(29):5769-5771,5785.
[5]冯兴中,王永炎.论“百病生于气也”[J].北京中医药大学学报,2014,37(1):5-8,14.
[6]许成群,李中南,周元平.糖尿病“瘀血阻滞”理论及其应用[J].世界中西医结合杂志,2015,10(2):290-292,296.
[7]张黎明,高凌.炎症细胞因子在2型糖尿病发病机制中的研究进展[J].重庆医学,2016,45(8):1113-1116.
[8]马凌云,孙凌玉,康静蕊,等.2型糖尿病与炎症因子CRP、TNF-α、IL-6的关系[J].临床医药文献电子杂志,2017,4(56):11052.
[9]姚燕琴,师社会.阿司匹林对糖尿病模型大鼠血糖的影响[J].中国药师,2012,15(9):1299-1301.
[10]余琛琳,宗英,张晓芳,等.IL-1抑制剂研发策略及临床应用进展[J].中国新药杂志,2014,23(10):1121-1126.
[11]王颖,王兴亚.抗炎药物用于2型糖尿病预防与治疗的研究进展[J].药学进展,2016,40(3):178-188.
[12]阮承超,高平进.免疫与炎症参与高血压发生发展的机制探讨[J].中华高血压杂志,2017,25(4):319-321.
[13]杨秀颖,张莉,陈熙,等.2型糖尿病周围神经病变机制研究进展[J].中国药理学通报,2016,32(5):598-602.
[14]庞博,赵进喜,王颖辉,等.糖尿病清热解毒治法探讨[J].中华中医药杂志,2011,26(7):1471-1474.
[15]柴可夫,王亚丽.从痰瘀论治胰岛素抵抗[J].中华中医药杂志,2005(9):542-543.
[16]杜丽坤,徐洪涛,王冰梅.益气养阴、化瘀涤痰法改善2型糖尿病胰岛素抵抗机制研究[J].哈尔滨医科大学学报,2014,48(2):149-151.
[17]单亮亮,邓小敏,郭超峰,等.五味消渴方治疗气阴两虚证2型糖尿病患者临床观察[J].中国实验方剂学杂志,2017,23(24):170-174.
[18]谢君艳,王振刚,邓小敏.自拟五味消渴方加减治疗2型糖尿病30例临床观察[J].湖南中医杂志,2018,34(1):60-62.
[19]单亮亮,邓小敏,郭超峰,等.邓小敏应用五味消渴方治疗糖尿病经验[J].中医药临床杂志,2017,29(5):631-633.
[20]Chen L,Magliano DJ,Zimmet PZ. The world wide epidemiologyof type 2 diabetes mellitus present and future perspectives[J].Nat Rev Endocrinol,2012,8(4):228-236.
[21]周方圆,陈璇.糖尿病中医体质研究现状[J].中医学报,2015,30(3):343-345.
[22]贾伟平,陆菊明,纪立农,等.中国2型糖尿病防治指南(2017年版)[J].中国实用内科杂志,2018,38(4):292-344.